FI67215C - Foerfarande foer framstaellning av saosom laekemedel anvaendbara 2,3,4,5-tetrahydro-1h-3-bensazepiner - Google Patents

Foerfarande foer framstaellning av saosom laekemedel anvaendbara 2,3,4,5-tetrahydro-1h-3-bensazepiner Download PDF

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Publication number
FI67215C
FI67215C FI792125A FI792125A FI67215C FI 67215 C FI67215 C FI 67215C FI 792125 A FI792125 A FI 792125A FI 792125 A FI792125 A FI 792125A FI 67215 C FI67215 C FI 67215C
Authority
FI
Finland
Prior art keywords
tetrahydro
methyl
benzazepine
dihydroxy
mol
Prior art date
Application number
FI792125A
Other languages
English (en)
Finnish (fi)
Other versions
FI67215B (fi
FI792125A7 (fi
Inventor
Kenneth George Holden
Carl Kaiser
Original Assignee
Smithkline Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Smithkline Corp filed Critical Smithkline Corp
Publication of FI792125A7 publication Critical patent/FI792125A7/fi
Application granted granted Critical
Publication of FI67215B publication Critical patent/FI67215B/fi
Publication of FI67215C publication Critical patent/FI67215C/fi

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
    • C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D223/16—Benzazepines; Hydrogenated benzazepines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C41/00—Preparation of ethers; Preparation of compounds having groups, groups or groups
    • C07C41/01—Preparation of ethers
    • C07C41/18—Preparation of ethers by reactions not forming ether-oxygen bonds
    • C07C41/22—Preparation of ethers by reactions not forming ether-oxygen bonds by introduction of halogens; by substitution of halogen atoms by other halogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C41/00—Preparation of ethers; Preparation of compounds having groups, groups or groups
    • C07C41/01—Preparation of ethers
    • C07C41/18—Preparation of ethers by reactions not forming ether-oxygen bonds
    • C07C41/26—Preparation of ethers by reactions not forming ether-oxygen bonds by introduction of hydroxy or O-metal groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic Table
    • C07F5/02—Boron compounds
    • C07F5/022—Boron compounds without C-boron linkages

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurosurgery (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Anesthesiology (AREA)
  • Neurology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
FI792125A 1978-07-07 1979-07-05 Foerfarande foer framstaellning av saosom laekemedel anvaendbara 2,3,4,5-tetrahydro-1h-3-bensazepiner FI67215C (fi)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US92261378A 1978-07-07 1978-07-07
US92261378 1978-07-07

Publications (3)

Publication Number Publication Date
FI792125A7 FI792125A7 (fi) 1980-01-08
FI67215B FI67215B (fi) 1984-10-31
FI67215C true FI67215C (fi) 1985-02-11

Family

ID=25447325

Family Applications (1)

Application Number Title Priority Date Filing Date
FI792125A FI67215C (fi) 1978-07-07 1979-07-05 Foerfarande foer framstaellning av saosom laekemedel anvaendbara 2,3,4,5-tetrahydro-1h-3-bensazepiner

Country Status (24)

Country Link
EP (2) EP0080012B1 (cs)
JP (1) JPS5511584A (cs)
AR (1) AR222828A1 (cs)
AU (1) AU525789B2 (cs)
CA (1) CA1115271A (cs)
CS (1) CS213381B2 (cs)
DD (1) DD147355A5 (cs)
DE (1) DE2964530D1 (cs)
DK (1) DK156001C (cs)
ES (3) ES482282A1 (cs)
FI (1) FI67215C (cs)
GR (1) GR69675B (cs)
HU (1) HU179315B (cs)
IE (1) IE48654B1 (cs)
IL (1) IL57532A (cs)
IT (1) IT1193190B (cs)
JO (1) JO1273B1 (cs)
NO (1) NO152213C (cs)
NZ (1) NZ190745A (cs)
PH (1) PH15754A (cs)
PL (1) PL216908A1 (cs)
PT (1) PT69855A (cs)
SU (1) SU1029827A3 (cs)
ZA (1) ZA792785B (cs)

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Publication number Priority date Publication date Assignee Title
DE3119874A1 (de) 1981-05-19 1982-12-09 Dr. Karl Thomae Gmbh, 7950 Biberach "benzazepinderivate, ihre herstellung und ihre verwendung als arzneimittel"
US4469634A (en) * 1982-07-29 1984-09-04 Smithkline Beckman Corporation Allyloxy- and allylthio-2,3,4,5-tetrahydro-1H-3-benzazepines
US4652642A (en) * 1984-08-23 1987-03-24 Smithkline Beckman Corporation Azidobenzazepines
US4683229A (en) * 1986-03-17 1987-07-28 Smithkline Beckman Corporation 6-halo-9-alkenyleneoxy-3-alkyl-2,3,4,5-tetrahydro-(1H-3)-benzazepines and their use as selective alpha-adrenergic receptor antagonists
US5942250A (en) * 1986-12-23 1999-08-24 Tristrata Technology, Inc. Compositions and methods for enhancing the topical effects of sunscreen agents
US6384079B1 (en) 1986-12-23 2002-05-07 Tristrata Technology, Incorporated Compositions comprising 2-hydroxycarboxylic acids and related compounds, and methods for alleviating signs of dermatological aging
GB9119467D0 (en) * 1991-09-12 1991-10-23 Smithkline Beecham Corp Chemical compounds
GB9708805D0 (en) 1997-05-01 1997-06-25 Smithkline Beecham Plc Compounds
GB9810876D0 (en) 1998-05-20 1998-07-22 Smithkline Beecham Plc Compounds
IL142388A0 (en) * 1998-10-08 2002-03-10 Smithkline Beecham Plc Tetrahydrobenzazepine derivatives useful as modulators of dopamine d3 receptors (antipsychotic agents)
US6953787B2 (en) 2002-04-12 2005-10-11 Arena Pharmaceuticals, Inc. 5HT2C receptor modulators
DE60305519T2 (de) 2002-10-07 2006-11-23 Glaxo Group Ltd., Greenford Sulfonamidderivate als antipsychotische mittel
US7704993B2 (en) 2003-06-17 2010-04-27 Arena Pharmaceuticals, Inc. Benzazepine derivatives and methods of prophylaxis or treatment of 5ht2c receptor associated diseases
SI2332921T1 (sl) 2003-06-17 2016-06-30 Arena Pharmaceuticals, Inc. 8-kloro-1-metil-2,3,4,5-tetrahidro-1H-3-benzazapin hidroklorid
EA011011B1 (ru) * 2004-02-25 2008-12-30 Эли Лилли Энд Компани 6-ЗАМЕЩЁННЫЕ 2,3,4,5-ТЕТРАГИДРО-1H-БЕНЗО[d]АЗЕПИНЫ В КАЧЕСТВЕ АГОНИСТОВ РЕЦЕПТОРОВ 5-HT
CA2589988C (en) 2004-12-21 2017-02-14 Arena Pharmaceuticals, Inc. Crystalline forms of (r)-8-chloro-1-methyl- 2,3,4,5-tetrahydro-1h-3-benzazepine hydrochloride
PT1833473E (pt) 2004-12-23 2009-12-17 Arena Pharm Inc Composições de modulador de receptor 5ht2c e métodos de utilização
EP2518053A1 (en) 2006-04-03 2012-10-31 Arena Pharmaceuticals, Inc. Process for the preparation of 8-chloro-1-methyl-2,3,4,5-tetrahydro-1h-3-benzazepine
EP2099743B1 (en) 2006-12-05 2014-08-27 Arena Pharmaceuticals, Inc. Processes for preparing (r)-8-chloro-1-methyl-2,3,4,5-tetrahydro-1h-3-benzazepine and intermediates thereof
JP5491421B2 (ja) 2008-03-04 2014-05-14 アリーナ ファーマシューティカルズ， インコーポレイテッド ５−ｈｔ２ｃアゴニストである（ｒ）−８−クロロ−１−メチル−２，３，４，５−テトラヒドロ−１ｈ−３−ベンゾアゼピンに関連する中間体の調製のためのプロセス
CN102648170A (zh) 2009-06-18 2012-08-22 艾尼纳制药公司 制备5-ht2c受体激动剂的方法
WO2011153206A1 (en) 2010-06-02 2011-12-08 Arena Pharmaceuticals, Inc. Processes for the preparation of 5-ht2c receptor agonists
CN103347523A (zh) 2010-09-01 2013-10-09 艾尼纳制药公司 向具有肾损伤的个体给药氯卡色林
MX2013002422A (es) 2010-09-01 2013-05-17 Arena Pharm Inc Sales de lorcaserina con acidos opticamente activos.
KR20180118801A (ko) 2010-09-01 2018-10-31 에자이 알앤드디 매니지먼트 가부시키가이샤 체중 관리에 유용한 5-ｈｔ2ｃ 작동제의 변형-방출 투여 형태
WO2012030957A2 (en) 2010-09-01 2012-03-08 Arena Pharmaceuticals, Inc. Non-hygroscopic salts of 5-ht2c agonists
WO2014058441A1 (en) 2012-10-09 2014-04-17 Arena Pharmaceuticals, Inc. Method of weight management
CN116655892A (zh) * 2023-05-18 2023-08-29 常州大学 一种交联聚合物有机电极材料及其制备方法与应用

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2520264A (en) * 1947-08-26 1950-08-29 Maltbie Lab Inc Substituted 3, 1-benz-2, 3, 4, 5-tetrahydroazepines
US3483185A (en) * 1966-08-16 1969-12-09 American Home Prod N-substituted 2,3,4,5-tetrahydro-1h-3-benzazepines
GB1268243A (en) * 1968-03-11 1972-03-22 Wallace & Tiernan Inc 0,2,4,5,-tetrahydro-3h,3-benzazepines
US3671519A (en) * 1969-07-14 1972-06-20 American Home Prod N-substituted 2,3,4,5,-tetrahydro-1h-3-benzazepines
US3716639A (en) 1970-03-11 1973-02-13 Ciba Geigy Corp Anorexigenic tetrahydrobenzazepines
US3752892A (en) 1970-03-11 1973-08-14 Ciba Geigy Corp Anorexigenic tetrahydrobenzazepine derivative method and composition thereof
US4111957A (en) * 1977-02-02 1978-09-05 Smithkline Corporation Substituted 1-thienyl and furyl-2,3,4,5-tetrahydro-1H-3-benzazepine compounds
US4108989A (en) * 1977-04-01 1978-08-22 Smithkline Corporation 2,3,4,5-tetrahydro-1h-3-benzazepine-7,8-diones

Also Published As

Publication number Publication date
DK278379A (da) 1980-01-08
PH15754A (en) 1983-03-18
DK156001C (da) 1989-11-06
IT7924165A0 (it) 1979-07-06
DD147355A5 (de) 1981-04-01
IE791276L (en) 1980-01-07
NO792267L (no) 1980-01-08
GR69675B (cs) 1982-07-07
ZA792785B (en) 1980-08-27
JPS5511584A (en) 1980-01-26
PT69855A (en) 1979-08-01
AU525789B2 (en) 1982-12-02
ES482281A1 (es) 1980-04-01
IL57532A (en) 1982-08-31
JPH0153271B2 (cs) 1989-11-13
IT1193190B (it) 1988-06-02
AR222828A1 (es) 1981-06-30
JO1273B1 (en) 1986-11-30
NO152213C (no) 1985-08-28
NO152213B (no) 1985-05-13
EP0080012B1 (en) 1986-04-09
HU179315B (en) 1982-09-28
IL57532A0 (en) 1979-10-31
SU1029827A3 (ru) 1983-07-15
PL216908A1 (cs) 1980-08-11
NZ190745A (en) 1981-01-23
EP0007070A1 (en) 1980-01-23
FI67215B (fi) 1984-10-31
CS213381B2 (en) 1982-04-09
EP0007070B1 (en) 1983-01-19
DE2964530D1 (en) 1983-02-24
DK156001B (da) 1989-06-12
AU4861379A (en) 1980-02-07
FI792125A7 (fi) 1980-01-08
EP0080012A1 (en) 1983-06-01
CA1115271A (en) 1981-12-29
IE48654B1 (en) 1985-04-03
ES482276A1 (es) 1980-04-01
ES482282A1 (es) 1980-04-01

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Legal Events

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FD Application lapsed
MM Patent lapsed

Owner name: SMITHKLINE CORPORATION