FI792125A - Merkapto substituerade 2,3,4,5-tetrahydro-1h-3-benzazepiner - Google Patents

Merkapto substituerade 2,3,4,5-tetrahydro-1h-3-benzazepiner

Info

Publication number
FI792125A
FI792125A FI792125A FI792125A FI792125A FI 792125 A FI792125 A FI 792125A FI 792125 A FI792125 A FI 792125A FI 792125 A FI792125 A FI 792125A FI 792125 A FI792125 A FI 792125A
Authority
FI
Finland
Prior art keywords
benzazepiner
merkapto
substituerade
tetrahydro
merkapto substituerade
Prior art date
Application number
FI792125A
Other languages
English (en)
Other versions
FI67215C (fi
FI67215B (fi
Inventor
Kenneth George Holden
Carl Kaiser
Original Assignee
Smithkline Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Smithkline Corp filed Critical Smithkline Corp
Publication of FI792125A publication Critical patent/FI792125A/fi
Application granted granted Critical
Publication of FI67215B publication Critical patent/FI67215B/fi
Publication of FI67215C publication Critical patent/FI67215C/fi

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
    • C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D223/16—Benzazepines; Hydrogenated benzazepines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C41/00—Preparation of ethers; Preparation of compounds having groups, groups or groups
    • C07C41/01—Preparation of ethers
    • C07C41/18—Preparation of ethers by reactions not forming ether-oxygen bonds
    • C07C41/22—Preparation of ethers by reactions not forming ether-oxygen bonds by introduction of halogens; by substitution of halogen atoms by other halogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C41/00—Preparation of ethers; Preparation of compounds having groups, groups or groups
    • C07C41/01—Preparation of ethers
    • C07C41/18—Preparation of ethers by reactions not forming ether-oxygen bonds
    • C07C41/26—Preparation of ethers by reactions not forming ether-oxygen bonds by introduction of hydroxy or O-metal groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic Table
    • C07F5/02—Boron compounds
    • C07F5/022—Boron compounds without C-boron linkages

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Anesthesiology (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
FI792125A 1978-07-07 1979-07-05 Foerfarande foer framstaellning av saosom laekemedel anvaendbara 2,3,4,5-tetrahydro-1h-3-bensazepiner FI67215C (fi)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US92261378A 1978-07-07 1978-07-07
US92261378 1978-07-07

Publications (3)

Publication Number Publication Date
FI792125A true FI792125A (fi) 1980-01-08
FI67215B FI67215B (fi) 1984-10-31
FI67215C FI67215C (fi) 1985-02-11

Family

ID=25447325

Family Applications (1)

Application Number Title Priority Date Filing Date
FI792125A FI67215C (fi) 1978-07-07 1979-07-05 Foerfarande foer framstaellning av saosom laekemedel anvaendbara 2,3,4,5-tetrahydro-1h-3-bensazepiner

Country Status (24)

Country Link
EP (2) EP0080012B1 (fi)
JP (1) JPS5511584A (fi)
AR (1) AR222828A1 (fi)
AU (1) AU525789B2 (fi)
CA (1) CA1115271A (fi)
CS (1) CS213381B2 (fi)
DD (1) DD147355A5 (fi)
DE (1) DE2964530D1 (fi)
DK (1) DK156001C (fi)
ES (3) ES482276A1 (fi)
FI (1) FI67215C (fi)
GR (1) GR69675B (fi)
HU (1) HU179315B (fi)
IE (1) IE48654B1 (fi)
IL (1) IL57532A (fi)
IT (1) IT1193190B (fi)
JO (1) JO1273B1 (fi)
NO (1) NO152213C (fi)
NZ (1) NZ190745A (fi)
PH (1) PH15754A (fi)
PL (1) PL216908A1 (fi)
PT (1) PT69855A (fi)
SU (1) SU1029827A3 (fi)
ZA (1) ZA792785B (fi)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3119874A1 (de) 1981-05-19 1982-12-09 Dr. Karl Thomae Gmbh, 7950 Biberach "benzazepinderivate, ihre herstellung und ihre verwendung als arzneimittel"
US4469634A (en) * 1982-07-29 1984-09-04 Smithkline Beckman Corporation Allyloxy- and allylthio-2,3,4,5-tetrahydro-1H-3-benzazepines
US4652642A (en) * 1984-08-23 1987-03-24 Smithkline Beckman Corporation Azidobenzazepines
US4683229A (en) * 1986-03-17 1987-07-28 Smithkline Beckman Corporation 6-halo-9-alkenyleneoxy-3-alkyl-2,3,4,5-tetrahydro-(1H-3)-benzazepines and their use as selective alpha-adrenergic receptor antagonists
US6384079B1 (en) 1986-12-23 2002-05-07 Tristrata Technology, Incorporated Compositions comprising 2-hydroxycarboxylic acids and related compounds, and methods for alleviating signs of dermatological aging
US5942250A (en) * 1986-12-23 1999-08-24 Tristrata Technology, Inc. Compositions and methods for enhancing the topical effects of sunscreen agents
GB9119467D0 (en) * 1991-09-12 1991-10-23 Smithkline Beecham Corp Chemical compounds
GB9708805D0 (en) 1997-05-01 1997-06-25 Smithkline Beecham Plc Compounds
GB9810876D0 (en) 1998-05-20 1998-07-22 Smithkline Beecham Plc Compounds
BR9914370A (pt) * 1998-10-08 2001-11-27 Smithkline Beecham Plc Derivados de tetraidrobenzazepina úteis comomoduladores de receptores para a dopamina d3(agentes antipsicóticos)
US6953787B2 (en) 2002-04-12 2005-10-11 Arena Pharmaceuticals, Inc. 5HT2C receptor modulators
ES2264003T3 (es) * 2002-10-07 2006-12-16 Glaxo Group Limited Derivados de sulfonamida como agentges antipsicoticos.
CA2888392A1 (en) 2003-06-17 2005-03-03 Arena Pharmaceuticals, Inc. Processes for preparing 3-benzazepines
ES2571220T3 (es) 2003-06-17 2016-05-24 Arena Pharm Inc Clorhidrato de 8-cloro-1-metil-2,3,4,5-tetrahidro-1H-3-benzazepina
CA2556390C (en) * 2004-02-25 2012-10-02 Eli Lilly And Company 6-substituted 2,3,4,5-tetrahydro-1h-benzo[d]azepines as 5-ht2c receptor agonists
PL1838677T3 (pl) 2004-12-21 2010-02-26 Arena Pharm Inc Krystaliczne postacie agonisty chlorowodorku (R)-8-chloro-1-metylo-2,3,4,5-tetrahydro-1H-3-benzazepiny
NZ589951A (en) 2004-12-23 2012-11-30 Arena Pharm Inc 5HT2C receptor modulator compositions and methods of use
WO2007120517A2 (en) 2006-04-03 2007-10-25 Arena Pharmaceuticals, Inc. Processes for the preparation of 8-chloro-1-methyl-2,3,4,5-tetrahydro-1h-3-benzazepine and intermediates related thereto
ES2522587T3 (es) 2006-12-05 2014-11-17 Arena Pharmaceuticals, Inc. Procesos para preparar (R)-8-cloro-1-metil-2,3,4,5-tetrahidro-1H-3-benzacepina e intermedios de la misma
US8822727B2 (en) 2008-03-04 2014-09-02 Arena Pharmaceuticals, Inc. Processes for the preparation of intermediates related to the 5-HT2C agonist (R)-8-chloro-1-methyl-2,3,4,5-tetrahydro-1H-3-benzazepine
CN102648170A (zh) 2009-06-18 2012-08-22 艾尼纳制药公司 制备5-ht2c受体激动剂的方法
WO2011153206A1 (en) 2010-06-02 2011-12-08 Arena Pharmaceuticals, Inc. Processes for the preparation of 5-ht2c receptor agonists
EP2611433A2 (en) 2010-09-01 2013-07-10 Arena Pharmaceuticals, Inc. Non-hygroscopic salts of 5-ht2c agonists
CN103189053A (zh) 2010-09-01 2013-07-03 艾尼纳制药公司 用于体重控制的5-ht2c激动剂的调节释放剂型
CN103347523A (zh) 2010-09-01 2013-10-09 艾尼纳制药公司 向具有肾损伤的个体给药氯卡色林
US9248133B2 (en) 2010-09-01 2016-02-02 Arena Pharmaceuticals, Inc. Salts of lorcaserin with optically active acids
KR20190128001A (ko) 2012-10-09 2019-11-13 에자이 알앤드디 매니지먼트 가부시키가이샤 체중 관리 방법

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2520264A (en) * 1947-08-26 1950-08-29 Maltbie Lab Inc Substituted 3, 1-benz-2, 3, 4, 5-tetrahydroazepines
US3483185A (en) 1966-08-16 1969-12-09 American Home Prod N-substituted 2,3,4,5-tetrahydro-1h-3-benzazepines
CA974989A (en) * 1968-03-11 1975-09-23 Wallace And Tiernan Inc. Process for preparing 1,2,4,5-tetrahydro-3h,3-benzazepines and products obtained thereby
US3671519A (en) 1969-07-14 1972-06-20 American Home Prod N-substituted 2,3,4,5,-tetrahydro-1h-3-benzazepines
US3716639A (en) 1970-03-11 1973-02-13 Ciba Geigy Corp Anorexigenic tetrahydrobenzazepines
US3752892A (en) 1970-03-11 1973-08-14 Ciba Geigy Corp Anorexigenic tetrahydrobenzazepine derivative method and composition thereof
US4111957A (en) * 1977-02-02 1978-09-05 Smithkline Corporation Substituted 1-thienyl and furyl-2,3,4,5-tetrahydro-1H-3-benzazepine compounds
US4108989A (en) * 1977-04-01 1978-08-22 Smithkline Corporation 2,3,4,5-tetrahydro-1h-3-benzazepine-7,8-diones

Also Published As

Publication number Publication date
DD147355A5 (de) 1981-04-01
EP0007070A1 (en) 1980-01-23
IE791276L (en) 1980-01-07
DE2964530D1 (en) 1983-02-24
PL216908A1 (fi) 1980-08-11
FI67215C (fi) 1985-02-11
EP0007070B1 (en) 1983-01-19
NO792267L (no) 1980-01-08
IT7924165A0 (it) 1979-07-06
IL57532A0 (en) 1979-10-31
JO1273B1 (en) 1986-11-30
DK156001B (da) 1989-06-12
DK156001C (da) 1989-11-06
ZA792785B (en) 1980-08-27
CA1115271A (en) 1981-12-29
HU179315B (en) 1982-09-28
CS213381B2 (en) 1982-04-09
EP0080012A1 (en) 1983-06-01
AR222828A1 (es) 1981-06-30
ES482282A1 (es) 1980-04-01
DK278379A (da) 1980-01-08
NO152213C (no) 1985-08-28
GR69675B (fi) 1982-07-07
NO152213B (no) 1985-05-13
ES482281A1 (es) 1980-04-01
FI67215B (fi) 1984-10-31
JPS5511584A (en) 1980-01-26
JPH0153271B2 (fi) 1989-11-13
AU4861379A (en) 1980-02-07
EP0080012B1 (en) 1986-04-09
NZ190745A (en) 1981-01-23
AU525789B2 (en) 1982-12-02
IL57532A (en) 1982-08-31
ES482276A1 (es) 1980-04-01
IE48654B1 (en) 1985-04-03
PT69855A (en) 1979-08-01
SU1029827A3 (ru) 1983-07-15
PH15754A (en) 1983-03-18
IT1193190B (it) 1988-06-02

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Legal Events

Date Code Title Description
FD Application lapsed
MM Patent lapsed

Owner name: SMITHKLINE CORPORATION