SG10201506865WA - Non-hygroscopic salts of 5-ht2c agonists - Google Patents

Non-hygroscopic salts of 5-ht2c agonists

Info

Publication number
SG10201506865WA
SG10201506865WA SG10201506865WA SG10201506865WA SG10201506865WA SG 10201506865W A SG10201506865W A SG 10201506865WA SG 10201506865W A SG10201506865W A SG 10201506865WA SG 10201506865W A SG10201506865W A SG 10201506865WA SG 10201506865W A SG10201506865W A SG 10201506865WA
Authority
SG
Singapore
Prior art keywords
hygroscopic salts
ht2c agonists
ht2c
agonists
hygroscopic
Prior art date
Application number
SG10201506865WA
Inventor
Anthony C Blackburn
Yun Shan
Anna Shifrina
Scott Stirn
Original Assignee
Arena Pharm Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Arena Pharm Inc filed Critical Arena Pharm Inc
Publication of SG10201506865WA publication Critical patent/SG10201506865WA/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
    • C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D223/16—Benzazepines; Hydrogenated benzazepines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/155—Amidines (), e.g. guanidine (H2N—C(=NH)—NH2), isourea (N=C(OH)—NH2), isothiourea (—N=C(SH)—NH2)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
    • C07C309/01—Sulfonic acids
    • C07C309/02—Sulfonic acids having sulfo groups bound to acyclic carbon atoms
    • C07C309/03—Sulfonic acids having sulfo groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton
    • C07C309/05—Sulfonic acids having sulfo groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton containing at least two sulfo groups bound to the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C55/00—Saturated compounds having more than one carboxyl group bound to acyclic carbon atoms
    • C07C55/02—Dicarboxylic acids
    • C07C55/06—Oxalic acid
    • C07C55/07—Salts thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C55/00—Saturated compounds having more than one carboxyl group bound to acyclic carbon atoms
    • C07C55/02—Dicarboxylic acids
    • C07C55/10—Succinic acid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/235—Saturated compounds containing more than one carboxyl group
    • C07C59/245—Saturated compounds containing more than one carboxyl group containing hydroxy or O-metal groups
    • C07C59/265—Citric acid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/235—Saturated compounds containing more than one carboxyl group
    • C07C59/347—Saturated compounds containing more than one carboxyl group containing keto groups
SG10201506865WA 2010-09-01 2011-08-31 Non-hygroscopic salts of 5-ht2c agonists SG10201506865WA (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US40261110P 2010-09-01 2010-09-01

Publications (1)

Publication Number Publication Date
SG10201506865WA true SG10201506865WA (en) 2015-10-29

Family

ID=44645828

Family Applications (2)

Application Number Title Priority Date Filing Date
SG2013015581A SG188361A1 (en) 2010-09-01 2011-08-31 Non-hygroscopic salts of 5-ht2c agonists
SG10201506865WA SG10201506865WA (en) 2010-09-01 2011-08-31 Non-hygroscopic salts of 5-ht2c agonists

Family Applications Before (1)

Application Number Title Priority Date Filing Date
SG2013015581A SG188361A1 (en) 2010-09-01 2011-08-31 Non-hygroscopic salts of 5-ht2c agonists

Country Status (10)

Country Link
US (2) US9365521B2 (en)
EP (1) EP2611433A2 (en)
JP (1) JP2013536859A (en)
KR (1) KR20130101524A (en)
CN (1) CN103189360A (en)
AU (1) AU2011296033A1 (en)
CA (1) CA2808904A1 (en)
MX (1) MX2013002421A (en)
SG (2) SG188361A1 (en)
WO (1) WO2012030957A2 (en)

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SG188364A1 (en) 2010-09-01 2013-04-30 Arena Pharm Inc Salts of lorcaserin with optically active acids
WO2012030927A2 (en) 2010-09-01 2012-03-08 Arena Pharmaceuticals, Inc. Modified-release dosage forms of 5-ht2c agonists useful for weight management
EP2611433A2 (en) * 2010-09-01 2013-07-10 Arena Pharmaceuticals, Inc. Non-hygroscopic salts of 5-ht2c agonists
KR20150070249A (en) 2012-10-09 2015-06-24 아레나 파마슈티칼스, 인크. Method of weight management
WO2015096119A1 (en) * 2013-12-27 2015-07-02 杭州普晒医药科技有限公司 Lorcaserin salts and crystals thereof, preparation methods and uses thereof
CN105228986B (en) 2014-04-21 2017-11-07 杭州普晒医药科技有限公司 A kind of lorcaserin eutectic and preparation method thereof, pharmaceutical composition and purposes
WO2016069875A1 (en) 2014-10-30 2016-05-06 Arena Pharmaceuticals, Inc. Compositions and methods for ceasing tobacco smoking
EP3860996A4 (en) 2018-10-02 2022-08-31 Northwestern University Beta-carbolines as positive allosteric modulators of the human serotonin receptor 2c (5-ht2c)

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US9365521B2 (en) 2016-06-14
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