FI63015C - Foerfarande foer framstaellning av terapeutiskt aktiva di-n-propylmetylaminderivat - Google Patents
Foerfarande foer framstaellning av terapeutiskt aktiva di-n-propylmetylaminderivat Download PDFInfo
- Publication number
- FI63015C FI63015C FI771780A FI771780A FI63015C FI 63015 C FI63015 C FI 63015C FI 771780 A FI771780 A FI 771780A FI 771780 A FI771780 A FI 771780A FI 63015 C FI63015 C FI 63015C
- Authority
- FI
- Finland
- Prior art keywords
- propyl
- butylamine
- tai
- compound
- compounds
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D203/00—Heterocyclic compounds containing three-membered rings with one nitrogen atom as the only ring hetero atom
- C07D203/04—Heterocyclic compounds containing three-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
- C07D203/06—Heterocyclic compounds containing three-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
- C07D203/08—Heterocyclic compounds containing three-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring nitrogen atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
- C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
- C07D205/04—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/02—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms containing only hydrogen and carbon atoms in addition to the ring hetero elements
- C07D295/027—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms containing only hydrogen and carbon atoms in addition to the ring hetero elements containing only one hetero ring
- C07D295/03—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms containing only hydrogen and carbon atoms in addition to the ring hetero elements containing only one hetero ring with the ring nitrogen atoms directly attached to acyclic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/14—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D295/145—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
- C07D295/15—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Neurology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Claims (5)
1. Menetelmä terapeuttisesti vaikuttavien di-n-propyyli-metyyliamiinijohdannaisten ja niiden farmaseuttisesti hyväksyttävien happoadditiosuolojen valmistamiseksi, joiden johdannaisten yleinen kaava on °'C3H7\s /R1 R-C-N m / \ 11 n-C337 *2 jossa kaavassa R tarkoittaa n-propyyliä, isopropyyliä, isobu-tyyliä tai allyyliä, tarkoittaa vetyä, metyyliä tai propar-gyyliä ja R2 tarkoittaa metyyliä tai propargyyliä, N,N-dime-tyyli-1,1-di-n-propyyli-n-butyyli-amiinin valmistusta lukuunottamatta, tunnettu siitä, että lämmitetään yhdistettä, jonka yleinen kaava on n-cyi?^ R- C-NHR, / 3 (II) n-C3H7 tai sen happoadditiosuolaa, jossa kaavassa R tarkoittaa samaa kuin edellä on määritelty, ja R3 tarkoittaa vetyä, metyyliä tai propargyyliä, alkalisen väliaineen läsnäollessa sopivan määrän kanssa seuraavan yleisen kaavan mukaista halogenidia R4X (III) jossa kaavassa R4 tarkoittaa metyyliä tai propargyyliä ja X tarkoittaa kloori-, bromi- tai jodiatomia, jolloin tämä reaktio suoritetaan joko liuotinta käyttäen tai käyttämättä halutun metyyliamiinijohdannaisen saamiseksi, joka sitten voidaan saattaa reagoimaan orgaanisen tai epäorgaanisen hapon kanssa tämän yhdisteen farmaseuttisesti hyväksyttävän happoadditiosuolan saamiseksi. 19 6301 5
2. Patenttivaatimuksen 1 mukainen menetelmä, tunnettu siitä, että alkalisena väliaineena on natriumbikarbonaatti.
3. Patenttivaatimuksen 1 mukainen menetelmä, tunnettu siitä, että liuottimena on etanoli.
4. Patenttivaatimuksen 1 mukainen menetelmä, tunnettu siitä, että lähtöyhdisteen happoadditiosuolana on hydrokloridi.
1. Förfarande för framställning av terapeutiskt verkande di-n-propyl-metylaminderivat och deras farmaceutiskt acceptabla syraadditionssalter, varvid den allmänna formeln för dessa der ivat är n-SH7\ Λ R C-N (I) / \ E. 3. c. i vilken formel R betecknar n-propyl, isopropyl, isobutyl eller allyl, betecknar väte, metyl eller propargyl och R2 betecknar metyl eller propargyl, framställningen av N,N-dimetyl- 1,1-di-n-propyl-n-butylamin undantagen, kännetecknat därav, att man uppvärmer en förening med den allmänna formeln n-c387 R C-NHR (II) / "‘SV
Priority Applications (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FI823148A FI68219C (fi) | 1976-06-03 | 1982-09-10 | Foerfarande foer framstaellning av terapeutiskt aktiva di-n-propylmetylaminderivat |
FI823147A FI68218C (fi) | 1976-06-03 | 1982-09-10 | Foerfarande foer framstaellning av terapeutiskt aktiva di-n-propylmetylaminderivat |
FI823149A FI823149A0 (fi) | 1976-06-03 | 1982-09-10 | Foerfarande foer framstaellning av terapeutiskt aktiva di-n-propylmetylaminderivat |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
BE842528 | 1976-06-03 | ||
BE842528 | 1976-06-03 |
Publications (3)
Publication Number | Publication Date |
---|---|
FI771780A FI771780A (sv) | 1977-12-04 |
FI63015B FI63015B (fi) | 1982-12-31 |
FI63015C true FI63015C (fi) | 1983-04-11 |
Family
ID=3861370
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
FI771780A FI63015C (fi) | 1976-06-03 | 1977-06-03 | Foerfarande foer framstaellning av terapeutiskt aktiva di-n-propylmetylaminderivat |
Country Status (17)
Country | Link |
---|---|
JP (1) | JPS6039261B2 (sv) |
AR (4) | AR213646A1 (sv) |
AT (1) | AT352088B (sv) |
AU (1) | AU511705B2 (sv) |
DK (1) | DK146063C (sv) |
ES (2) | ES459466A1 (sv) |
FI (1) | FI63015C (sv) |
FR (2) | FR2374901A1 (sv) |
GR (1) | GR61148B (sv) |
MX (1) | MX4778E (sv) |
NL (1) | NL7706052A (sv) |
NO (1) | NO145337C (sv) |
NZ (1) | NZ184161A (sv) |
PT (1) | PT66623B (sv) |
SE (2) | SE452317B (sv) |
YU (1) | YU129577A (sv) |
ZA (1) | ZA773151B (sv) |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
BE815273A (fr) * | 1974-05-20 | 1974-11-20 | Derives actifs de methylamine | |
BE842528R (fr) * | 1976-06-03 | 1976-12-03 | Derives actifs de methylamine, compositions therapeutiques les contenant ainsi que les procedes de preparation de ces derives et compositions |
-
1977
- 1977-05-14 GR GR53468A patent/GR61148B/el unknown
- 1977-05-20 NZ NZ184161A patent/NZ184161A/xx unknown
- 1977-05-24 YU YU01295/77A patent/YU129577A/xx unknown
- 1977-05-25 ZA ZA00773151A patent/ZA773151B/xx unknown
- 1977-05-27 AU AU25561/77A patent/AU511705B2/en not_active Ceased
- 1977-05-27 FR FR7716280A patent/FR2374901A1/fr active Granted
- 1977-06-02 AR AR267925A patent/AR213646A1/es active
- 1977-06-02 NO NO771941A patent/NO145337C/no unknown
- 1977-06-02 SE SE7706448A patent/SE452317B/sv not_active IP Right Cessation
- 1977-06-02 NL NL7706052A patent/NL7706052A/xx not_active Application Discontinuation
- 1977-06-02 DK DK244677A patent/DK146063C/da not_active IP Right Cessation
- 1977-06-02 PT PT66623A patent/PT66623B/pt unknown
- 1977-06-03 JP JP52066217A patent/JPS6039261B2/ja not_active Expired
- 1977-06-03 AT AT395877A patent/AT352088B/de not_active IP Right Cessation
- 1977-06-03 MX MX775778U patent/MX4778E/es unknown
- 1977-06-03 ES ES459466A patent/ES459466A1/es not_active Expired
- 1977-06-03 FI FI771780A patent/FI63015C/fi not_active IP Right Cessation
-
1978
- 1978-03-21 FR FR7808094A patent/FR2372795A1/fr active Granted
- 1978-04-26 AR AR271895A patent/AR215052A1/es active
- 1978-04-26 AR AR271896A patent/AR215175A1/es active
- 1978-04-26 AR AR271897A patent/AR215053A1/es active
- 1978-05-31 ES ES470379A patent/ES470379A1/es not_active Expired
-
1982
- 1982-11-12 SE SE8206445A patent/SE452763B/sv not_active IP Right Cessation
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
MM | Patent lapsed |
Owner name: SANOFI |