SE8505887L - indoles - Google Patents
indolesInfo
- Publication number
- SE8505887L SE8505887L SE8505887A SE8505887A SE8505887L SE 8505887 L SE8505887 L SE 8505887L SE 8505887 A SE8505887 A SE 8505887A SE 8505887 A SE8505887 A SE 8505887A SE 8505887 L SE8505887 L SE 8505887L
- Authority
- SE
- Sweden
- Prior art keywords
- alkyl
- represents hydrogen
- phenyl
- group
- r7r8n
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/14—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
- C07D209/16—Tryptamines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Health & Medical Sciences (AREA)
- Cardiology (AREA)
- Pain & Pain Management (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Heart & Thoracic Surgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Indole Compounds (AREA)
Abstract
Novel indoles of the general formula (I): <IMAGE> wherein R1 represents hydrogen, alkyl, cycloalkyl, alkenyl, phenyl or phenyl alkyl in which the phenyl ring may be unsubstituted or substituted by one or two substituents selected from alkoxy, hydroxy, halogen, a group R5R6NCO- where R5 and R6 each represents hydrogen or alkyl, or a group R7R8N-, where R7 and R8 each represents hydrogen or alkyl, or R7R8N- represents a saturated monocyclic 5- to 7- membered ring; R2 represents hydrogen or alkyl; or R1 and R2 together with the nitrogen atom form a saturated monocyclic 5- to 7-membered ring; R3 and R4 each represents hydrogen, alkyl or a 2-propenyl group; and n is an integer from 2 to 5; and physiologically acceptable salts and solvates thereof have selective vasoconstrictor activity and are useful in treating and/or preventing pain resulting from dilatation of the cranial vasculature, in particular migraine.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB848431426A GB8431426D0 (en) | 1984-12-13 | 1984-12-13 | Chemical compounds |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| SE8505887D0 SE8505887D0 (en) | 1985-12-12 |
| SE8505887L true SE8505887L (en) | 1986-06-14 |
Family
ID=10571103
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SE8505887A SE8505887L (en) | 1984-12-13 | 1985-12-12 | indoles |
Country Status (11)
| Country | Link |
|---|---|
| JP (1) | JPS61151172A (en) |
| AU (1) | AU579687B2 (en) |
| BE (1) | BE903846A (en) |
| CH (1) | CH667454A5 (en) |
| DE (1) | DE3543982A1 (en) |
| FR (1) | FR2574793B1 (en) |
| GB (2) | GB8431426D0 (en) |
| IT (1) | IT1182089B (en) |
| NL (1) | NL8503424A (en) |
| SE (1) | SE8505887L (en) |
| ZA (1) | ZA859520B (en) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB8530507D0 (en) * | 1985-12-11 | 1986-01-22 | Glaxo Group Plc | Chemical compounds |
| GB8607824D0 (en) * | 1986-03-27 | 1986-04-30 | Glaxo Group Ltd | Chemical compounds |
| GB8614287D0 (en) * | 1986-06-12 | 1986-07-16 | Glaxo Group Ltd | Chemical compounds |
| US4894386A (en) * | 1987-04-15 | 1990-01-16 | Ici Americas Inc. | Aliphatic carboxamides |
| GB8719167D0 (en) * | 1987-08-13 | 1987-09-23 | Glaxo Group Ltd | Chemical compounds |
| US5225431A (en) * | 1987-10-23 | 1993-07-06 | Burroughs Wellcome Co. | Therapeutic substituted indole compounds and compositions thereof |
| CZ288351B6 (en) * | 1990-06-07 | 2001-05-16 | Astrazeneca Ab | Nitrogenous heterocyclic compound, process of its preparation and use as well as a medicament containing thereof |
| GB9209882D0 (en) * | 1992-05-07 | 1992-06-24 | Glaxo Lab Sa | Compositions |
| GB9211277D0 (en) | 1992-05-28 | 1992-07-15 | Glaxo Group Inc | Pharmaceutical compositions |
| GB9216009D0 (en) * | 1992-07-28 | 1992-09-09 | Almirall Lab | New indol derivatives |
| ES2056025B1 (en) * | 1992-10-08 | 1995-05-01 | Almirall Lab | NEW DERIVATIVES OF INDOL. |
| FR2707639B1 (en) * | 1993-06-30 | 1995-10-13 | Pf Medicament | New indole compounds derived from arylamines as selective ligands for the 5HT1D and 5HT1B receptors. |
| EP1572647B1 (en) * | 2002-12-20 | 2016-09-21 | Basf Se | Synthesis of amines and intermediates for the synthesis thereof |
| WO2005118551A2 (en) | 2004-05-28 | 2005-12-15 | Ligand Pharmaceuticals Inc. | Thrombopoietin activity modulating compounds and methods |
| WO2006047344A1 (en) * | 2004-10-25 | 2006-05-04 | Ligand Pharmaceuticals, Inc. | Thrombopoietin activity modulating compounds and methods |
| CN101679248A (en) | 2007-03-29 | 2010-03-24 | 阿斯比奥制药株式会社 | Indole derivative having cpla2 inhibitory activity, use of the same and method for producing the same |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ZA795239B (en) * | 1978-10-12 | 1980-11-26 | Glaxo Group Ltd | Heterocyclic compounds |
| GB2082175B (en) * | 1980-08-12 | 1984-05-02 | Glaxo Group Ltd | Heterocyclic compounds |
| NL8503337A (en) * | 1984-12-04 | 1986-07-01 | Glaxo Group Ltd | INDOLE DERIVATIVES. |
| GB8530507D0 (en) * | 1985-12-11 | 1986-01-22 | Glaxo Group Plc | Chemical compounds |
-
1984
- 1984-12-13 GB GB848431426A patent/GB8431426D0/en active Pending
-
1985
- 1985-12-12 JP JP60278124A patent/JPS61151172A/en active Pending
- 1985-12-12 GB GB08530591A patent/GB2168347B/en not_active Expired
- 1985-12-12 CH CH5301/85A patent/CH667454A5/en not_active IP Right Cessation
- 1985-12-12 BE BE0/216004A patent/BE903846A/en not_active IP Right Cessation
- 1985-12-12 FR FR8518416A patent/FR2574793B1/en not_active Expired
- 1985-12-12 SE SE8505887A patent/SE8505887L/en not_active Application Discontinuation
- 1985-12-12 DE DE19853543982 patent/DE3543982A1/en not_active Withdrawn
- 1985-12-12 AU AU51151/85A patent/AU579687B2/en not_active Ceased
- 1985-12-12 NL NL8503424A patent/NL8503424A/en not_active Application Discontinuation
- 1985-12-12 IT IT48921/85A patent/IT1182089B/en active
- 1985-12-12 ZA ZA859520A patent/ZA859520B/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| AU579687B2 (en) | 1988-12-01 |
| IT8548921A0 (en) | 1985-12-12 |
| GB8431426D0 (en) | 1985-01-23 |
| CH667454A5 (en) | 1988-10-14 |
| GB2168347A (en) | 1986-06-18 |
| NL8503424A (en) | 1986-07-01 |
| SE8505887D0 (en) | 1985-12-12 |
| IT1182089B (en) | 1987-09-30 |
| DE3543982A1 (en) | 1986-06-19 |
| BE903846A (en) | 1986-06-12 |
| AU5115185A (en) | 1986-06-19 |
| JPS61151172A (en) | 1986-07-09 |
| ZA859520B (en) | 1986-08-27 |
| FR2574793A1 (en) | 1986-06-20 |
| FR2574793B1 (en) | 1988-10-14 |
| GB2168347B (en) | 1988-02-03 |
| GB8530591D0 (en) | 1986-01-22 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| NAV | Patent application has lapsed |
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