CS192000B2 - Process for preparing 2,6-substituted 9-/d-arabinofuranosyl/purin-5'-phosphates - Google Patents

Process for preparing 2,6-substituted 9-/d-arabinofuranosyl/purin-5'-phosphates

Info

Publication number
CS192000B2
CS192000B2 CS777259A CS725976A CS192000B2 CS 192000 B2 CS192000 B2 CS 192000B2 CS 777259 A CS777259 A CS 777259A CS 725976 A CS725976 A CS 725976A CS 192000 B2 CS192000 B2 CS 192000B2
Authority
CS
Czechoslovakia
Prior art keywords
arabinofuranosyl
purin
phosphates
substituted
preparing
Prior art date
Application number
CS777259A
Other languages
English (en)
Inventor
Gertrude B Elion
Janet E Rideout
Richard L Miller
Original Assignee
Wellcome Found
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wellcome Found filed Critical Wellcome Found
Publication of CS192000B2 publication Critical patent/CS192000B2/cs

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • C07H19/20—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A61P31/22—Antivirals for DNA viruses for herpes viruses

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Virology (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Artificial Filaments (AREA)
CS777259A 1975-06-17 1976-06-17 Process for preparing 2,6-substituted 9-/d-arabinofuranosyl/purin-5'-phosphates CS192000B2 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB25768/75A GB1562899A (en) 1975-06-17 1975-06-17 Pharmaceutical compositions containing substituted 9-( -d-arabnofuranosyl)purine-5'-phosphate and salts thereof

Publications (1)

Publication Number Publication Date
CS192000B2 true CS192000B2 (en) 1979-07-31

Family

ID=10232986

Family Applications (2)

Application Number Title Priority Date Filing Date
CS764004A CS191976B2 (en) 1975-06-17 1976-06-17 Process for preparing purine derivatives of sugars
CS777259A CS192000B2 (en) 1975-06-17 1976-06-17 Process for preparing 2,6-substituted 9-/d-arabinofuranosyl/purin-5'-phosphates

Family Applications Before (1)

Application Number Title Priority Date Filing Date
CS764004A CS191976B2 (en) 1975-06-17 1976-06-17 Process for preparing purine derivatives of sugars

Country Status (17)

Country Link
US (1) US4136175A (cs)
JP (1) JPS52295A (cs)
AU (1) AU507515B2 (cs)
BE (1) BE843082A (cs)
CA (1) CA1052309A (cs)
CH (1) CH632771A5 (cs)
CS (2) CS191976B2 (cs)
DE (1) DE2627156A1 (cs)
DK (1) DK139727B (cs)
FI (1) FI61315C (cs)
FR (1) FR2361901A1 (cs)
GB (1) GB1562899A (cs)
HU (1) HU176046B (cs)
IL (1) IL49822A (cs)
NL (1) NL7606576A (cs)
SE (1) SE429656B (cs)
ZA (1) ZA763611B (cs)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS58763B2 (ja) * 1978-07-18 1983-01-07 三井造船株式会社 浮き防氷堤
EP0015584A3 (de) * 1979-03-12 1980-12-10 Kailash Kumar Dr. Prof. Gauri Neue Nukleotide, Verfahren zu ihrer Herstellung und Arzneimittel
US4357324A (en) * 1981-02-24 1982-11-02 The United States Of America As Represented By The Department Of Health And Human Services Prodrug derivatives of 9β-D-arabinofuranosyl-2-fluoroadenine
FR2518882A1 (fr) * 1981-12-30 1983-07-01 Pos Lab Composition therapeutique, a base de monophosphate d'inosine, pour le traitement des troubles d'accommodation de l'oeil
US4594415A (en) * 1982-03-29 1986-06-10 Robins Roland K Azole dinucleotide compositions and methods of use
DE3784655T2 (de) * 1986-12-18 1993-07-15 Kyowa Hakko Kogyo Kk Verfahren zur herstellung von ascorbinsaeure-2-phosphat.
EP0487719B1 (en) * 1990-06-27 1998-08-12 Ash Stevens, Inc. Process for the preparation of 9-beta-d-arabinofuranosyl-2-fluoroadenine 5'-phosphate
US5866429A (en) * 1991-04-03 1999-02-02 Bloch; Will Precision and accuracy of anion-exchange separation of nucleic acids
US6319908B1 (en) * 1996-07-03 2001-11-20 Inspire Pharmaceuticals, Inc. Method for large-scale production of di(uridine 5′-tetraphosphate) and salts thereof
TW593331B (en) * 1997-07-25 2004-06-21 Inspire Pharmaceuticals Inc Method for large-scale production of di(uridine 5')-tetraphosphate and salts thereof
US6872710B2 (en) * 1997-07-25 2005-03-29 Inspire Pharmaceuticals, Inc. Di(uridine 5′)-tetraphosphate and salts thereof
US7678836B2 (en) 1999-11-04 2010-03-16 Fxs Ventures, Llc Method for rendering a contact lens wettable
US8557868B2 (en) * 2000-11-04 2013-10-15 Fxs Ventures, Llc Ophthalmic and contact lens solutions using low molecular weight amines
US20070110782A1 (en) * 2000-11-08 2007-05-17 Fxs Ventures, Llc L-histidine in ophthalmic solutions
US20060148665A1 (en) * 2000-11-08 2006-07-06 Bioconcept Laboratories Ophthalmic and contact lens solutions containing forms of vitamin b
US9308264B2 (en) 2000-11-08 2016-04-12 Fxs Ventures, Llc Ophthalmic contact lens solutions containing forms of vitamin B
AU2002227206B2 (en) 2000-11-08 2006-09-21 Fxs Ventures, Llc Improved ophthalmic and contact lens solutions containing simple saccharides as preservative enhancers
US9492582B2 (en) * 2000-11-08 2016-11-15 Fxs Ventures, Llc Ophthalmic and contact lens solutions containing simple saccharides as preservative enhancers
DK1331902T3 (da) * 2000-11-08 2008-12-08 Fxs Ventures Llc Forbedrede ophthalmiske og kontaktlinseoplösninger indeholdende former af vitamin B
US20070098813A1 (en) * 2000-11-08 2007-05-03 Fxs Ventures, Llc Ophthalmic and contact lens solutions with a peroxide source and a preservative
US20070104744A1 (en) * 2000-11-08 2007-05-10 Fxs Ventures, Llc Ophthalmic and contact lens solutions containing forms of vitamin b
US6624203B1 (en) * 2001-11-08 2003-09-23 Francis X. Smith Nucleic acid bases used in ophthalmic solutions
US20040127435A1 (en) * 2002-08-02 2004-07-01 Regents Of The University Of California Uses for inhibitors of inosine monophosphate dehydrogenase
WO2004091438A2 (en) * 2003-04-15 2004-10-28 Fxs Ventures, Llc Improved ophthalmic and contact lens solutions containing peptides as representative enhancers

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3328389A (en) * 1964-08-07 1967-06-27 Sankyo Co Process for preparing nucleotide derivatives
US3300478A (en) * 1965-06-01 1967-01-24 Upjohn Co Arabinofuranosyl 2', 5'-and 3'-5'-dinucleoside phosphates and process therefor
US3382232A (en) * 1965-08-26 1968-05-07 Takeda Chemical Industries Ltd Method for the production of 5'-ribonucleotide
US3337530A (en) * 1965-09-20 1967-08-22 Upjohn Co Dinucleoside 3', 5' -and 2', 5'-phosphates containing one 7-deazapurin riboside moiety
US3448098A (en) * 1966-09-27 1969-06-03 Merck & Co Inc Production of guanylic acid
BE756704A (fr) * 1969-09-26 1971-03-01 Parke Davis & Co Procede de production du 5'-phosphate de 9-(beta-d- arabinofuranosyl) adenine et de ses sels
BE759011A (fr) * 1969-11-17 1971-05-17 Wellcome Found Aminopurines
GB1386585A (en) * 1970-11-16 1975-03-12 Wellcome Found Purine sugar derivatives
GB1386584A (en) * 1970-11-16 1975-03-12 Wellcome Found Method of preparation of purine sugar derivatives
FR2222092B1 (cs) * 1973-03-19 1978-01-13 Icn Pharmaceuticals

Also Published As

Publication number Publication date
DK139727C (cs) 1979-09-17
NL7606576A (nl) 1976-12-21
BE843082A (fr) 1976-12-17
JPS52295A (en) 1977-01-05
SE429656B (sv) 1983-09-19
GB1562899A (en) 1980-03-19
DK271876A (cs) 1976-12-18
US4136175A (en) 1979-01-23
AU507515B2 (en) 1980-02-21
HU176046B (en) 1980-11-28
FI61315B (fi) 1982-03-31
DK139727B (da) 1979-04-02
CS191976B2 (en) 1979-07-31
FR2361901A1 (fr) 1978-03-17
FR2361901B1 (cs) 1978-12-15
DE2627156A1 (de) 1977-01-13
CA1052309A (en) 1979-04-10
FI761759A (cs) 1976-12-18
CH632771A5 (de) 1982-10-29
AU1500476A (en) 1977-12-22
ZA763611B (en) 1978-01-25
FI61315C (fi) 1982-07-12
IL49822A (en) 1979-11-30
SE7606913L (sv) 1976-12-18

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