FI74973C - Foerfarande foer framstaellning av terapeutiskt aktiva 3-/(1-metyl-1-pyrrolidinium)metyl/-3-cefem-4 -karboxylatderivat. - Google Patents

Foerfarande foer framstaellning av terapeutiskt aktiva 3-/(1-metyl-1-pyrrolidinium)metyl/-3-cefem-4 -karboxylatderivat. Download PDF

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Publication number
FI74973C
FI74973C FI830689A FI830689A FI74973C FI 74973 C FI74973 C FI 74973C FI 830689 A FI830689 A FI 830689A FI 830689 A FI830689 A FI 830689A FI 74973 C FI74973 C FI 74973C
Authority
FI
Finland
Prior art keywords
methyl
carboxylate
pyrrolidinium
cephem
compound
Prior art date
Application number
FI830689A
Other languages
English (en)
Finnish (fi)
Swedish (sv)
Other versions
FI830689L (fi
FI74973B (fi
FI830689A0 (fi
Inventor
Jun Okumura
Takayuki Naito
Hajime Kamachi
Shimpei Aburaki
Yukio Narita
Original Assignee
Bristol Myers Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US06/354,851 external-priority patent/US4406899A/en
Application filed by Bristol Myers Co filed Critical Bristol Myers Co
Publication of FI830689A0 publication Critical patent/FI830689A0/fi
Publication of FI830689L publication Critical patent/FI830689L/fi
Publication of FI74973B publication Critical patent/FI74973B/fi
Application granted granted Critical
Publication of FI74973C publication Critical patent/FI74973C/fi

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
    • C07D501/24—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3
    • C07D501/38—Methylene radicals, substituted by nitrogen atoms; Lactams thereof with the 2-carboxyl group; Methylene radicals substituted by nitrogen-containing hetero rings attached by the ring nitrogen atom; Quaternary compounds thereof
    • C07D501/46—Methylene radicals, substituted by nitrogen atoms; Lactams thereof with the 2-carboxyl group; Methylene radicals substituted by nitrogen-containing hetero rings attached by the ring nitrogen atom; Quaternary compounds thereof with the 7-amino radical acylated by carboxylic acids containing hetero rings
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Cephalosporin Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
FI830689A 1982-03-04 1983-03-01 Foerfarande foer framstaellning av terapeutiskt aktiva 3-/(1-metyl-1-pyrrolidinium)metyl/-3-cefem-4 -karboxylatderivat. FI74973C (fi)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US35485182 1982-03-04
US06/354,851 US4406899A (en) 1982-03-04 1982-03-04 Cephalosporins
US35753482A 1982-03-12 1982-03-12
US35753482 1982-03-12

Publications (4)

Publication Number Publication Date
FI830689A0 FI830689A0 (fi) 1983-03-01
FI830689L FI830689L (fi) 1983-09-05
FI74973B FI74973B (fi) 1987-12-31
FI74973C true FI74973C (fi) 1988-04-11

Family

ID=26998584

Family Applications (1)

Application Number Title Priority Date Filing Date
FI830689A FI74973C (fi) 1982-03-04 1983-03-01 Foerfarande foer framstaellning av terapeutiskt aktiva 3-/(1-metyl-1-pyrrolidinium)metyl/-3-cefem-4 -karboxylatderivat.

Country Status (29)

Country Link
KR (1) KR870001986B1 (xx)
AT (2) AT382155B (xx)
AU (1) AU562776B2 (xx)
BE (1) BE896086A (xx)
CA (1) CA1213882A (xx)
CH (1) CH654313A5 (xx)
CS (1) CS249512B2 (xx)
DD (1) DD210280A5 (xx)
DE (1) DE3307550A1 (xx)
DK (1) DK156900C (xx)
EG (1) EG15934A (xx)
ES (2) ES8403919A1 (xx)
FI (1) FI74973C (xx)
FR (1) FR2522659B1 (xx)
GB (1) GB2116180B (xx)
GR (1) GR77916B (xx)
HU (1) HU193158B (xx)
IE (1) IE56647B1 (xx)
IL (1) IL68011A0 (xx)
IT (1) IT1170307B (xx)
LU (1) LU84674A1 (xx)
MY (1) MY8700943A (xx)
NL (2) NL193284C (xx)
NZ (1) NZ203312A (xx)
PH (1) PH18002A (xx)
PT (1) PT76330B (xx)
SE (1) SE453091B (xx)
SU (1) SU1250173A3 (xx)
YU (2) YU43822B (xx)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3409431A1 (de) * 1983-10-08 1985-04-18 Hoechst Ag, 6230 Frankfurt Cephalosporinderivate und verfahren zu ihrer herstellung
DE3404906A1 (de) * 1984-02-11 1985-08-14 Bayer Ag, 5090 Leverkusen 1-oxadethiacephalosporinderivate sowie verfahren zu ihrer herstellung
DE3419013A1 (de) * 1984-05-22 1985-11-28 Bayer Ag, 5090 Leverkusen Neue cephalosporine und verfahren zu ihrer herstellung
GB8424692D0 (en) * 1984-10-01 1984-11-07 Glaxo Group Ltd Chemical compounds
US4698336A (en) * 1985-01-30 1987-10-06 Eisai Co., Ltd. 3-(pyrrolidinio)methyl-3-cephem derivatives
US4910301A (en) * 1985-08-05 1990-03-20 Bristol-Myers Company Cefepime cephalosporin salts
CA1284994C (en) * 1985-08-05 1991-06-18 Murray Arthur Kaplan Cephalosporin salts and injectable compositions
US4808617A (en) * 1985-12-18 1989-02-28 Bristol-Myers Company Lyophilized or precipitated cephalosporin zwitterion and salt combination
EP0237735B1 (en) * 1986-03-17 1994-03-30 Fujisawa Pharmaceutical Co., Ltd. 3,7-Disubstituted-3-cephem compounds and process for production of the same
CA2011116C (en) * 1989-03-06 1999-11-16 Murray A. Kaplan Lyophilized bmy-28142 dihydrochloride for parenteral use
DE69231815T2 (de) 1991-03-08 2001-09-27 Biochemie Ges.M.B.H., Kundl Verfahren zur Herstellung von Cephalosporinen und Zwischenprodukte in diesem Verfahren
MY108872A (en) * 1991-09-10 1996-11-30 Bristol Myers Squibb Co Preparation of a cephalosporin antibiotic using the syn-isomer of a thiazolyl intermediate.
YU81692A (sh) * 1991-09-10 1995-03-27 Bristol-Myers Co. Postupak za proizvodnju cefalosporinskog antibiotika
US5523400A (en) * 1993-04-16 1996-06-04 Hoffmann-La Roche Inc. Cephalosporin antibiotics
JP4616844B2 (ja) * 2003-12-23 2011-01-19 サンド・ゲーエムベーハー セファロスポリン合成に使用するための中間体の生成プロセス

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2760484C2 (xx) * 1976-04-14 1992-12-03 Takeda Chemical Industries, Ltd., Osaka, Jp
GB1591439A (en) * 1976-10-01 1981-06-24 Glaxo Operations Ltd 7-syn (oxyimino -acylamido) cephalosporins
AR229883A1 (es) * 1978-05-26 1983-12-30 Glaxo Group Ltd Procedimiento para la preparacion de antibiotico(6r,7r)-7-((z)-2-(2-aminotiazol-4-il)-2-(2-carboxiprop-2-oxiimino)-acetamido)-3-(1-piridinometil)-cef-3-em-4-carboxilato
SE7908895L (sv) * 1978-10-27 1980-04-28 Glaxo Group Ltd Cefalosporinforeningar
US4443444A (en) * 1980-08-11 1984-04-17 Fujisawa Pharmaceutical Co., Ltd. Cephem compounds

Also Published As

Publication number Publication date
CH654313A5 (de) 1986-02-14
ES520224A0 (es) 1984-04-01
LU84674A1 (fr) 1983-11-17
GB2116180A (en) 1983-09-21
YU149685A (en) 1986-02-28
BE896086A (fr) 1983-09-05
ES526397A0 (es) 1985-09-16
ES8507557A1 (es) 1985-09-16
NL8300755A (nl) 1983-10-03
SE453091B (sv) 1988-01-11
DE3307550C2 (xx) 1988-11-24
NZ203312A (en) 1985-12-13
PT76330A (en) 1983-04-01
FI830689L (fi) 1983-09-05
GB2116180B (en) 1985-09-18
IE830455L (en) 1983-09-04
CA1213882A (en) 1986-11-12
NL193284B (nl) 1999-01-04
ES8403919A1 (es) 1984-04-01
NL193284C (nl) 1999-05-06
DK86283D0 (da) 1983-02-24
PT76330B (en) 1986-02-04
KR870001986B1 (ko) 1987-10-24
AT382155B (de) 1987-01-26
FI74973B (fi) 1987-12-31
ATA76183A (de) 1986-06-15
HU193158B (en) 1987-08-28
IE56647B1 (en) 1991-10-23
DK156900B (da) 1989-10-16
IT8347826A0 (it) 1983-03-01
YU44777B (en) 1991-02-28
FI830689A0 (fi) 1983-03-01
DE3307550A1 (de) 1983-09-15
AU1130483A (en) 1983-09-08
NL990039I2 (nl) 2000-04-03
SE8301178D0 (sv) 1983-03-03
NL990039I1 (nl) 2000-01-03
PH18002A (en) 1985-02-28
DK156900C (da) 1990-03-12
CS249512B2 (en) 1987-03-12
SE8301178L (sv) 1983-09-05
ATA228285A (de) 1987-05-15
EG15934A (en) 1987-10-30
IL68011A0 (en) 1983-06-15
IT1170307B (it) 1987-06-03
SU1250173A3 (ru) 1986-08-07
FR2522659A1 (fr) 1983-09-09
YU43822B (en) 1989-12-31
FR2522659B1 (fr) 1986-10-24
GR77916B (xx) 1984-09-25
AU562776B2 (en) 1987-06-18
AT384612B (de) 1987-12-10
DD210280A5 (de) 1984-06-06
MY8700943A (en) 1987-12-31
KR840004118A (ko) 1984-10-06
YU52383A (en) 1986-02-28
DK86283A (da) 1983-09-05
GB8305940D0 (en) 1983-04-07

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Legal Events

Date Code Title Description
ND Supplementary protection certificate (spc) granted
SPCG Supplementary protection certificate granted

Spc suppl protection certif: L31

Extension date: 20080301

MA Patent expired

Owner name: BRISTOL-MYERS CO