FI61315C - Foerfarande foer framstaellning av antivirala 9-(beta-d-arabinofuranosyl)purin-5'-fosfater - Google Patents

Foerfarande foer framstaellning av antivirala 9-(beta-d-arabinofuranosyl)purin-5'-fosfater Download PDF

Info

Publication number
FI61315C
FI61315C FI761759A FI761759A FI61315C FI 61315 C FI61315 C FI 61315C FI 761759 A FI761759 A FI 761759A FI 761759 A FI761759 A FI 761759A FI 61315 C FI61315 C FI 61315C
Authority
FI
Finland
Prior art keywords
phosphate
arabinofuranosyl
formula
ara
purine
Prior art date
Application number
FI761759A
Other languages
English (en)
Finnish (fi)
Other versions
FI761759A (sk
FI61315B (fi
Inventor
Gertrude Belle Elion
Janet Elizabeth Rideout
Richard Lee Miller
Original Assignee
Wellcome Found
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wellcome Found filed Critical Wellcome Found
Publication of FI761759A publication Critical patent/FI761759A/fi
Application granted granted Critical
Publication of FI61315B publication Critical patent/FI61315B/fi
Publication of FI61315C publication Critical patent/FI61315C/fi

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • C07H19/20—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A61P31/22—Antivirals for DNA viruses for herpes viruses

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Virology (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biochemistry (AREA)
  • Oncology (AREA)
  • Genetics & Genomics (AREA)
  • Communicable Diseases (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Artificial Filaments (AREA)
FI761759A 1975-06-17 1976-06-17 Foerfarande foer framstaellning av antivirala 9-(beta-d-arabinofuranosyl)purin-5'-fosfater FI61315C (fi)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB25768/75A GB1562899A (en) 1975-06-17 1975-06-17 Pharmaceutical compositions containing substituted 9-( -d-arabnofuranosyl)purine-5'-phosphate and salts thereof
GB2576875 1975-06-17

Publications (3)

Publication Number Publication Date
FI761759A FI761759A (sk) 1976-12-18
FI61315B FI61315B (fi) 1982-03-31
FI61315C true FI61315C (fi) 1982-07-12

Family

ID=10232986

Family Applications (1)

Application Number Title Priority Date Filing Date
FI761759A FI61315C (fi) 1975-06-17 1976-06-17 Foerfarande foer framstaellning av antivirala 9-(beta-d-arabinofuranosyl)purin-5'-fosfater

Country Status (17)

Country Link
US (1) US4136175A (sk)
JP (1) JPS52295A (sk)
AU (1) AU507515B2 (sk)
BE (1) BE843082A (sk)
CA (1) CA1052309A (sk)
CH (1) CH632771A5 (sk)
CS (2) CS192000B2 (sk)
DE (1) DE2627156A1 (sk)
DK (1) DK139727B (sk)
FI (1) FI61315C (sk)
FR (1) FR2361901A1 (sk)
GB (1) GB1562899A (sk)
HU (1) HU176046B (sk)
IL (1) IL49822A (sk)
NL (1) NL7606576A (sk)
SE (1) SE429656B (sk)
ZA (1) ZA763611B (sk)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS58763B2 (ja) * 1978-07-18 1983-01-07 三井造船株式会社 浮き防氷堤
EP0015584A3 (de) * 1979-03-12 1980-12-10 Kailash Kumar Dr. Prof. Gauri Neue Nukleotide, Verfahren zu ihrer Herstellung und Arzneimittel
US4357324A (en) * 1981-02-24 1982-11-02 The United States Of America As Represented By The Department Of Health And Human Services Prodrug derivatives of 9β-D-arabinofuranosyl-2-fluoroadenine
FR2518882A1 (fr) * 1981-12-30 1983-07-01 Pos Lab Composition therapeutique, a base de monophosphate d'inosine, pour le traitement des troubles d'accommodation de l'oeil
US4594415A (en) * 1982-03-29 1986-06-10 Robins Roland K Azole dinucleotide compositions and methods of use
DE3784655T2 (de) * 1986-12-18 1993-07-15 Kyowa Hakko Kogyo Kk Verfahren zur herstellung von ascorbinsaeure-2-phosphat.
ES2118752T3 (es) * 1990-06-27 1998-10-01 Ash Stevens Inc Procedimiento para la preparacion de 9-beta-d-arabinofuranosil-2-fluoroadenina-5'-fosfato.
US5866429A (en) * 1991-04-03 1999-02-02 Bloch; Will Precision and accuracy of anion-exchange separation of nucleic acids
US6319908B1 (en) * 1996-07-03 2001-11-20 Inspire Pharmaceuticals, Inc. Method for large-scale production of di(uridine 5′-tetraphosphate) and salts thereof
TW593331B (en) * 1997-07-25 2004-06-21 Inspire Pharmaceuticals Inc Method for large-scale production of di(uridine 5')-tetraphosphate and salts thereof
US6872710B2 (en) * 1997-07-25 2005-03-29 Inspire Pharmaceuticals, Inc. Di(uridine 5′)-tetraphosphate and salts thereof
US7678836B2 (en) * 1999-11-04 2010-03-16 Fxs Ventures, Llc Method for rendering a contact lens wettable
US8557868B2 (en) * 2000-11-04 2013-10-15 Fxs Ventures, Llc Ophthalmic and contact lens solutions using low molecular weight amines
US20070098813A1 (en) * 2000-11-08 2007-05-03 Fxs Ventures, Llc Ophthalmic and contact lens solutions with a peroxide source and a preservative
US9308264B2 (en) 2000-11-08 2016-04-12 Fxs Ventures, Llc Ophthalmic contact lens solutions containing forms of vitamin B
JP5258139B2 (ja) * 2000-11-08 2013-08-07 エフエックスエス・ベンチャーズ・エルエルシー ビタミンｂの形態を含有する改良した眼科用およびコンタクトレンズ用溶液
US20070104744A1 (en) * 2000-11-08 2007-05-10 Fxs Ventures, Llc Ophthalmic and contact lens solutions containing forms of vitamin b
US9492582B2 (en) * 2000-11-08 2016-11-15 Fxs Ventures, Llc Ophthalmic and contact lens solutions containing simple saccharides as preservative enhancers
US20070110782A1 (en) * 2000-11-08 2007-05-17 Fxs Ventures, Llc L-histidine in ophthalmic solutions
US20060148665A1 (en) * 2000-11-08 2006-07-06 Bioconcept Laboratories Ophthalmic and contact lens solutions containing forms of vitamin b
AU2720602A (en) * 2000-11-08 2002-05-21 Bio Concept Lab Improved ophthalmic and contact lens solutions containing simple saccharides as preservative enhancers
US6624203B1 (en) * 2001-11-08 2003-09-23 Francis X. Smith Nucleic acid bases used in ophthalmic solutions
US20040127435A1 (en) * 2002-08-02 2004-07-01 Regents Of The University Of California Uses for inhibitors of inosine monophosphate dehydrogenase
US7939501B2 (en) * 2003-04-15 2011-05-10 Smith Francis X Ophthalmic and contact lens solutions containing peptides as preservative

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3328389A (en) * 1964-08-07 1967-06-27 Sankyo Co Process for preparing nucleotide derivatives
US3300478A (en) * 1965-06-01 1967-01-24 Upjohn Co Arabinofuranosyl 2', 5'-and 3'-5'-dinucleoside phosphates and process therefor
US3382232A (en) * 1965-08-26 1968-05-07 Takeda Chemical Industries Ltd Method for the production of 5'-ribonucleotide
US3337530A (en) * 1965-09-20 1967-08-22 Upjohn Co Dinucleoside 3', 5' -and 2', 5'-phosphates containing one 7-deazapurin riboside moiety
US3448098A (en) * 1966-09-27 1969-06-03 Merck & Co Inc Production of guanylic acid
BE756704A (fr) * 1969-09-26 1971-03-01 Parke Davis & Co Procede de production du 5'-phosphate de 9-(beta-d- arabinofuranosyl) adenine et de ses sels
BE759011A (fr) * 1969-11-17 1971-05-17 Wellcome Found Aminopurines
GB1386584A (en) * 1970-11-16 1975-03-12 Wellcome Found Method of preparation of purine sugar derivatives
GB1386585A (en) * 1970-11-16 1975-03-12 Wellcome Found Purine sugar derivatives
JPS5046696A (sk) * 1973-03-19 1975-04-25

Also Published As

Publication number Publication date
CA1052309A (en) 1979-04-10
DE2627156A1 (de) 1977-01-13
CS191976B2 (en) 1979-07-31
DK139727C (sk) 1979-09-17
DK139727B (da) 1979-04-02
JPS52295A (en) 1977-01-05
SE7606913L (sv) 1976-12-18
DK271876A (sk) 1976-12-18
AU1500476A (en) 1977-12-22
IL49822A (en) 1979-11-30
FI761759A (sk) 1976-12-18
FR2361901B1 (sk) 1978-12-15
SE429656B (sv) 1983-09-19
US4136175A (en) 1979-01-23
GB1562899A (en) 1980-03-19
AU507515B2 (en) 1980-02-21
BE843082A (fr) 1976-12-17
CS192000B2 (en) 1979-07-31
FI61315B (fi) 1982-03-31
FR2361901A1 (fr) 1978-03-17
ZA763611B (en) 1978-01-25
CH632771A5 (de) 1982-10-29
HU176046B (en) 1980-11-28
NL7606576A (nl) 1976-12-21

Similar Documents

Publication Publication Date Title
FI61315C (fi) Foerfarande foer framstaellning av antivirala 9-(beta-d-arabinofuranosyl)purin-5'-fosfater
Smith et al. Cyclic Phosphates. IV. 1 Ribonucleoside-3', 5'Cyclic Phosphates. A General Method of Synthesis and Some Properties
CA1333390C (en) Fluorinated nucleosides and process for treating retrovirus infections therewith
Meier cycloSal-pronucleotides-design of chemical Trojan horses
JPH0780898B2 (ja) 抗ウイルスヌクレオシド
Farquhar et al. 5'-[4-(Pivaloyloxy)-1, 3, 2-dioxaphosphorinan-2-yl]-2'-deoxy-5-fluorouridine: a membrane-permeating prodrug of 5-fluoro-2'-deoxyuridylic acid (FdUMP)
HU221501B (en) N-alkyl-2-substituted atp analogues
KR890000762B1 (ko) 1-β-D-아라비노프라노실-(E)-5-(2-할로게노비닐)우라실-5'-인산의 제조방법
JPS59205394A (ja) ２’，５’―リボアデニレート―モルホリノアデニレートヌクレオチド、これを有効成分とする抗腫瘍剤，これを有効成分とする自己免疫性の病気の治療剤
US4210746A (en) Nucleotide inhibitor of protein synthesis
EP2646449B1 (en) Uridine di- or tri-phosphate derivatives and uses thereof
WO2003053989A1 (en) Masked phosphate containing nucleoside derivatives and their use as antivirals
US5770725A (en) Phosphotriester type biologically active compounds
US5434143A (en) Pharmaceutical compositions comprising phosphite-borane compounds
JP2947580B2 (ja) ２′，５′―オリゴアデニレート誘導体の治療的使用
US5260427A (en) Nucleosidylphosphite-borane compounds and method of making the same
US5153180A (en) Fluorinated nucleosides and process for treating retrovirus infections therewith
JP4879398B2 (ja) グリセリルヌクレオチド、それらの製造法および使用
Long et al. Synthesis and antitumor antiviral activities of 1-. beta.-D-arabinofuranosylpyrimidine 3', 5'-cyclic phosphates
Drabikowska et al. Studies on the mechanism of antiviral action of 1-(. beta.-D-ribofuranosyl)-1, 2, 4-triazole-3-carboxamide (ribavirin)
JPS6338360B2 (sk)
Alexandrova 4′-C-nucleoside derivatives: Synthesis and antiviral properties
US6020482A (en) Phosphotriester type biologically active compounds
EP4151646A1 (en) 5-fluorouracil derivatives as prodrugs for cancer treatment
US6812365B2 (en) Disulfone reagents and methods of preparing and using same

Legal Events

Date Code Title Description
MM Patent lapsed

Owner name: THE WELLCOME FOUNDATION LIMITED