FI66611C - Foerfarande foer framstaellning av nya terapeutiskt anvaendbara fenyl-kinolizidiner - Google Patents

Foerfarande foer framstaellning av nya terapeutiskt anvaendbara fenyl-kinolizidiner Download PDF

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Publication number
FI66611C
FI66611C FI793182A FI793182A FI66611C FI 66611 C FI66611 C FI 66611C FI 793182 A FI793182 A FI 793182A FI 793182 A FI793182 A FI 793182A FI 66611 C FI66611 C FI 66611C
Authority
FI
Finland
Prior art keywords
general formula
hydrogen
compounds
preparation
compound
Prior art date
Application number
FI793182A
Other languages
English (en)
Finnish (fi)
Swedish (sv)
Other versions
FI66611B (fi
FI793182A (fi
Inventor
Rene Imhof
Emilio Kyburz
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of FI793182A publication Critical patent/FI793182A/fi
Priority to FI841359A priority Critical patent/FI70017C/fi
Publication of FI66611B publication Critical patent/FI66611B/fi
Application granted granted Critical
Publication of FI66611C publication Critical patent/FI66611C/fi

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/68—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D211/72—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D211/74—Oxygen atoms
    • C07D211/76—Oxygen atoms attached in position 2 or 6
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D455/00—Heterocyclic compounds containing quinolizine ring systems, e.g. emetine alkaloids, protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine
    • C07D455/02—Heterocyclic compounds containing quinolizine ring systems, e.g. emetine alkaloids, protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine containing not further condensed quinolizine ring systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
FI793182A 1978-10-13 1979-10-12 Foerfarande foer framstaellning av nya terapeutiskt anvaendbara fenyl-kinolizidiner FI66611C (fi)

Priority Applications (1)

Application Number Priority Date Filing Date Title
FI841359A FI70017C (fi) 1978-10-13 1984-04-05 Foerfarande foer framstaellning av nya farmakologiskt aktiva fenylkinolizidiner

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
CH1065478 1978-10-13
CH1065478 1978-10-13
CH715679 1979-08-03
CH715679 1979-08-03

Publications (3)

Publication Number Publication Date
FI793182A FI793182A (fi) 1980-04-14
FI66611B FI66611B (fi) 1984-07-31
FI66611C true FI66611C (fi) 1984-11-12

Family

ID=25700857

Family Applications (2)

Application Number Title Priority Date Filing Date
FI793182A FI66611C (fi) 1978-10-13 1979-10-12 Foerfarande foer framstaellning av nya terapeutiskt anvaendbara fenyl-kinolizidiner
FI841359A FI70017C (fi) 1978-10-13 1984-04-05 Foerfarande foer framstaellning av nya farmakologiskt aktiva fenylkinolizidiner

Family Applications After (1)

Application Number Title Priority Date Filing Date
FI841359A FI70017C (fi) 1978-10-13 1984-04-05 Foerfarande foer framstaellning av nya farmakologiskt aktiva fenylkinolizidiner

Country Status (22)

Country Link
US (6) US4236010A (pt)
EP (2) EP0012170B1 (pt)
AR (3) AR230446A1 (pt)
AT (1) ATE877T1 (pt)
AU (1) AU533075B2 (pt)
BR (1) BR7906543A (pt)
CA (1) CA1140927A (pt)
CS (2) CS613879A2 (pt)
CU (1) CU35149A (pt)
DE (2) DE2962580D1 (pt)
DK (1) DK433779A (pt)
ES (7) ES8200680A1 (pt)
FI (2) FI66611C (pt)
GR (1) GR73144B (pt)
HU (1) HU180249B (pt)
IE (1) IE49082B1 (pt)
IL (1) IL58415A (pt)
MC (1) MC1289A1 (pt)
NO (1) NO152787C (pt)
NZ (1) NZ191763A (pt)
PH (1) PH16131A (pt)
PT (1) PT70309A (pt)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MC1289A1 (fr) * 1978-10-13 1980-07-22 Hoffmann La Roche Phenyl quinolizidines
DK116181A (da) * 1980-04-11 1981-10-12 Hoffmann La Roche Fremgangsmaade til fremstilling af quinolizidinderivater
US4889848A (en) * 1984-11-06 1989-12-26 Hoffmann-La Roche Inc. Tricyclic pyridine derivatives
ZW17385A1 (en) * 1984-11-06 1986-02-19 Hoffmann La Roche Tricyclic pyridine derivatives
CA1317945C (en) * 1985-12-13 1993-05-18 Ulf Fischer Tricyclic pyridazopyridone derivatives
DE3614005A1 (de) * 1986-04-25 1987-10-29 Westfael Elekt Werke Verfahren zur rauchgasentschwefelung
EP0294599A3 (de) * 1987-06-12 1990-05-09 F. Hoffmann-La Roche Ag Tricyclische Pyridonderivate
US6992090B2 (en) * 2003-06-16 2006-01-31 Adolor Corporation Substituted piperidine compounds and methods of their use
US7538110B2 (en) 2005-10-27 2009-05-26 Adolor Corporation Opioid antagonists
US20100311782A1 (en) * 2009-06-08 2010-12-09 Adolor Corporation Substituted piperidinylpropanoic acid compounds and methods of their use
US8143273B2 (en) 2010-06-22 2012-03-27 Hoffman-La Roche Inc. Quinolizidine and indolizidine derivatives

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3031454A (en) * 1962-04-24 Hexahydro quinolizeses
CA668487A (en) * 1963-08-13 H. Tilford Charles Hexahydro quinolizines
GB1096589A (en) * 1964-03-31 1967-12-29 Chugai Pharmaceutical Co Ltd Novel quinolizidine derivatives or salts thereof and process for preparing the same
DE1470084A1 (de) * 1964-08-19 1969-05-29 Merck Ag E Verfahren zur Herstellung von substituierten Piperidin-derivaten
US3394141A (en) * 1965-11-12 1968-07-23 Fabio Sparatore Z-benzyaminobenzimidazoles
US3852452A (en) * 1970-02-10 1974-12-03 Ayerst Mckenna & Harrison Benzocycloheptaisoquinoline derivatives as cns depressants
MC1289A1 (fr) * 1978-10-13 1980-07-22 Hoffmann La Roche Phenyl quinolizidines

Also Published As

Publication number Publication date
EP0044573B1 (de) 1984-02-29
US4329467A (en) 1982-05-11
NO152787B (no) 1985-08-12
GR73144B (pt) 1984-02-09
CS241050B2 (en) 1986-03-13
DE2966740D1 (de) 1984-04-05
ES8105997A1 (es) 1981-07-01
ES493204A0 (es) 1981-07-01
AU533075B2 (en) 1983-10-27
US4316030A (en) 1982-02-16
FI841359A0 (fi) 1984-04-05
ES493196A0 (es) 1981-07-01
HU180249B (en) 1983-02-28
ES8106304A1 (es) 1981-06-16
ATE877T1 (de) 1982-05-15
ES8105993A1 (es) 1981-07-01
AR230446A1 (es) 1984-04-30
ES8105994A1 (es) 1981-07-01
FI70017B (fi) 1986-01-31
FI841359A (fi) 1984-04-05
FI66611B (fi) 1984-07-31
FI70017C (fi) 1986-09-12
ES484930A0 (es) 1981-11-16
EP0012170B1 (de) 1982-04-21
DK433779A (da) 1980-04-14
US4236010A (en) 1980-11-25
MC1289A1 (fr) 1980-07-22
AU5154579A (en) 1980-04-17
NZ191763A (en) 1984-05-31
IE791943L (en) 1980-04-13
CA1140927A (en) 1983-02-08
IL58415A0 (en) 1980-01-31
US4338444A (en) 1982-07-06
IL58415A (en) 1982-11-30
ES8200680A1 (es) 1981-11-16
IE49082B1 (en) 1985-07-24
CS613879A2 (en) 1985-06-13
US4272627A (en) 1981-06-09
ES8105991A1 (es) 1981-07-01
EP0012170A1 (de) 1980-06-25
ES493198A0 (es) 1981-07-01
PH16131A (en) 1983-07-08
US4306067A (en) 1981-12-15
CU35149A (en) 1983-04-06
NO793300L (no) 1980-04-15
EP0044573A1 (de) 1982-01-27
DE2962580D1 (en) 1982-06-03
AR230636A1 (es) 1984-05-31
NO152787C (no) 1985-11-20
ES493199A0 (es) 1981-06-16
ES493202A0 (es) 1981-07-01
FI793182A (fi) 1980-04-14
PT70309A (en) 1979-11-01
AR230637A1 (es) 1984-05-31
ES493195A0 (es) 1981-07-01
ES8105992A1 (es) 1981-07-01
BR7906543A (pt) 1980-07-15

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Legal Events

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MM Patent lapsed

Owner name: F. HOFFMANN-LA ROCHE & CO. AG