AU7019881A - Substituted thienobenzodiazepinone compounds - Google Patents
Substituted thienobenzodiazepinone compoundsInfo
- Publication number
- AU7019881A AU7019881A AU70198/81A AU7019881A AU7019881A AU 7019881 A AU7019881 A AU 7019881A AU 70198/81 A AU70198/81 A AU 70198/81A AU 7019881 A AU7019881 A AU 7019881A AU 7019881 A AU7019881 A AU 7019881A
- Authority
- AU
- Australia
- Prior art keywords
- group
- compounds
- formula
- symbol
- alkyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 150000001875 compounds Chemical class 0.000 title abstract 5
- -1 morpholino, pyrrolidino, piperidino group Chemical group 0.000 abstract 5
- 125000000217 alkyl group Chemical group 0.000 abstract 4
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 abstract 2
- 125000005843 halogen group Chemical group 0.000 abstract 2
- 210000000936 intestine Anatomy 0.000 abstract 2
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 2
- 210000000056 organ Anatomy 0.000 abstract 2
- 230000000144 pharmacologic effect Effects 0.000 abstract 2
- 210000002784 stomach Anatomy 0.000 abstract 2
- 125000003342 alkenyl group Chemical group 0.000 abstract 1
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 229910052757 nitrogen Inorganic materials 0.000 abstract 1
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Heterocyclic Compounds Containing Sulfur Atoms (AREA)
- Plural Heterocyclic Compounds (AREA)
- Steroid Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Compositions Of Macromolecular Compounds (AREA)
Abstract
The new compounds, defined as thieno-benzodiazepinones, are represented by the general formula I, (FORMULA) wherein R<s1>s represents a hydrogen atom or an alkyl residue from C<u1>u to C<u4>u, R<s2>s represents a halogen atom or has the same representation as R<s1>s, and R<s3>s represents a halogen atom or a group-N (R<s4>s)R<s5>s, wherein R<s4>s represents an alkyl residue from C<u1>u to C<u4>u or an alkenyl residue from C<u3>u to C<u5>u and wherein R<s5>s has one of the representations of R<s4>s or represents a group having the partial formula -(CH<u2>u)<um>u-N (R<s6>s)R<s7>s, or wherein R<s4>s and R<s5>s in common, including the nitrogen atom to which they are bound, represent a morpholino, pyrrolidino, piperidino group, a hexa-hydro-azepin-1-yl group, a piperazine-1-yl group optionally substituted in position 4 by methyl or ethyl or benzyl, a 2, 4-dimethyl-piperazine-1-yl group or an hexa-hydro-1H-1, 4-diazepin-1-yl group substituted in position 4 by methyl or ethyl, the symbol R<s6>s representing an alkyl group in C<u1>u to C<u4>u and R<s7>s representing an alkyl group in C<u1>u to C<u4>u, the symbol A of the formula I represents an alkylen group with a straight or branched chain C<u1>u to C<u5>u and the symbol m hereabove is 2 or 3; their addition salts may also be formed. All these compounds exhibit a pharmacologic activity for the protection of the stomach and intestine organs and are therefore appropriate for the treatment of diseases affecting the stomach or intestine organs; these compounds may also be used as intermediary products. There are also disclosed methods for the preparation of said new compounds which exhibit an interesting pharmacological activity and also form intermediary products.
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CH358180 | 1980-05-07 | ||
| CH3581/80 | 1980-05-07 | ||
| CH65281 | 1981-02-02 | ||
| CH652/81 | 1981-02-02 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| AU7019881A true AU7019881A (en) | 1981-11-12 |
| AU538031B2 AU538031B2 (en) | 1984-07-26 |
Family
ID=25685262
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AU70198/81A Ceased AU538031B2 (en) | 1980-05-07 | 1981-05-06 | Substituted thienobenzodiazepinone compounds |
Country Status (21)
| Country | Link |
|---|---|
| EP (1) | EP0039519B1 (en) |
| JP (1) | JPS6021994B2 (en) |
| KR (1) | KR850000241B1 (en) |
| AT (1) | ATE7299T1 (en) |
| AU (1) | AU538031B2 (en) |
| DD (1) | DD158902A5 (en) |
| DE (1) | DE3163361D1 (en) |
| DK (1) | DK157872C (en) |
| ES (1) | ES8205802A1 (en) |
| FI (1) | FI66002C (en) |
| GR (1) | GR82676B (en) |
| HK (1) | HK6890A (en) |
| HU (1) | HU182712B (en) |
| IE (1) | IE51200B1 (en) |
| IL (1) | IL62792A (en) |
| NO (1) | NO156753C (en) |
| NZ (1) | NZ197017A (en) |
| PL (1) | PL139428B1 (en) |
| PT (1) | PT72982B (en) |
| WO (1) | WO1981003173A1 (en) |
| YU (1) | YU42398B (en) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3204169A1 (en) * | 1982-02-06 | 1983-08-11 | Dr. Karl Thomae Gmbh, 7950 Biberach | SUBSTITUTED THIENOBENZODIAZEPINONE, METHOD FOR THE PRODUCTION THEREOF, AND MEDICINAL PRODUCTS CONTAINING THESE COMPOUNDS |
| DE3204153A1 (en) * | 1982-02-06 | 1983-08-11 | Dr. Karl Thomae Gmbh, 7950 Biberach | SUBSTITUTED THIENOBENZODIAZEPINONE, METHOD FOR THE PRODUCTION THEREOF AND MEDICINAL PRODUCTS CONTAINING IT |
| DE3409237A1 (en) * | 1984-03-14 | 1985-09-19 | Dr. Karl Thomae Gmbh, 7950 Biberach | CONDENSED DIAZEPINONE, METHOD FOR THE PRODUCTION THEREOF AND MEDICINAL PRODUCTS CONTAINING THESE COMPOUNDS |
| DE3529372A1 (en) * | 1985-08-16 | 1987-02-19 | Dompe Farmaceutici Spa | AMINOACYL DERIVATIVE OF 4,9-DIHYDRO-10H-PYRIDO (3,2-B) -THIENO (3,2-E) (1,4) -DIAZEPINONE AND OF 4,9-DIHYDRO-10H-PYRIDO (3, 2-B) THIENO (3,4-E) (1,4) DIAZEPINONE, METHOD FOR THE PRODUCTION THEREOF AND PHARMACEUTICAL COMPOSITIONS CONTAINING THESE COMPOUNDS |
| DE3643666A1 (en) * | 1986-12-20 | 1988-06-30 | Thomae Gmbh Dr K | NEW CONDENSED DIAZEPINONE, METHOD FOR THE PRODUCTION THEREOF, AND MEDICINAL PRODUCTS CONTAINING THESE COMPOUNDS |
| DE3726908A1 (en) * | 1987-08-13 | 1989-02-23 | Thomae Gmbh Dr K | NEW CONDENSED DIAZEPINONE, PROCESS FOR THEIR MANUFACTURE AND MEDICAMENTS CONTAINING THESE COMPOUNDS |
| EP0330756B1 (en) * | 1987-12-22 | 1996-03-27 | Byk Gulden Lomberg Chemische Fabrik GmbH | Thienotricyclics for the treatment of bronchial diseases |
| DE3802334A1 (en) * | 1988-01-27 | 1989-08-10 | Thomae Gmbh Dr K | NEW CONDENSED DIAZEPINONE, PROCESS FOR THEIR MANUFACTURE AND MEDICAMENTS CONTAINING THESE COMPOUNDS |
| DE3820346A1 (en) * | 1988-06-15 | 1989-12-21 | Thomae Gmbh Dr K | NEW CONDENSED DIAZEPINONE, PROCESS FOR THEIR MANUFACTURE AND MEDICAMENTS CONTAINING THESE COMPOUNDS |
| DE3820345A1 (en) * | 1988-06-15 | 1989-12-21 | Thomae Gmbh Dr K | CONDENSED DIAZEPINONE, METHOD FOR THE PRODUCTION THEREOF AND MEDICAMENT CONTAINING THESE COMPOUNDS |
| DE4003322C1 (en) * | 1990-02-05 | 1991-06-20 | Byk Gulden Lomberg Chemische Fabrik Gmbh, 7750 Konstanz, De |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR1505795A (en) * | 1965-12-17 | 1967-12-15 | Thomae Gmbh Dr K | Process for making new 11h-pyrido [2, 3-b] [1, 5] benzodiazepine-5 (6h) -ones substituted in position 11 |
| DE1931487C3 (en) * | 1969-06-20 | 1975-12-18 | Dr. Karl Thomae Gmbh, 7950 Biberach | 5,10-Dihydro-11H-dibenzo substituted in the 5-position, square brackets on b, square brackets on square brackets on 1,4 square brackets on diazepin-11-one and process for their preparation |
| DE1795183B1 (en) * | 1968-08-20 | 1972-07-20 | Thomae Gmbh Dr K | 5,11-dihydro-6H-pyrido [2,3-b] [1,4] benzodiazepin-6-one derivatives and drugs |
| DE1795176C3 (en) * | 1968-08-20 | 1974-10-24 | Dr. Karl Thomae Gmbh, 7950 Biberach | hT-substituted 5-aminoacetyl-5,10-dihydro-l lH-dibenzo square bracket to b, square bracket to square bracket to 1,4 square bracket to diazepine-11one and process for their preparation |
| DE2424811C3 (en) * | 1974-05-22 | 1981-08-20 | Dr. Karl Thomae Gmbh, 7950 Biberach | Pyrido-benzodiazepinones, process for their preparation and medicaments containing them |
| SU629879A3 (en) * | 1974-11-26 | 1978-10-25 | Лилли Индастриз Лимитед, (Фирма) | Method of obtaining thieno(1,5)-benzodiazepines or salts thereof |
| US4115568A (en) * | 1974-11-26 | 1978-09-19 | Lilly Industries Limited | Thieno[3,2-b]-[1,5]benzodiazepines |
| US4172831A (en) * | 1974-11-26 | 1979-10-30 | Lilly Industries Limited | Thieno-benzodiazepines |
| US3951981A (en) * | 1975-02-24 | 1976-04-20 | American Cyanamid Company | Substituted benzodiazepines and method of use |
| US3953430A (en) * | 1975-02-24 | 1976-04-27 | American Cyanamid Company | Substituted benzodiazepin-10-ones and method of use |
| US4144235A (en) * | 1978-03-13 | 1979-03-13 | American Cyanamid Company | Thieno[3,4-b][1,5]benzoxazepin-10-ones and thieno[3,4-b][1,5]benzothiazepin-10-ones |
| US4168269A (en) * | 1978-04-12 | 1979-09-18 | American Cyanamid Company | Substituted thieno-benzodiazepines |
| US4263207A (en) * | 1978-08-01 | 1981-04-21 | Merck & Co., Inc. | 10,11-Dihydrodibenzo[b,f][1,4]thiazepine carboxylic acids esters and amides thereof |
-
1981
- 1981-05-05 IL IL62792A patent/IL62792A/en not_active IP Right Cessation
- 1981-05-06 AU AU70198/81A patent/AU538031B2/en not_active Ceased
- 1981-05-06 DE DE8181103437T patent/DE3163361D1/en not_active Expired
- 1981-05-06 DD DD81229765A patent/DD158902A5/en unknown
- 1981-05-06 ES ES501929A patent/ES8205802A1/en not_active Expired
- 1981-05-06 AT AT81103437T patent/ATE7299T1/en not_active IP Right Cessation
- 1981-05-06 HU HU811799A patent/HU182712B/en not_active IP Right Cessation
- 1981-05-06 WO PCT/EP1981/000042 patent/WO1981003173A1/en active IP Right Grant
- 1981-05-06 KR KR1019810001564A patent/KR850000241B1/en active
- 1981-05-06 YU YU1161/81A patent/YU42398B/en unknown
- 1981-05-06 NZ NZ197017A patent/NZ197017A/en unknown
- 1981-05-06 JP JP56501690A patent/JPS6021994B2/en not_active Expired
- 1981-05-06 EP EP81103437A patent/EP0039519B1/en not_active Expired
- 1981-05-06 PL PL1981231003A patent/PL139428B1/en unknown
- 1981-05-06 PT PT72982A patent/PT72982B/en unknown
- 1981-05-06 GR GR64851A patent/GR82676B/el unknown
- 1981-05-06 IE IE997/81A patent/IE51200B1/en not_active IP Right Cessation
- 1981-12-15 FI FI814028A patent/FI66002C/en not_active IP Right Cessation
-
1982
- 1982-01-05 DK DK001582A patent/DK157872C/en not_active IP Right Cessation
- 1982-01-06 NO NO82820025A patent/NO156753C/en unknown
-
1990
- 1990-01-25 HK HK68/90A patent/HK6890A/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| IL62792A0 (en) | 1981-07-31 |
| EP0039519B1 (en) | 1984-05-02 |
| NO156753C (en) | 1987-11-18 |
| PT72982B (en) | 1982-10-21 |
| HU182712B (en) | 1984-03-28 |
| NO156753B (en) | 1987-08-10 |
| DK157872B (en) | 1990-02-26 |
| KR830006300A (en) | 1983-09-20 |
| WO1981003173A1 (en) | 1981-11-12 |
| JPS57500695A (en) | 1982-04-22 |
| IE51200B1 (en) | 1986-10-29 |
| PL139428B1 (en) | 1987-01-31 |
| PT72982A (en) | 1981-06-01 |
| HK6890A (en) | 1990-02-02 |
| IL62792A (en) | 1985-02-28 |
| IE810997L (en) | 1981-11-07 |
| YU116181A (en) | 1984-02-29 |
| KR850000241B1 (en) | 1985-03-12 |
| FI814028L (en) | 1981-12-15 |
| DK1582A (en) | 1982-01-05 |
| DK157872C (en) | 1990-07-30 |
| FI66002B (en) | 1984-04-30 |
| FI66002C (en) | 1984-08-10 |
| ATE7299T1 (en) | 1984-05-15 |
| JPS6021994B2 (en) | 1985-05-30 |
| DE3163361D1 (en) | 1984-06-07 |
| NO820025L (en) | 1982-01-06 |
| YU42398B (en) | 1988-08-31 |
| DD158902A5 (en) | 1983-02-09 |
| GR82676B (en) | 1985-02-07 |
| ES501929A0 (en) | 1982-08-16 |
| AU538031B2 (en) | 1984-07-26 |
| PL231003A1 (en) | 1981-12-23 |
| EP0039519A1 (en) | 1981-11-11 |
| NZ197017A (en) | 1983-09-30 |
| ES8205802A1 (en) | 1982-08-16 |
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