NO792267L - Fremgangsmaate ved fremstilling av substituerte benzapiner - Google Patents

Fremgangsmaate ved fremstilling av substituerte benzapiner

Info

Publication number
NO792267L
NO792267L NO792267A NO792267A NO792267L NO 792267 L NO792267 L NO 792267L NO 792267 A NO792267 A NO 792267A NO 792267 A NO792267 A NO 792267A NO 792267 L NO792267 L NO 792267L
Authority
NO
Norway
Prior art keywords
benzapines
procedure
manufacturing substituted
substituted
manufacturing
Prior art date
Application number
NO792267A
Other languages
English (en)
Other versions
NO152213C (no
NO152213B (no
Inventor
Kenneth George Holden
Carl Kaiser
Original Assignee
Smithkline Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Smithkline Corp filed Critical Smithkline Corp
Publication of NO792267L publication Critical patent/NO792267L/no
Publication of NO152213B publication Critical patent/NO152213B/no
Publication of NO152213C publication Critical patent/NO152213C/no

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D223/00Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
    • C07D223/14Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D223/16Benzazepines; Hydrogenated benzazepines
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/20Hypnotics; Sedatives
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C41/00Preparation of ethers; Preparation of compounds having groups, groups or groups
    • C07C41/01Preparation of ethers
    • C07C41/18Preparation of ethers by reactions not forming ether-oxygen bonds
    • C07C41/22Preparation of ethers by reactions not forming ether-oxygen bonds by introduction of halogens; by substitution of halogen atoms by other halogen atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C41/00Preparation of ethers; Preparation of compounds having groups, groups or groups
    • C07C41/01Preparation of ethers
    • C07C41/18Preparation of ethers by reactions not forming ether-oxygen bonds
    • C07C41/26Preparation of ethers by reactions not forming ether-oxygen bonds by introduction of hydroxy or O-metal groups
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F5/00Compounds containing elements of Groups 3 or 13 of the Periodic Table
    • C07F5/02Boron compounds
    • C07F5/022Boron compounds without C-boron linkages

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurosurgery (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Anesthesiology (AREA)
  • Neurology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
NO792267A 1978-07-07 1979-07-06 Analogifremgangsmaate ved fremstilling av terapeutisk aktive substituerte benzazepiner NO152213C (no)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US92261378A 1978-07-07 1978-07-07

Publications (3)

Publication Number Publication Date
NO792267L true NO792267L (no) 1980-01-08
NO152213B NO152213B (no) 1985-05-13
NO152213C NO152213C (no) 1985-08-28

Family

ID=25447325

Family Applications (1)

Application Number Title Priority Date Filing Date
NO792267A NO152213C (no) 1978-07-07 1979-07-06 Analogifremgangsmaate ved fremstilling av terapeutisk aktive substituerte benzazepiner

Country Status (24)

Country Link
EP (2) EP0080012B1 (no)
JP (1) JPS5511584A (no)
AR (1) AR222828A1 (no)
AU (1) AU525789B2 (no)
CA (1) CA1115271A (no)
CS (1) CS213381B2 (no)
DD (1) DD147355A5 (no)
DE (1) DE2964530D1 (no)
DK (1) DK156001C (no)
ES (3) ES482282A1 (no)
FI (1) FI67215C (no)
GR (1) GR69675B (no)
HU (1) HU179315B (no)
IE (1) IE48654B1 (no)
IL (1) IL57532A (no)
IT (1) IT1193190B (no)
JO (1) JO1273B1 (no)
NO (1) NO152213C (no)
NZ (1) NZ190745A (no)
PH (1) PH15754A (no)
PL (1) PL216908A1 (no)
PT (1) PT69855A (no)
SU (1) SU1029827A3 (no)
ZA (1) ZA792785B (no)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3119874A1 (de) 1981-05-19 1982-12-09 Dr. Karl Thomae Gmbh, 7950 Biberach "benzazepinderivate, ihre herstellung und ihre verwendung als arzneimittel"
US4469634A (en) * 1982-07-29 1984-09-04 Smithkline Beckman Corporation Allyloxy- and allylthio-2,3,4,5-tetrahydro-1H-3-benzazepines
US4652642A (en) * 1984-08-23 1987-03-24 Smithkline Beckman Corporation Azidobenzazepines
US4683229A (en) * 1986-03-17 1987-07-28 Smithkline Beckman Corporation 6-halo-9-alkenyleneoxy-3-alkyl-2,3,4,5-tetrahydro-(1H-3)-benzazepines and their use as selective alpha-adrenergic receptor antagonists
US5942250A (en) * 1986-12-23 1999-08-24 Tristrata Technology, Inc. Compositions and methods for enhancing the topical effects of sunscreen agents
US6384079B1 (en) 1986-12-23 2002-05-07 Tristrata Technology, Incorporated Compositions comprising 2-hydroxycarboxylic acids and related compounds, and methods for alleviating signs of dermatological aging
GB9119467D0 (en) * 1991-09-12 1991-10-23 Smithkline Beecham Corp Chemical compounds
GB9708805D0 (en) 1997-05-01 1997-06-25 Smithkline Beecham Plc Compounds
GB9810876D0 (en) 1998-05-20 1998-07-22 Smithkline Beecham Plc Compounds
IL142388A0 (en) * 1998-10-08 2002-03-10 Smithkline Beecham Plc Tetrahydrobenzazepine derivatives useful as modulators of dopamine d3 receptors (antipsychotic agents)
US6953787B2 (en) 2002-04-12 2005-10-11 Arena Pharmaceuticals, Inc. 5HT2C receptor modulators
EP1549639B1 (en) * 2002-10-07 2006-05-24 Glaxo Group Limited Sulphonamide derivatives as antipsychotic agents
HUE028976T2 (en) 2003-06-17 2017-02-28 Arena Pharm Inc 8-Chloro-1-methyl-2,3,4,5-tetrahydro-1H-3-benzazepine hydrochloride
CN1805939B (zh) 2003-06-17 2010-10-13 艾尼纳制药公司 用于治疗5ht2c受体相关病症的苯并氮杂卓衍生物
EA011011B1 (ru) * 2004-02-25 2008-12-30 Эли Лилли Энд Компани 6-ЗАМЕЩЁННЫЕ 2,3,4,5-ТЕТРАГИДРО-1H-БЕНЗО[d]АЗЕПИНЫ В КАЧЕСТВЕ АГОНИСТОВ РЕЦЕПТОРОВ 5-HT
DK1838677T3 (da) 2004-12-21 2010-01-11 Arena Pharm Inc Krystallinske former af (R)-8-chlor-1.methyl-2,3,4,5-tetrahydro-1H-3-benzazepinhydrochlorid
SI1833473T1 (sl) 2004-12-23 2010-01-29 Arena Pharm Inc Sestavki modulatorjev 5HT2C receptorjev in postopki uporabe
JP5199997B2 (ja) 2006-04-03 2013-05-15 アリーナ ファーマシューティカルズ, インコーポレイテッド 8−クロロ−1−メチル−2,3,4,5−テトラヒドロ−1h−3−ベンズアゼピンおよびこれに関連する中間体を調製するためのプロセス
SG177128A1 (en) 2006-12-05 2012-01-30 Arena Pharm Inc Processes for preparing (r)-8-chloro-1-methyl-2,3,4,5-tetrahydro-1h-3-benzazepine and intermediates thereof
US8822727B2 (en) 2008-03-04 2014-09-02 Arena Pharmaceuticals, Inc. Processes for the preparation of intermediates related to the 5-HT2C agonist (R)-8-chloro-1-methyl-2,3,4,5-tetrahydro-1H-3-benzazepine
EP2443080A2 (en) 2009-06-18 2012-04-25 Arena Pharmaceuticals, Inc. Process for the preparation of 5-ht2c receptor agonists
KR20130112848A (ko) 2010-06-02 2013-10-14 아레나 파마슈티칼스, 인크. 5-ht2c 수용체 아고니스트의 제조 방법
CN103347523A (zh) 2010-09-01 2013-10-09 艾尼纳制药公司 向具有肾损伤的个体给药氯卡色林
CA2808904A1 (en) 2010-09-01 2012-03-08 Arena Pharmaceuticals, Inc. Non-hygroscopic salts of 5-ht2c agonists
EP2611782A1 (en) 2010-09-01 2013-07-10 Arena Pharmaceuticals, Inc. Salts of lorcaserin with optically active acids
EP3485878A1 (en) 2010-09-01 2019-05-22 Arena Pharmaceuticals, Inc. Modified-release dosage forms of 5-ht2c agonists useful for weight management
MY181736A (en) 2012-10-09 2021-01-05 Arena Pharm Inc Method of weight management

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2520264A (en) * 1947-08-26 1950-08-29 Maltbie Lab Inc Substituted 3, 1-benz-2, 3, 4, 5-tetrahydroazepines
US3483185A (en) * 1966-08-16 1969-12-09 American Home Prod N-substituted 2,3,4,5-tetrahydro-1h-3-benzazepines
CA974989A (en) * 1968-03-11 1975-09-23 Wallace And Tiernan Inc. Process for preparing 1,2,4,5-tetrahydro-3h,3-benzazepines and products obtained thereby
US3671519A (en) * 1969-07-14 1972-06-20 American Home Prod N-substituted 2,3,4,5,-tetrahydro-1h-3-benzazepines
US3752892A (en) 1970-03-11 1973-08-14 Ciba Geigy Corp Anorexigenic tetrahydrobenzazepine derivative method and composition thereof
US3716639A (en) 1970-03-11 1973-02-13 Ciba Geigy Corp Anorexigenic tetrahydrobenzazepines
US4111957A (en) * 1977-02-02 1978-09-05 Smithkline Corporation Substituted 1-thienyl and furyl-2,3,4,5-tetrahydro-1H-3-benzazepine compounds
US4108989A (en) * 1977-04-01 1978-08-22 Smithkline Corporation 2,3,4,5-tetrahydro-1h-3-benzazepine-7,8-diones

Also Published As

Publication number Publication date
AR222828A1 (es) 1981-06-30
IL57532A (en) 1982-08-31
JPS5511584A (en) 1980-01-26
DK278379A (da) 1980-01-08
CA1115271A (en) 1981-12-29
PL216908A1 (no) 1980-08-11
EP0007070A1 (en) 1980-01-23
SU1029827A3 (ru) 1983-07-15
DD147355A5 (de) 1981-04-01
IT1193190B (it) 1988-06-02
PH15754A (en) 1983-03-18
HU179315B (en) 1982-09-28
ES482276A1 (es) 1980-04-01
AU525789B2 (en) 1982-12-02
DK156001C (da) 1989-11-06
DK156001B (da) 1989-06-12
NO152213C (no) 1985-08-28
NZ190745A (en) 1981-01-23
EP0080012A1 (en) 1983-06-01
GR69675B (no) 1982-07-07
ES482282A1 (es) 1980-04-01
AU4861379A (en) 1980-02-07
EP0080012B1 (en) 1986-04-09
JPH0153271B2 (no) 1989-11-13
JO1273B1 (en) 1986-11-30
ES482281A1 (es) 1980-04-01
FI792125A (fi) 1980-01-08
IT7924165A0 (it) 1979-07-06
EP0007070B1 (en) 1983-01-19
FI67215C (fi) 1985-02-11
IL57532A0 (en) 1979-10-31
IE48654B1 (en) 1985-04-03
DE2964530D1 (en) 1983-02-24
FI67215B (fi) 1984-10-31
NO152213B (no) 1985-05-13
ZA792785B (en) 1980-08-27
CS213381B2 (en) 1982-04-09
PT69855A (en) 1979-08-01
IE791276L (en) 1980-01-07

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