DK1582A - SUBSTITUTED THIENOTRICYCLES PROCEDURE FOR PREPARING IT AND USING SUCH COMPOUNDS - Google Patents
SUBSTITUTED THIENOTRICYCLES PROCEDURE FOR PREPARING IT AND USING SUCH COMPOUNDS Download PDFInfo
- Publication number
- DK1582A DK1582A DK1582A DK1582A DK1582A DK 1582 A DK1582 A DK 1582A DK 1582 A DK1582 A DK 1582A DK 1582 A DK1582 A DK 1582A DK 1582 A DK1582 A DK 1582A
- Authority
- DK
- Denmark
- Prior art keywords
- group
- denotes
- carbon atoms
- compounds
- acid addition
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
Abstract
Substituted thienobenzodiazepinones of the general formula I <IMAGE> where R1 denotes hydrogen or alkyl having 1-4 carbon atoms, R2 denotes halogen or has one of the meanings of R1, R3 denotes halogen or a group -N(R4)R5, and R4 denotes alkyl having 1-4 carbon atoms or alkenyl having 3-5 carbon atoms, R5 has one of the meanings of R4 or denotes a group -(CH2)m-N(R6)R7, or R4 and R5, together with the nitrogen atom to which they are bonded, form a morpholino group, a pyrrolidino group, a piperidino group, a hexahydroazapin-1-yl group, a piperazin-1-yl group which is optionally substituted in the 4 position by methyl, ethyl or benzyl, a 2,4-dimethylpiperazin-1-yl group or a hexahydro-1H-1,4-diazapin-1-yl group which is substituted in the 4 position by methyl or ethyl, and R6 denotes alkyl having 1-4 carbon atoms, R7 denotes alkyl having 1-4 carbon atoms, A denotes a straight-chain or branched alkylene group having 1-5 carbon atoms, and m denotes 2 or 3, and acid addition salts thereof, are prepared by acylating compounds II <IMAGE> and, where appropriate, subsequently amidating and/or converting resulting bases into acid addition salts or resulting acid addition salts into the free base or pharmacologically tolerable acid addition salts. The compounds I are previously unknown compounds which have a protective effect on the stomach and intestine and can be used for treating diseases which are due to disorders in the stomach or the intestine, or the compounds are intermediates.
Applications Claiming Priority (6)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CH358180 | 1980-05-07 | ||
| CH358180 | 1980-05-07 | ||
| CH65281 | 1981-02-02 | ||
| CH65281 | 1981-02-02 | ||
| PCT/EP1981/000042 WO1981003173A1 (en) | 1980-05-07 | 1981-05-06 | Thieno-tricyclic compounds,method for the preparation thereof,utilization of such compounds and drugs containing them |
| EP8100042 | 1981-05-06 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| DK1582A true DK1582A (en) | 1982-01-05 |
| DK157872B DK157872B (en) | 1990-02-26 |
| DK157872C DK157872C (en) | 1990-07-30 |
Family
ID=25685262
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK001582A DK157872C (en) | 1980-05-07 | 1982-01-05 | ANALOGY PROCEDURE FOR THE PREPARATION OF SUBSTITUTED THIENOBENZODIAZEPINONES AND INTERMEDIATES FOR USING THIS PROCEDURE |
Country Status (21)
| Country | Link |
|---|---|
| EP (1) | EP0039519B1 (en) |
| JP (1) | JPS6021994B2 (en) |
| KR (1) | KR850000241B1 (en) |
| AT (1) | ATE7299T1 (en) |
| AU (1) | AU538031B2 (en) |
| DD (1) | DD158902A5 (en) |
| DE (1) | DE3163361D1 (en) |
| DK (1) | DK157872C (en) |
| ES (1) | ES8205802A1 (en) |
| FI (1) | FI66002C (en) |
| GR (1) | GR82676B (en) |
| HK (1) | HK6890A (en) |
| HU (1) | HU182712B (en) |
| IE (1) | IE51200B1 (en) |
| IL (1) | IL62792A (en) |
| NO (1) | NO156753C (en) |
| NZ (1) | NZ197017A (en) |
| PL (1) | PL139428B1 (en) |
| PT (1) | PT72982B (en) |
| WO (1) | WO1981003173A1 (en) |
| YU (1) | YU42398B (en) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3204169A1 (en) * | 1982-02-06 | 1983-08-11 | Dr. Karl Thomae Gmbh, 7950 Biberach | SUBSTITUTED THIENOBENZODIAZEPINONE, METHOD FOR THE PRODUCTION THEREOF, AND MEDICINAL PRODUCTS CONTAINING THESE COMPOUNDS |
| DE3204153A1 (en) * | 1982-02-06 | 1983-08-11 | Dr. Karl Thomae Gmbh, 7950 Biberach | SUBSTITUTED THIENOBENZODIAZEPINONE, METHOD FOR THE PRODUCTION THEREOF AND MEDICINAL PRODUCTS CONTAINING IT |
| DE3409237A1 (en) * | 1984-03-14 | 1985-09-19 | Dr. Karl Thomae Gmbh, 7950 Biberach | CONDENSED DIAZEPINONE, METHOD FOR THE PRODUCTION THEREOF AND MEDICINAL PRODUCTS CONTAINING THESE COMPOUNDS |
| DE3529372A1 (en) * | 1985-08-16 | 1987-02-19 | Dompe Farmaceutici Spa | AMINOACYL DERIVATIVE OF 4,9-DIHYDRO-10H-PYRIDO (3,2-B) -THIENO (3,2-E) (1,4) -DIAZEPINONE AND OF 4,9-DIHYDRO-10H-PYRIDO (3, 2-B) THIENO (3,4-E) (1,4) DIAZEPINONE, METHOD FOR THE PRODUCTION THEREOF AND PHARMACEUTICAL COMPOSITIONS CONTAINING THESE COMPOUNDS |
| DE3643666A1 (en) * | 1986-12-20 | 1988-06-30 | Thomae Gmbh Dr K | NEW CONDENSED DIAZEPINONE, METHOD FOR THE PRODUCTION THEREOF, AND MEDICINAL PRODUCTS CONTAINING THESE COMPOUNDS |
| DE3726908A1 (en) * | 1987-08-13 | 1989-02-23 | Thomae Gmbh Dr K | NEW CONDENSED DIAZEPINONE, PROCESS FOR THEIR MANUFACTURE AND MEDICAMENTS CONTAINING THESE COMPOUNDS |
| WO1989005644A2 (en) * | 1987-12-22 | 1989-06-29 | Byk Gulden Lomberg Chemische Fabrik Gmbh | Thienotricyclene for the treatment of bronchial diseases |
| DE3802334A1 (en) * | 1988-01-27 | 1989-08-10 | Thomae Gmbh Dr K | NEW CONDENSED DIAZEPINONE, PROCESS FOR THEIR MANUFACTURE AND MEDICAMENTS CONTAINING THESE COMPOUNDS |
| DE3820346A1 (en) * | 1988-06-15 | 1989-12-21 | Thomae Gmbh Dr K | NEW CONDENSED DIAZEPINONE, PROCESS FOR THEIR MANUFACTURE AND MEDICAMENTS CONTAINING THESE COMPOUNDS |
| DE3820345A1 (en) * | 1988-06-15 | 1989-12-21 | Thomae Gmbh Dr K | CONDENSED DIAZEPINONE, METHOD FOR THE PRODUCTION THEREOF AND MEDICAMENT CONTAINING THESE COMPOUNDS |
| DE4003322C1 (en) * | 1990-02-05 | 1991-06-20 | Byk Gulden Lomberg Chemische Fabrik Gmbh, 7750 Konstanz, De |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR1505795A (en) * | 1965-12-17 | 1967-12-15 | Thomae Gmbh Dr K | Process for making new 11h-pyrido [2, 3-b] [1, 5] benzodiazepine-5 (6h) -ones substituted in position 11 |
| DE1795176C3 (en) * | 1968-08-20 | 1974-10-24 | Dr. Karl Thomae Gmbh, 7950 Biberach | hT-substituted 5-aminoacetyl-5,10-dihydro-l lH-dibenzo square bracket to b, square bracket to square bracket to 1,4 square bracket to diazepine-11one and process for their preparation |
| DE1931487C3 (en) * | 1969-06-20 | 1975-12-18 | Dr. Karl Thomae Gmbh, 7950 Biberach | 5,10-Dihydro-11H-dibenzo substituted in the 5-position, square brackets on b, square brackets on square brackets on 1,4 square brackets on diazepin-11-one and process for their preparation |
| DE1795183B1 (en) * | 1968-08-20 | 1972-07-20 | Thomae Gmbh Dr K | 5,11-dihydro-6H-pyrido [2,3-b] [1,4] benzodiazepin-6-one derivatives and drugs |
| DE2424811C3 (en) * | 1974-05-22 | 1981-08-20 | Dr. Karl Thomae Gmbh, 7950 Biberach | Pyrido-benzodiazepinones, process for their preparation and medicaments containing them |
| US4115568A (en) * | 1974-11-26 | 1978-09-19 | Lilly Industries Limited | Thieno[3,2-b]-[1,5]benzodiazepines |
| SU629879A3 (en) * | 1974-11-26 | 1978-10-25 | Лилли Индастриз Лимитед, (Фирма) | Method of obtaining thieno(1,5)-benzodiazepines or salts thereof |
| US4172831A (en) * | 1974-11-26 | 1979-10-30 | Lilly Industries Limited | Thieno-benzodiazepines |
| US3953430A (en) * | 1975-02-24 | 1976-04-27 | American Cyanamid Company | Substituted benzodiazepin-10-ones and method of use |
| US3951981A (en) * | 1975-02-24 | 1976-04-20 | American Cyanamid Company | Substituted benzodiazepines and method of use |
| US4144235A (en) * | 1978-03-13 | 1979-03-13 | American Cyanamid Company | Thieno[3,4-b][1,5]benzoxazepin-10-ones and thieno[3,4-b][1,5]benzothiazepin-10-ones |
| US4168269A (en) * | 1978-04-12 | 1979-09-18 | American Cyanamid Company | Substituted thieno-benzodiazepines |
| US4263207A (en) * | 1978-08-01 | 1981-04-21 | Merck & Co., Inc. | 10,11-Dihydrodibenzo[b,f][1,4]thiazepine carboxylic acids esters and amides thereof |
-
1981
- 1981-05-05 IL IL62792A patent/IL62792A/en not_active IP Right Cessation
- 1981-05-06 AU AU70198/81A patent/AU538031B2/en not_active Ceased
- 1981-05-06 PL PL1981231003A patent/PL139428B1/en unknown
- 1981-05-06 EP EP81103437A patent/EP0039519B1/en not_active Expired
- 1981-05-06 WO PCT/EP1981/000042 patent/WO1981003173A1/en active IP Right Grant
- 1981-05-06 YU YU1161/81A patent/YU42398B/en unknown
- 1981-05-06 GR GR64851A patent/GR82676B/el unknown
- 1981-05-06 DE DE8181103437T patent/DE3163361D1/en not_active Expired
- 1981-05-06 KR KR1019810001564A patent/KR850000241B1/en active
- 1981-05-06 JP JP56501690A patent/JPS6021994B2/en not_active Expired
- 1981-05-06 PT PT72982A patent/PT72982B/en unknown
- 1981-05-06 AT AT81103437T patent/ATE7299T1/en not_active IP Right Cessation
- 1981-05-06 HU HU811799A patent/HU182712B/en not_active IP Right Cessation
- 1981-05-06 ES ES501929A patent/ES8205802A1/en not_active Expired
- 1981-05-06 NZ NZ197017A patent/NZ197017A/en unknown
- 1981-05-06 IE IE997/81A patent/IE51200B1/en not_active IP Right Cessation
- 1981-05-06 DD DD81229765A patent/DD158902A5/en unknown
- 1981-12-15 FI FI814028A patent/FI66002C/en not_active IP Right Cessation
-
1982
- 1982-01-05 DK DK001582A patent/DK157872C/en not_active IP Right Cessation
- 1982-01-06 NO NO82820025A patent/NO156753C/en unknown
-
1990
- 1990-01-25 HK HK68/90A patent/HK6890A/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| PL139428B1 (en) | 1987-01-31 |
| IL62792A0 (en) | 1981-07-31 |
| YU42398B (en) | 1988-08-31 |
| PL231003A1 (en) | 1981-12-23 |
| KR850000241B1 (en) | 1985-03-12 |
| EP0039519A1 (en) | 1981-11-11 |
| ES501929A0 (en) | 1982-08-16 |
| KR830006300A (en) | 1983-09-20 |
| DE3163361D1 (en) | 1984-06-07 |
| HK6890A (en) | 1990-02-02 |
| NZ197017A (en) | 1983-09-30 |
| FI814028L (en) | 1981-12-15 |
| DK157872B (en) | 1990-02-26 |
| WO1981003173A1 (en) | 1981-11-12 |
| IE51200B1 (en) | 1986-10-29 |
| JPS57500695A (en) | 1982-04-22 |
| NO820025L (en) | 1982-01-06 |
| IE810997L (en) | 1981-11-07 |
| PT72982B (en) | 1982-10-21 |
| NO156753B (en) | 1987-08-10 |
| GR82676B (en) | 1985-02-07 |
| JPS6021994B2 (en) | 1985-05-30 |
| AU7019881A (en) | 1981-11-12 |
| DK157872C (en) | 1990-07-30 |
| ATE7299T1 (en) | 1984-05-15 |
| IL62792A (en) | 1985-02-28 |
| AU538031B2 (en) | 1984-07-26 |
| DD158902A5 (en) | 1983-02-09 |
| FI66002C (en) | 1984-08-10 |
| PT72982A (en) | 1981-06-01 |
| NO156753C (en) | 1987-11-18 |
| YU116181A (en) | 1984-02-29 |
| HU182712B (en) | 1984-03-28 |
| ES8205802A1 (en) | 1982-08-16 |
| FI66002B (en) | 1984-04-30 |
| EP0039519B1 (en) | 1984-05-02 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| AHB | Application shelved due to non-payment | ||
| PBP | Patent lapsed |