IL57532A - Mercapto substituted-2,3,4,5-tetrahydro-1h-3-benzazepines,process for their preparation and pharmaceutical compositions containing them - Google Patents

Mercapto substituted-2,3,4,5-tetrahydro-1h-3-benzazepines,process for their preparation and pharmaceutical compositions containing them

Info

Publication number
IL57532A
IL57532A IL57532A IL5753279A IL57532A IL 57532 A IL57532 A IL 57532A IL 57532 A IL57532 A IL 57532A IL 5753279 A IL5753279 A IL 5753279A IL 57532 A IL57532 A IL 57532A
Authority
IL
Israel
Prior art keywords
benzazepines
tetrahydro
preparation
pharmaceutical compositions
compositions containing
Prior art date
Application number
IL57532A
Other languages
English (en)
Other versions
IL57532A0 (en
Original Assignee
Smithkline Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Smithkline Corp filed Critical Smithkline Corp
Publication of IL57532A0 publication Critical patent/IL57532A0/xx
Publication of IL57532A publication Critical patent/IL57532A/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
    • C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D223/16—Benzazepines; Hydrogenated benzazepines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C41/00—Preparation of ethers; Preparation of compounds having groups, groups or groups
    • C07C41/01—Preparation of ethers
    • C07C41/18—Preparation of ethers by reactions not forming ether-oxygen bonds
    • C07C41/22—Preparation of ethers by reactions not forming ether-oxygen bonds by introduction of halogens; by substitution of halogen atoms by other halogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C41/00—Preparation of ethers; Preparation of compounds having groups, groups or groups
    • C07C41/01—Preparation of ethers
    • C07C41/18—Preparation of ethers by reactions not forming ether-oxygen bonds
    • C07C41/26—Preparation of ethers by reactions not forming ether-oxygen bonds by introduction of hydroxy or O-metal groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic Table
    • C07F5/02—Boron compounds
    • C07F5/022—Boron compounds without C-boron linkages

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurosurgery (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Anesthesiology (AREA)
  • Neurology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
IL57532A 1978-07-07 1979-06-11 Mercapto substituted-2,3,4,5-tetrahydro-1h-3-benzazepines,process for their preparation and pharmaceutical compositions containing them IL57532A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US92261378A 1978-07-07 1978-07-07

Publications (2)

Publication Number Publication Date
IL57532A0 IL57532A0 (en) 1979-10-31
IL57532A true IL57532A (en) 1982-08-31

Family

ID=25447325

Family Applications (1)

Application Number Title Priority Date Filing Date
IL57532A IL57532A (en) 1978-07-07 1979-06-11 Mercapto substituted-2,3,4,5-tetrahydro-1h-3-benzazepines,process for their preparation and pharmaceutical compositions containing them

Country Status (24)

Country Link
EP (2) EP0080012B1 (xx)
JP (1) JPS5511584A (xx)
AR (1) AR222828A1 (xx)
AU (1) AU525789B2 (xx)
CA (1) CA1115271A (xx)
CS (1) CS213381B2 (xx)
DD (1) DD147355A5 (xx)
DE (1) DE2964530D1 (xx)
DK (1) DK156001C (xx)
ES (3) ES482281A1 (xx)
FI (1) FI67215C (xx)
GR (1) GR69675B (xx)
HU (1) HU179315B (xx)
IE (1) IE48654B1 (xx)
IL (1) IL57532A (xx)
IT (1) IT1193190B (xx)
JO (1) JO1273B1 (xx)
NO (1) NO152213C (xx)
NZ (1) NZ190745A (xx)
PH (1) PH15754A (xx)
PL (1) PL216908A1 (xx)
PT (1) PT69855A (xx)
SU (1) SU1029827A3 (xx)
ZA (1) ZA792785B (xx)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3119874A1 (de) 1981-05-19 1982-12-09 Dr. Karl Thomae Gmbh, 7950 Biberach "benzazepinderivate, ihre herstellung und ihre verwendung als arzneimittel"
US4469634A (en) * 1982-07-29 1984-09-04 Smithkline Beckman Corporation Allyloxy- and allylthio-2,3,4,5-tetrahydro-1H-3-benzazepines
US4652642A (en) * 1984-08-23 1987-03-24 Smithkline Beckman Corporation Azidobenzazepines
US4683229A (en) * 1986-03-17 1987-07-28 Smithkline Beckman Corporation 6-halo-9-alkenyleneoxy-3-alkyl-2,3,4,5-tetrahydro-(1H-3)-benzazepines and their use as selective alpha-adrenergic receptor antagonists
US5942250A (en) * 1986-12-23 1999-08-24 Tristrata Technology, Inc. Compositions and methods for enhancing the topical effects of sunscreen agents
US6384079B1 (en) 1986-12-23 2002-05-07 Tristrata Technology, Incorporated Compositions comprising 2-hydroxycarboxylic acids and related compounds, and methods for alleviating signs of dermatological aging
GB9119467D0 (en) * 1991-09-12 1991-10-23 Smithkline Beecham Corp Chemical compounds
GB9708805D0 (en) 1997-05-01 1997-06-25 Smithkline Beecham Plc Compounds
GB9810876D0 (en) 1998-05-20 1998-07-22 Smithkline Beecham Plc Compounds
HUP0104280A3 (en) 1998-10-08 2002-07-29 Smithkline Beecham Plc Tetrahydrobenzazepine derivatives useful as modulators of dopamine d3 receptors, process for their preparation, medicaments containing them
US6953787B2 (en) 2002-04-12 2005-10-11 Arena Pharmaceuticals, Inc. 5HT2C receptor modulators
US7122538B2 (en) 2002-10-07 2006-10-17 Glaxo Group Limited Sulfonamide derivatives as antipsychotic agents
AU2004253888B2 (en) 2003-06-17 2010-11-11 Arena Pharmaceuticals, Inc. Benzazepine derivatives useful for the treatment of 5HT2C receptor associated diseases
JP4920409B2 (ja) 2003-06-17 2012-04-18 アリーナ ファーマシューティカルズ， インコーポレイテッド ３−ベンズアゼピンを調製する方法
CN102311387A (zh) * 2004-02-25 2012-01-11 伊莱利利公司 作为5-HT2C受体激动剂的6-取代的2,3,4,5-四氢-1H-苯并[d]氮杂䓬
ATE442359T1 (de) 2004-12-21 2009-09-15 Arena Pharm Inc Kristalline formen von (r)-8-chlor-1-methyl-2,3,4,5-tetrahydro-1h-3-be zazepinhydrochlorid
CN102627607A (zh) 2004-12-23 2012-08-08 艾尼纳制药公司 5HT2c受体调节剂组合物和使用方法
CA2646044A1 (en) 2006-04-03 2007-10-25 Arena Pharmaceuticals, Inc. Processes for the preparation of 8-chloro-1-methyl-2,3,4,5-tetrahydro-1h-3-benzazepine and intermediates related thereto
SG177128A1 (en) 2006-12-05 2012-01-30 Arena Pharm Inc Processes for preparing (r)-8-chloro-1-methyl-2,3,4,5-tetrahydro-1h-3-benzazepine and intermediates thereof
EP2288585A1 (en) 2008-03-04 2011-03-02 Arena Pharmaceuticals, Inc. Processes for the preparation of intermediates related to the 5-ht2c agonist (r)-8-chloro-1-methyl-2,3,4,5-tetrahydro-1h-3-benzazepine
EP2443080A2 (en) 2009-06-18 2012-04-25 Arena Pharmaceuticals, Inc. Process for the preparation of 5-ht2c receptor agonists
US9045431B2 (en) 2010-06-02 2015-06-02 Arena Pharmaceuticals, Inc. Processes for the preparation of 5-HT2C receptor agonists
US9248133B2 (en) 2010-09-01 2016-02-02 Arena Pharmaceuticals, Inc. Salts of lorcaserin with optically active acids
SG10201506865WA (en) 2010-09-01 2015-10-29 Arena Pharm Inc Non-hygroscopic salts of 5-ht2c agonists
JP2013540719A (ja) 2010-09-01 2013-11-07 アリーナ ファーマシューティカルズ， インコーポレイテッド 腎欠陥を有する個体へのロルカセリンの投与
CN103189053A (zh) 2010-09-01 2013-07-03 艾尼纳制药公司 用于体重控制的5-ht2c激动剂的调节释放剂型
MY181736A (en) 2012-10-09 2021-01-05 Arena Pharm Inc Method of weight management

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2520264A (en) * 1947-08-26 1950-08-29 Maltbie Lab Inc Substituted 3, 1-benz-2, 3, 4, 5-tetrahydroazepines
US3483185A (en) * 1966-08-16 1969-12-09 American Home Prod N-substituted 2,3,4,5-tetrahydro-1h-3-benzazepines
CA974989A (en) * 1968-03-11 1975-09-23 Wallace And Tiernan Inc. Process for preparing 1,2,4,5-tetrahydro-3h,3-benzazepines and products obtained thereby
US3671519A (en) 1969-07-14 1972-06-20 American Home Prod N-substituted 2,3,4,5,-tetrahydro-1h-3-benzazepines
US3752892A (en) 1970-03-11 1973-08-14 Ciba Geigy Corp Anorexigenic tetrahydrobenzazepine derivative method and composition thereof
US3716639A (en) 1970-03-11 1973-02-13 Ciba Geigy Corp Anorexigenic tetrahydrobenzazepines
US4111957A (en) * 1977-02-02 1978-09-05 Smithkline Corporation Substituted 1-thienyl and furyl-2,3,4,5-tetrahydro-1H-3-benzazepine compounds
US4108989A (en) * 1977-04-01 1978-08-22 Smithkline Corporation 2,3,4,5-tetrahydro-1h-3-benzazepine-7,8-diones

Also Published As

Publication number Publication date
AU525789B2 (en) 1982-12-02
FI67215C (fi) 1985-02-11
CS213381B2 (en) 1982-04-09
EP0007070A1 (en) 1980-01-23
NO792267L (no) 1980-01-08
JO1273B1 (en) 1986-11-30
DE2964530D1 (en) 1983-02-24
CA1115271A (en) 1981-12-29
ES482276A1 (es) 1980-04-01
EP0080012A1 (en) 1983-06-01
IT7924165A0 (it) 1979-07-06
PH15754A (en) 1983-03-18
EP0007070B1 (en) 1983-01-19
NZ190745A (en) 1981-01-23
JPS5511584A (en) 1980-01-26
JPH0153271B2 (xx) 1989-11-13
DK278379A (da) 1980-01-08
GR69675B (xx) 1982-07-07
IE791276L (en) 1980-01-07
NO152213B (no) 1985-05-13
ES482281A1 (es) 1980-04-01
AU4861379A (en) 1980-02-07
AR222828A1 (es) 1981-06-30
DD147355A5 (de) 1981-04-01
SU1029827A3 (ru) 1983-07-15
IL57532A0 (en) 1979-10-31
ES482282A1 (es) 1980-04-01
FI792125A (fi) 1980-01-08
IT1193190B (it) 1988-06-02
DK156001B (da) 1989-06-12
NO152213C (no) 1985-08-28
PL216908A1 (xx) 1980-08-11
HU179315B (en) 1982-09-28
PT69855A (en) 1979-08-01
EP0080012B1 (en) 1986-04-09
DK156001C (da) 1989-11-06
IE48654B1 (en) 1985-04-03
FI67215B (fi) 1984-10-31
ZA792785B (en) 1980-08-27

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