DK156001C - Analogifremgangsmaade til fremstilling af mercaptosubstituerede 2,3,4,5-tetrahydro-1h-3-benzazepiner - Google Patents

Analogifremgangsmaade til fremstilling af mercaptosubstituerede 2,3,4,5-tetrahydro-1h-3-benzazepiner

Info

Publication number
DK156001C
DK156001C DK278379A DK278379A DK156001C DK 156001 C DK156001 C DK 156001C DK 278379 A DK278379 A DK 278379A DK 278379 A DK278379 A DK 278379A DK 156001 C DK156001 C DK 156001C
Authority
DK
Denmark
Prior art keywords
benzazepines
mercaptos
tetrahydro
analogue
substituted
Prior art date
Application number
DK278379A
Other languages
Danish (da)
English (en)
Other versions
DK278379A (da
DK156001B (da
Inventor
Kenneth George Holden
Carl Kaiser
Original Assignee
Smithkline Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Smithkline Corp filed Critical Smithkline Corp
Publication of DK278379A publication Critical patent/DK278379A/da
Publication of DK156001B publication Critical patent/DK156001B/da
Application granted granted Critical
Publication of DK156001C publication Critical patent/DK156001C/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
    • C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D223/16—Benzazepines; Hydrogenated benzazepines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C41/00—Preparation of ethers; Preparation of compounds having groups, groups or groups
    • C07C41/01—Preparation of ethers
    • C07C41/18—Preparation of ethers by reactions not forming ether-oxygen bonds
    • C07C41/22—Preparation of ethers by reactions not forming ether-oxygen bonds by introduction of halogens; by substitution of halogen atoms by other halogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C41/00—Preparation of ethers; Preparation of compounds having groups, groups or groups
    • C07C41/01—Preparation of ethers
    • C07C41/18—Preparation of ethers by reactions not forming ether-oxygen bonds
    • C07C41/26—Preparation of ethers by reactions not forming ether-oxygen bonds by introduction of hydroxy or O-metal groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic Table
    • C07F5/02—Boron compounds
    • C07F5/022—Boron compounds without C-boron linkages

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurosurgery (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Anesthesiology (AREA)
  • Neurology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
DK278379A 1978-07-07 1979-07-02 Analogifremgangsmaade til fremstilling af mercaptosubstituerede 2,3,4,5-tetrahydro-1h-3-benzazepiner DK156001C (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US92261378A 1978-07-07 1978-07-07
US92261378 1978-07-07

Publications (3)

Publication Number Publication Date
DK278379A DK278379A (da) 1980-01-08
DK156001B DK156001B (da) 1989-06-12
DK156001C true DK156001C (da) 1989-11-06

Family

ID=25447325

Family Applications (1)

Application Number Title Priority Date Filing Date
DK278379A DK156001C (da) 1978-07-07 1979-07-02 Analogifremgangsmaade til fremstilling af mercaptosubstituerede 2,3,4,5-tetrahydro-1h-3-benzazepiner

Country Status (24)

Country Link
EP (2) EP0007070B1 (ja)
JP (1) JPS5511584A (ja)
AR (1) AR222828A1 (ja)
AU (1) AU525789B2 (ja)
CA (1) CA1115271A (ja)
CS (1) CS213381B2 (ja)
DD (1) DD147355A5 (ja)
DE (1) DE2964530D1 (ja)
DK (1) DK156001C (ja)
ES (3) ES482282A1 (ja)
FI (1) FI67215C (ja)
GR (1) GR69675B (ja)
HU (1) HU179315B (ja)
IE (1) IE48654B1 (ja)
IL (1) IL57532A (ja)
IT (1) IT1193190B (ja)
JO (1) JO1273B1 (ja)
NO (1) NO152213C (ja)
NZ (1) NZ190745A (ja)
PH (1) PH15754A (ja)
PL (1) PL216908A1 (ja)
PT (1) PT69855A (ja)
SU (1) SU1029827A3 (ja)
ZA (1) ZA792785B (ja)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3119874A1 (de) 1981-05-19 1982-12-09 Dr. Karl Thomae Gmbh, 7950 Biberach "benzazepinderivate, ihre herstellung und ihre verwendung als arzneimittel"
US4469634A (en) * 1982-07-29 1984-09-04 Smithkline Beckman Corporation Allyloxy- and allylthio-2,3,4,5-tetrahydro-1H-3-benzazepines
US4652642A (en) * 1984-08-23 1987-03-24 Smithkline Beckman Corporation Azidobenzazepines
US4683229A (en) * 1986-03-17 1987-07-28 Smithkline Beckman Corporation 6-halo-9-alkenyleneoxy-3-alkyl-2,3,4,5-tetrahydro-(1H-3)-benzazepines and their use as selective alpha-adrenergic receptor antagonists
US5942250A (en) * 1986-12-23 1999-08-24 Tristrata Technology, Inc. Compositions and methods for enhancing the topical effects of sunscreen agents
US6384079B1 (en) 1986-12-23 2002-05-07 Tristrata Technology, Incorporated Compositions comprising 2-hydroxycarboxylic acids and related compounds, and methods for alleviating signs of dermatological aging
GB9119467D0 (en) * 1991-09-12 1991-10-23 Smithkline Beecham Corp Chemical compounds
GB9708805D0 (en) 1997-05-01 1997-06-25 Smithkline Beecham Plc Compounds
GB9810876D0 (en) 1998-05-20 1998-07-22 Smithkline Beecham Plc Compounds
US6605607B1 (en) * 1998-10-08 2003-08-12 Smithkline Beecham P.L.C. Tetrahydrobenzazepine derivatives useful as modulators of dopamine D3 receptors (antipsychotic agents)
US6953787B2 (en) 2002-04-12 2005-10-11 Arena Pharmaceuticals, Inc. 5HT2C receptor modulators
DE60305519T2 (de) 2002-10-07 2006-11-23 Glaxo Group Ltd., Greenford Sulfonamidderivate als antipsychotische mittel
SI2332921T1 (sl) 2003-06-17 2016-06-30 Arena Pharmaceuticals, Inc. 8-kloro-1-metil-2,3,4,5-tetrahidro-1H-3-benzazapin hidroklorid
CN101792417A (zh) 2003-06-17 2010-08-04 艾尼纳制药公司 用于治疗5ht2c受体相关疾病的苯并氮杂卓衍生物
PL1720836T3 (pl) * 2004-02-25 2014-09-30 Lilly Co Eli 6-podstawione 2,3,4,5-tetrahydro-1h-benzo [d]azepiny jako agoniści receptora 5-ht2c
ES2332009T3 (es) 2004-12-21 2010-01-22 Arena Pharmaceuticals, Inc. Formas cristalinas de hidrocloruro de (r)-8-cloro-1-metil-2,3,4,5-tetrahidro-1h-3-benzazepina.
SI1833473T1 (sl) 2004-12-23 2010-01-29 Arena Pharm Inc Sestavki modulatorjev 5HT2C receptorjev in postopki uporabe
CA2646044A1 (en) 2006-04-03 2007-10-25 Arena Pharmaceuticals, Inc. Processes for the preparation of 8-chloro-1-methyl-2,3,4,5-tetrahydro-1h-3-benzazepine and intermediates related thereto
SG177128A1 (en) 2006-12-05 2012-01-30 Arena Pharm Inc Processes for preparing (r)-8-chloro-1-methyl-2,3,4,5-tetrahydro-1h-3-benzazepine and intermediates thereof
JP5491421B2 (ja) 2008-03-04 2014-05-14 アリーナ ファーマシューティカルズ， インコーポレイテッド ５−ｈｔ２ｃアゴニストである（ｒ）−８−クロロ−１−メチル−２，３，４，５−テトラヒドロ−１ｈ−３−ベンゾアゼピンに関連する中間体の調製のためのプロセス
EP2443080A2 (en) 2009-06-18 2012-04-25 Arena Pharmaceuticals, Inc. Process for the preparation of 5-ht2c receptor agonists
KR20130112848A (ko) 2010-06-02 2013-10-14 아레나 파마슈티칼스, 인크. 5-ｈｔ2ｃ 수용체 아고니스트의 제조 방법
MX2013002422A (es) 2010-09-01 2013-05-17 Arena Pharm Inc Sales de lorcaserina con acidos opticamente activos.
EP3485878A1 (en) 2010-09-01 2019-05-22 Arena Pharmaceuticals, Inc. Modified-release dosage forms of 5-ht2c agonists useful for weight management
SG188365A1 (en) 2010-09-01 2013-04-30 Arena Pharm Inc Administration of lorcaserin to individuals with renal impairment
CN103189360A (zh) 2010-09-01 2013-07-03 艾尼纳制药公司 5-ht2c激动剂的非吸湿性盐
AU2012392187B2 (en) 2012-10-09 2018-07-12 Arena Pharmaceuticals, Inc. Method of weight management

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2520264A (en) * 1947-08-26 1950-08-29 Maltbie Lab Inc Substituted 3, 1-benz-2, 3, 4, 5-tetrahydroazepines
US3483185A (en) * 1966-08-16 1969-12-09 American Home Prod N-substituted 2,3,4,5-tetrahydro-1h-3-benzazepines
GB1268243A (en) * 1968-03-11 1972-03-22 Wallace & Tiernan Inc 0,2,4,5,-tetrahydro-3h,3-benzazepines
US3671519A (en) * 1969-07-14 1972-06-20 American Home Prod N-substituted 2,3,4,5,-tetrahydro-1h-3-benzazepines
US3752892A (en) 1970-03-11 1973-08-14 Ciba Geigy Corp Anorexigenic tetrahydrobenzazepine derivative method and composition thereof
US3716639A (en) 1970-03-11 1973-02-13 Ciba Geigy Corp Anorexigenic tetrahydrobenzazepines
US4111957A (en) * 1977-02-02 1978-09-05 Smithkline Corporation Substituted 1-thienyl and furyl-2,3,4,5-tetrahydro-1H-3-benzazepine compounds
US4108989A (en) * 1977-04-01 1978-08-22 Smithkline Corporation 2,3,4,5-tetrahydro-1h-3-benzazepine-7,8-diones

Also Published As

Publication number Publication date
PL216908A1 (ja) 1980-08-11
CS213381B2 (en) 1982-04-09
ES482276A1 (es) 1980-04-01
JPH0153271B2 (ja) 1989-11-13
NO792267L (no) 1980-01-08
SU1029827A3 (ru) 1983-07-15
AR222828A1 (es) 1981-06-30
EP0080012A1 (en) 1983-06-01
EP0080012B1 (en) 1986-04-09
ES482281A1 (es) 1980-04-01
IE791276L (en) 1980-01-07
DE2964530D1 (en) 1983-02-24
DK278379A (da) 1980-01-08
HU179315B (en) 1982-09-28
FI792125A (fi) 1980-01-08
IT1193190B (it) 1988-06-02
JPS5511584A (en) 1980-01-26
DK156001B (da) 1989-06-12
DD147355A5 (de) 1981-04-01
NZ190745A (en) 1981-01-23
NO152213C (no) 1985-08-28
CA1115271A (en) 1981-12-29
IT7924165A0 (it) 1979-07-06
FI67215B (fi) 1984-10-31
ES482282A1 (es) 1980-04-01
EP0007070A1 (en) 1980-01-23
JO1273B1 (en) 1986-11-30
FI67215C (fi) 1985-02-11
PH15754A (en) 1983-03-18
AU4861379A (en) 1980-02-07
IL57532A (en) 1982-08-31
AU525789B2 (en) 1982-12-02
PT69855A (en) 1979-08-01
IE48654B1 (en) 1985-04-03
NO152213B (no) 1985-05-13
IL57532A0 (en) 1979-10-31
ZA792785B (en) 1980-08-27
EP0007070B1 (en) 1983-01-19
GR69675B (ja) 1982-07-07

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PBP Patent lapsed