GB1386584A - Method of preparation of purine sugar derivatives - Google Patents

Method of preparation of purine sugar derivatives

Info

Publication number
GB1386584A
GB1386584A GB5450370A GB5450370A GB1386584A GB 1386584 A GB1386584 A GB 1386584A GB 5450370 A GB5450370 A GB 5450370A GB 5450370 A GB5450370 A GB 5450370A GB 1386584 A GB1386584 A GB 1386584A
Authority
GB
United Kingdom
Prior art keywords
purine
alkylamino
compounds
preparation
give compounds
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB5450370A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Wellcome Foundation Ltd
Original Assignee
Wellcome Foundation Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wellcome Foundation Ltd filed Critical Wellcome Foundation Ltd
Priority to GB5450370A priority Critical patent/GB1386584A/en
Priority to NL7115682A priority patent/NL7115682A/xx
Priority to CS797071A priority patent/CS176178B2/cs
Priority to HUWE000452 priority patent/HU163969B/hu
Priority to ES397037A priority patent/ES397037A1/en
Priority to AT982371A priority patent/AT339335B/en
Priority to CA127,718A priority patent/CA983484A/en
Priority to CH1662871A priority patent/CH561228A5/xx
Priority to AR23906371A priority patent/AR193229A1/en
Publication of GB1386584A publication Critical patent/GB1386584A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Saccharide Compounds (AREA)

Abstract

1386584 Purine-sugars WELLCOME FOUNDATION Ltd (Burroughs Wellcome Co) 16 Feb 1972 [16 Nov 1970] 54503/70 Heading C2C The invention comprises a process for making compounds (II) by acylating (V) to give compounds (IV), condensing (IV) with (VI) to give compounds (III) and subjecting (III) to basic hydrolysis; (II) may be reduced to give compounds (I) (R<SP>1</SP> is NH 2 , alkylamino or alkylthio, R<SP>2</SP> is H, NH 2 or alkylamino provided that one of R<SP>1</SP> and R<SP>2</SP> is NH 2 or alkylamino, Z is a blocking group or one or two of the Z's is/are H and at least one of Y<SP>1</SP> and Y<SP>2</SP> is a protected group R<SP>3</SP>CON(A)- wherein A is H or alkyl and R<SP>3</SP> is C 1 to C 20 alkyl and, when only one of Y<SP>1</SP> and Y<SP>2</SP> is R<SP>3</SP>CON(A), the other is R<SP>1</SP> or R<SP>2</SP>: the reduction gives I where R<SP>1</SP> is additionally SH or OH and R<SP>2</SP> is additionally OH with the proviso still being applicable). Compounds (II) where R<SP>1</SP> is NH 2 , lakylamino or alkylthio and R 2 is alkylamino are novel. The preparations of 2-amino-6-hydroxy-9-(#- D-arabinofuranosyl)purine and 2-hydroxy-6- amino-9-(#-D-arabinofuranosyl)purine are described.
GB5450370A 1970-11-16 1970-11-16 Method of preparation of purine sugar derivatives Expired GB1386584A (en)

Priority Applications (9)

Application Number Priority Date Filing Date Title
GB5450370A GB1386584A (en) 1970-11-16 1970-11-16 Method of preparation of purine sugar derivatives
NL7115682A NL7115682A (en) 1970-11-16 1971-11-15
CS797071A CS176178B2 (en) 1970-11-16 1971-11-15
HUWE000452 HU163969B (en) 1970-11-16 1971-11-15
ES397037A ES397037A1 (en) 1970-11-16 1971-11-15 Method of preparation of purine sugar derivatives
AT982371A AT339335B (en) 1970-11-16 1971-11-15 PROCESS FOR PRODUCING PURINE SUGAR DERIVATIVES
CA127,718A CA983484A (en) 1970-11-16 1971-11-15 Method of preparation of purine sugar derivatives
CH1662871A CH561228A5 (en) 1970-11-16 1971-11-16
AR23906371A AR193229A1 (en) 1970-11-16 1971-11-16 A METHOD TO PREPARE PURINE SUGAR DERIVATIVES

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB5450370A GB1386584A (en) 1970-11-16 1970-11-16 Method of preparation of purine sugar derivatives

Publications (1)

Publication Number Publication Date
GB1386584A true GB1386584A (en) 1975-03-12

Family

ID=10471222

Family Applications (1)

Application Number Title Priority Date Filing Date
GB5450370A Expired GB1386584A (en) 1970-11-16 1970-11-16 Method of preparation of purine sugar derivatives

Country Status (9)

Country Link
AR (1) AR193229A1 (en)
AT (1) AT339335B (en)
CA (1) CA983484A (en)
CH (1) CH561228A5 (en)
CS (1) CS176178B2 (en)
ES (1) ES397037A1 (en)
GB (1) GB1386584A (en)
HU (1) HU163969B (en)
NL (1) NL7115682A (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4136175A (en) * 1975-06-17 1979-01-23 Burroughs Wellcome Co. Purine nucleotide antiveral composition and methods of use
US5262531A (en) * 1988-07-05 1993-11-16 Japan Tobacco, Inc. Process for preparing 2'-deoxy-β-adenosine

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4136175A (en) * 1975-06-17 1979-01-23 Burroughs Wellcome Co. Purine nucleotide antiveral composition and methods of use
US5262531A (en) * 1988-07-05 1993-11-16 Japan Tobacco, Inc. Process for preparing 2'-deoxy-β-adenosine

Also Published As

Publication number Publication date
AR193229A1 (en) 1973-04-11
HU163969B (en) 1973-11-28
AT339335B (en) 1977-10-10
ATA982371A (en) 1977-02-15
CS176178B2 (en) 1977-06-30
CA983484A (en) 1976-02-10
CH561228A5 (en) 1975-04-30
NL7115682A (en) 1972-05-18
ES397037A1 (en) 1975-03-01

Similar Documents

Publication Publication Date Title
DE3760463D1 (en) Coffee and process for its production
NZ214305A (en) Inhibiting the precipitation and deposition of alkaline earth metal scales in aqueous systems using an anionic polyelectrolyte and an anionic surfactant
GB1338905A (en) Amino purine derivatives
GB1445710A (en) Method of removing nitrogen oxides from plant exhaust
ES8203887A1 (en) Protection of lyophilized betalactams from color formation
GB1386584A (en) Method of preparation of purine sugar derivatives
IE35816L (en) Purine sugar derivatives
GB1309041A (en) Processes for preparing lincomycins
GB1187824A (en) Nucleosides and their Preparation
GB1252435A (en)
GB1442772A (en) Inhibition of leukaemia utilizing 5-methyl-tetrahydrohomofolate
GB1292410A (en) Thienobenzothiazepine derivatives
GB1134729A (en) Quinoxaline-di-n-oxides
GB1350878A (en) Coumarin derivatives and production thereof
GB1346279A (en) Hydantoin derivatives processes for their preparation and compositions incorporating them
GB1525084A (en) Cyanuric acid manufacture
GB1502519A (en) Process for the preparation of acyltaurides
GB1465794A (en) Thiourea derivatives
GB1154993A (en) Improvements in a process for the preparation of High Viscosity Gums
JPS5248626A (en) Disaccharide derivatives and their preparation process
GB1053177A (en)
GB1249538A (en) Adenosine derivatives
GB1524162A (en) Cyanuric acid manufacture
GB1263677A (en) Process for the preparation of quinoxaline-di-n-oxide-aldehyde
GB1395929A (en) Thioureas

Legal Events

Date Code Title Description
PS Patent sealed
PCNP Patent ceased through non-payment of renewal fee