FI64589C - Foerfarande foer framstaellning av nya terapeutiskt anvaendbara 4-amino-2-piperidinokinazolinderivat - Google Patents

Foerfarande foer framstaellning av nya terapeutiskt anvaendbara 4-amino-2-piperidinokinazolinderivat Download PDF

Info

Publication number
FI64589C
FI64589C FI791562A FI791562A FI64589C FI 64589 C FI64589 C FI 64589C FI 791562 A FI791562 A FI 791562A FI 791562 A FI791562 A FI 791562A FI 64589 C FI64589 C FI 64589C
Authority
FI
Finland
Prior art keywords
alkyl
formula
group
preparation
alkoxy
Prior art date
Application number
FI791562A
Other languages
English (en)
Finnish (fi)
Other versions
FI791562A (fi
FI64589B (fi
Inventor
Simon Fraser Campbell
John Christopher Danilewicz
Colin William Greengrass
Rhona Plews
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Publication of FI791562A publication Critical patent/FI791562A/fi
Publication of FI64589B publication Critical patent/FI64589B/fi
Application granted granted Critical
Publication of FI64589C publication Critical patent/FI64589C/fi

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/60—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D211/62—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals attached in position 4
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/40—Oxygen atoms
    • C07D211/44—Oxygen atoms attached in position 4
    • C07D211/46—Oxygen atoms attached in position 4 having a hydrogen atom as the second substituent in position 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/60—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Cardiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Pyridine Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
FI791562A 1978-05-18 1979-05-16 Foerfarande foer framstaellning av nya terapeutiskt anvaendbara 4-amino-2-piperidinokinazolinderivat FI64589C (fi)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB2035178 1978-05-18
GB2035178 1978-05-18

Publications (3)

Publication Number Publication Date
FI791562A FI791562A (fi) 1979-11-19
FI64589B FI64589B (fi) 1983-08-31
FI64589C true FI64589C (fi) 1983-12-12

Family

ID=10144517

Family Applications (1)

Application Number Title Priority Date Filing Date
FI791562A FI64589C (fi) 1978-05-18 1979-05-16 Foerfarande foer framstaellning av nya terapeutiskt anvaendbara 4-amino-2-piperidinokinazolinderivat

Country Status (30)

Country Link
US (1) US4243666A (es)
JP (1) JPS554370A (es)
AR (2) AR223487A1 (es)
AT (1) ATA363379A (es)
AU (1) AU512947B2 (es)
BE (1) BE876297A (es)
CA (1) CA1240325A (es)
CH (1) CH643553A5 (es)
CS (1) CS214796B2 (es)
DD (1) DD143613A5 (es)
DE (1) DE2919800A1 (es)
DK (1) DK159079A (es)
ES (2) ES480671A1 (es)
FI (1) FI64589C (es)
FR (1) FR2434162A1 (es)
GR (1) GR72824B (es)
HU (1) HU182562B (es)
IL (1) IL57297A (es)
IN (1) IN153045B (es)
IT (1) IT1114222B (es)
LU (1) LU81284A1 (es)
NL (1) NL172157C (es)
NO (1) NO791648L (es)
NZ (1) NZ190465A (es)
PH (1) PH14802A (es)
PL (2) PL121158B1 (es)
PT (1) PT69622A (es)
SE (1) SE439306B (es)
YU (2) YU115279A (es)
ZA (1) ZA792390B (es)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4607034A (en) * 1979-10-29 1986-08-19 Mitsubishi Yuka Pharmaceutical Co., Ltd. Quinazoline derivatives and pharmaceutical composition thereof
JPS5962766U (ja) * 1982-06-30 1984-04-25 守田　智 小動物用給水器
GB8414518D0 (en) * 1984-06-07 1984-07-11 Pfizer Ltd Therapeutic agents
US5801195A (en) * 1994-12-30 1998-09-01 Celgene Corporation Immunotherapeutic aryl amides
US6248888B1 (en) 1997-11-14 2001-06-19 Teva Pharmaceutical Industries Ltd. Process for the preparation of terazosin hydrochloride dihydrate
WO2002057235A1 (fr) * 2001-01-18 2002-07-25 Takeda Chemical Industries, Ltd. Procede de preparation de composes de benzylpiperidine
US6746460B2 (en) * 2002-08-07 2004-06-08 Satiety, Inc. Intra-gastric fastening devices
WO2005042501A1 (en) * 2003-11-03 2005-05-12 Warner-Lambert Company Llc Novel norepinephrine reuptake inhibitors for the treatment of central nervous system disorders
AR063275A1 (es) * 2006-10-12 2009-01-14 Epix Delaware Inc Compuestos de carboxamida, una composicion farmaceutica que los comprende y su uso en la preparacion de un medicamento para el tratamiento de enfermedades mediadas por la activacion de ccr2.
JP5524041B2 (ja) * 2007-04-04 2014-06-18 シプラ・リミテッド エルロチニブおよびその薬学的に許容可能な塩の製造方法
WO2009076512A1 (en) * 2007-12-11 2009-06-18 Epix Delaware, Inc. Carboxamidξ compounds and their use as chemokine receptor agonists
AU2009315761A1 (en) * 2008-11-14 2010-05-20 F. Hoffmann-La Roche Ag Quinazoline derivatives as NK3 receptor antagonists

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1156973A (en) * 1965-07-06 1969-07-02 Quinazoline Derivatives
US3511836A (en) * 1967-12-13 1970-05-12 Pfizer & Co C 2,4,6,7-tetra substituted quinazolines
FR2321890A1 (fr) * 1975-08-26 1977-03-25 Synthelabo Nouveaux derives de la quinazoline, leurs sels, leur preparation et les medicaments qui en renferment
DK140695C (da) * 1976-05-07 1980-05-12 Synthelabo Analogifremgangsmaade til fremstilling af 2,4-diamino-6,7-dimethoxyquinazolinderivater eller syreadditionssalte heraf

Also Published As

Publication number Publication date
AU512947B2 (en) 1980-11-06
PL223844A1 (es) 1981-01-02
CH643553A5 (de) 1984-06-15
US4243666A (en) 1981-01-06
FR2434162B1 (es) 1983-04-22
ES488210A0 (es) 1980-12-16
ATA363379A (de) 1983-05-15
NO791648L (no) 1979-11-20
ZA792390B (en) 1980-07-30
NL172157B (nl) 1983-02-16
FR2434162A1 (fr) 1980-03-21
NL7903853A (nl) 1979-11-20
PT69622A (en) 1979-06-01
DE2919800A1 (de) 1979-11-22
GR72824B (es) 1983-12-06
JPS554370A (en) 1980-01-12
JPS5623992B2 (es) 1981-06-03
AR224784A1 (es) 1982-01-15
HU182562B (en) 1984-02-28
CA1240325A (en) 1988-08-09
LU81284A1 (fr) 1980-12-16
NL172157C (nl) 1983-07-18
SE7904358L (sv) 1979-11-19
IL57297A (en) 1983-02-23
DK159079A (da) 1979-11-19
IN153045B (es) 1984-05-26
ES480671A1 (es) 1980-08-16
SE439306B (sv) 1985-06-10
YU256382A (en) 1983-04-30
DD143613A5 (de) 1980-09-03
FI791562A (fi) 1979-11-19
PL121158B1 (en) 1982-04-30
YU115279A (en) 1983-04-30
NZ190465A (en) 1981-05-01
AU4710179A (en) 1979-11-22
ES8101584A1 (es) 1980-12-16
IT1114222B (it) 1986-01-27
FI64589B (fi) 1983-08-31
PL215626A1 (es) 1980-08-25
PH14802A (en) 1981-12-14
CS214796B2 (en) 1982-05-28
AR223487A1 (es) 1981-08-31
IL57297A0 (en) 1979-09-30
BE876297A (fr) 1979-11-16
PL120651B1 (en) 1982-03-31
IT7922720A0 (it) 1979-05-16

Similar Documents

Publication Publication Date Title
JP4493503B2 (ja) 複素環式化合物及びそれを有効成分とする抗腫瘍剤
FI64589C (fi) Foerfarande foer framstaellning av nya terapeutiskt anvaendbara 4-amino-2-piperidinokinazolinderivat
SK1582003A3 (en) Benzimidazole derivatives, preparation and therapeutic use thereof
CS223977B2 (en) Method of preparation of the chinazoline derivatives
JPS6049192B2 (ja) 新規置換ベンズアミド、その製造方法及びこれを有効成分とする向精神薬
JPS63146874A (ja) インドール誘導体
US4950670A (en) 6-phenyl-3-(piperazinyalalkyl)-2,4(1H,3H)-pyrimidinedione derivatives, their preparation and their application in therapy
PT86082B (pt) Processo para a preparacao de agentes di-hidropiridinicos anti-alergicos e anti-inflamatorios
CN109232358A (zh) 吲哚类衍生物或其盐及其制备方法和用途
PT91783B (pt) Processo para a preparacao de {(diarilmetoxi) alquil}-1-pirrolidinas e piperidinas
US5340814A (en) 3-substituted methyl-2,3-dihydroimidazo[1,2-C] quinazoline derivatives, the preparation and use thereof
US5958945A (en) Naphthamide derivatives of 3-beta-amino azabicyclo octane or nonane as neuroleptic agents
JP2003509494A (ja) ムスカリン拮抗薬
CZ325196A3 (en) Derivatives of hydroximic acid, pharmaceutical compositions containing thereof, process of their preparation and intermediates used in the preparation process
EP0073645B1 (en) 2-cyclic amino-2-(1,2-benzisoxazol-3-yl)acetic acid ester derivatives, process for the preparation thereof and composition containing the same
US4139621A (en) N-(4-substituted-3,5-dichloro-phenyl)-piperazines
US4438121A (en) Isoquinoline amidoxime derivatives
US5633255A (en) 1,2-dihydro-2-oxo-3-aminoquinoxaline derivatives, their preparation and their therapeutic application
CS344191A3 (en) Novel isoquinoline derivatives, process of their preparation and pharmaceuticals comprising them
JPH11508588A (ja) キナゾリン誘導体
JP3359722B2 (ja) メトトレキセート誘導体
US5109013A (en) 2-(2-substituted aminoethyl)-1,4-dialkyl-3,4-dihydro-1H-1,3,5]triazepino[3,2-a]benzimidazol-5(2H)-ones as muscle relaxants
JPH075545B2 (ja) ピロリジノン化合物及び脳機能障害改善剤
DK151885B (da) Fremgangsmaade til fremstilling af pyridooe1,2aaapyrimidin-3-carboxamider eller optisk aktive isomere eller farmaceutisk acceptable salte deraf
JPH05331149A (ja) フェノール誘導体

Legal Events

Date Code Title Description
MM Patent lapsed

Owner name: PFIZER CORPORATION