ATA606377A - Verfahren zur herstellung von neuen 1-disubstiuierten phenoxy-2-hydroxy-3-diphenylmethylamino- und -3- (9'-fluorenylamino)-propanen sowie deren saureadditionssalzen - Google Patents

Verfahren zur herstellung von neuen 1-disubstiuierten phenoxy-2-hydroxy-3-diphenylmethylamino- und -3- (9'-fluorenylamino)-propanen sowie deren saureadditionssalzen

Info

Publication number
ATA606377A
ATA606377A AT606377A AT606377A ATA606377A AT A606377 A ATA606377 A AT A606377A AT 606377 A AT606377 A AT 606377A AT 606377 A AT606377 A AT 606377A AT A606377 A ATA606377 A AT A606377A
Authority
AT
Austria
Prior art keywords
disubstuuted
diphenylmethylamino
fluorenylamino
propanes
phenoxy
Prior art date
Application number
AT606377A
Other languages
English (en)
Other versions
AT345792B (de
Original Assignee
Bayer Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Ag filed Critical Bayer Ag
Publication of ATA606377A publication Critical patent/ATA606377A/de
Application granted granted Critical
Publication of AT345792B publication Critical patent/AT345792B/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A61K31/138—Aryloxyalkylamines, e.g. propranolol, tamoxifen, phenoxybenzamine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C217/00—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
    • C07C217/02—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C217/04—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C217/28—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having one amino group and at least two singly-bound oxygen atoms, with at least one being part of an etherified hydroxy group, bound to the carbon skeleton, e.g. ethers of polyhydroxy amines
    • C07C217/30—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having one amino group and at least two singly-bound oxygen atoms, with at least one being part of an etherified hydroxy group, bound to the carbon skeleton, e.g. ethers of polyhydroxy amines having the oxygen atom of at least one of the etherified hydroxy groups further bound to a carbon atom of a six-membered aromatic ring
    • C07C217/32—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having one amino group and at least two singly-bound oxygen atoms, with at least one being part of an etherified hydroxy group, bound to the carbon skeleton, e.g. ethers of polyhydroxy amines having the oxygen atom of at least one of the etherified hydroxy groups further bound to a carbon atom of a six-membered aromatic ring the six-membered aromatic ring or condensed ring system containing that ring being further substituted
    • C07C217/34—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having one amino group and at least two singly-bound oxygen atoms, with at least one being part of an etherified hydroxy group, bound to the carbon skeleton, e.g. ethers of polyhydroxy amines having the oxygen atom of at least one of the etherified hydroxy groups further bound to a carbon atom of a six-membered aromatic ring the six-membered aromatic ring or condensed ring system containing that ring being further substituted by halogen atoms, by trihalomethyl, nitro or nitroso groups, or by singly-bound oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C217/00—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
    • C07C217/02—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C217/04—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C217/28—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having one amino group and at least two singly-bound oxygen atoms, with at least one being part of an etherified hydroxy group, bound to the carbon skeleton, e.g. ethers of polyhydroxy amines
    • C07C217/30—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having one amino group and at least two singly-bound oxygen atoms, with at least one being part of an etherified hydroxy group, bound to the carbon skeleton, e.g. ethers of polyhydroxy amines having the oxygen atom of at least one of the etherified hydroxy groups further bound to a carbon atom of a six-membered aromatic ring
    • C07C217/32—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having one amino group and at least two singly-bound oxygen atoms, with at least one being part of an etherified hydroxy group, bound to the carbon skeleton, e.g. ethers of polyhydroxy amines having the oxygen atom of at least one of the etherified hydroxy groups further bound to a carbon atom of a six-membered aromatic ring the six-membered aromatic ring or condensed ring system containing that ring being further substituted
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C217/00—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
    • C07C217/02—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C217/04—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C217/28—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having one amino group and at least two singly-bound oxygen atoms, with at least one being part of an etherified hydroxy group, bound to the carbon skeleton, e.g. ethers of polyhydroxy amines
    • C07C217/30—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having one amino group and at least two singly-bound oxygen atoms, with at least one being part of an etherified hydroxy group, bound to the carbon skeleton, e.g. ethers of polyhydroxy amines having the oxygen atom of at least one of the etherified hydroxy groups further bound to a carbon atom of a six-membered aromatic ring
    • C07C217/32—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having one amino group and at least two singly-bound oxygen atoms, with at least one being part of an etherified hydroxy group, bound to the carbon skeleton, e.g. ethers of polyhydroxy amines having the oxygen atom of at least one of the etherified hydroxy groups further bound to a carbon atom of a six-membered aromatic ring the six-membered aromatic ring or condensed ring system containing that ring being further substituted
    • C07C217/36—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having one amino group and at least two singly-bound oxygen atoms, with at least one being part of an etherified hydroxy group, bound to the carbon skeleton, e.g. ethers of polyhydroxy amines having the oxygen atom of at least one of the etherified hydroxy groups further bound to a carbon atom of a six-membered aromatic ring the six-membered aromatic ring or condensed ring system containing that ring being further substituted by carbon atoms having at least two bonds to oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2603/00—Systems containing at least three condensed rings
    • C07C2603/02—Ortho- or ortho- and peri-condensed systems
    • C07C2603/04—Ortho- or ortho- and peri-condensed systems containing three rings
    • C07C2603/06—Ortho- or ortho- and peri-condensed systems containing three rings containing at least one ring with less than six ring members
    • C07C2603/10—Ortho- or ortho- and peri-condensed systems containing three rings containing at least one ring with less than six ring members containing five-membered rings
    • C07C2603/12—Ortho- or ortho- and peri-condensed systems containing three rings containing at least one ring with less than six ring members containing five-membered rings only one five-membered ring
    • C07C2603/18—Fluorenes; Hydrogenated fluorenes

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Epoxy Compounds (AREA)
AT606377A 1975-10-23 1976-10-21 Verfahren zur herstellung von neuen 1- disubstiuierten phenoxy-2-hydroxy-3-diphenylmethylamino- und - 3- (9'-fluorenylamino)-propanen sowie deren saeureadditionssalzen AT345792B (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19752547524 DE2547524A1 (de) 1975-10-23 1975-10-23 Disubstituierte phenolaether des 3-amino-2-hydroxypropans, verfahren zu ihrer herstellung sowie ihre verwendung als arzneimittel
AT784476A AT344682B (de) 1975-10-23 1976-10-21 Verfahren zur herstellung von neuen 1-disubstituierten phenoxy-2-hydroxy-3-diphenylmethylamino- und -3- (9'-fluorenylamino)-propanen sowie deren saeureadditionssalzen

Publications (2)

Publication Number Publication Date
ATA606377A true ATA606377A (de) 1978-02-15
AT345792B AT345792B (de) 1978-10-10

Family

ID=5959934

Family Applications (2)

Application Number Title Priority Date Filing Date
AT784476A AT344682B (de) 1975-10-23 1976-10-21 Verfahren zur herstellung von neuen 1-disubstituierten phenoxy-2-hydroxy-3-diphenylmethylamino- und -3- (9'-fluorenylamino)-propanen sowie deren saeureadditionssalzen
AT606377A AT345792B (de) 1975-10-23 1976-10-21 Verfahren zur herstellung von neuen 1- disubstiuierten phenoxy-2-hydroxy-3-diphenylmethylamino- und - 3- (9'-fluorenylamino)-propanen sowie deren saeureadditionssalzen

Family Applications Before (1)

Application Number Title Priority Date Filing Date
AT784476A AT344682B (de) 1975-10-23 1976-10-21 Verfahren zur herstellung von neuen 1-disubstituierten phenoxy-2-hydroxy-3-diphenylmethylamino- und -3- (9'-fluorenylamino)-propanen sowie deren saeureadditionssalzen

Country Status (29)

Country Link
US (1) US4110472A (de)
JP (1) JPS5935387B2 (de)
AT (2) AT344682B (de)
AU (1) AU502167B2 (de)
BE (1) BE847541A (de)
BG (2) BG27732A3 (de)
CA (1) CA1085417A (de)
CH (2) CH623562A5 (de)
CS (2) CS191322B2 (de)
DD (1) DD128555A5 (de)
DE (1) DE2547524A1 (de)
DK (1) DK480376A (de)
ES (1) ES452616A1 (de)
FI (1) FI67075C (de)
FR (1) FR2328458A1 (de)
GB (1) GB1497500A (de)
GR (1) GR61598B (de)
HU (1) HU174097B (de)
IE (1) IE43745B1 (de)
IL (1) IL50732A (de)
LU (1) LU76057A1 (de)
NL (1) NL7611683A (de)
NO (1) NO143844C (de)
PL (2) PL110002B1 (de)
PT (1) PT65737B (de)
RO (1) RO76883A (de)
SE (1) SE432926B (de)
SU (2) SU639443A3 (de)
ZA (1) ZA766303B (de)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1223395B (it) * 1987-12-01 1990-09-19 Simes Composti ad attivita' cardiovascolare
US5541204A (en) * 1994-12-02 1996-07-30 Bristol-Myers Squibb Company Aryloxypropanolamine β 3 adrenergic agonists
EP2076124A4 (de) 2007-04-20 2011-08-03 Acucela Inc Styrenylderivatverbindungen für die behandlung von ophthalmologischen krankheiten und leiden
FR3030514A1 (fr) * 2014-12-18 2016-06-24 Centre De Coop Int En Rech Agronomique Pour Le Dev (Cirad) Dimeres polyaromatiques
EP3144289A1 (de) * 2015-09-16 2017-03-22 Evonik Technochemie GmbH [(2-ethoxy-5-trans-1-propen-1-yl)-phenoxyl]-terminierte verbindungen
US11040935B2 (en) 2016-10-05 2021-06-22 University of Pittsburgh—of the Commonwealth System of Higher Education Small molecule AMPK activators

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3758583A (en) * 1971-01-21 1973-09-11 Syntex Corp 2-(2-hydroxy-3-aminopropyl-1-yloxy)-1,6-dilfuoro-and-1,6-methano-{8 10{9 annulenes and the salts thereof

Also Published As

Publication number Publication date
NO143844B (no) 1981-01-12
NO143844C (no) 1981-04-22
AT345792B (de) 1978-10-10
RO76883A (ro) 1981-08-30
PT65737B (en) 1978-04-20
PL110002B1 (en) 1980-06-30
DE2547524A1 (de) 1977-04-28
GB1497500A (en) 1978-01-12
FR2328458B1 (de) 1979-03-02
IE43745L (en) 1977-04-23
GR61598B (en) 1978-12-02
BE847541A (fr) 1977-04-22
AT344682B (de) 1978-08-10
ZA766303B (en) 1977-09-28
SE432926B (sv) 1984-04-30
PT65737A (en) 1976-11-01
IL50732A (en) 1979-12-30
FI763010A (de) 1977-04-24
FR2328458A1 (fr) 1977-05-20
HU174097B (hu) 1979-11-28
DK480376A (da) 1977-04-24
IL50732A0 (en) 1976-12-31
CS191322B2 (en) 1979-06-29
CH623562A5 (de) 1981-06-15
NO763442L (de) 1977-04-26
CS191344B2 (en) 1979-06-29
AU1879776A (en) 1978-04-27
ATA784476A (de) 1977-12-15
DD128555A5 (de) 1977-11-23
NL7611683A (nl) 1977-04-26
BG27732A3 (en) 1979-12-12
AU502167B2 (en) 1979-07-12
PL110007B1 (en) 1980-06-30
CH630058A5 (de) 1982-05-28
SU639443A3 (ru) 1978-12-25
FI67075C (fi) 1985-01-10
ES452616A1 (es) 1978-01-16
SU664559A3 (ru) 1979-05-25
SE7611686L (sv) 1977-04-24
US4110472A (en) 1978-08-29
CA1085417A (en) 1980-09-09
LU76057A1 (de) 1977-05-31
IE43745B1 (en) 1981-05-20
FI67075B (fi) 1984-09-28
JPS5935387B2 (ja) 1984-08-28
BG31796A3 (en) 1982-03-15
PL193206A1 (pl) 1979-03-12
JPS5251352A (en) 1977-04-25

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