FI65246C - Foerfarande foer framstaellning av nya terapeutiskt anvaendbara 4-oxo-4h-pyrimido(2,1-a)isokinolin-3-karboxylsyraderivat - Google Patents

Foerfarande foer framstaellning av nya terapeutiskt anvaendbara 4-oxo-4h-pyrimido(2,1-a)isokinolin-3-karboxylsyraderivat Download PDF

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Publication number
FI65246C
FI65246C FI782849A FI782849A FI65246C FI 65246 C FI65246 C FI 65246C FI 782849 A FI782849 A FI 782849A FI 782849 A FI782849 A FI 782849A FI 65246 C FI65246 C FI 65246C
Authority
FI
Finland
Prior art keywords
isoquinoline
compound
alkyl
pyrimido
mixture
Prior art date
Application number
FI782849A
Other languages
English (en)
Finnish (fi)
Other versions
FI65246B (fi
FI782849A (fi
Inventor
Peter Frederick Juby
Thomas William Hudyma
Richard Anthony Partyka
Original Assignee
Bristol Myers Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Co filed Critical Bristol Myers Co
Publication of FI782849A publication Critical patent/FI782849A/fi
Priority to FI824509A priority Critical patent/FI68051C/fi
Application granted granted Critical
Publication of FI65246B publication Critical patent/FI65246B/fi
Publication of FI65246C publication Critical patent/FI65246C/fi

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C331/00—Derivatives of thiocyanic acid or of isothiocyanic acid
    • C07C331/16—Isothiocyanates
    • C07C331/18—Isothiocyanates having isothiocyanate groups bound to acyclic carbon atoms
    • C07C331/22—Isothiocyanates having isothiocyanate groups bound to acyclic carbon atoms of an unsaturated carbon skeleton
    • C07C331/24—Isothiocyanates having isothiocyanate groups bound to acyclic carbon atoms of an unsaturated carbon skeleton the carbon skeleton containing six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
    • C07D217/24—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/12—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains three hetero rings
    • C07D491/14—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Pulmonology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
FI782849A 1977-09-21 1978-09-18 Foerfarande foer framstaellning av nya terapeutiskt anvaendbara 4-oxo-4h-pyrimido(2,1-a)isokinolin-3-karboxylsyraderivat FI65246C (fi)

Priority Applications (1)

Application Number Priority Date Filing Date Title
FI824509A FI68051C (fi) 1977-09-21 1982-12-29 Foerfarande foer framstaellning av nya terapeutiskt anvaendbara 3-(1h-tetrazol-5-yl)-4h-pyrimido(2,1-a)isokinolin-4-oner samt farmaceutiskt godtagbara salter av dessa foereningar

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US83526677 1977-09-21
US05/835,266 US4127720A (en) 1977-09-21 1977-09-21 Pyrimido[2,1-a]isoquinoline derivatives having antiallergy activity

Publications (3)

Publication Number Publication Date
FI782849A FI782849A (fi) 1979-03-22
FI65246B FI65246B (fi) 1983-12-30
FI65246C true FI65246C (fi) 1984-04-10

Family

ID=25269074

Family Applications (1)

Application Number Title Priority Date Filing Date
FI782849A FI65246C (fi) 1977-09-21 1978-09-18 Foerfarande foer framstaellning av nya terapeutiskt anvaendbara 4-oxo-4h-pyrimido(2,1-a)isokinolin-3-karboxylsyraderivat

Country Status (18)

Country Link
US (1) US4127720A (de)
JP (1) JPS5463099A (de)
AU (1) AU522646B2 (de)
BE (1) BE870634A (de)
CA (1) CA1108613A (de)
CH (1) CH642967A5 (de)
DE (1) DE2841126A1 (de)
DK (1) DK164553C (de)
FI (1) FI65246C (de)
FR (1) FR2404010A1 (de)
GB (1) GB2004876B (de)
GR (1) GR72144B (de)
IE (1) IE47189B1 (de)
LU (1) LU80272A1 (de)
NL (1) NL190071C (de)
SE (1) SE438335B (de)
YU (2) YU41598B (de)
ZA (1) ZA785354B (de)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4209620A (en) * 1978-06-19 1980-06-24 Bristol-Myers Company Substituted 3-(1H-tetrazol-5-yl)-4H-pyrido[1,2-a]pyrimidin-4-one derivatives having antiallergy activity
US4472401A (en) * 1981-11-27 1984-09-18 Roussel Uclaf Pyrimido-quinoxalines having antiallergic properties
NO162019C (no) * 1983-11-23 1989-10-25 Fujisawa Pharmaceutical Co Analogifremgangsmaate for fremstilling av terapeutisk aktive pyrimidoiskinolinderivater.
GB8331228D0 (en) * 1983-11-23 1983-12-29 Fujisawa Pharmaceutical Co Pyrimidoisoquinoline derivatives
US4661592A (en) * 1984-06-27 1987-04-28 G. D. Searle & Co. 4H-pyrimido[2,1-a]isoquinolin-4-one derivatives
JP2000509028A (ja) * 1996-04-13 2000-07-18 アストラ・フアーマシユウテイカルズ・リミテツド アミノイソキノリンおよびアミノチエノピリジン誘導体ならびに抗炎症剤としてのそれらの使用
JP2008524232A (ja) * 2004-12-20 2008-07-10 ワイス ラパマイシン誘導体及び神経障害の治療におけるその使用
DK1828202T3 (da) * 2004-12-20 2012-05-07 Wyeth Llc Rapamycinanaloge samt deres anvendelse ved behandling af neurologiske, proliferative og inflammatoriske lidelser
WO2022216552A2 (en) * 2021-04-04 2022-10-13 Baruch S. Blumberg Institute Novel hepatoselective polyadenylating polymerases inhibitors and their method of use

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1356937A (en) * 1970-08-27 1974-06-19 Wellcome Found Pyrimido-isoquinolines
BE792648A (fr) * 1971-12-13 1973-06-12 May & Baker Ltd Derives de l'isoquinoleine
CA1033731A (en) * 1974-04-01 1978-06-27 Saul B. Kadin Process for preparing 1-oxo-1h-6-hydroxypyrimido (1,2-a)quinoline-2-carboxylic acids and derivatives
US4066766A (en) * 1975-03-03 1978-01-03 Pfizer Inc. 1-Oxo-6-substituted pyrimido [1,2-a]quinoline-2-carboxylic acids and derivatives thereof and their use as antiallergy agents
US4017625A (en) * 1975-08-01 1977-04-12 Pfizer Inc. Anti-allergic N-(5-tetrazolyl)-1-oxo-1H-6-alkoxypyrimido-[1,2-a]quinoline-2-carboxamides and intermediates therefor
SU685156A3 (ru) * 1975-08-01 1979-09-05 Пфайзер Инк (Фирма) Способ получени -(5-тетразолил(1-оксо-1н-пиримидо-)1,2-а) хинолин-2-карбоксамида
US4033961A (en) * 1975-10-07 1977-07-05 Warner-Lambert Company Pyrido[2-1-b]quinazolin-ones and their methods of preparation

Also Published As

Publication number Publication date
CH642967A5 (de) 1984-05-15
NL190071B (nl) 1993-05-17
GR72144B (de) 1983-09-20
FR2404010B1 (de) 1980-10-31
FR2404010A1 (fr) 1979-04-20
LU80272A1 (fr) 1979-06-01
GB2004876B (en) 1982-03-10
DK413578A (da) 1979-03-22
DE2841126C2 (de) 1990-05-17
IE47189B1 (en) 1984-01-11
NL190071C (nl) 1993-10-18
AU4004278A (en) 1980-03-27
FI65246B (fi) 1983-12-30
BE870634A (fr) 1979-03-20
DE2841126A1 (de) 1979-04-05
YU41598B (en) 1987-10-31
SE7809887L (sv) 1979-03-22
IE781897L (en) 1979-03-21
US4127720A (en) 1978-11-28
JPS6212225B2 (de) 1987-03-17
YU63585A (en) 1986-04-30
FI782849A (fi) 1979-03-22
ZA785354B (en) 1979-09-26
YU44501B (en) 1990-08-31
JPS5463099A (en) 1979-05-21
SE438335B (sv) 1985-04-15
YU222778A (en) 1984-02-29
DK164553C (da) 1992-11-30
GB2004876A (en) 1979-04-11
NL7809626A (nl) 1979-03-23
AU522646B2 (en) 1982-06-17
CA1108613A (en) 1981-09-08
DK164553B (da) 1992-07-13

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Owner name: BRISTOL-MYERS CO