FI67372C - Foerfarande foer framstaellning av analgetiskt och/eller morfinantagonistiskt aktiva 6,7-bensomorfanderivat - Google Patents

Foerfarande foer framstaellning av analgetiskt och/eller morfinantagonistiskt aktiva 6,7-bensomorfanderivat Download PDF

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Publication number
FI67372C
FI67372C FI791239A FI791239A FI67372C FI 67372 C FI67372 C FI 67372C FI 791239 A FI791239 A FI 791239A FI 791239 A FI791239 A FI 791239A FI 67372 C FI67372 C FI 67372C
Authority
FI
Finland
Prior art keywords
alkyl
formula
hydroxy
hydrogen
alkoxy
Prior art date
Application number
FI791239A
Other languages
English (en)
Finnish (fi)
Other versions
FI791239A (fi
FI67372B (fi
Inventor
Antony Marie Akkerman
Hermanus Carolus Cathari Bakel
Original Assignee
Acf Chemiefarma Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Acf Chemiefarma Nv filed Critical Acf Chemiefarma Nv
Publication of FI791239A publication Critical patent/FI791239A/fi
Priority to FI833577A priority Critical patent/FI68227C/fi
Priority to FI833578A priority patent/FI68228C/fi
Publication of FI67372B publication Critical patent/FI67372B/fi
Application granted granted Critical
Publication of FI67372C publication Critical patent/FI67372C/fi

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
    • C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
    • C07D221/22—Bridged ring systems
    • C07D221/26—Benzomorphans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pain & Pain Management (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biomedical Technology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
FI791239A 1978-04-26 1979-04-17 Foerfarande foer framstaellning av analgetiskt och/eller morfinantagonistiskt aktiva 6,7-bensomorfanderivat FI67372C (fi)

Priority Applications (2)

Application Number Priority Date Filing Date Title
FI833577A FI68227C (fi) 1978-04-26 1983-10-03 Foerfarande foer framstaellning av analgetiskt och/eller morfinantagonistiskt aktiva 6,7-bentsomorfanderivat
FI833578A FI68228C (fi) 1978-04-26 1983-10-03 Foerfarande foer framstaellning av analgetiskt och/eller morfinantagonistiskt aktiva 6,7-bensomorfanderivat

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
NL7804509A NL7804509A (nl) 1978-04-26 1978-04-26 Nieuwe 6,7-benzomorfanderivaten en zuuradditiezouten daarvan.
NL7804509 1978-04-26

Publications (3)

Publication Number Publication Date
FI791239A FI791239A (fi) 1979-10-27
FI67372B FI67372B (fi) 1984-11-30
FI67372C true FI67372C (fi) 1985-03-11

Family

ID=19830738

Family Applications (1)

Application Number Title Priority Date Filing Date
FI791239A FI67372C (fi) 1978-04-26 1979-04-17 Foerfarande foer framstaellning av analgetiskt och/eller morfinantagonistiskt aktiva 6,7-bensomorfanderivat

Country Status (19)

Country Link
US (1) US4473576A (it)
EP (1) EP0004960B1 (it)
JP (1) JPS54151979A (it)
AT (1) AT373585B (it)
AU (1) AU529456B2 (it)
CA (1) CA1111422A (it)
DE (1) DE2966325D1 (it)
DK (1) DK157979A (it)
ES (2) ES479928A1 (it)
FI (1) FI67372C (it)
HU (1) HU182470B (it)
IE (1) IE48276B1 (it)
IL (1) IL57129A (it)
IT (1) IT1115132B (it)
NL (1) NL7804509A (it)
NZ (1) NZ190278A (it)
PH (1) PH17142A (it)
PT (1) PT69536A (it)
ZA (1) ZA792005B (it)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5607941A (en) * 1992-06-26 1997-03-04 Boehringer Ingelheim Kg Useful for treating neurodegenerative diseases
DE4121821A1 (de) * 1991-07-02 1993-01-14 Boehringer Ingelheim Kg Neue benzomorphane und ihre verwendung als arzneimittel
EP1053238B1 (en) * 1998-01-29 2005-12-28 Monash University Therapeutic compounds
DE19826365A1 (de) * 1998-06-12 1999-12-16 Gruenenthal Gmbh Verwendung von Benzomorphanderivaten als Analgetikum
DE10204276A1 (de) * 2002-02-02 2003-08-07 Boehringer Ingelheim Pharma N-Allyloxyethyl-1,2,3,4,5,6-Hexahydro-2,6-methano-3-benzazocine und ihre Verwendung als Arzneimittel

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL130089C (it) * 1963-11-07
NL132138C (it) * 1966-05-20
IE34235B1 (en) * 1969-06-04 1975-03-19 Acf Chemiefarma Nv 6,7-benzomorphans and their preparation
US3883536A (en) * 1970-05-27 1975-05-13 Acf Chemiefarma Nv 3,3-Disubstituted-2-benzyl-4-piperidinols
DE2233088A1 (de) * 1972-06-30 1974-01-17 Schering Ag Benzomorphanderivate
US4020164A (en) * 1972-06-30 1977-04-26 Schering Aktiengesellschaft Benzomorphan derivatives
DE2315339A1 (de) * 1973-03-28 1974-10-17 Boehringer Sohn Ingelheim N-(heteroarylmethyl)-2'-hydroxy-5.9. 9-trimethyl-benzomorphane, deren saeureadditionssalze, diese enthaltende arzneimittel sowie verfahren zu ihrer herstellung
US4087532A (en) * 1974-03-09 1978-05-02 Boehringer Ingelheim Gmbh Analgesically useful 2-tetrahydrofurfuryl-5-lower alkyl-2-oxy-6,7-benzomorphans and salts thereof
DE2437610A1 (de) * 1974-08-05 1976-02-26 Boehringer Sohn Ingelheim Neue 5,9-beta-disubstituierte 2-tetrahydrofurfuryl-6,7-benzomorphane, deren saeureadditionssalze, ihre verwendung als arzneimittel und verfahren zu deren herstellung
GB1513961A (en) * 1975-02-25 1978-06-14 Acf Chemiefarma Nv 6,7-benzomorphans method for their preparation and intermediates
DE2828039A1 (de) * 1978-06-26 1980-01-10 Boehringer Sohn Ingelheim 2-(2-alkoxyethyl)-2'-hydroxy-6,7-benzomorphane deren saeureadditionssalze diese enthaltende arzneimittel und verfahren zu deren herstellung

Also Published As

Publication number Publication date
AU4633079A (en) 1979-11-01
IL57129A0 (en) 1979-07-25
IE48276B1 (en) 1984-11-28
FI791239A (fi) 1979-10-27
ZA792005B (en) 1980-11-26
IT1115132B (it) 1986-02-03
ES488134A1 (es) 1980-09-16
ES479928A1 (es) 1980-08-16
EP0004960A1 (en) 1979-10-31
JPS54151979A (en) 1979-11-29
CA1111422A (en) 1981-10-27
FI67372B (fi) 1984-11-30
IL57129A (en) 1983-12-30
NZ190278A (en) 1981-12-15
US4473576A (en) 1984-09-25
DK157979A (da) 1979-11-23
DE2966325D1 (en) 1983-11-24
IT7948786A0 (it) 1979-04-19
AT373585B (de) 1984-02-10
NL7804509A (nl) 1979-10-30
IE790838L (en) 1979-10-26
ATA307579A (de) 1983-06-15
PT69536A (fr) 1979-05-01
EP0004960B1 (en) 1983-10-19
PH17142A (en) 1984-06-04
HU182470B (en) 1984-01-30
AU529456B2 (en) 1983-06-09

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MM Patent lapsed

Owner name: ACF CHEMIEFARMA NV