FI66002B - Foerfarande foer framstaellning av nya terapeutiskt anvaendbara substituerade 9,10-dihydro-4h-tieno(3,4-b)(1,5)bensodiazepin-10-oner samt deras syraadditionssalter - Google Patents
Foerfarande foer framstaellning av nya terapeutiskt anvaendbara substituerade 9,10-dihydro-4h-tieno(3,4-b)(1,5)bensodiazepin-10-oner samt deras syraadditionssalter Download PDFInfo
- Publication number
- FI66002B FI66002B FI814028A FI814028A FI66002B FI 66002 B FI66002 B FI 66002B FI 814028 A FI814028 A FI 814028A FI 814028 A FI814028 A FI 814028A FI 66002 B FI66002 B FI 66002B
- Authority
- FI
- Finland
- Prior art keywords
- thieno
- dihydro
- group
- benzodiazepin
- methyl
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Heterocyclic Compounds Containing Sulfur Atoms (AREA)
- Plural Heterocyclic Compounds (AREA)
- Steroid Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Compositions Of Macromolecular Compounds (AREA)
Claims (5)
1. Förfarande för framställning av nya terapeutiskt användbara substituerade 9,10-dihydro-4H-tieno/3,4-b7£I,57-5 bensodiazepin-10-oner med den allmänna formeln I H O R1 I / (I)
10. N R2 CO-A-N(R4)R5 väri R3 är en väteatom eller en alkylrest med 1-4 kolatomer, 2 15 r är en halogenatom, en väteatom eller en alkylrest med 1-4 kolatomer, 4 R är en alkylrest med 1-4 kolatomer, 5 R är en alkylrest med 1-4 kolatomer, eller 4 5 R och R betecknar tillsammans med kväveatomen, vid 20 vilken de är bundna, en morfolinogrupp, en pyrrolidinogrupp, en piperidinogrupp eller en eventuellt i 4-positionen medelst en metyl-, etyl- eller bensylgrupp substituerad piperazin-l-yl-grupp och A är en rakkedjad eller förgrenad alkylengrupp med 25 1-5 kolatomer, samt deras syraadditionssalter, kännetecknat därav, att a) en halogenacyltienobensodiazepinon med den allmänna formeln XI 30 HO R1 CX.^Ci
35. X2 CO-A-R3 26 6 5 0 0 2 12 3 van R och R betecknar detsamma sow ovan och R är en halogenatom, amineras med en sekundär amin med den allmänna formeIn V
5 HN(R1)R2 (V) 4 5 van R och R betecknar detsamma som ovan, b) en reaktionsprodukt som har erhällits genom aminering med piperazin och vilken har den allmänna formeln X 11 „ „ „> "-V< s (X) 2
15 I /—\R CO-A-N NH v__y 1 2 väri R , R och A betecknar detsamma som ovan, metyleras eller etyleras, eller 20 c) en tienobensodiazepinon med den allmänna formeln II H ,P R1 (r’^< H VR2 1 2 van R och R betecknar detsamma som ovan, acyleras med en förening med den allmänna formeln IX 30 Z-CO-N(R1)R2 (IX) 5 väri A, R och R betecknar detsamma som ovan och Z är en avlägsnande grupp, och 35 eventuellt överförs de erhällna baserna i syraadditions- 2 salterna eller de erhällna syraadditionssalterna överförs i den
Applications Claiming Priority (6)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CH358180 | 1980-05-07 | ||
| CH358180 | 1980-05-07 | ||
| CH65281 | 1981-02-02 | ||
| CH65281 | 1981-02-02 | ||
| EP8100042 | 1981-05-06 | ||
| PCT/EP1981/000042 WO1981003173A1 (en) | 1980-05-07 | 1981-05-06 | Thieno-tricyclic compounds,method for the preparation thereof,utilization of such compounds and drugs containing them |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| FI814028L FI814028L (fi) | 1981-12-15 |
| FI66002B true FI66002B (fi) | 1984-04-30 |
| FI66002C FI66002C (fi) | 1984-08-10 |
Family
ID=25685262
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FI814028A FI66002C (fi) | 1980-05-07 | 1981-12-15 | Foerfarande foer framstaellning av nya terapeutiskt anvaendbara substituerade 9,10-dihydro-4h-tieno(3,4-b)(1,5)bensodiazepin-10-oner samt deras syraadditionssalter |
Country Status (21)
| Country | Link |
|---|---|
| EP (1) | EP0039519B1 (sv) |
| JP (1) | JPS6021994B2 (sv) |
| KR (1) | KR850000241B1 (sv) |
| AT (1) | ATE7299T1 (sv) |
| AU (1) | AU538031B2 (sv) |
| DD (1) | DD158902A5 (sv) |
| DE (1) | DE3163361D1 (sv) |
| DK (1) | DK157872C (sv) |
| ES (1) | ES8205802A1 (sv) |
| FI (1) | FI66002C (sv) |
| GR (1) | GR82676B (sv) |
| HK (1) | HK6890A (sv) |
| HU (1) | HU182712B (sv) |
| IE (1) | IE51200B1 (sv) |
| IL (1) | IL62792A (sv) |
| NO (1) | NO156753C (sv) |
| NZ (1) | NZ197017A (sv) |
| PL (1) | PL139428B1 (sv) |
| PT (1) | PT72982B (sv) |
| WO (1) | WO1981003173A1 (sv) |
| YU (1) | YU42398B (sv) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3204169A1 (de) * | 1982-02-06 | 1983-08-11 | Dr. Karl Thomae Gmbh, 7950 Biberach | Substituierte thienobenzodiazepinone, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel |
| DE3204153A1 (de) * | 1982-02-06 | 1983-08-11 | Dr. Karl Thomae Gmbh, 7950 Biberach | Substituierte thienobenzodiazepinone, verfahren zu ihrer herstellung und sie enthaltende arzneimittel |
| DE3409237A1 (de) * | 1984-03-14 | 1985-09-19 | Dr. Karl Thomae Gmbh, 7950 Biberach | Kondensierte diazepinone, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel |
| DE3529372A1 (de) * | 1985-08-16 | 1987-02-19 | Dompe Farmaceutici Spa | Aminoacyl-derivat von 4,9-dihydro-10h-pyrido(3,2-b)-thieno(3,2-e) (1,4)-diazepinon und von 4,9-dihydro-10h-pyrido(3,2-b)thieno(3,4-e) (1,4)diazepinon, verfahren zu deren herstellung und diese verbindungen enthaltende pharmazeutische zusammensetzungen |
| DE3643666A1 (de) * | 1986-12-20 | 1988-06-30 | Thomae Gmbh Dr K | Neue kondensierte diazepinone, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel |
| DE3726908A1 (de) * | 1987-08-13 | 1989-02-23 | Thomae Gmbh Dr K | Neue kondensierte diazepinone, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel |
| EP0330756B1 (de) * | 1987-12-22 | 1996-03-27 | Byk Gulden Lomberg Chemische Fabrik GmbH | Thienotricyclen zur Behandlung von Erkrankungen der Bronchien |
| DE3802334A1 (de) * | 1988-01-27 | 1989-08-10 | Thomae Gmbh Dr K | Neue kondensierte diazepinone, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel |
| DE3820346A1 (de) * | 1988-06-15 | 1989-12-21 | Thomae Gmbh Dr K | Neue kondensierte diazepinone, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel |
| DE3820345A1 (de) * | 1988-06-15 | 1989-12-21 | Thomae Gmbh Dr K | Kondensierte diazepinone, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel |
| DE4003322C1 (sv) * | 1990-02-05 | 1991-06-20 | Byk Gulden Lomberg Chemische Fabrik Gmbh, 7750 Konstanz, De |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR1505795A (fr) * | 1965-12-17 | 1967-12-15 | Thomae Gmbh Dr K | Procédé pour fabriquer de nouvelles 11h-pyrido[2, 3-b][1, 5]benzodiazépine-5(6h)-ones substituées en position 11 |
| DE1931487C3 (de) * | 1969-06-20 | 1975-12-18 | Dr. Karl Thomae Gmbh, 7950 Biberach | In 5-Stellung substituierte 5,10-Dihydro-11H-dibenzo eckige Klammer auf b,e eckige Klammer zu eckige Klammer auf 1,4 eckige Klammer zu diazepin-11 -one und Verfahren zu ihrer Herstellung |
| DE1795183B1 (de) * | 1968-08-20 | 1972-07-20 | Thomae Gmbh Dr K | 5,11-Dihydro-6H-pyrido[2,3-b][1,4]benzodiazepin-6-on-derivate und Arzneimittel |
| DE1795176C3 (de) * | 1968-08-20 | 1974-10-24 | Dr. Karl Thomae Gmbh, 7950 Biberach | hT-substituierte 5-Aminoacetyl-5,10-dihydro-l lH-dibenzo eckige Klammer auf b,e eckige Klammer zu eckige Klammer auf 1,4 eckige Klammer zu diazepin-11one und Verfahren zu ihrer Herstellung |
| DE2424811C3 (de) * | 1974-05-22 | 1981-08-20 | Dr. Karl Thomae Gmbh, 7950 Biberach | Pyrido-benzodiazepinone, Verfahren zu ihrer Herstellung und diese enthaltende Arzneimittel |
| SU629879A3 (ru) * | 1974-11-26 | 1978-10-25 | Лилли Индастриз Лимитед, (Фирма) | Способ получени тиено(1,5) бензодиазепинов или их солей |
| US4115568A (en) * | 1974-11-26 | 1978-09-19 | Lilly Industries Limited | Thieno[3,2-b]-[1,5]benzodiazepines |
| US4172831A (en) * | 1974-11-26 | 1979-10-30 | Lilly Industries Limited | Thieno-benzodiazepines |
| US3951981A (en) * | 1975-02-24 | 1976-04-20 | American Cyanamid Company | Substituted benzodiazepines and method of use |
| US3953430A (en) * | 1975-02-24 | 1976-04-27 | American Cyanamid Company | Substituted benzodiazepin-10-ones and method of use |
| US4144235A (en) * | 1978-03-13 | 1979-03-13 | American Cyanamid Company | Thieno[3,4-b][1,5]benzoxazepin-10-ones and thieno[3,4-b][1,5]benzothiazepin-10-ones |
| US4168269A (en) * | 1978-04-12 | 1979-09-18 | American Cyanamid Company | Substituted thieno-benzodiazepines |
| US4263207A (en) * | 1978-08-01 | 1981-04-21 | Merck & Co., Inc. | 10,11-Dihydrodibenzo[b,f][1,4]thiazepine carboxylic acids esters and amides thereof |
-
1981
- 1981-05-05 IL IL62792A patent/IL62792A/xx not_active IP Right Cessation
- 1981-05-06 AU AU70198/81A patent/AU538031B2/en not_active Ceased
- 1981-05-06 DE DE8181103437T patent/DE3163361D1/de not_active Expired
- 1981-05-06 DD DD81229765A patent/DD158902A5/de unknown
- 1981-05-06 ES ES501929A patent/ES8205802A1/es not_active Expired
- 1981-05-06 AT AT81103437T patent/ATE7299T1/de not_active IP Right Cessation
- 1981-05-06 HU HU811799A patent/HU182712B/hu not_active IP Right Cessation
- 1981-05-06 WO PCT/EP1981/000042 patent/WO1981003173A1/de active IP Right Grant
- 1981-05-06 KR KR1019810001564A patent/KR850000241B1/ko active
- 1981-05-06 YU YU1161/81A patent/YU42398B/xx unknown
- 1981-05-06 NZ NZ197017A patent/NZ197017A/xx unknown
- 1981-05-06 JP JP56501690A patent/JPS6021994B2/ja not_active Expired
- 1981-05-06 EP EP81103437A patent/EP0039519B1/de not_active Expired
- 1981-05-06 PL PL1981231003A patent/PL139428B1/pl unknown
- 1981-05-06 PT PT72982A patent/PT72982B/pt unknown
- 1981-05-06 GR GR64851A patent/GR82676B/el unknown
- 1981-05-06 IE IE997/81A patent/IE51200B1/en not_active IP Right Cessation
- 1981-12-15 FI FI814028A patent/FI66002C/fi not_active IP Right Cessation
-
1982
- 1982-01-05 DK DK001582A patent/DK157872C/da not_active IP Right Cessation
- 1982-01-06 NO NO82820025A patent/NO156753C/no unknown
-
1990
- 1990-01-25 HK HK68/90A patent/HK6890A/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| IL62792A0 (en) | 1981-07-31 |
| EP0039519B1 (de) | 1984-05-02 |
| NO156753C (no) | 1987-11-18 |
| PT72982B (fr) | 1982-10-21 |
| HU182712B (en) | 1984-03-28 |
| NO156753B (no) | 1987-08-10 |
| DK157872B (da) | 1990-02-26 |
| KR830006300A (ko) | 1983-09-20 |
| WO1981003173A1 (en) | 1981-11-12 |
| JPS57500695A (sv) | 1982-04-22 |
| IE51200B1 (en) | 1986-10-29 |
| PL139428B1 (en) | 1987-01-31 |
| PT72982A (en) | 1981-06-01 |
| HK6890A (en) | 1990-02-02 |
| IL62792A (en) | 1985-02-28 |
| IE810997L (en) | 1981-11-07 |
| YU116181A (en) | 1984-02-29 |
| KR850000241B1 (ko) | 1985-03-12 |
| FI814028L (fi) | 1981-12-15 |
| DK1582A (da) | 1982-01-05 |
| DK157872C (da) | 1990-07-30 |
| FI66002C (fi) | 1984-08-10 |
| ATE7299T1 (de) | 1984-05-15 |
| JPS6021994B2 (ja) | 1985-05-30 |
| DE3163361D1 (en) | 1984-06-07 |
| NO820025L (no) | 1982-01-06 |
| YU42398B (en) | 1988-08-31 |
| DD158902A5 (de) | 1983-02-09 |
| GR82676B (sv) | 1985-02-07 |
| ES501929A0 (es) | 1982-08-16 |
| AU538031B2 (en) | 1984-07-26 |
| PL231003A1 (sv) | 1981-12-23 |
| EP0039519A1 (de) | 1981-11-11 |
| NZ197017A (en) | 1983-09-30 |
| ES8205802A1 (es) | 1982-08-16 |
| AU7019881A (en) | 1981-11-12 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MM | Patent lapsed | ||
| MM | Patent lapsed |
Owner name: BYK GULDEN LOMBERG CHEMISCHE FABRIK |