FI67655C - Foerfarande foer behandling av kaseinbaserat material som innehaoller bivalenta katjoner av fosfokaseinater - Google Patents

Foerfarande foer behandling av kaseinbaserat material som innehaoller bivalenta katjoner av fosfokaseinater Download PDF

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Publication number
FI67655C
FI67655C FI810174A FI810174A FI67655C FI 67655 C FI67655 C FI 67655C FI 810174 A FI810174 A FI 810174A FI 810174 A FI810174 A FI 810174A FI 67655 C FI67655 C FI 67655C
Authority
FI
Finland
Prior art keywords
ultrafiltration
phosphopeptides
retentate
process according
milk
Prior art date
Application number
FI810174A
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English (en)
Finnish (fi)
Other versions
FI67655B (fi
FI810174L (fi
Inventor
Gerard Brule
Loic Roger
Jacques Fauquant
Michel Piot
Original Assignee
Roussel Uclaf
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Roussel Uclaf filed Critical Roussel Uclaf
Publication of FI810174L publication Critical patent/FI810174L/fi
Publication of FI67655B publication Critical patent/FI67655B/fi
Application granted granted Critical
Publication of FI67655C publication Critical patent/FI67655C/fi

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Classifications

    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23J—PROTEIN COMPOSITIONS FOR FOODSTUFFS; WORKING-UP PROTEINS FOR FOODSTUFFS; PHOSPHATIDE COMPOSITIONS FOR FOODSTUFFS
    • A23J3/00—Working-up of proteins for foodstuffs
    • A23J3/30—Working-up of proteins for foodstuffs by hydrolysis
    • A23J3/32—Working-up of proteins for foodstuffs by hydrolysis using chemical agents
    • A23J3/34—Working-up of proteins for foodstuffs by hydrolysis using chemical agents using enzymes
    • A23J3/341—Working-up of proteins for foodstuffs by hydrolysis using chemical agents using enzymes of animal proteins
    • A23J3/343—Working-up of proteins for foodstuffs by hydrolysis using chemical agents using enzymes of animal proteins of dairy proteins
    • A23J3/344—Working-up of proteins for foodstuffs by hydrolysis using chemical agents using enzymes of animal proteins of dairy proteins of casein
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23C—DAIRY PRODUCTS, e.g. MILK, BUTTER OR CHEESE; MILK OR CHEESE SUBSTITUTES; MAKING THEREOF
    • A23C9/00—Milk preparations; Milk powder or milk powder preparations
    • A23C9/14—Milk preparations; Milk powder or milk powder preparations in which the chemical composition of the milk is modified by non-chemical treatment
    • A23C9/142—Milk preparations; Milk powder or milk powder preparations in which the chemical composition of the milk is modified by non-chemical treatment by dialysis, reverse osmosis or ultrafiltration
    • A23C9/1422—Milk preparations; Milk powder or milk powder preparations in which the chemical composition of the milk is modified by non-chemical treatment by dialysis, reverse osmosis or ultrafiltration by ultrafiltration, microfiltration or diafiltration of milk, e.g. for separating protein and lactose; Treatment of the UF permeate
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23J—PROTEIN COMPOSITIONS FOR FOODSTUFFS; WORKING-UP PROTEINS FOR FOODSTUFFS; PHOSPHATIDE COMPOSITIONS FOR FOODSTUFFS
    • A23J7/00—Phosphatide compositions for foodstuffs, e.g. lecithin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/01—Hydrolysed proteins; Derivatives thereof
    • A61K38/012—Hydrolysed proteins; Derivatives thereof from animals
    • A61K38/018—Hydrolysed proteins; Derivatives thereof from animals from milk
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
    • A61P3/14—Drugs for disorders of the metabolism for electrolyte homeostasis for calcium homeostasis
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
    • Y10S530/827—Proteins from mammals or birds
    • Y10S530/832—Milk; colostrum

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  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Polymers & Plastics (AREA)
  • Food Science & Technology (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Zoology (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nutrition Science (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Epidemiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Water Supply & Treatment (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • Rheumatology (AREA)
  • Peptides Or Proteins (AREA)
  • Coloring Foods And Improving Nutritive Qualities (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Cereal-Derived Products (AREA)
  • Vacuum Packaging (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)

Claims (13)

1. Förfarande för behandling av mjölk, mjölkultrafiltrerings-retentat eller isolerade bivalentkatjonfosfokaseinater, säsom t.ex. kalcium- och/eller magnesiumfosfokaseinater, k ä n n e -t e c k n a t därav, att rämaterialet hydrolyseras enzymatiskt i pH-omrädet 7-9 och en temperatur av 37 - 45 °C, med tillhjälp av &tminstone en proteolytisk enzym,s&som pankreatin, trypsin och/eller alfakymotrypsin, som ästadkommer en sädan protein-spjälkning som sker in vivo i människokroppen; det erhällna hyd-rolysatet tillvaratages; nämnda hydrolysat ultrafiltreras &t-minstone en gäng med membraner, som h&ller tillhaka fosfopepti-derna och samtidigt släpper igenom peptiderna, varvid ultrafil-tratet innehäller ofosforyliserade peptider; ultrafiltreringsre-tentatet tillvaratages och de i retentatet befintliga fosfopep-tiderna upplöses; och nämnda retentat ultrafiltreras pä nytt ät-minstone en g&ng med membraner, som icke h&ller tillbaka fosfo-peptider, varvid dessa separerar sig fr&n enzymen och kan tillva-ratagas som produkt.
2. Förfarande enligt patentkrav 1, kännetecknat därav, att som rämaterial användes ett geronmjölkultrafiltrering er-hället retentat i ett koncentrationsförhällande av 1,5 - 3» före-trädesvis ca 2, varvid nämnda ultrafiltreringsskede eventuellt ef-terföljes av ett diafiltreringsskede.
3. Förfarande enligt patentkrav 1 eller 2, kännetecknat därav, att nämnda enzymatiska hydrolys utföres i en anord-ning, där ultrafiltreringsanordningarna ansluter sig tili en en-zymatisk reaktor, varvid bildas en membranförsedd enzymatisk reak-tor.
4. Förfarande-enligt patentkrav 3, kännetecknat därav, att den enzymatiska hydrolysen utföres kontinuerligt»genom att mata kaseinbaserat rämaterial tili reaktionsomr&det för att kraf-tigt bringa det i kontakt med enzymet, reaktionsprodukten avlägs-nas kontinuerligt genom att förflytta den fr&n reaktionsomr&det 33 67655 till ultrefiltreringsomrädet, varifrän likasä kontinuerligt av-lägsnas permeat, som bildar ett peptidiskt hydrolysat.
5« Förfarande enligt nägot av patentkraven 1-4, kanne -t e c k n a t därav, att pH regleras tili omrädet 7 - 8,5, t.ex. tili ett värde av ca 8 under nämnda enzymatiska hydrolys.
6. Förfarande enligt nägot av patentkraven 1-5, k ä n n e -t e c k n a t därav, att som enzym användes pankreatin i form av ett naturligt pankreatinextrakt eller syntetiska blandningar av trypsin ooh alfakymotrypsin.
7. Förfarande enligt nägot av patentkraven 1-6, kanne-t e c k n a t därav, att hydrolystemperaturen hälles i omrädet 37 - 40°C, företrädesvis vid ett värde av ca 37°C.
8. Förfarande enligt nägot av patentkraven 1-7, känne- t e c k n a t därav, att i de n enzymatiska reaktorn av membran-typ utnyttjas membraner, vilka är i ständ att hindra enzymet frän att passera igenom.
9. Förfarande enligt nägot av patentkraven 1-8, känne- t e c k n a t därav, att efter nämnda hydrolys den i den enzymatiska reaktorn äterstäende lösningen ultrafiltreras med membraner, vilka häller tillbaka fosfopeptiderna och genomsläpper de ofosfo-ryliserade peptiderna, varvid membranernas isoleringströskel är i omrädet ca 2000 - 50,000.
10. Förfarande enligt patentkrav 9, kännetecknat därav, att nämnda ultrafiltrering efterföljes av ett diafiltre-ringsskede för att tömma den ofosforyliserade peptidiska fraktio-nen, genom att tili den i kontakt med membranen försatta produk-ten tillsätta antingen vatten eller salthaltig vattenlösning eller företrädesvis mjölkultraflitrat, vara pH höjts tili ett värde av ca 7 - 8.
11. Förfarande enligt nägot av patentkraven 1-10, kännetecknat därav, att upplösningen av de i retentatet befint-
FI810174A 1980-02-01 1981-01-22 Foerfarande foer behandling av kaseinbaserat material som innehaoller bivalenta katjoner av fosfokaseinater FI67655C (fi)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR8002280 1980-02-01
FR8002280A FR2474828B1 (fr) 1980-02-01 1980-02-01 Procede de traitement d'une matiere premiere a base de caseine, contenant des phosphocaseinates de cations bivalents, produits obtenus et application

Publications (3)

Publication Number Publication Date
FI810174L FI810174L (fi) 1981-08-02
FI67655B FI67655B (fi) 1985-01-31
FI67655C true FI67655C (fi) 1985-05-10

Family

ID=9238131

Family Applications (1)

Application Number Title Priority Date Filing Date
FI810174A FI67655C (fi) 1980-02-01 1981-01-22 Foerfarande foer behandling av kaseinbaserat material som innehaoller bivalenta katjoner av fosfokaseinater

Country Status (13)

Country Link
US (3) US4361587A (sv)
EP (1) EP0033686B1 (sv)
JP (3) JPS56123921A (sv)
AT (1) ATE10330T1 (sv)
AU (1) AU548657B2 (sv)
CA (1) CA1165711A (sv)
DE (1) DE3167245D1 (sv)
DK (1) DK42781A (sv)
ES (1) ES8201407A1 (sv)
FI (1) FI67655C (sv)
FR (1) FR2474828B1 (sv)
NO (1) NO151442C (sv)
ZA (1) ZA81590B (sv)

Families Citing this family (52)

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US5216123A (en) * 1980-02-01 1993-06-01 Institut National De La Recherche Agronomique Non-phosphorylated peptides from casein-based material
US5334408A (en) * 1980-02-01 1994-08-02 Institut National De La Recherche Agronomique Nutrient composition containing non-phosphorylated peptides from casin-based material
FR2474828B1 (fr) * 1980-02-01 1983-09-09 Agronomique Inst Nat Rech Procede de traitement d'une matiere premiere a base de caseine, contenant des phosphocaseinates de cations bivalents, produits obtenus et application
FR2474829B1 (fr) * 1980-02-01 1983-09-09 Agronomique Inst Nat Rech Procede de traitement d'une matiere a base de caseine contenant des phosphocaseinates de cations monovalents ou leurs derives, produits obtenus et applications
ES492470A0 (es) * 1980-06-16 1981-06-01 Tena Guillermo Procedimiento de obtencion de una solucion de aminoacidos y peptidos de origen animal por proceso enzimatico
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US7183507B2 (en) * 2005-01-20 2007-02-27 Susan Simoneau Appliance having a timer
RU2012125878A (ru) * 2010-01-29 2014-03-10 Эбботт Лэборетриз Асептически упакованные питательные жидкости, содержащие бета-гидрокси-бета-метилбутират (гмб)
US9138455B2 (en) 2013-03-15 2015-09-22 Mead Johnson Nutrition Company Activating adiponectin by casein hydrolysate
US9345741B2 (en) 2013-03-15 2016-05-24 Mead Johnson Nutrition Company Nutritional composition containing a peptide component with adiponectin simulating properties and uses thereof
US9345727B2 (en) 2013-03-15 2016-05-24 Mead Johnson Nutrition Company Nutritional compositions containing a peptide component and uses thereof
US8889633B2 (en) 2013-03-15 2014-11-18 Mead Johnson Nutrition Company Nutritional compositions containing a peptide component with anti-inflammatory properties and uses thereof
US9289461B2 (en) 2013-03-15 2016-03-22 Mead Johnson Nutrition Company Reducing the risk of autoimmune disease
US9352020B2 (en) 2013-03-15 2016-05-31 Mead Johnson Nutrition Company Reducing proinflammatory response
CN113710094A (zh) * 2019-04-15 2021-11-26 巴斯夫欧洲公司 用于烘焙产品的发泡剂

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US5216123A (en) * 1980-02-01 1993-06-01 Institut National De La Recherche Agronomique Non-phosphorylated peptides from casein-based material
FR2474828B1 (fr) * 1980-02-01 1983-09-09 Agronomique Inst Nat Rech Procede de traitement d'une matiere premiere a base de caseine, contenant des phosphocaseinates de cations bivalents, produits obtenus et application

Also Published As

Publication number Publication date
AU548657B2 (en) 1986-01-02
JPS56123921A (en) 1981-09-29
FR2474828A1 (fr) 1981-08-07
US4361587A (en) 1982-11-30
EP0033686B1 (fr) 1984-11-21
JP2509436B2 (ja) 1996-06-19
JPH0558691B2 (sv) 1993-08-27
AU6678281A (en) 1981-08-06
FI67655B (fi) 1985-01-31
JPH07114634B2 (ja) 1995-12-13
NO151442B (no) 1985-01-02
US4980450A (en) 1990-12-25
US5352476A (en) 1994-10-04
ATE10330T1 (de) 1984-12-15
DK42781A (da) 1981-08-02
EP0033686A3 (en) 1981-08-26
CA1165711A (en) 1984-04-17
ZA81590B (en) 1982-02-24
FR2474828B1 (fr) 1983-09-09
EP0033686A2 (fr) 1981-08-12
NO810334L (no) 1981-08-03
FI810174L (fi) 1981-08-02
NO151442C (no) 1985-04-10
ES498962A0 (es) 1981-11-16
DE3167245D1 (en) 1985-01-03
ES8201407A1 (es) 1981-11-16
JPH06205645A (ja) 1994-07-26
JPH06205646A (ja) 1994-07-26

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