FI71153C - Foerfarande foer framstaellning av nya terapeutiskt anvaendbara 7-/3,6-dihydro-1h(2h)-pyridyl/-2-oxo-2h/1,2,4/-oxadiazolo-/2,3-c/pyrimidin-5-karbamat - Google Patents

Foerfarande foer framstaellning av nya terapeutiskt anvaendbara 7-/3,6-dihydro-1h(2h)-pyridyl/-2-oxo-2h/1,2,4/-oxadiazolo-/2,3-c/pyrimidin-5-karbamat Download PDF

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Publication number
FI71153C
FI71153C FI814048A FI814048A FI71153C FI 71153 C FI71153 C FI 71153C FI 814048 A FI814048 A FI 814048A FI 814048 A FI814048 A FI 814048A FI 71153 C FI71153 C FI 71153C
Authority
FI
Finland
Prior art keywords
dihydro
oxadiazolo
formula
oxo
carbamate
Prior art date
Application number
FI814048A
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English (en)
Finnish (fi)
Other versions
FI71153B (fi
FI814048L (fi
Inventor
Urs Hengartner
Jean-Claude Muller
Henri Ramuz
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of FI814048L publication Critical patent/FI814048L/fi
Publication of FI71153B publication Critical patent/FI71153B/fi
Application granted granted Critical
Publication of FI71153C publication Critical patent/FI71153C/fi

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/06—Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Claims (10)

1 H Ux" 30 /N. 35 med ett azolderivat med den allmänna formeln III 17 71153 \ Ν I COOR 5 väri R betecknar samma som ovan och A Sr -CH=CH- eller ^ | 10 och ifali önskvärt, överför en erhällen förening raed for-meln I i ett sait eller ett sait i ett annat sait.
1. Förfarande för framställning av nya terapeutiskt användbara 7-£3,6-dihydro-1 (2H) -pyridyl7“2-oxo-2H-//t,2,4_7~ 5 oxadiazolo/^,3-c7pyrimidin-5-karbamat med den allmänna formeIn I %-0 I i H
10 N-COOR I lj N /N 0 väri R är C^g-alkyl, C-,_g-alkenyl, C2_g-alkinyl eller 20 C^g-alkoxialkyl, och deras salter, känneteck-n a t därav, att man omsätter 5-amino-7-£3,6-dihydro-1 (2H) ”pyridyl7-2H-Z’l / 2,47oxadiazolo^2,3~q7pyrimidin-2-on med formeln II 25 %-o
2. Förfarande enligt patentkravet 1, k ä n n e - t e c k n a t därav, att man omsStter föreningen med for-meln II med ett azolderivat med formeln III, väri R Sr 15 C^_g-alkyl eller __g-alkoxialkyl.
3. Förfarande enligt patentkravet 2 för framställ-ning av metyl-7-/3,6-dihydro-1(2H)-pyridyl7-2-oxo-2H- C\ ,2,4_7oxadiazolo/2,3-c7pyrimidin-5“karbamat, känne-t e c k n a t därav, att man omsätter föreningen med for-20 mein II med ett azolderivat med formeln II, väri R Sr metyl.
4. Förfarande enligt patentkravet 2 för framställ-ning av etyl-7-/f3,6-dihydro-1(2H)-pyridyl7-2-oxo-2H- ,0,2,47oxadiazolo/2,3-c7"*pyi‘idimin-5-karbamat eller ett 25 sait därav, kännetecknat därav, att man omsätter föreningen med formeln II med ett azolderivat med formeln III, väri R Sr etyl.
5. Förfarande enligt patentkravet 2 för framställ-ning av isobutyl-7-/f3,6-dihydro-1 (2H) -pyridyl7-2-oxo-2H-
30 C\ ,2,47oxadiazolo/2,3-c7pyrimidin-5-karbamat eller ett sait därav, kännetecknat därav, att man omsätter föreningen med formeln II med ett azolderivat med formeln III, väri R är isobutyl.
6. Förfarande enligt patentkravet 2 för framställ-35 ning av butyl-7-,/3,6-dlhydro-1 (2H)-pyridyl7-2-oxo-2H- C\ ,2,47oxadiazolo£2,3-c7pyridimin-5-karbamat eller ett
FI814048A 1980-12-19 1981-12-16 Foerfarande foer framstaellning av nya terapeutiskt anvaendbara 7-/3,6-dihydro-1h(2h)-pyridyl/-2-oxo-2h/1,2,4/-oxadiazolo-/2,3-c/pyrimidin-5-karbamat FI71153C (fi)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
CH941080 1980-12-19
CH941080 1980-12-19
CH635081 1981-10-02
CH635081 1981-10-02

Publications (3)

Publication Number Publication Date
FI814048L FI814048L (fi) 1982-06-20
FI71153B FI71153B (fi) 1986-08-14
FI71153C true FI71153C (fi) 1986-11-24

Family

ID=25699419

Family Applications (1)

Application Number Title Priority Date Filing Date
FI814048A FI71153C (fi) 1980-12-19 1981-12-16 Foerfarande foer framstaellning av nya terapeutiskt anvaendbara 7-/3,6-dihydro-1h(2h)-pyridyl/-2-oxo-2h/1,2,4/-oxadiazolo-/2,3-c/pyrimidin-5-karbamat

Country Status (23)

Country Link
US (2) US4410698A (sv)
EP (1) EP0054866B1 (sv)
KR (1) KR880001636B1 (sv)
AR (1) AR229169A1 (sv)
AT (1) ATE14734T1 (sv)
AU (1) AU545324B2 (sv)
BR (1) BR8108269A (sv)
CA (1) CA1162538A (sv)
CS (1) CS226738B2 (sv)
DE (1) DE3171744D1 (sv)
DK (1) DK148826C (sv)
ES (1) ES8304125A1 (sv)
FI (1) FI71153C (sv)
GR (1) GR76969B (sv)
HU (1) HU183744B (sv)
IE (1) IE51800B1 (sv)
IL (1) IL64524A (sv)
MC (1) MC1438A1 (sv)
NO (1) NO158422C (sv)
NZ (1) NZ199250A (sv)
PH (1) PH17300A (sv)
PT (1) PT74153B (sv)
ZW (1) ZW28581A1 (sv)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK148826C (da) * 1980-12-19 1986-03-24 Hoffmann La Roche Analogifremgangsmaade til fremstilling af oxadiazolopyrimidinderivater eller salte deraf med baser og pyrimidinderivat til anvendelse som mellemprodukt ved denne fremgangsmaade
CH649291A5 (de) * 1982-03-16 1985-05-15 Hoffmann La Roche Dicarbamate.
EP0187854A4 (en) * 1984-07-13 1987-01-22 Gail S Bazzano SUBSTITUTED PYRIMIDINE OXIDES USEFUL FOR PROMOTING HAIR GROWTH.
LU86959A1 (fr) * 1987-07-31 1989-03-08 Oreal Nouveaux derives d'ureylene triamino-2,4,6 pyrimidine oxyde-3,leur preparation et leur utilisation en cosmetique et dermopharmacie
DE69715869T2 (de) * 1996-07-26 2003-05-28 Vantico Ag, Basel Auf epoxyharzen basierende imidazole enthaltende härtbare mischungen
CN117946133B (zh) * 2024-01-05 2024-08-06 南京理工大学 一种5-(4-氨基-1,2,5-噁二唑-3-基)[1,2,5]噁二唑并[3,4-d]嘧啶-7-胺及其制备方法

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH638215A5 (de) * 1977-02-04 1983-09-15 Hoffmann La Roche Oxadiazolopyrimidin-derivate.
CH638216A5 (de) * 1977-02-04 1983-09-15 Hoffmann La Roche Oxadiazolopyrimidin-deriate.
CA1103245A (en) * 1978-07-21 1981-06-16 Jean-Claude Muller Process for the manufacture of novel oxadiazolopyrimidine derivatives
NZ190915A (en) * 1978-07-31 1984-07-31 Hoffmann La Roche Oxadiazolotriazine derivatives and pharmaceutical compositions
DK148826C (da) * 1980-12-19 1986-03-24 Hoffmann La Roche Analogifremgangsmaade til fremstilling af oxadiazolopyrimidinderivater eller salte deraf med baser og pyrimidinderivat til anvendelse som mellemprodukt ved denne fremgangsmaade

Also Published As

Publication number Publication date
FI71153B (fi) 1986-08-14
ZW28581A1 (en) 1982-08-11
DK504881A (da) 1982-06-20
AU545324B2 (en) 1985-07-11
FI814048L (fi) 1982-06-20
IL64524A0 (en) 1982-03-31
EP0054866B1 (de) 1985-08-07
NO158422C (no) 1988-09-07
ATE14734T1 (de) 1985-08-15
ES508152A0 (es) 1983-02-16
HU183744B (en) 1984-05-28
AU7846481A (en) 1982-06-24
US4360521A (en) 1982-11-23
ES8304125A1 (es) 1983-02-16
DE3171744D1 (en) 1985-09-12
NZ199250A (en) 1984-04-27
EP0054866A3 (en) 1982-09-01
PT74153B (en) 1984-01-05
US4410698A (en) 1983-10-18
IE812990L (en) 1982-06-19
IE51800B1 (en) 1987-04-01
AR229169A1 (es) 1983-06-30
CA1162538A (en) 1984-02-21
IL64524A (en) 1985-05-31
GR76969B (sv) 1984-09-04
PT74153A (en) 1982-01-01
DK148826B (da) 1985-10-14
PH17300A (en) 1984-07-18
EP0054866A2 (de) 1982-06-30
CS226738B2 (en) 1984-04-16
BR8108269A (pt) 1982-10-05
DK148826C (da) 1986-03-24
NO158422B (no) 1988-05-30
MC1438A1 (fr) 1982-12-06
NO814359L (no) 1982-06-21
KR880001636B1 (ko) 1988-09-03

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Owner name: F. HOFFMANN-LA ROCHE AG