JPS5511584A - Mercapto substitutedd2*3*4*55tetrahydroo1hh 33benzazepin - Google Patents

Mercapto substitutedd2*3*4*55tetrahydroo1hh 33benzazepin

Info

Publication number
JPS5511584A
JPS5511584A JP8252779A JP8252779A JPS5511584A JP S5511584 A JPS5511584 A JP S5511584A JP 8252779 A JP8252779 A JP 8252779A JP 8252779 A JP8252779 A JP 8252779A JP S5511584 A JPS5511584 A JP S5511584A
Authority
JP
Japan
Prior art keywords
mercapto
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP8252779A
Other languages
English (en)
Other versions
JPH0153271B2 (ja
Inventor
Jiyooji Hooruden Kenesu
Kaizaa Kaaru
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
GlaxoSmithKline LLC
Original Assignee
SmithKline Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by SmithKline Corp filed Critical SmithKline Corp
Publication of JPS5511584A publication Critical patent/JPS5511584A/ja
Publication of JPH0153271B2 publication Critical patent/JPH0153271B2/ja
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
    • C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D223/16—Benzazepines; Hydrogenated benzazepines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C41/00—Preparation of ethers; Preparation of compounds having groups, groups or groups
    • C07C41/01—Preparation of ethers
    • C07C41/18—Preparation of ethers by reactions not forming ether-oxygen bonds
    • C07C41/22—Preparation of ethers by reactions not forming ether-oxygen bonds by introduction of halogens; by substitution of halogen atoms by other halogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C41/00—Preparation of ethers; Preparation of compounds having groups, groups or groups
    • C07C41/01—Preparation of ethers
    • C07C41/18—Preparation of ethers by reactions not forming ether-oxygen bonds
    • C07C41/26—Preparation of ethers by reactions not forming ether-oxygen bonds by introduction of hydroxy or O-metal groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic System
    • C07F5/02—Boron compounds
    • C07F5/022—Boron compounds without C-boron linkages
JP8252779A 1978-07-07 1979-06-28 Mercapto substitutedd2*3*4*55tetrahydroo1hh 33benzazepin Granted JPS5511584A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US92261378A 1978-07-07 1978-07-07

Publications (2)

Publication Number Publication Date
JPS5511584A true JPS5511584A (en) 1980-01-26
JPH0153271B2 JPH0153271B2 (ja) 1989-11-13

Family

ID=25447325

Family Applications (1)

Application Number Title Priority Date Filing Date
JP8252779A Granted JPS5511584A (en) 1978-07-07 1979-06-28 Mercapto substitutedd2*3*4*55tetrahydroo1hh 33benzazepin

Country Status (24)

Country Link
EP (2) EP0080012B1 (ja)
JP (1) JPS5511584A (ja)
AR (1) AR222828A1 (ja)
AU (1) AU525789B2 (ja)
CA (1) CA1115271A (ja)
CS (1) CS213381B2 (ja)
DD (1) DD147355A5 (ja)
DE (1) DE2964530D1 (ja)
DK (1) DK156001C (ja)
ES (3) ES482276A1 (ja)
FI (1) FI67215C (ja)
GR (1) GR69675B (ja)
HU (1) HU179315B (ja)
IE (1) IE48654B1 (ja)
IL (1) IL57532A (ja)
IT (1) IT1193190B (ja)
JO (1) JO1273B1 (ja)
NO (1) NO152213C (ja)
NZ (1) NZ190745A (ja)
PH (1) PH15754A (ja)
PL (1) PL216908A1 (ja)
PT (1) PT69855A (ja)
SU (1) SU1029827A3 (ja)
ZA (1) ZA792785B (ja)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP4796047B2 (ja) * 2004-02-25 2011-10-19 イーライ リリー アンド カンパニー ５−ＨＴ２Ｃ受容体作用薬としての６−置換２，３，４，５−テトラヒドロ−１Ｈ−ベンゾ［ｄ］アゼピン

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3119874A1 (de) 1981-05-19 1982-12-09 Dr. Karl Thomae Gmbh, 7950 Biberach "benzazepinderivate, ihre herstellung und ihre verwendung als arzneimittel"
US4469634A (en) * 1982-07-29 1984-09-04 Smithkline Beckman Corporation Allyloxy- and allylthio-2,3,4,5-tetrahydro-1H-3-benzazepines
US4652642A (en) * 1984-08-23 1987-03-24 Smithkline Beckman Corporation Azidobenzazepines
US4683229A (en) * 1986-03-17 1987-07-28 Smithkline Beckman Corporation 6-halo-9-alkenyleneoxy-3-alkyl-2,3,4,5-tetrahydro-(1H-3)-benzazepines and their use as selective alpha-adrenergic receptor antagonists
US5942250A (en) * 1986-12-23 1999-08-24 Tristrata Technology, Inc. Compositions and methods for enhancing the topical effects of sunscreen agents
US6384079B1 (en) 1986-12-23 2002-05-07 Tristrata Technology, Incorporated Compositions comprising 2-hydroxycarboxylic acids and related compounds, and methods for alleviating signs of dermatological aging
GB9119467D0 (en) * 1991-09-12 1991-10-23 Smithkline Beecham Corp Chemical compounds
GB9708805D0 (en) 1997-05-01 1997-06-25 Smithkline Beecham Plc Compounds
GB9810876D0 (en) 1998-05-20 1998-07-22 Smithkline Beecham Plc Compounds
PL347237A1 (en) 1998-10-08 2002-03-25 Smithkline Beecham Plc Tetrahydrobenzazepine derivatives useful as modulators of dopamine d3 receptors (antipsychotic agents)
US6953787B2 (en) 2002-04-12 2005-10-11 Arena Pharmaceuticals, Inc. 5HT2C receptor modulators
DE60305519T2 (de) 2002-10-07 2006-11-23 Glaxo Group Ltd., Greenford Sulfonamidderivate als antipsychotische mittel
CN1805939B (zh) 2003-06-17 2010-10-13 艾尼纳制药公司 用于治疗5ht2c受体相关病症的苯并氮杂卓衍生物
SI2332921T1 (sl) 2003-06-17 2016-06-30 Arena Pharmaceuticals, Inc. 8-kloro-1-metil-2,3,4,5-tetrahidro-1H-3-benzazapin hidroklorid
EP1838677B1 (en) 2004-12-21 2009-09-09 Arena Pharmaceuticals, Inc. Crystalline forms of (r)-8-chloro-1-methyl- 2,3,4,5-tetrahydro-1h-3-benzazepine hydrochloride
EP2322162A1 (en) 2004-12-23 2011-05-18 Arena Pharmaceuticals, Inc. 5HT2C receptor modulator compositions and methods of use
JP5199997B2 (ja) 2006-04-03 2013-05-15 アリーナ ファーマシューティカルズ， インコーポレイテッド ８−クロロ−１−メチル−２，３，４，５−テトラヒドロ−１ｈ−３−ベンズアゼピンおよびこれに関連する中間体を調製するためのプロセス
EP2099743B1 (en) 2006-12-05 2014-08-27 Arena Pharmaceuticals, Inc. Processes for preparing (r)-8-chloro-1-methyl-2,3,4,5-tetrahydro-1h-3-benzazepine and intermediates thereof
US8822727B2 (en) 2008-03-04 2014-09-02 Arena Pharmaceuticals, Inc. Processes for the preparation of intermediates related to the 5-HT2C agonist (R)-8-chloro-1-methyl-2,3,4,5-tetrahydro-1H-3-benzazepine
US8952197B2 (en) 2009-06-18 2015-02-10 Arena Pharmaceuticals, Inc. Processes for the preparation of 5-HT2C receptor agonists
KR20130112848A (ko) 2010-06-02 2013-10-14 아레나 파마슈티칼스, 인크. 5-ｈｔ2ｃ 수용체 아고니스트의 제조 방법
EP2611449A1 (en) 2010-09-01 2013-07-10 Arena Pharmaceuticals, Inc. Administration of lorcaserin to individuals with renal impairment
CA2808904A1 (en) 2010-09-01 2012-03-08 Arena Pharmaceuticals, Inc. Non-hygroscopic salts of 5-ht2c agonists
EP3485878A1 (en) 2010-09-01 2019-05-22 Arena Pharmaceuticals, Inc. Modified-release dosage forms of 5-ht2c agonists useful for weight management
SG188364A1 (en) 2010-09-01 2013-04-30 Arena Pharm Inc Salts of lorcaserin with optically active acids
RU2674670C1 (ru) 2012-10-09 2018-12-12 Арена Фармасьютикалз, Инк. Способ коррекции массы тела

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2520264A (en) * 1947-08-26 1950-08-29 Maltbie Lab Inc Substituted 3, 1-benz-2, 3, 4, 5-tetrahydroazepines
US3483185A (en) * 1966-08-16 1969-12-09 American Home Prod N-substituted 2,3,4,5-tetrahydro-1h-3-benzazepines
CA974989A (en) * 1968-03-11 1975-09-23 Wallace And Tiernan Inc. Process for preparing 1,2,4,5-tetrahydro-3h,3-benzazepines and products obtained thereby
US3671519A (en) 1969-07-14 1972-06-20 American Home Prod N-substituted 2,3,4,5,-tetrahydro-1h-3-benzazepines
US3752892A (en) 1970-03-11 1973-08-14 Ciba Geigy Corp Anorexigenic tetrahydrobenzazepine derivative method and composition thereof
US3716639A (en) 1970-03-11 1973-02-13 Ciba Geigy Corp Anorexigenic tetrahydrobenzazepines
US4111957A (en) * 1977-02-02 1978-09-05 Smithkline Corporation Substituted 1-thienyl and furyl-2,3,4,5-tetrahydro-1H-3-benzazepine compounds
US4108989A (en) * 1977-04-01 1978-08-22 Smithkline Corporation 2,3,4,5-tetrahydro-1h-3-benzazepine-7,8-diones

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP4796047B2 (ja) * 2004-02-25 2011-10-19 イーライ リリー アンド カンパニー ５−ＨＴ２Ｃ受容体作用薬としての６−置換２，３，４，５−テトラヒドロ−１Ｈ−ベンゾ［ｄ］アゼピン

Also Published As

Publication number Publication date
NO152213B (no) 1985-05-13
JO1273B1 (en) 1986-11-30
IL57532A0 (en) 1979-10-31
DK156001B (da) 1989-06-12
DK278379A (da) 1980-01-08
AU525789B2 (en) 1982-12-02
EP0007070A1 (en) 1980-01-23
SU1029827A3 (ru) 1983-07-15
PH15754A (en) 1983-03-18
ES482281A1 (es) 1980-04-01
EP0080012A1 (en) 1983-06-01
ES482276A1 (es) 1980-04-01
ES482282A1 (es) 1980-04-01
AU4861379A (en) 1980-02-07
PT69855A (en) 1979-08-01
NZ190745A (en) 1981-01-23
DK156001C (da) 1989-11-06
IT1193190B (it) 1988-06-02
NO152213C (no) 1985-08-28
DD147355A5 (de) 1981-04-01
JPH0153271B2 (ja) 1989-11-13
IE48654B1 (en) 1985-04-03
DE2964530D1 (en) 1983-02-24
GR69675B (ja) 1982-07-07
FI67215C (fi) 1985-02-11
CA1115271A (en) 1981-12-29
NO792267L (no) 1980-01-08
PL216908A1 (ja) 1980-08-11
IL57532A (en) 1982-08-31
CS213381B2 (en) 1982-04-09
FI792125A (fi) 1980-01-08
EP0007070B1 (en) 1983-01-19
HU179315B (en) 1982-09-28
IT7924165A0 (it) 1979-07-06
AR222828A1 (es) 1981-06-30
IE791276L (en) 1980-01-07
ZA792785B (en) 1980-08-27
FI67215B (fi) 1984-10-31
EP0080012B1 (en) 1986-04-09

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