FI75337C - Foerfarande foer framstaellning av 9-(3-isopropylaminopropyl)-9-karbamoylfluoren, samt ny mellanprodukt. - Google Patents
Foerfarande foer framstaellning av 9-(3-isopropylaminopropyl)-9-karbamoylfluoren, samt ny mellanprodukt. Download PDFInfo
- Publication number
- FI75337C FI75337C FI811176A FI811176A FI75337C FI 75337 C FI75337 C FI 75337C FI 811176 A FI811176 A FI 811176A FI 811176 A FI811176 A FI 811176A FI 75337 C FI75337 C FI 75337C
- Authority
- FI
- Finland
- Prior art keywords
- fluorene
- carbamoyl
- isopropylaminopropyl
- compound
- mixture
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C253/00—Preparation of carboxylic acid nitriles
- C07C253/30—Preparation of carboxylic acid nitriles by reactions not involving the formation of cyano groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C255/00—Carboxylic acid nitriles
- C07C255/45—Carboxylic acid nitriles having cyano groups bound to carbon atoms of rings other than six-membered aromatic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C255/00—Carboxylic acid nitriles
- C07C255/01—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms
- C07C255/24—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms containing cyano groups and singly-bound nitrogen atoms, not being further bound to other hetero atoms, bound to the same saturated acyclic carbon skeleton
- C07C255/29—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms containing cyano groups and singly-bound nitrogen atoms, not being further bound to other hetero atoms, bound to the same saturated acyclic carbon skeleton containing cyano groups and acylated amino groups bound to the carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2603/00—Systems containing at least three condensed rings
- C07C2603/02—Ortho- or ortho- and peri-condensed systems
- C07C2603/04—Ortho- or ortho- and peri-condensed systems containing three rings
- C07C2603/06—Ortho- or ortho- and peri-condensed systems containing three rings containing at least one ring with less than six ring members
- C07C2603/10—Ortho- or ortho- and peri-condensed systems containing three rings containing at least one ring with less than six ring members containing five-membered rings
- C07C2603/12—Ortho- or ortho- and peri-condensed systems containing three rings containing at least one ring with less than six ring members containing five-membered rings only one five-membered ring
- C07C2603/18—Fluorenes; Hydrogenated fluorenes
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Heart & Thoracic Surgery (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Cardiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US06/141,229 US4282170A (en) | 1980-04-17 | 1980-04-17 | 9-Carbamoyl-9-(2-cyanoethyl)fluorenes |
| US14122980 | 1980-04-17 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| FI811176L FI811176L (fi) | 1981-10-18 |
| FI75337B FI75337B (fi) | 1988-02-29 |
| FI75337C true FI75337C (fi) | 1988-06-09 |
Family
ID=22494758
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FI811176A FI75337C (fi) | 1980-04-17 | 1981-04-15 | Foerfarande foer framstaellning av 9-(3-isopropylaminopropyl)-9-karbamoylfluoren, samt ny mellanprodukt. |
Country Status (26)
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4552982A (en) * | 1983-08-01 | 1985-11-12 | Eli Lilly And Company | Synthesis of 9-carbamoyl-9-(3-aminopropyl)fluorenes |
| US4508735A (en) * | 1983-09-21 | 1985-04-02 | Eli Lilly And Company | Anti-arrhythmic N-alkanoylaminoalkyl fluorenes |
| US4486592A (en) * | 1983-10-19 | 1984-12-04 | Eli Lilly And Company | 9-Carbamoylfluorene derivatives |
| IL73261A (en) * | 1983-10-19 | 1988-03-31 | Lilly Co Eli | Process for producing 9-carbamoyl-9-aminoalkyl fluorene derivatives,and certain intermediates thereof |
| US4585894A (en) * | 1983-10-19 | 1986-04-29 | Eli Lilly And Company | Process for producing 9-carbamoyl fluorene derivatives |
| US4842420A (en) * | 1987-12-14 | 1989-06-27 | Mobil Oil Corporation | Variable-width draw tape for thermoplastic bags |
| US5736578A (en) * | 1995-06-06 | 1998-04-07 | Bristol-Myers Squibb Company | Ethylamido fluorenes and improved method of making same |
| CN1209803A (zh) * | 1996-01-16 | 1999-03-03 | 布里斯托尔-迈尔斯斯奎布公司 | 微粒体甘油三酯转移蛋白的构象限制性芳族抑制剂及方法 |
| US5760246A (en) | 1996-12-17 | 1998-06-02 | Biller; Scott A. | Conformationally restricted aromatic inhibitors of microsomal triglyceride transfer protein and method |
| CN100463249C (zh) * | 2006-01-24 | 2009-02-18 | 吉林大学 | 电化学沉积制备有机发光薄膜的方法及在发光器件中的应用 |
| US7520124B2 (en) * | 2006-09-12 | 2009-04-21 | United Technologies Corporation | Asymmetric serrated nozzle for exhaust noise reduction |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2280058A (en) * | 1942-04-21 | Cyanoethylation of carbocycijc | ||
| GB960758A (en) | 1962-12-21 | 1964-06-17 | Boehringer & Soehne Gmbh | Basic fluorene derivatives |
| US3325544A (en) * | 1965-06-10 | 1967-06-13 | Upjohn Co | 9-(2-amino-1-methylethyl) fluoren-9-ol and salts thereof |
| US3660485A (en) * | 1970-10-05 | 1972-05-02 | Searle & Co | Fluorene-9-carboxylic acid hydrazides |
| US3843657A (en) * | 1972-12-08 | 1974-10-22 | Searle & Co | 9-dialkylamin oalkyl-n-substituted fluorene-9-carboxamides |
-
1980
- 1980-04-17 US US06/141,229 patent/US4282170A/en not_active Expired - Lifetime
-
1981
- 1981-04-14 GR GR64688A patent/GR73824B/el unknown
- 1981-04-14 NZ NZ196814A patent/NZ196814A/en unknown
- 1981-04-14 CA CA000375408A patent/CA1172646A/en not_active Expired
- 1981-04-14 PT PT72854A patent/PT72854B/pt not_active IP Right Cessation
- 1981-04-14 PH PH25498A patent/PH15857A/en unknown
- 1981-04-14 CS CS812820A patent/CS225833B2/cs unknown
- 1981-04-14 AR AR284966A patent/AR228596A1/es active
- 1981-04-14 ES ES501339A patent/ES8302632A1/es not_active Expired
- 1981-04-14 ZA ZA00812482A patent/ZA812482B/xx unknown
- 1981-04-15 FI FI811176A patent/FI75337C/fi not_active IP Right Cessation
- 1981-04-15 AT AT81301666T patent/ATE9897T1/de active
- 1981-04-15 EP EP81301666A patent/EP0038676B1/en not_active Expired
- 1981-04-15 DE DE8181301666T patent/DE3166679D1/de not_active Expired
- 1981-04-15 DK DK172181A patent/DK172181A/da active IP Right Grant
- 1981-04-15 GB GB8111886A patent/GB2074161B/en not_active Expired
- 1981-04-16 SU SU813310061A patent/SU1297724A3/ru active
- 1981-04-16 AU AU69611/81A patent/AU543345B2/en not_active Ceased
- 1981-04-16 JP JP5835681A patent/JPS574954A/ja active Granted
- 1981-04-16 DD DD81229304A patent/DD158395A5/de not_active IP Right Cessation
- 1981-04-16 RO RO104045A patent/RO82739B/ro unknown
- 1981-04-16 IE IE873/81A patent/IE51221B1/en not_active IP Right Cessation
- 1981-04-16 PL PL1981230714A patent/PL131122B1/pl unknown
- 1981-04-16 BG BG8151701A patent/BG35464A3/xx unknown
- 1981-04-17 IL IL62669A patent/IL62669A/xx unknown
- 1981-04-17 KR KR1019810001317A patent/KR840001071B1/ko active
-
1988
- 1988-10-04 JP JP63251711A patent/JPH01125363A/ja active Granted
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| Broughton et al. | Antiallergic activity of 2-phenyl-8-azapurin-6-ones | |
| FI75337C (fi) | Foerfarande foer framstaellning av 9-(3-isopropylaminopropyl)-9-karbamoylfluoren, samt ny mellanprodukt. | |
| CH630359A5 (de) | Verfahren zur herstellung von neuen aminoalkylheterocyclen und ihren saeureadditionssalzen. | |
| Byrnes et al. | New antiarrhythmic agents. 1. Primary. alpha.-amino anilides | |
| PL113997B1 (en) | Process for preparing novel 4-acyloaminophenylethanoloamines | |
| Banitt et al. | Resolution of flecainide acetate, N-(2-piperidylmethyl)-2, 5-bis (2, 2, 2-trifluoroethoxy) benzamide acetate, and antiarrhythmic properties of the enantiomers | |
| US4072760A (en) | Bronchospasmolytic phenylethanolamines | |
| EP0379483B1 (en) | 1,2,3,4,10,14b-HEXAHYDRODIBENZO c,f]PYRAZINO- 1,2-a]AZEPINO DERIVATIVES | |
| Di Parsia et al. | Synthesis and study of the potential antiallergic activity of some pyrazole derivatives | |
| FI77650C (fi) | Foerfarande foer framstaellning av terapeutiskt aktiva 2-amino-1,2,3,4-tetrahydronaftalenderivat. | |
| AU615203B2 (en) | Tertiary 2,5-dialkyl-3-phenylpiperidine derivatives having opiate-antagonistic activity | |
| PL141640B1 (en) | Method of obtaining novel derivatives of hexahydropyrol/1,2-a/quinoline,hexahydro-1h-pyrid/1,2-a/quinoline or octahydroxyphenathrene | |
| DE2413102B2 (de) | Verfahren zur Herstellung von t-(33-Dihydroxyphenyl)-)-hydroxy-2- eckige Klammer auf l-methyl-2-(4-hydroxyphenyl)- äthyl] -aminoäthan | |
| Thyrum et al. | p-Amino-N-[2-(substituted amino) ethyl] benzamides. Potential antifibrillatory drugs | |
| US4603019A (en) | N-(methoxyphenacyl)-amine derivatives | |
| US4013679A (en) | Substituted 6,7-dihydro [1,7-ab](1) benzazepine compounds | |
| Counsell et al. | Esters of Bicyclic Aminoalcohols II: The Synthesis of the Hydroxyquinolizidines and Some of Their Esters as Potential Therapeutic Agents | |
| Iorio et al. | Synthesis, stereochemistry, and biological activity of the 1-(1-phenyl-2-methylcyclohexyl) piperidines and the 1-(1-phenyl-4-methylcyclohexyl) piperidines. Absolute configuration of the potent trans-(-)-1-(1-phenyl-2-methylcyclohexyl) piperidine | |
| Klioze et al. | Synthesis and antihypertensive activity of 2-benzamido-1, 2, 3, 4, 6, 7, 12, 12b-octahydroindolo [2, 3-a] quinolizines | |
| EP0000013A1 (de) | 4-Phenyl-8-amino-tetrahydroisochinoline, diese enthaltende pharmazeutische Präparate und Verfahren zur Herstellung dieser Präparate | |
| PL94151B1 (US08197722-20120612-C00042.png) | ||
| Jacoby et al. | Structure-activity studies on narcotic antagonists. 1. N-Substituted ethyl 3-phenylpyrrolidine-3-carboxylates and ethyl 3-phenylnipecotates | |
| Mathison et al. | Synthesis, stereochemistry, and antiarrhythmic activity of some 8-substituted decahydroisoquinolines | |
| KR840002104B1 (ko) | 신규 이소퀴놀린 유도체의 제법 | |
| Johnson et al. | Synthesis of substituted 2-aminopyrrole analogs of lidocaine I |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MM | Patent lapsed | ||
| MM | Patent lapsed |
Owner name: ELI LILLY AND COMPANY |