FI67215C - Foerfarande foer framstaellning av saosom laekemedel anvaendbara 2,3,4,5-tetrahydro-1h-3-bensazepiner - Google Patents

Foerfarande foer framstaellning av saosom laekemedel anvaendbara 2,3,4,5-tetrahydro-1h-3-bensazepiner Download PDF

Info

Publication number
FI67215C
FI67215C FI792125A FI792125A FI67215C FI 67215 C FI67215 C FI 67215C FI 792125 A FI792125 A FI 792125A FI 792125 A FI792125 A FI 792125A FI 67215 C FI67215 C FI 67215C
Authority
FI
Finland
Prior art keywords
tetrahydro
methyl
benzazepine
dihydroxy
mol
Prior art date
Application number
FI792125A
Other languages
English (en)
Finnish (fi)
Other versions
FI67215B (fi
FI792125A7 (fi
Inventor
Kenneth George Holden
Carl Kaiser
Original Assignee
Smithkline Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Smithkline Corp filed Critical Smithkline Corp
Publication of FI792125A7 publication Critical patent/FI792125A7/fi
Application granted granted Critical
Publication of FI67215B publication Critical patent/FI67215B/fi
Publication of FI67215C publication Critical patent/FI67215C/fi

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
    • C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D223/16—Benzazepines; Hydrogenated benzazepines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C41/00—Preparation of ethers; Preparation of compounds having groups, groups or groups
    • C07C41/01—Preparation of ethers
    • C07C41/18—Preparation of ethers by reactions not forming ether-oxygen bonds
    • C07C41/22—Preparation of ethers by reactions not forming ether-oxygen bonds by introduction of halogens; by substitution of halogen atoms by other halogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C41/00—Preparation of ethers; Preparation of compounds having groups, groups or groups
    • C07C41/01—Preparation of ethers
    • C07C41/18—Preparation of ethers by reactions not forming ether-oxygen bonds
    • C07C41/26—Preparation of ethers by reactions not forming ether-oxygen bonds by introduction of hydroxy or O-metal groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic Table
    • C07F5/02—Boron compounds
    • C07F5/022—Boron compounds without C-boron linkages

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurosurgery (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Anesthesiology (AREA)
  • Neurology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
FI792125A 1978-07-07 1979-07-05 Foerfarande foer framstaellning av saosom laekemedel anvaendbara 2,3,4,5-tetrahydro-1h-3-bensazepiner FI67215C (fi)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US92261378A 1978-07-07 1978-07-07
US92261378 1978-07-07

Publications (3)

Publication Number Publication Date
FI792125A7 FI792125A7 (fi) 1980-01-08
FI67215B FI67215B (fi) 1984-10-31
FI67215C true FI67215C (fi) 1985-02-11

Family

ID=25447325

Family Applications (1)

Application Number Title Priority Date Filing Date
FI792125A FI67215C (fi) 1978-07-07 1979-07-05 Foerfarande foer framstaellning av saosom laekemedel anvaendbara 2,3,4,5-tetrahydro-1h-3-bensazepiner

Country Status (24)

Country Link
EP (2) EP0080012B1 (cs)
JP (1) JPS5511584A (cs)
AR (1) AR222828A1 (cs)
AU (1) AU525789B2 (cs)
CA (1) CA1115271A (cs)
CS (1) CS213381B2 (cs)
DD (1) DD147355A5 (cs)
DE (1) DE2964530D1 (cs)
DK (1) DK156001C (cs)
ES (3) ES482281A1 (cs)
FI (1) FI67215C (cs)
GR (1) GR69675B (cs)
HU (1) HU179315B (cs)
IE (1) IE48654B1 (cs)
IL (1) IL57532A (cs)
IT (1) IT1193190B (cs)
JO (1) JO1273B1 (cs)
NO (1) NO152213C (cs)
NZ (1) NZ190745A (cs)
PH (1) PH15754A (cs)
PL (1) PL216908A1 (cs)
PT (1) PT69855A (cs)
SU (1) SU1029827A3 (cs)
ZA (1) ZA792785B (cs)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3119874A1 (de) 1981-05-19 1982-12-09 Dr. Karl Thomae Gmbh, 7950 Biberach "benzazepinderivate, ihre herstellung und ihre verwendung als arzneimittel"
US4469634A (en) * 1982-07-29 1984-09-04 Smithkline Beckman Corporation Allyloxy- and allylthio-2,3,4,5-tetrahydro-1H-3-benzazepines
US4652642A (en) * 1984-08-23 1987-03-24 Smithkline Beckman Corporation Azidobenzazepines
US4683229A (en) * 1986-03-17 1987-07-28 Smithkline Beckman Corporation 6-halo-9-alkenyleneoxy-3-alkyl-2,3,4,5-tetrahydro-(1H-3)-benzazepines and their use as selective alpha-adrenergic receptor antagonists
US6384079B1 (en) 1986-12-23 2002-05-07 Tristrata Technology, Incorporated Compositions comprising 2-hydroxycarboxylic acids and related compounds, and methods for alleviating signs of dermatological aging
US5942250A (en) * 1986-12-23 1999-08-24 Tristrata Technology, Inc. Compositions and methods for enhancing the topical effects of sunscreen agents
GB9119467D0 (en) * 1991-09-12 1991-10-23 Smithkline Beecham Corp Chemical compounds
GB9708805D0 (en) 1997-05-01 1997-06-25 Smithkline Beecham Plc Compounds
GB9810876D0 (en) 1998-05-20 1998-07-22 Smithkline Beecham Plc Compounds
JP2002527433A (ja) * 1998-10-08 2002-08-27 スミスクライン・ビーチャム・パブリック・リミテッド・カンパニー ドーパミンｄ３受容体のモジュレーター（抗精神病薬）として有用なテトラヒドロベンズアゼピン誘導体
US6953787B2 (en) 2002-04-12 2005-10-11 Arena Pharmaceuticals, Inc. 5HT2C receptor modulators
AU2003273969A1 (en) 2002-10-07 2004-04-23 Glaxo Group Limited Sulfonamide derivatives as antipsychotic agents
MXPA05013366A (es) 2003-06-17 2006-04-05 Arena Pharm Inc Derivados de benzazepina utiles para el tratamiento de enfermedades asociadas con el receptor 5ht2c.
US8367657B2 (en) 2003-06-17 2013-02-05 Arena Pharmaceuticals, Inc. Processes for preparing 3-benzazepines
DK1720836T3 (da) * 2004-02-25 2014-05-05 Lilly Co Eli 6-substituerede 2,3,4,5-tetrahydro-1h-benzo [d]azepiner som 5-ht2c-receptoragonister
PT1838677E (pt) 2004-12-21 2009-11-16 Arena Pharm Inc Formas cristalinas do cloridrato de (r)-8-cloro-1-metil- 2,3,4,5-tetra-hidro-1h-3-benzazepina
CN102631349A (zh) 2004-12-23 2012-08-15 艾尼纳制药公司 5HT2c受体调节剂组合物和使用方法
EP2518053A1 (en) 2006-04-03 2012-10-31 Arena Pharmaceuticals, Inc. Process for the preparation of 8-chloro-1-methyl-2,3,4,5-tetrahydro-1h-3-benzazepine
ES2522587T3 (es) 2006-12-05 2014-11-17 Arena Pharmaceuticals, Inc. Procesos para preparar (R)-8-cloro-1-metil-2,3,4,5-tetrahidro-1H-3-benzacepina e intermedios de la misma
US8822727B2 (en) 2008-03-04 2014-09-02 Arena Pharmaceuticals, Inc. Processes for the preparation of intermediates related to the 5-HT2C agonist (R)-8-chloro-1-methyl-2,3,4,5-tetrahydro-1H-3-benzazepine
EP2443080A2 (en) 2009-06-18 2012-04-25 Arena Pharmaceuticals, Inc. Process for the preparation of 5-ht2c receptor agonists
WO2011153206A1 (en) 2010-06-02 2011-12-08 Arena Pharmaceuticals, Inc. Processes for the preparation of 5-ht2c receptor agonists
SG188361A1 (en) 2010-09-01 2013-04-30 Arena Pharm Inc Non-hygroscopic salts of 5-ht2c agonists
BR112013004707A2 (pt) 2010-09-01 2016-05-10 Arena Pharm Inc administração de um composto antiobesidade a indivíduos com comprometimento renal
AU2011296003B2 (en) 2010-09-01 2015-11-12 Arena Pharmaceuticals, Inc. Modified-release dosage forms of 5-HT2C agonist useful for weight management
CA2808909A1 (en) 2010-09-01 2012-03-08 Arena Pharmaceuticals, Inc. Salts of lorcaserin with optically active acids
WO2014058441A1 (en) 2012-10-09 2014-04-17 Arena Pharmaceuticals, Inc. Method of weight management
CN116655892A (zh) * 2023-05-18 2023-08-29 常州大学 一种交联聚合物有机电极材料及其制备方法与应用

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2520264A (en) * 1947-08-26 1950-08-29 Maltbie Lab Inc Substituted 3, 1-benz-2, 3, 4, 5-tetrahydroazepines
US3483185A (en) 1966-08-16 1969-12-09 American Home Prod N-substituted 2,3,4,5-tetrahydro-1h-3-benzazepines
GB1268243A (en) * 1968-03-11 1972-03-22 Wallace & Tiernan Inc 0,2,4,5,-tetrahydro-3h,3-benzazepines
US3671519A (en) * 1969-07-14 1972-06-20 American Home Prod N-substituted 2,3,4,5,-tetrahydro-1h-3-benzazepines
US3716639A (en) 1970-03-11 1973-02-13 Ciba Geigy Corp Anorexigenic tetrahydrobenzazepines
US3752892A (en) 1970-03-11 1973-08-14 Ciba Geigy Corp Anorexigenic tetrahydrobenzazepine derivative method and composition thereof
US4111957A (en) * 1977-02-02 1978-09-05 Smithkline Corporation Substituted 1-thienyl and furyl-2,3,4,5-tetrahydro-1H-3-benzazepine compounds
US4108989A (en) * 1977-04-01 1978-08-22 Smithkline Corporation 2,3,4,5-tetrahydro-1h-3-benzazepine-7,8-diones

Also Published As

Publication number Publication date
HU179315B (en) 1982-09-28
SU1029827A3 (ru) 1983-07-15
IE791276L (en) 1980-01-07
ES482281A1 (es) 1980-04-01
EP0080012B1 (en) 1986-04-09
IE48654B1 (en) 1985-04-03
EP0007070A1 (en) 1980-01-23
ES482282A1 (es) 1980-04-01
DD147355A5 (de) 1981-04-01
PH15754A (en) 1983-03-18
NZ190745A (en) 1981-01-23
NO152213C (no) 1985-08-28
EP0080012A1 (en) 1983-06-01
JPH0153271B2 (cs) 1989-11-13
AU525789B2 (en) 1982-12-02
DK156001C (da) 1989-11-06
DK156001B (da) 1989-06-12
NO152213B (no) 1985-05-13
NO792267L (no) 1980-01-08
ZA792785B (en) 1980-08-27
AU4861379A (en) 1980-02-07
PL216908A1 (cs) 1980-08-11
JPS5511584A (en) 1980-01-26
PT69855A (en) 1979-08-01
IT7924165A0 (it) 1979-07-06
IT1193190B (it) 1988-06-02
DE2964530D1 (en) 1983-02-24
IL57532A (en) 1982-08-31
GR69675B (cs) 1982-07-07
DK278379A (da) 1980-01-08
CA1115271A (en) 1981-12-29
JO1273B1 (en) 1986-11-30
EP0007070B1 (en) 1983-01-19
FI67215B (fi) 1984-10-31
CS213381B2 (en) 1982-04-09
AR222828A1 (es) 1981-06-30
IL57532A0 (en) 1979-10-31
ES482276A1 (es) 1980-04-01
FI792125A7 (fi) 1980-01-08

Similar Documents

Publication Publication Date Title
FI67215C (fi) Foerfarande foer framstaellning av saosom laekemedel anvaendbara 2,3,4,5-tetrahydro-1h-3-bensazepiner
JPH09501442A (ja) 免疫抑制剤として有用な炭素環式および複素環式縮合環キノリンカルボン酸
US3420851A (en) Novel dibenzoxepines
US4265890A (en) 6-Phenyl thio- and 6-cyclohexyl thio-2,3,4,5-tetrahydro-1H-3-benzazepines
US4374139A (en) Levorotatory N-substituted acylmorphinans useful as analgesic agents
KR19990087110A (ko) 캄토테신 유도체와 이를 활성 성분으로 하는 항암제
EP0001002B1 (en) Indanamines, processes for their preparation and compositions containing them
JPH05132477A (ja) 三環式化合物およびその中間体
US4112112A (en) Pyrrolo[2,1-b] [3]benzazepines useful for producing a skeletal muscle relaxing or tranquilizing effect
ITMI20000293A1 (it) Derivati del 3,9-diazabiciclo [3.3.1]nonano ad attivita' analgesica
US4163853A (en) 1-(P-phenoxy)benzyl-1,2,3,4,5,6,7,8-octahydroisoquinolines
Dunn et al. Antiinflammatory 5, 6-dihydro-11-oxodibenz [b, e] azepine-3-acetic acids
JPH0435459B2 (cs)
US3712946A (en) Certain oxy-substituted benzo quinolizinium compounds and their use
KR830001501B1 (ko) 메르캎토 치환-2, 3, 4, 5-테트라히드로-1h-3-벤자제핀류의 제조방법
GB1597911A (en) Benzazepines
EP0172692B1 (en) Hexahydroindolizine compounds, pharmaceutical compositions and methods and intermediates
US4522946A (en) Dioxy hexahydrobenzo[6,7]cyclohepta[1,2,3-de]isoquinoline derivatives useful as neuroleptic agents
US3826839A (en) Anti-arthritic compositions comprising ester derivatives of pulvinic acid and methods of producing anti-arthritic activity
Lee et al. Synthesis of tetracyclic pyrido [2, 3-b] azepine derivatives as analogues of mirtazapine via N-acyliminium ion cyclization
PT101034A (pt) Composicoes farmaceuticas contendo tetra-hidropiridinas, tetra-hidropiridinas ai utilizadas , processo para a sua preparacao e sua utilizacao como medicamentos
USRE30452E (en) 3-Phenoxymorphinans and derivatives thereof
CA1129415A (en) Thiadiazolo- and oxadiazolotetrahydroisoquinoline compounds
US3458578A (en) Aminodibenzocycloalkenones
KR830001213B1 (ko) 4-페닐-1,3-벤조디아제핀류의 제조방법

Legal Events

Date Code Title Description
FD Application lapsed
MM Patent lapsed

Owner name: SMITHKLINE CORPORATION