FI66010C - Foerfarande foer framstaellning av nya vid avbrytande av havandeskap anvaendbara 4- och/eller 6-alkylerade 4alfa 5alfa-epoxi-2alfa-cyan-3-oxosteroid-derivat - Google Patents

Foerfarande foer framstaellning av nya vid avbrytande av havandeskap anvaendbara 4- och/eller 6-alkylerade 4alfa 5alfa-epoxi-2alfa-cyan-3-oxosteroid-derivat Download PDF

Info

Publication number
FI66010C
FI66010C FI783901A FI783901A FI66010C FI 66010 C FI66010 C FI 66010C FI 783901 A FI783901 A FI 783901A FI 783901 A FI783901 A FI 783901A FI 66010 C FI66010 C FI 66010C
Authority
FI
Finland
Prior art keywords
methyl
hydroxy
epoxy
hydrogen
formula
Prior art date
Application number
FI783901A
Other languages
English (en)
Finnish (fi)
Other versions
FI66010B (fi
FI783901A (fi
Inventor
Robert George Christiansen
Original Assignee
Sterling Drug Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sterling Drug Inc filed Critical Sterling Drug Inc
Publication of FI783901A publication Critical patent/FI783901A/fi
Publication of FI66010B publication Critical patent/FI66010B/fi
Application granted granted Critical
Publication of FI66010C publication Critical patent/FI66010C/fi

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
    • C07J1/0003—Androstane derivatives
    • C07J1/0033—Androstane derivatives substituted in position 17 alfa and 17 beta
    • C07J1/004—Androstane derivatives substituted in position 17 alfa and 17 beta the substituent in position 17 alfa being an unsaturated hydrocarbon group
    • C07J1/0048—Alkynyl derivatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
    • C07J1/0003—Androstane derivatives
    • C07J1/0018—Androstane derivatives substituted in position 17 beta, not substituted in position 17 alfa
    • C07J1/0022—Androstane derivatives substituted in position 17 beta, not substituted in position 17 alfa the substituent being an OH group free esterified or etherified
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
    • C07J1/0003—Androstane derivatives
    • C07J1/0033—Androstane derivatives substituted in position 17 alfa and 17 beta
    • C07J1/0037—Androstane derivatives substituted in position 17 alfa and 17 beta the substituent in position 17 alfa being a saturated hydrocarbon group
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J31/00—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring
    • C07J31/006—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring not covered by C07J31/003
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
    • C07J41/0094—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 containing nitrile radicals, including thiocyanide radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
    • C07J71/0005—Oxygen-containing hetero ring
    • C07J71/001—Oxiranes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
    • C07J71/0036—Nitrogen-containing hetero ring
    • C07J71/0057—Nitrogen and oxygen
    • C07J71/0063—Nitrogen and oxygen at position 2(3)

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Toxicology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Endocrinology (AREA)
  • Urology & Nephrology (AREA)
  • Reproductive Health (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
FI783901A 1977-12-20 1978-12-19 Foerfarande foer framstaellning av nya vid avbrytande av havandeskap anvaendbara 4- och/eller 6-alkylerade 4alfa 5alfa-epoxi-2alfa-cyan-3-oxosteroid-derivat FI66010C (fi)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US86241777 1977-12-20
US05/862,417 US4160027A (en) 1977-12-20 1977-12-20 Steroid cyanoketones and intermediates

Publications (3)

Publication Number Publication Date
FI783901A FI783901A (fi) 1979-06-21
FI66010B FI66010B (fi) 1984-04-30
FI66010C true FI66010C (fi) 1984-08-10

Family

ID=25338450

Family Applications (1)

Application Number Title Priority Date Filing Date
FI783901A FI66010C (fi) 1977-12-20 1978-12-19 Foerfarande foer framstaellning av nya vid avbrytande av havandeskap anvaendbara 4- och/eller 6-alkylerade 4alfa 5alfa-epoxi-2alfa-cyan-3-oxosteroid-derivat

Country Status (27)

Country Link
US (1) US4160027A (ja)
JP (2) JPS5488253A (ja)
AR (1) AR222645A1 (ja)
AT (1) AT367070B (ja)
AU (1) AU518997B2 (ja)
BE (1) BE872886A (ja)
CA (1) CA1121340A (ja)
CH (1) CH637409A5 (ja)
DE (1) DE2855091A1 (ja)
DK (1) DK156727C (ja)
ES (1) ES476117A1 (ja)
FI (1) FI66010C (ja)
FR (1) FR2412569A1 (ja)
GB (2) GB2088878B (ja)
HK (1) HK89287A (ja)
IE (1) IE48076B1 (ja)
IL (1) IL56076A (ja)
IT (1) IT1195258B (ja)
LU (1) LU80673A1 (ja)
MX (1) MX5535E (ja)
NL (1) NL190848C (ja)
NO (1) NO151467C (ja)
NZ (1) NZ189035A (ja)
PH (2) PH14778A (ja)
PT (1) PT68926A (ja)
SE (1) SE433221B (ja)
ZA (1) ZA786746B (ja)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4349474A (en) * 1981-07-27 1982-09-14 G. D. Searle & Co. 2-Cyanosteroids
ES8504486A1 (es) * 1982-11-02 1985-05-01 Sterwin Ag Procedimiento de trituracion de compuestos esteroides
DK23984A (da) * 1983-02-11 1984-08-12 Hoffmann La Roche D-homosteroider
US4459235A (en) * 1983-03-03 1984-07-10 G. D. Searle & Co. 2-Cyanosteroids
GB8328929D0 (en) * 1983-10-29 1983-11-30 Sterwin Ag Steroid compounds
GB8404980D0 (en) * 1984-02-25 1984-03-28 Sterwin Ag Steroid compound
DE3531903A1 (de) * 1985-09-05 1987-03-12 Schering Ag Oxytocin und antigestagen zur einleitung der geburt bzw. zum therapeutischen abbruch der graviditaet
US4755595A (en) * 1985-11-01 1988-07-05 Sterling Drug Inc. Enhanced production of 4,5-unsaturated steroids utilizing methanol solvation
US4833133A (en) * 1986-05-22 1989-05-23 Sterling Drug Inc. Method of regulating fertility in cattle using epostane
US4870068A (en) * 1986-05-22 1989-09-26 Sterling Drug Inc. Method of regulating fertility in swine using epostane
US5795881A (en) * 1987-06-16 1998-08-18 Schering Aktiengesellschaft Combined use of an antigestagen and a progesterone synthesis inhibitor of the trilostane and epostane type
US5215978A (en) * 1989-06-16 1993-06-01 The Upjohn Company Method of enhancing egg laying in turkeys using epostane
JPH0538929A (ja) * 1991-08-02 1993-02-19 Mitsubishi Heavy Ind Ltd 車両用空気調和装置
GB2375958B (en) * 2001-04-09 2005-03-02 George Margetts The use of steroids to lower the levels of cortisol
GB2414238B (en) * 2004-05-22 2006-12-13 Stegram Pharmaceuticals Ltd Method for the preparation of trilostane
EP2462959B1 (en) * 2005-07-12 2016-06-22 Ampio Pharmaceuticals, Inc. Methods and products for treatment of diseases
SG177302A1 (en) * 2009-06-22 2012-02-28 Dmi Acquisition Corp Methods and products for treatment of diseases
PL2554171T3 (pl) * 2009-06-22 2015-03-31 Ampio Pharmaceuticals Inc Sposób leczenia chorób
EP2934546A4 (en) 2012-12-19 2016-06-22 Ampio Pharmaceuticals Inc METHOD OF TREATING DISEASES

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3296255A (en) * 1963-11-29 1967-01-03 Sterling Drug Inc 2-cyano steroids
US3980638A (en) * 1974-09-20 1976-09-14 The Upjohn Company Testosterone derivatives
US4062954A (en) * 1976-12-27 1977-12-13 Sterling Drug Inc. Process for using a steroid compound

Also Published As

Publication number Publication date
PT68926A (en) 1979-01-01
AR222645A1 (es) 1981-06-15
CH637409A5 (fr) 1983-07-29
DK156727C (da) 1990-03-12
GB2010278B (en) 1982-10-20
MX5535E (es) 1983-09-27
SE7813067L (sv) 1979-06-21
FR2412569A1 (fr) 1979-07-20
JPS6361314B2 (ja) 1988-11-28
NO151467C (no) 1985-04-17
FI66010B (fi) 1984-04-30
NO784281L (no) 1979-06-21
PH16835A (en) 1984-03-15
GB2088878B (en) 1983-01-19
ATA888578A (de) 1981-10-15
CA1121340A (en) 1982-04-06
ES476117A1 (es) 1979-11-16
BE872886A (fr) 1979-06-20
GB2088878A (en) 1982-06-16
SE433221B (sv) 1984-05-14
NL190848C (nl) 1994-09-16
JPS6220998B2 (ja) 1987-05-11
US4160027A (en) 1979-07-03
IT7831011A0 (it) 1978-12-19
IL56076A (en) 1983-06-15
DE2855091C2 (ja) 1988-12-22
AU4208978A (en) 1979-06-28
AT367070B (de) 1982-05-25
JPS5488253A (en) 1979-07-13
PH14778A (en) 1981-12-09
FI783901A (fi) 1979-06-21
AU518997B2 (en) 1981-10-29
NL190848B (nl) 1994-04-18
JPS62142198A (ja) 1987-06-25
LU80673A1 (fr) 1979-07-20
ZA786746B (en) 1979-11-28
DK156727B (da) 1989-09-25
IL56076A0 (en) 1979-01-31
FR2412569B1 (ja) 1982-05-28
DE2855091A1 (de) 1979-06-28
NO151467B (no) 1985-01-02
IE782492L (en) 1979-06-20
NZ189035A (en) 1980-08-26
IE48076B1 (en) 1984-09-19
IT1195258B (it) 1988-10-12
GB2010278A (en) 1979-06-27
NL7812309A (nl) 1979-06-22
HK89287A (en) 1987-12-11
DK569678A (da) 1979-06-21

Similar Documents

Publication Publication Date Title
FI66010C (fi) Foerfarande foer framstaellning av nya vid avbrytande av havandeskap anvaendbara 4- och/eller 6-alkylerade 4alfa 5alfa-epoxi-2alfa-cyan-3-oxosteroid-derivat
JP5075626B2 (ja) エストロンおよびエストラジオールの２−置換誘導体の調製方法
US4082780A (en) Estradiol derivatives
US3953483A (en) 17-Nor-6-methyl-steroids
CS205009B2 (en) Process for preparing 7-hydroxyestradioles
KR20020092907A (ko) 11번 위치에 탄화수소 치환기를 보유한 비방향족에스트로겐 스테로이드
US4331663A (en) 4α,5α-Epoxy-3,20-dioxopregnane-2α,16α-dicarbonitrile and intermediates and process for preparation, method of use and compositions thereof
US4096253A (en) 1-Oxygenated steroids
US3422097A (en) 6,6-ethylene spirolactones
US3515719A (en) 7-methyl-6,19-epoxy steroids of the androstane series
US3096350A (en) 6, 16alpha-dimethyl-delta1, 4, 6-pregnatriene-17alpha-ol-3, 20-dione and esters thereof
RO119366B1 (ro) Derivaţi de 19-nor-progesteron cu punte etanică 14 alfa, 17 alfa
CA2359218A1 (en) 14.beta., 17-alpha-hydroxymethylandrostane derivatives as androgens
US3415820A (en) 2',2'-difluoro-2',3'-dihydrofuran derivatives of the androstane and 19-norandrostane series
KR820000059B1 (ko) 2α-시아노-3-옥소스테로이드 유도체의 제조방법
US3565918A (en) 7alpha-difluoromethyl-a-nor-b-homo steroids and their preparation
Kohen et al. Hypocholesterolemic agents. 9. C-20 Epimeric 22, 25-diazacholesterols
US3476783A (en) 6,6-ethylene-9alpha-fluoro steroids
US3458579A (en) D-homo-gona-4,9-dienes and process
DE2855091C3 (ja)
US3682984A (en) 17{60 -(2,3-methylene-prop-1-en-1 yl)-steroids and 17{60 -(2,3-monohalomethylene and 2,3-dihalomethylene) derivatives thereof
CA2212204A1 (en) 8-substituted b-nor-6-thiaequilenin compounds having activity as selective estrogen receptor modulators
US3541118A (en) 3 - alkoxyalkoxy - 13 - alkylgona - 1,3,5(10)-trienes unsaturated at the delta-6-,delta-7-,delta-8(9)-,delta-9(11)- and delta-6,8(9)-positions and 8-isogona analogs thereof
US3595856A (en) 17beta-hydroxy-20,21-pregnanedicarboxylic acid gamma-lactones and derivatives
JPH06321782A (ja) ステロイド化合物

Legal Events

Date Code Title Description
MA Patent expired
TC Name/ company changed in patent

Owner name: SANOFI

PC Transfer of assignment of patent

Owner name: SANOFI

MA Patent expired

Owner name: SANOFI