FI67542C - Foerfarande foer framstaellning av terapeutiskt anvaendbara dienylbutyl-1-acylpiperazinderivat - Google Patents
Foerfarande foer framstaellning av terapeutiskt anvaendbara dienylbutyl-1-acylpiperazinderivat Download PDFInfo
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- FI67542C FI67542C FI822508A FI822508A FI67542C FI 67542 C FI67542 C FI 67542C FI 822508 A FI822508 A FI 822508A FI 822508 A FI822508 A FI 822508A FI 67542 C FI67542 C FI 67542C
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- formula
- carbon atoms
- compounds
- therapeutic
- alkyl
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- 238000000034 method Methods 0.000 title claims abstract description 9
- 230000001225 therapeutic effect Effects 0.000 title abstract description 8
- 150000001875 compounds Chemical class 0.000 claims abstract description 56
- 125000004432 carbon atom Chemical group C* 0.000 claims abstract description 16
- 150000003839 salts Chemical class 0.000 claims abstract description 11
- 125000000217 alkyl group Chemical group 0.000 claims abstract description 10
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims abstract description 8
- 125000003545 alkoxy group Chemical group 0.000 claims abstract description 6
- 230000008569 process Effects 0.000 claims abstract description 6
- 125000005530 alkylenedioxy group Chemical group 0.000 claims abstract description 4
- 125000003710 aryl alkyl group Chemical group 0.000 claims abstract description 4
- 125000000753 cycloalkyl group Chemical group 0.000 claims abstract description 4
- 229910052794 bromium Inorganic materials 0.000 claims abstract description 3
- 229910052801 chlorine Inorganic materials 0.000 claims abstract description 3
- 229910052731 fluorine Inorganic materials 0.000 claims abstract description 3
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 claims abstract 3
- GLUUGHFHXGJENI-UHFFFAOYSA-N Piperazine Chemical compound C1CNCCN1 GLUUGHFHXGJENI-UHFFFAOYSA-N 0.000 claims description 8
- 125000004093 cyano group Chemical group *C#N 0.000 claims description 5
- 150000001263 acyl chlorides Chemical class 0.000 claims description 4
- 238000002360 preparation method Methods 0.000 claims description 4
- 239000000460 chlorine Substances 0.000 claims description 3
- WKBOTKDWSSQWDR-UHFFFAOYSA-N Bromine atom Chemical compound [Br] WKBOTKDWSSQWDR-UHFFFAOYSA-N 0.000 claims description 2
- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 claims description 2
- PXGOKWXKJXAPGV-UHFFFAOYSA-N Fluorine Chemical compound FF PXGOKWXKJXAPGV-UHFFFAOYSA-N 0.000 claims description 2
- GDTBXPJZTBHREO-UHFFFAOYSA-N bromine Substances BrBr GDTBXPJZTBHREO-UHFFFAOYSA-N 0.000 claims description 2
- 125000001246 bromo group Chemical group Br* 0.000 claims description 2
- 125000004185 ester group Chemical group 0.000 claims description 2
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- 125000001153 fluoro group Chemical group F* 0.000 claims description 2
- 229910052736 halogen Inorganic materials 0.000 claims description 2
- 150000002367 halogens Chemical group 0.000 claims description 2
- 125000004170 methylsulfonyl group Chemical group [H]C([H])([H])S(*)(=O)=O 0.000 claims description 2
- 125000002088 tosyl group Chemical group [H]C1=C([H])C(=C([H])C([H])=C1C([H])([H])[H])S(*)(=O)=O 0.000 claims description 2
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- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 17
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- PMZURENOXWZQFD-UHFFFAOYSA-L Sodium Sulfate Chemical compound [Na+].[Na+].[O-]S([O-])(=O)=O PMZURENOXWZQFD-UHFFFAOYSA-L 0.000 description 4
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- FBTBZOJNRCJVRU-UHFFFAOYSA-N cyclohexyl(piperazin-1-yl)methanone;hydrochloride Chemical compound Cl.C1CNCCN1C(=O)C1CCCCC1 FBTBZOJNRCJVRU-UHFFFAOYSA-N 0.000 description 3
- 125000004212 difluorophenyl group Chemical group 0.000 description 3
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 description 3
- MSQACBWWAIBWIC-UHFFFAOYSA-N hydron;piperazine;chloride Chemical compound Cl.C1CNCCN1 MSQACBWWAIBWIC-UHFFFAOYSA-N 0.000 description 3
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- KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 description 2
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
- C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
- C07D295/182—Radicals derived from carboxylic acids
- C07D295/185—Radicals derived from carboxylic acids from aliphatic carboxylic acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
- C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
- C07D295/182—Radicals derived from carboxylic acids
- C07D295/192—Radicals derived from carboxylic acids from aromatic carboxylic acids
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Compositions Of Macromolecular Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Plural Heterocyclic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SE8004465 | 1980-06-16 | ||
| SE8004465 | 1980-06-16 | ||
| SE8100169 | 1981-06-05 | ||
| PCT/SE1981/000169 WO1981003658A1 (en) | 1980-06-16 | 1981-06-05 | Diphenylbutyl-1-acylpiperazines |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| FI822508A0 FI822508A0 (fi) | 1982-07-14 |
| FI67542B FI67542B (fi) | 1984-12-31 |
| FI67542C true FI67542C (fi) | 1985-04-10 |
Family
ID=20341224
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FI822508A FI67542C (fi) | 1980-06-16 | 1982-07-14 | Foerfarande foer framstaellning av terapeutiskt anvaendbara dienylbutyl-1-acylpiperazinderivat |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US4492698A (cs) |
| EP (2) | EP0061453A1 (cs) |
| JP (1) | JPS57500828A (cs) |
| AT (1) | ATE10193T1 (cs) |
| AU (1) | AU546260B2 (cs) |
| CA (1) | CA1173832A (cs) |
| DE (1) | DE3167049D1 (cs) |
| DK (1) | DK149058C (cs) |
| ES (1) | ES503093A0 (cs) |
| FI (1) | FI67542C (cs) |
| NZ (1) | NZ197346A (cs) |
| WO (1) | WO1981003658A1 (cs) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3276754D1 (en) * | 1981-12-02 | 1987-08-20 | Ferrosan Ab | 1-piperazinocarboxylates, process for their preparation and pharmaceutical compositions containing them |
| US4547505A (en) * | 1983-03-25 | 1985-10-15 | Degussa Aktiengesellschaft | N-Phenyl-N-'-cycloalkylalkanoylpiperazine useful as analgetics and process for its production |
| DE3410613A1 (de) * | 1983-03-25 | 1984-10-11 | Degussa Ag, 6000 Frankfurt | Neue n-phenyl-n'-cycloalkylalkanoyl-piperazine und verfahren zu deren herstellung |
| AT387572B (de) * | 1983-05-20 | 1989-02-10 | Ferrosan Ab | Verfahren zur herstellung von neuen 4-(4,4-bis-(p-fluorphenyl)-butyl)-1-carbophenox -piperazinen und von 1-piperazincarboxamiden |
| SE8304361D0 (sv) * | 1983-08-10 | 1983-08-10 | Ferrosan Ab | Novel 1-acylpiperazine derivatives novel 1-acylpiperazine derivatives |
| IT1207990B (it) * | 1983-11-15 | 1989-06-01 | Euroresearch Srl | Attivita' analgesica, processo per derivati metil-piperazinici edla loro preparazione e composizioni terapeutiche che li contengono. |
| SE8500573D0 (sv) * | 1985-02-08 | 1985-02-08 | Ferrosan Ab | Novel piperazinecarboxamides having a phenoxyalkyl or thiophenoxyalkyl side chain |
| MY102447A (en) * | 1986-06-16 | 1992-06-30 | Ciba Geigy Ag | Disubtituted piperazines |
| ES2046107B1 (es) * | 1992-03-05 | 1994-08-01 | Espanola Prod Quimicos | Procedimiento de preparacion de nuevos derivados de la difenilmetilpiperacina. |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2742472A (en) * | 1956-04-17 | Spasmolytic pipergzjnes | ||
| US2794804A (en) * | 1955-03-24 | 1957-06-04 | American Cyanamid Co | Substituted piperazines and method of preparing the same |
| DK89564C (da) * | 1956-04-20 | 1960-08-22 | Lab Pharmaceutica Dr C Janssen | Fremgangsmåde til fremstilling af piperazinforbindelser. |
| NL137318C (cs) * | 1964-06-09 | |||
| DE2304153A1 (de) * | 1973-01-29 | 1974-08-01 | Ichthyol Ges Cordes Hermanni & | Substituierte piperazin- und homopiperazinderivate |
| CH583713A5 (cs) * | 1973-06-29 | 1977-01-14 | Cermol Sa | |
| JPS606946B2 (ja) * | 1974-03-12 | 1985-02-21 | 東京田辺製薬株式会社 | Ｎ−（３，３−ジフエニルプロピル）−ｎ’−アラルキル置換ピペラジンおよびその塩の製法 |
| JPS50151885A (cs) * | 1974-05-29 | 1975-12-06 | ||
| US4080453A (en) * | 1975-03-12 | 1978-03-21 | Dainippon Pharmaceutical Co., Ltd. | 1-Substituted-4-(1,2-diphenylethyl)piperazine derivatives and compositions containing the same |
| FR2350100A1 (fr) * | 1976-05-06 | 1977-12-02 | Sauba Lab | Derives disubstitues de la piperazine, leur procede de preparation et leurs applications therapeutiques |
| GB1545094A (en) * | 1976-12-14 | 1979-05-02 | Gist Brocades Nv | Piperazine derivatives |
| NO154582C (no) * | 1978-10-20 | 1986-11-05 | Ferrosan Ab | Analogifremgangsmaate for fremstilling av terapeutisk aktive difenyl-dibutylpiperazinkarboksamider. |
-
1981
- 1981-06-05 JP JP56501881A patent/JPS57500828A/ja active Pending
- 1981-06-05 WO PCT/SE1981/000169 patent/WO1981003658A1/en not_active Ceased
- 1981-06-05 DE DE8181850102T patent/DE3167049D1/de not_active Expired
- 1981-06-05 US US06/354,088 patent/US4492698A/en not_active Expired - Fee Related
- 1981-06-05 EP EP81901493A patent/EP0061453A1/en not_active Withdrawn
- 1981-06-05 AU AU72250/81A patent/AU546260B2/en not_active Ceased
- 1981-06-05 AT AT81850102T patent/ATE10193T1/de active
- 1981-06-05 EP EP81850102A patent/EP0042366B1/en not_active Expired
- 1981-06-08 NZ NZ197346A patent/NZ197346A/en unknown
- 1981-06-15 CA CA000379765A patent/CA1173832A/en not_active Expired
- 1981-06-16 ES ES503093A patent/ES503093A0/es active Granted
-
1982
- 1982-02-12 DK DK63382A patent/DK149058C/da not_active IP Right Cessation
- 1982-07-14 FI FI822508A patent/FI67542C/fi not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| EP0042366B1 (en) | 1984-11-07 |
| JPS57500828A (cs) | 1982-05-13 |
| NZ197346A (en) | 1985-03-20 |
| FI822508A0 (fi) | 1982-07-14 |
| ES8203870A1 (es) | 1982-04-01 |
| ES503093A0 (es) | 1982-04-01 |
| EP0042366A1 (en) | 1981-12-23 |
| ATE10193T1 (de) | 1984-11-15 |
| WO1981003658A1 (en) | 1981-12-24 |
| DK149058B (da) | 1986-01-06 |
| FI67542B (fi) | 1984-12-31 |
| AU546260B2 (en) | 1985-08-22 |
| US4492698A (en) | 1985-01-08 |
| DE3167049D1 (de) | 1984-12-13 |
| EP0061453A1 (en) | 1982-10-06 |
| DK149058C (da) | 1986-07-28 |
| DK63382A (da) | 1982-02-12 |
| CA1173832A (en) | 1984-09-04 |
| AU7225081A (en) | 1982-01-07 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MM | Patent lapsed |
Owner name: AB FERROSAN |