FI67699C - Foerfarande foer framstaellning av 6,7-dimetoxi-4-amino-2-(4-(2-furoyl)-1-piperazinyl)kinazolinhydroklorid med blodtryckssaenkande verkan - Google Patents

Foerfarande foer framstaellning av 6,7-dimetoxi-4-amino-2-(4-(2-furoyl)-1-piperazinyl)kinazolinhydroklorid med blodtryckssaenkande verkan Download PDF

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Publication number
FI67699C
FI67699C FI790320A FI790320A FI67699C FI 67699 C FI67699 C FI 67699C FI 790320 A FI790320 A FI 790320A FI 790320 A FI790320 A FI 790320A FI 67699 C FI67699 C FI 67699C
Authority
FI
Finland
Prior art keywords
furoyl
piperazinyl
dimethoxy
amino
yield
Prior art date
Application number
FI790320A
Other languages
English (en)
Finnish (fi)
Other versions
FI790320A (fi
FI67699B (fi
Inventor
Erkki Juhani Honkanen
Aino Kyllikki Pippuri
Pekka Juhani Kairisalo
Heinrich Thaler
Maija Katriina Koivisto
Sirpa Anneli Tuomi
Original Assignee
Orion Yhtymae Oy
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Orion Yhtymae Oy filed Critical Orion Yhtymae Oy
Priority to FI790320A priority Critical patent/FI67699C/fi
Priority to NO794279A priority patent/NO152298C/no
Priority to US06/110,589 priority patent/US4271300A/en
Priority to CA343,361A priority patent/CA1128945A/fr
Priority to CH12180A priority patent/CH644605A5/de
Priority to YU58/80A priority patent/YU41498B/xx
Priority to SI8010058A priority patent/SI8010058A8/sl
Priority to AT0019580A priority patent/AT374475B/de
Priority to NL8000289A priority patent/NL190701C/xx
Priority to BE0/199070A priority patent/BE881297A/fr
Priority to DE19803002553 priority patent/DE3002553A1/de
Priority to CS80588A priority patent/CS214692B2/cs
Priority to ZA00800501A priority patent/ZA80501B/xx
Priority to HU8080182A priority patent/HU181016B/hu
Priority to GB8002903A priority patent/GB2041932B/en
Priority to JP1081580A priority patent/JPS55104280A/ja
Priority to PL1980221684A priority patent/PL126994B1/pl
Priority to FR8001991A priority patent/FR2447920A1/fr
Priority to SU802874898A priority patent/SU900812A3/ru
Priority to DK042680A priority patent/DK158352C/da
Priority to SE8000777A priority patent/SE430692B/sv
Priority to DD80218776A priority patent/DD148952A1/de
Publication of FI790320A publication Critical patent/FI790320A/fi
Application granted granted Critical
Publication of FI67699B publication Critical patent/FI67699B/fi
Publication of FI67699C publication Critical patent/FI67699C/fi

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C07D239/72—Quinazolines; Hydrogenated quinazolines
    • C07D239/78—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 2
    • C07D239/84—Nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D307/56—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D307/68—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
    • C07D407/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing three or more hetero rings
FI790320A 1979-01-31 1979-01-31 Foerfarande foer framstaellning av 6,7-dimetoxi-4-amino-2-(4-(2-furoyl)-1-piperazinyl)kinazolinhydroklorid med blodtryckssaenkande verkan FI67699C (fi)

Priority Applications (22)

Application Number Priority Date Filing Date Title
FI790320A FI67699C (fi) 1979-01-31 1979-01-31 Foerfarande foer framstaellning av 6,7-dimetoxi-4-amino-2-(4-(2-furoyl)-1-piperazinyl)kinazolinhydroklorid med blodtryckssaenkande verkan
NO794279A NO152298C (no) 1979-01-31 1979-12-27 Fremgangsmaate til fremstilling av 6,7-dimetoksy-4-amino-2-(4-(furoyl)-1-piperazinyl)-kinazolin-hydroklorid
US06/110,589 US4271300A (en) 1979-01-31 1980-01-09 Method for producing 6,7-dimethoxy-4-amino-2-[4-(2-furoyl)-1-piperazinyl] qu
CA343,361A CA1128945A (fr) 1979-01-31 1980-01-09 Procede de fabrication de chlorhydrate de 6,7-dimethoxy-4-amino-2/4-(2-furoyl)-1- piperazinyl/quinazoline, ayant une action antihypertensive
CH12180A CH644605A5 (de) 1979-01-31 1980-01-09 Verfahren zur herstellung von blutdrucksenkendem 6,7-dimethoxy-4-amino-2-(4-(2-furoyl)-1-piperazinyl)chinazolinhydrochlorid.
YU58/80A YU41498B (en) 1979-01-31 1980-01-10 Proces for obtaining 6,7-dimethoxy-4-amino-2-(4-(2-furoyl)-1-piperazinyl)-guinazoline chlorohydrate of an antihypertensive effec
SI8010058A SI8010058A8 (sl) 1979-01-31 1980-01-10 Postopek za prodobivanje 6,7-dimetoksi-4-amino-2-/4-(2-furoil)-piperazinil/-kinazolin klorhidrata z antihipertenzivnim učinkom
AT0019580A AT374475B (de) 1979-01-31 1980-01-15 Verfahren zur herstellung von blutdrucksenkendem 6,7-dimethoxy-4-amino-2-(4-(2-furoyl)-1piperazinyl) chinazolinhydrochlorid
NL8000289A NL190701C (nl) 1979-01-31 1980-01-16 Werkwijze voor de bereiding van 6,7-dimethoxy-4-amino-2-[4-(2-furoyl)-1-piperazinyl]chinazolinehydrochloride.
BE0/199070A BE881297A (fr) 1979-01-31 1980-01-23 Procede pour la fabrication de chlorhydrate de 6,7-dimethoxy-4-amino-2- 4-(2-furoyl)-1-piperazinyl quinazoline ayant un effet antihypertensif
DE19803002553 DE3002553A1 (de) 1979-01-31 1980-01-25 Verfahren zur herstellung von 6,7- dimethoxy-4-amino-2-eckige klammer auf 4-(2-furoyl)-1-piperazinyl eckige klammer zu chinazolinhydrochlorid
CS80588A CS214692B2 (en) 1979-01-31 1980-01-28 Method of making the hydrochloride of 6,7-dimethoxy-4-amino-2-+l4-+l2-furoyl+p-1-piperazinyl+pchnazoline
ZA00800501A ZA80501B (en) 1979-01-31 1980-01-28 Method for producing 6,7-dimethoxy-4-amino-2-(4-(2-furoyl)-1-piperazinyl)quinazoline hydrochloride having an antihypertensive effect
GB8002903A GB2041932B (en) 1979-01-31 1980-01-29 Method for producing 6,7-dimethoxy-4-amino-2-(4-(2-furoyl)-1-piper-azinyl) quinazoline hydrochloride
HU8080182A HU181016B (en) 1979-01-31 1980-01-29 Process for producing 6,7-dimethoxy-5-amino-2-square bracket-4-bracket-2-furoyl-bracket closed-1-piperazinyl-square bracket c.osed-quinazoline hydrochlokike
PL1980221684A PL126994B1 (en) 1979-01-31 1980-01-30 Method for producing 6,7-dimethoxy-4-amino-2-/4-(2-furoyl)-1-piperazinyl/-quinazoline hydrochloride
JP1081580A JPS55104280A (en) 1979-01-31 1980-01-30 Manufacture of 6*77dimethoxyy44aminoo22 *44*22furoyl**11piperazinyl*quinazoline hydrochloride
FR8001991A FR2447920A1 (fr) 1979-01-31 1980-01-30 Procede pour la fabrication de chlorhydrate de 6,7-dimethoxy-4-amino-2-(4-(2-furoyl)-1-piperazinyl)quinazoline ayant un effet antihypertensif
SU802874898A SU900812A3 (ru) 1979-01-31 1980-01-30 Способ получени гидрохлорида 6,7-диметокси-4-амино-2-[4-(2-фуроил)-1-пиперазинил-ХИНАЗОЛИНА
DK042680A DK158352C (da) 1979-01-31 1980-01-31 Fremgangsmaade til fremstilling af 6,7-dimethoxy-4-amino-2-(4-(2-furoyl)-1-piperazinyl)kinazolinhydrochlorid
SE8000777A SE430692B (sv) 1979-01-31 1980-01-31 Sett att framstella 6,7-dimetoxi-4-amino-2-(4-(2-furoyl)-1-piperazinyl) kinazolinhydroklorid med antihypertensiv verkan
DD80218776A DD148952A1 (de) 1979-01-31 1980-01-31 Verfahren zur herstellung von blutdrucksenkendem 6,7-dimethoxy-4-amino-2- eckige klammer auf 4-(2-furoyl)-1-piperazinyl eckige klammer zu chinazolinhydrochlorid

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FI790320 1979-01-31
FI790320A FI67699C (fi) 1979-01-31 1979-01-31 Foerfarande foer framstaellning av 6,7-dimetoxi-4-amino-2-(4-(2-furoyl)-1-piperazinyl)kinazolinhydroklorid med blodtryckssaenkande verkan

Publications (3)

Publication Number Publication Date
FI790320A FI790320A (fi) 1980-08-01
FI67699B FI67699B (fi) 1985-01-31
FI67699C true FI67699C (fi) 1985-05-10

Family

ID=8512343

Family Applications (1)

Application Number Title Priority Date Filing Date
FI790320A FI67699C (fi) 1979-01-31 1979-01-31 Foerfarande foer framstaellning av 6,7-dimetoxi-4-amino-2-(4-(2-furoyl)-1-piperazinyl)kinazolinhydroklorid med blodtryckssaenkande verkan

Country Status (21)

Country Link
US (1) US4271300A (fr)
JP (1) JPS55104280A (fr)
AT (1) AT374475B (fr)
BE (1) BE881297A (fr)
CA (1) CA1128945A (fr)
CH (1) CH644605A5 (fr)
CS (1) CS214692B2 (fr)
DD (1) DD148952A1 (fr)
DE (1) DE3002553A1 (fr)
DK (1) DK158352C (fr)
FI (1) FI67699C (fr)
FR (1) FR2447920A1 (fr)
GB (1) GB2041932B (fr)
HU (1) HU181016B (fr)
NL (1) NL190701C (fr)
NO (1) NO152298C (fr)
PL (1) PL126994B1 (fr)
SE (1) SE430692B (fr)
SU (1) SU900812A3 (fr)
YU (1) YU41498B (fr)
ZA (1) ZA80501B (fr)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FI70411C (fi) * 1980-12-29 1986-09-19 Pfizer Foerfarande foer framstaellning av nya antihypertensiva 4-amino-6,7-dimetoxi-2-piperazinokinazolin derivat
FI79107C (fi) * 1984-06-25 1989-11-10 Orion Yhtymae Oy Foerfarande foer framstaellning av stabil -form av prazosinhydroklorid.
US4601897A (en) * 1985-11-06 1986-07-22 Pfizer Inc. Prazosin-pirbuterol combination for bronchodilation
AT384218B (de) * 1985-12-04 1987-10-12 Gerot Pharmazeutika Verfahren zur herstellung von neuen chinazolin-derivaten
YU70890A (en) * 1989-04-21 1992-05-28 Egyt Gyogyszervegyeszeti Gyar Process for obtaining quinazoline derivatives
CA2077252C (fr) * 1992-08-31 2001-04-10 Khashayar Karimian Methodes de fabrication d'urees et de guanidines et composes intermediaires servant a ces syntheses

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3511836A (en) * 1967-12-13 1970-05-12 Pfizer & Co C 2,4,6,7-tetra substituted quinazolines
GB1390015A (en) * 1971-05-07 1975-04-09 Koninklijke Pharma Fab Nv 4-amino-quinazoline compounds
US3935213A (en) * 1973-12-05 1976-01-27 Pfizer Inc. Process for hypotensive 4-amino-2-(piperazin-1-yl) quinazoline derivatives
US4092315A (en) * 1976-03-01 1978-05-30 Pfizer Inc. Novel crystalline forms of prazosin hydrochloride
FI58125C (fi) * 1976-12-15 1985-01-02 Orion Yhtymae Oy Foerfarande foer framstaellning av 6,7-dimetoxi-4-amino-2-(4-(2-furoyl)-1-piperazinyl)kinazolin med blodtryckssaenkande vekan
FI58124C (fi) * 1976-12-15 1980-12-10 Orion Yhtymae Oy Ny mellanprodukt 3,4-dimetoxi-6-(4-(2-furoyl)-1-piperazinyltiokarbamido)-bensonitril foer framstaellning av 6,7-dimetoxi-4-amino-2-(4-(2-furoyl)-1-piperazinyl)kinazolin med blodtryckssaenkande verkan

Also Published As

Publication number Publication date
DE3002553A1 (de) 1980-08-07
DK158352C (da) 1990-10-08
NL8000289A (nl) 1980-08-04
YU41498B (en) 1987-08-31
FI790320A (fi) 1980-08-01
HU181016B (en) 1983-05-30
NO152298C (no) 1985-09-04
GB2041932A (en) 1980-09-17
GB2041932B (en) 1982-10-27
CH644605A5 (de) 1984-08-15
BE881297A (fr) 1980-05-16
DD148952A1 (de) 1981-06-17
PL221684A1 (fr) 1980-10-20
SE430692B (sv) 1983-12-05
JPS6310955B2 (fr) 1988-03-10
NO794279L (no) 1980-08-01
NL190701B (nl) 1994-02-01
JPS55104280A (en) 1980-08-09
CS214692B2 (en) 1982-05-28
YU5880A (en) 1983-02-28
NO152298B (no) 1985-05-28
SE8000777L (sv) 1980-08-01
ZA80501B (en) 1981-02-25
CA1128945A (fr) 1982-08-03
DK42680A (da) 1980-08-01
DE3002553C2 (fr) 1988-10-27
FR2447920A1 (fr) 1980-08-29
NL190701C (nl) 1994-07-01
FR2447920B1 (fr) 1982-12-03
ATA19580A (de) 1983-09-15
US4271300A (en) 1981-06-02
SU900812A3 (ru) 1982-01-23
DK158352B (da) 1990-05-07
AT374475B (de) 1984-04-25
FI67699B (fi) 1985-01-31
PL126994B1 (en) 1983-09-30

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