FI67075B - Foerfarande foer framstaellning av nya terapeutiskt anvaendbara disubstituerade fenoletrar av 3-amino-2-hydroxipropan och salter daerav - Google Patents

Foerfarande foer framstaellning av nya terapeutiskt anvaendbara disubstituerade fenoletrar av 3-amino-2-hydroxipropan och salter daerav Download PDF

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Publication number
FI67075B
FI67075B FI763010A FI763010A FI67075B FI 67075 B FI67075 B FI 67075B FI 763010 A FI763010 A FI 763010A FI 763010 A FI763010 A FI 763010A FI 67075 B FI67075 B FI 67075B
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FI
Finland
Prior art keywords
formula
compound
hydroxy
group
acid
Prior art date
Application number
FI763010A
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English (en)
Finnish (fi)
Other versions
FI67075C (fi
FI763010A (sv
Inventor
Rudolf Hiltmann
Arend Heise
Stanislav Kazda
Friedrich Hoffmeister
Original Assignee
Bayer Ag
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Publication date
Application filed by Bayer Ag filed Critical Bayer Ag
Publication of FI763010A publication Critical patent/FI763010A/fi
Publication of FI67075B publication Critical patent/FI67075B/fi
Application granted granted Critical
Publication of FI67075C publication Critical patent/FI67075C/fi

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A61K31/138—Aryloxyalkylamines, e.g. propranolol, tamoxifen, phenoxybenzamine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C217/00—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
    • C07C217/02—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C217/04—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C217/28—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having one amino group and at least two singly-bound oxygen atoms, with at least one being part of an etherified hydroxy group, bound to the carbon skeleton, e.g. ethers of polyhydroxy amines
    • C07C217/30—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having one amino group and at least two singly-bound oxygen atoms, with at least one being part of an etherified hydroxy group, bound to the carbon skeleton, e.g. ethers of polyhydroxy amines having the oxygen atom of at least one of the etherified hydroxy groups further bound to a carbon atom of a six-membered aromatic ring
    • C07C217/32—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having one amino group and at least two singly-bound oxygen atoms, with at least one being part of an etherified hydroxy group, bound to the carbon skeleton, e.g. ethers of polyhydroxy amines having the oxygen atom of at least one of the etherified hydroxy groups further bound to a carbon atom of a six-membered aromatic ring the six-membered aromatic ring or condensed ring system containing that ring being further substituted
    • C07C217/34—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having one amino group and at least two singly-bound oxygen atoms, with at least one being part of an etherified hydroxy group, bound to the carbon skeleton, e.g. ethers of polyhydroxy amines having the oxygen atom of at least one of the etherified hydroxy groups further bound to a carbon atom of a six-membered aromatic ring the six-membered aromatic ring or condensed ring system containing that ring being further substituted by halogen atoms, by trihalomethyl, nitro or nitroso groups, or by singly-bound oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C217/00—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
    • C07C217/02—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C217/04—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C217/28—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having one amino group and at least two singly-bound oxygen atoms, with at least one being part of an etherified hydroxy group, bound to the carbon skeleton, e.g. ethers of polyhydroxy amines
    • C07C217/30—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having one amino group and at least two singly-bound oxygen atoms, with at least one being part of an etherified hydroxy group, bound to the carbon skeleton, e.g. ethers of polyhydroxy amines having the oxygen atom of at least one of the etherified hydroxy groups further bound to a carbon atom of a six-membered aromatic ring
    • C07C217/32—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having one amino group and at least two singly-bound oxygen atoms, with at least one being part of an etherified hydroxy group, bound to the carbon skeleton, e.g. ethers of polyhydroxy amines having the oxygen atom of at least one of the etherified hydroxy groups further bound to a carbon atom of a six-membered aromatic ring the six-membered aromatic ring or condensed ring system containing that ring being further substituted
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C217/00—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
    • C07C217/02—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C217/04—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C217/28—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having one amino group and at least two singly-bound oxygen atoms, with at least one being part of an etherified hydroxy group, bound to the carbon skeleton, e.g. ethers of polyhydroxy amines
    • C07C217/30—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having one amino group and at least two singly-bound oxygen atoms, with at least one being part of an etherified hydroxy group, bound to the carbon skeleton, e.g. ethers of polyhydroxy amines having the oxygen atom of at least one of the etherified hydroxy groups further bound to a carbon atom of a six-membered aromatic ring
    • C07C217/32—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having one amino group and at least two singly-bound oxygen atoms, with at least one being part of an etherified hydroxy group, bound to the carbon skeleton, e.g. ethers of polyhydroxy amines having the oxygen atom of at least one of the etherified hydroxy groups further bound to a carbon atom of a six-membered aromatic ring the six-membered aromatic ring or condensed ring system containing that ring being further substituted
    • C07C217/36—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having one amino group and at least two singly-bound oxygen atoms, with at least one being part of an etherified hydroxy group, bound to the carbon skeleton, e.g. ethers of polyhydroxy amines having the oxygen atom of at least one of the etherified hydroxy groups further bound to a carbon atom of a six-membered aromatic ring the six-membered aromatic ring or condensed ring system containing that ring being further substituted by carbon atoms having at least two bonds to oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2603/00—Systems containing at least three condensed rings
    • C07C2603/02—Ortho- or ortho- and peri-condensed systems
    • C07C2603/04—Ortho- or ortho- and peri-condensed systems containing three rings
    • C07C2603/06—Ortho- or ortho- and peri-condensed systems containing three rings containing at least one ring with less than six ring members
    • C07C2603/10—Ortho- or ortho- and peri-condensed systems containing three rings containing at least one ring with less than six ring members containing five-membered rings
    • C07C2603/12—Ortho- or ortho- and peri-condensed systems containing three rings containing at least one ring with less than six ring members containing five-membered rings only one five-membered ring
    • C07C2603/18—Fluorenes; Hydrogenated fluorenes

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Epoxy Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)

Claims (3)

1. Förfarande för framställning av nya, terapeutiskt använd-bara disubstituerade fenoletrar av 3-amino-2-hydroxipropan med formeIn I r~\R ^cy.5 // y— o-ch2-ch-ch2-nh-ch<^ i R· ~ ^C6HS väri R är C-L_3~alkoxi eller klor och R' är C^^-alkyl eller C2_3-alkenyl samt farmakologiskt godtagbara salter därav, kännetecknat därav, att man a) omsätter en förening med formeln III
0-CH2-<j:H-CH2-Z III R'^ 7 Y väri R och R' betecknar detsamma som ovan, Y är en hydroxylgrupp och Z är en reaktionskapabel, förestrad hydroxylgrupp, ellär^Y och Z betecknar gemensamt en epoxigrupp, med difenylmetylamin, varvid med en reaktionskapabel förestrad hydroxylgrupp förstäs särskilt en med en stark oorganisk eller organisk syra, företrädesvis en halogenvätesyra, eller svavelsyra eller en stark organisk sulfonsyra förestrad hydroxylgrupp, och Z är särskilt klor, brom eller jod, eller b) omsätter en amin med formeln IV /R {o/—0-CH2"CH-CH2"NH2 Iv r'"A-/ oh väri R och R' betecknar detsamma som ovan, med en förening med formeln ^/C6H5 Z-CH'CT ^C6H5 väri Z betecknar detsamma som ovan, eller
FI763010A 1975-10-23 1976-10-21 Foerfarande foer framstaellning av nya terapeutiskt anvaendbara disubstituerade fenoletrar av 3-amino-2-hydroxipropan och salter daerav FI67075C (fi)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19752547524 DE2547524A1 (de) 1975-10-23 1975-10-23 Disubstituierte phenolaether des 3-amino-2-hydroxypropans, verfahren zu ihrer herstellung sowie ihre verwendung als arzneimittel
DE2547524 1975-10-23

Publications (3)

Publication Number Publication Date
FI763010A FI763010A (sv) 1977-04-24
FI67075B true FI67075B (fi) 1984-09-28
FI67075C FI67075C (fi) 1985-01-10

Family

ID=5959934

Family Applications (1)

Application Number Title Priority Date Filing Date
FI763010A FI67075C (fi) 1975-10-23 1976-10-21 Foerfarande foer framstaellning av nya terapeutiskt anvaendbara disubstituerade fenoletrar av 3-amino-2-hydroxipropan och salter daerav

Country Status (29)

Country Link
US (1) US4110472A (sv)
JP (1) JPS5935387B2 (sv)
AT (2) AT344682B (sv)
AU (1) AU502167B2 (sv)
BE (1) BE847541A (sv)
BG (2) BG31796A3 (sv)
CA (1) CA1085417A (sv)
CH (2) CH623562A5 (sv)
CS (2) CS191344B2 (sv)
DD (1) DD128555A5 (sv)
DE (1) DE2547524A1 (sv)
DK (1) DK480376A (sv)
ES (1) ES452616A1 (sv)
FI (1) FI67075C (sv)
FR (1) FR2328458A1 (sv)
GB (1) GB1497500A (sv)
GR (1) GR61598B (sv)
HU (1) HU174097B (sv)
IE (1) IE43745B1 (sv)
IL (1) IL50732A (sv)
LU (1) LU76057A1 (sv)
NL (1) NL7611683A (sv)
NO (1) NO143844C (sv)
PL (2) PL110002B1 (sv)
PT (1) PT65737B (sv)
RO (1) RO76883A (sv)
SE (1) SE432926B (sv)
SU (2) SU639443A3 (sv)
ZA (1) ZA766303B (sv)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1223395B (it) * 1987-12-01 1990-09-19 Simes Composti ad attivita' cardiovascolare
US5541204A (en) * 1994-12-02 1996-07-30 Bristol-Myers Squibb Company Aryloxypropanolamine β 3 adrenergic agonists
BRPI0810063A2 (pt) * 2007-04-20 2014-10-14 Acucela Inc Composto, composição farmacêutica, e, métodos para modular fluxo de cromóforo em um ciclo retinóide, para tratar uma doença ou distúrbio oftálmico em um indivíduo, para inibir adaptação ao escuro em uma célula fotorreceptora de bastão da retina, para inibir regeneração de rodopsina em uma célula fotoreceptora de bastão da retina, para reduzir isquemia em um olho de um indivíduo, para inibir neovascularização na retina de um olho de um indivíduo, e para inibir degeneração de uma célula da retina em uma retina
FR3030514A1 (fr) * 2014-12-18 2016-06-24 Centre De Coop Int En Rech Agronomique Pour Le Dev (Cirad) Dimeres polyaromatiques
EP3144289A1 (en) * 2015-09-16 2017-03-22 Evonik Technochemie GmbH [(2-ethoxy-5-trans-1-propen-1-yl)-phenoxyl]-terminated compounds
CN110035745B (zh) * 2016-10-05 2022-04-29 匹兹堡大学联邦系统高等教育 小分子ampk活化剂

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3758583A (en) * 1971-01-21 1973-09-11 Syntex Corp 2-(2-hydroxy-3-aminopropyl-1-yloxy)-1,6-dilfuoro-and-1,6-methano-{8 10{9 annulenes and the salts thereof

Also Published As

Publication number Publication date
PL110007B1 (en) 1980-06-30
RO76883A (ro) 1981-08-30
AT345792B (de) 1978-10-10
FR2328458B1 (sv) 1979-03-02
FR2328458A1 (fr) 1977-05-20
CS191344B2 (en) 1979-06-29
AT344682B (de) 1978-08-10
AU1879776A (en) 1978-04-27
GR61598B (en) 1978-12-02
NO763442L (sv) 1977-04-26
FI67075C (fi) 1985-01-10
ES452616A1 (es) 1978-01-16
GB1497500A (en) 1978-01-12
SE7611686L (sv) 1977-04-24
ATA606377A (de) 1978-02-15
JPS5251352A (en) 1977-04-25
ATA784476A (de) 1977-12-15
PT65737A (en) 1976-11-01
PL110002B1 (en) 1980-06-30
CS191322B2 (en) 1979-06-29
LU76057A1 (sv) 1977-05-31
HU174097B (hu) 1979-11-28
ZA766303B (en) 1977-09-28
AU502167B2 (en) 1979-07-12
IE43745L (en) 1977-04-23
DE2547524A1 (de) 1977-04-28
SU664559A3 (ru) 1979-05-25
SU639443A3 (ru) 1978-12-25
IL50732A0 (en) 1976-12-31
SE432926B (sv) 1984-04-30
DD128555A5 (de) 1977-11-23
IE43745B1 (en) 1981-05-20
NO143844B (no) 1981-01-12
NL7611683A (nl) 1977-04-26
BE847541A (fr) 1977-04-22
FI763010A (sv) 1977-04-24
JPS5935387B2 (ja) 1984-08-28
PL193206A1 (pl) 1979-03-12
BG27732A3 (en) 1979-12-12
CA1085417A (en) 1980-09-09
BG31796A3 (en) 1982-03-15
DK480376A (da) 1977-04-24
CH623562A5 (sv) 1981-06-15
US4110472A (en) 1978-08-29
IL50732A (en) 1979-12-30
NO143844C (no) 1981-04-22
CH630058A5 (de) 1982-05-28
PT65737B (en) 1978-04-20

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Owner name: BAYER AKTIENGESELLSCHAFT