FI60701C - Foerfarande foer framstaellning av terapeutiskt anvaendbar dihydrocyklosporin c - Google Patents

Foerfarande foer framstaellning av terapeutiskt anvaendbar dihydrocyklosporin c Download PDF

Info

Publication number
FI60701C
FI60701C FI763049A FI763049A FI60701C FI 60701 C FI60701 C FI 60701C FI 763049 A FI763049 A FI 763049A FI 763049 A FI763049 A FI 763049A FI 60701 C FI60701 C FI 60701C
Authority
FI
Finland
Prior art keywords
chj
therapeutic
dihydrocyclosporin
cyclosporin
iii
Prior art date
Application number
FI763049A
Other languages
English (en)
Finnish (fi)
Other versions
FI60701B (fi
FI763049A (ko
Inventor
Artur Rueegger
Max Kuhn
Original Assignee
Sandoz Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sandoz Ag filed Critical Sandoz Ag
Publication of FI763049A publication Critical patent/FI763049A/fi
Priority to FI802084A priority Critical patent/FI60718C/fi
Publication of FI60701B publication Critical patent/FI60701B/fi
Application granted granted Critical
Publication of FI60701C publication Critical patent/FI60701C/fi

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/64—Cyclic peptides containing only normal peptide links
    • C07K7/645—Cyclosporins; Related peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/14—Fungi; Culture media therefor
    • C12N1/145—Fungal isolates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
    • C12R2001/00—Microorganisms ; Processes using microorganisms
    • C12R2001/645—Fungi ; Processes using fungi
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
    • C12R2001/00—Microorganisms ; Processes using microorganisms
    • C12R2001/645—Fungi ; Processes using fungi
    • C12R2001/885—Trichoderma
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S930/00—Peptide or protein sequence
    • Y10S930/01—Peptide or protein sequence
    • Y10S930/27—Cyclic peptide or cyclic protein

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Immunology (AREA)
  • Mycology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Botany (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Virology (AREA)
  • Biomedical Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Microbiology (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biophysics (AREA)
  • General Engineering & Computer Science (AREA)
  • Transplantation (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
FI763049A 1975-11-04 1976-10-26 Foerfarande foer framstaellning av terapeutiskt anvaendbar dihydrocyklosporin c FI60701C (fi)

Priority Applications (1)

Application Number Priority Date Filing Date Title
FI802084A FI60718C (fi) 1975-11-04 1980-06-30 En ny ringpeptid cyklosporin c anvaendbar som mellanprodukt vid framstaellning av dihydrocyklosporin c och ett foerfarande foer dess framstaellning

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CH1419575A CH614931A5 (ko) 1975-11-04 1975-11-04
CH1419575 1975-11-04

Publications (3)

Publication Number Publication Date
FI763049A FI763049A (ko) 1977-05-05
FI60701B FI60701B (fi) 1981-11-30
FI60701C true FI60701C (fi) 1982-03-10

Family

ID=4398730

Family Applications (1)

Application Number Title Priority Date Filing Date
FI763049A FI60701C (fi) 1975-11-04 1976-10-26 Foerfarande foer framstaellning av terapeutiskt anvaendbar dihydrocyklosporin c

Country Status (23)

Country Link
US (1) US4108985A (ko)
JP (2) JPS5259180A (ko)
AT (1) AT359642B (ko)
AU (1) AU513538B2 (ko)
BE (1) BE847941A (ko)
CA (1) CA1087609A (ko)
CH (2) CH614931A5 (ko)
DE (2) DE2648121C2 (ko)
DK (1) DK148907C (ko)
ES (1) ES452942A1 (ko)
FI (1) FI60701C (ko)
FR (2) FR2330387A1 (ko)
GB (2) GB1567202A (ko)
IE (2) IE44749B1 (ko)
IL (1) IL50836A (ko)
NL (1) NL7612026A (ko)
NO (1) NO763667L (ko)
NZ (1) NZ182496A (ko)
PH (1) PH14725A (ko)
PT (1) PT65791B (ko)
SE (2) SE432247B (ko)
YU (1) YU270076A (ko)
ZA (1) ZA766340B (ko)

Families Citing this family (71)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4210581A (en) * 1975-11-04 1980-07-01 Sandoz Ltd. Organic compounds
DE2819094A1 (de) * 1977-05-10 1978-11-23 Sandoz Ag Cyclosporin-derivate, ihre verwendung und herstellung
FR2410658A1 (fr) * 1977-11-30 1979-06-29 Science Union & Cie Nouveau produit biologique d'origine fongique, son obtention et son application a la therapeutique
DE2907460A1 (de) * 1978-03-07 1979-09-13 Sandoz Ag Neue resorbierbare galenische kompositionen
SE448386B (sv) * 1978-10-18 1987-02-16 Sandoz Ag Nya cyklosporinderivat, forfarande for framstellning av dem samt farmaceutisk komposition innehallande dem
US4201771A (en) * 1979-03-12 1980-05-06 Merck & Co., Inc. Antibiotic A43F
JPS5665853A (en) * 1979-11-01 1981-06-03 Sankyo Co Ltd Mycoplanesin derivative and its preparation
ATE43335T1 (de) * 1980-02-14 1989-06-15 Sandoz Ag Peptide die einen (1s,2r,3r)- oder (1r,2s,3s)-1nitrilo-1-carbonyl-3-methyl-2-oxyheptan oder hept-5-en-rest enthalten brauchbar in totaler synsthese von cyclosporinen, und verfahren zu ihrer herstellung.
US4396542A (en) * 1980-02-14 1983-08-02 Sandoz Ltd. Method for the total synthesis of cyclosporins, novel cyclosporins and novel intermediates and methods for their production
US4370266A (en) * 1980-04-07 1983-01-25 Sankyo Company, Limited Mycoplanecin derivatives and their preparation
DE3260468D1 (en) * 1981-01-09 1984-09-06 Sandoz Ag Novel cyclosporins
US5639724A (en) 1984-07-24 1997-06-17 Sandoz Ltd. Cyclosporin galenic forms
GB8422253D0 (en) * 1984-09-04 1984-10-10 Sandoz Ltd Organic compounds
DE3587505T2 (de) 1984-10-04 1994-01-05 Sandoz Ag Monoklonale antikörper gegen zyklosporine.
US4727035A (en) * 1984-11-14 1988-02-23 Mahoney Walter C Immunoassay for cyclosporin
US4764503A (en) * 1986-11-19 1988-08-16 Sandoz Ltd. Novel cyclosporins
US4798823A (en) * 1987-06-03 1989-01-17 Merck & Co., Inc. New cyclosporin analogs with modified "C-9 amino acids"
ES2059558T3 (es) * 1987-06-17 1994-11-16 Sandoz Ag Ciclosporins y su uso como productos farmaceuticos.
EP0373260B1 (en) * 1987-06-22 1994-03-09 Merck & Co. Inc. Cyclosporin derivatives with modified "8-amino acid"
GB8717299D0 (en) * 1987-07-22 1987-08-26 Nat Res Dev Peptides
GB8717300D0 (en) * 1987-07-22 1987-08-26 Nat Res Dev Cyclosporins
US5227467A (en) * 1987-08-03 1993-07-13 Merck & Co., Inc. Immunosuppressive fluorinated cyclosporin analogs
DE3851152T2 (de) * 1987-09-03 1995-01-26 Univ Georgia Cyclosporin-augenmittel.
US4839342A (en) * 1987-09-03 1989-06-13 University Of Georgia Research Foundation, Inc. Method of increasing tear production by topical administration of cyclosporin
US5236899A (en) * 1987-11-16 1993-08-17 Merck & Co., Inc. 6-position cyclosporin a analogs as modifiers of cytotoxic drug resistance
US4914188A (en) * 1987-11-16 1990-04-03 Merck & Co., Inc. Novel 6-position cyclosporin analogs as non-immunosuppressive antagonists of cyclosporin binding to cyclophilin
HU203564B (en) * 1987-12-21 1991-08-28 Sandoz Ag Process for producing new orthorombos cyclosporin without solvatation
US4943560A (en) * 1988-04-06 1990-07-24 Regents Of The University Of Minnesota Solvent system for chronic vascular infusion of hydrophobic drugs
US5342625A (en) * 1988-09-16 1994-08-30 Sandoz Ltd. Pharmaceutical compositions comprising cyclosporins
US7081445B2 (en) * 1989-02-20 2006-07-25 Novartis Ag Cyclosporin galenic forms
US5540931A (en) * 1989-03-03 1996-07-30 Charles W. Hewitt Methods for inducing site-specific immunosuppression and compositions of site specific immunosuppressants
US4996193A (en) * 1989-03-03 1991-02-26 The Regents Of The University Of California Combined topical and systemic method of administration of cyclosporine
GB8916901D0 (en) 1989-07-24 1989-09-06 Sandoz Ltd Improvements in or relating to organic compounds
US5122511A (en) * 1990-02-27 1992-06-16 Merck & Co., Inc. Immunosuppressive cyclosporin analogs with modified amino acids at position-8
ATE158022T1 (de) * 1991-01-25 1997-09-15 Fujisawa Pharmaceutical Co Prozess zur produktion von cyclosporin-a und/oder c
ES2065273B1 (es) * 1993-05-25 1995-09-16 Biogal Gyogyszergyar Procedimiento para la purificacion de ciclosporina a.
US5709797A (en) * 1996-06-05 1998-01-20 Poli Industria Chimica S.P.A. Method of isolating cyclosporins
DE29824679U1 (de) 1997-01-30 2002-03-28 Novartis Ag, Basel Pharmazeutische Zusammensetzungen
US6187747B1 (en) 1997-09-08 2001-02-13 Panacea Biotech Limited Pharmaceutical composition comprising cyclosporin
US6008191A (en) * 1997-09-08 1999-12-28 Panacea Biotec Limited Pharmaceutical compositions containing cyclosporin
US6346511B1 (en) 1997-09-08 2002-02-12 Panacea Biotec Limited Pharmaceutical composition comprising cyclosporin
IN188719B (ko) * 1997-09-08 2002-11-02 Panacea Biotec Ltd
US20030220234A1 (en) * 1998-11-02 2003-11-27 Selvaraj Naicker Deuterated cyclosporine analogs and their use as immunodulating agents
KR100585348B1 (ko) 1997-10-08 2006-06-01 이소테크니카 인코포레이티드 중수소화된 시클로스포린 유사체 및 면역조절제로서 그의용도
JP4350898B2 (ja) 1998-07-01 2009-10-21 デビオファーム・ソシエテ・アノニム 活性の特徴が改善された新規のシクロスポリン
EP1435910B9 (en) * 2001-10-19 2010-02-03 Isotechnika Inc. Novel cyclosporin analog microemulsion preconcentrates
NZ531944A (en) * 2001-10-19 2006-03-31 Isotechnika Inc Synthesis of cyclosporin analogs
US20060014677A1 (en) * 2004-07-19 2006-01-19 Isotechnika International Inc. Method for maximizing efficacy and predicting and minimizing toxicity of calcineurin inhibitor compounds
EP1809656A4 (en) 2004-09-29 2009-03-25 Amr Technology Inc CYCLOSPORINAL KINANALOGA AND ITS PHARMACEUTICAL APPLICATIONS
US7511013B2 (en) 2004-09-29 2009-03-31 Amr Technology, Inc. Cyclosporin analogues and their pharmaceutical uses
WO2006041631A2 (en) 2004-10-06 2006-04-20 Amr Technology, Inc. Novel cyclosporin alkynes and their utility as pharmaceutical agents
US11311477B2 (en) 2006-03-07 2022-04-26 Sgn Nanopharma Inc. Ophthalmic preparations
US10137083B2 (en) * 2006-03-07 2018-11-27 SGN Nanopharma Inc Ophthalmic preparations
US7696166B2 (en) 2006-03-28 2010-04-13 Albany Molecular Research, Inc. Use of cyclosporin alkyne/alkene analogues for preventing or treating viral-induced disorders
US7696165B2 (en) 2006-03-28 2010-04-13 Albany Molecular Research, Inc. Use of cyclosporin alkyne analogues for preventing or treating viral-induced disorders
WO2008036244A1 (en) * 2006-09-18 2008-03-27 The Burham Institute For Medical Research Use of cyclosporin a to sensitize resistant cancer cells to death receptor ligands
TW200932240A (en) 2007-10-25 2009-08-01 Astellas Pharma Inc Pharmaceutical composition containing lipophilic substance which inhibits IL-2 production
NZ594755A (en) * 2009-01-30 2013-12-20 Enanta Pharm Inc Cyclosporin analogues for preventing or treating hepatitis c infection
US8481483B2 (en) * 2009-02-19 2013-07-09 Enanta Pharmaceuticals, Inc. Cyclosporin analogues
US8685917B2 (en) * 2009-07-09 2014-04-01 Enanta Pharmaceuticals, Inc. Cyclosporin analogues
US8349312B2 (en) * 2009-07-09 2013-01-08 Enanta Pharmaceuticals, Inc. Proline substituted cyclosporin analogues
US8367053B2 (en) 2009-07-09 2013-02-05 Enanta Pharmaceuticals, Inc. Cyclosporin analogues
US8623814B2 (en) * 2010-02-23 2014-01-07 Enanta Pharmaceuticals, Inc. Antiviral agents
CN103153329A (zh) 2010-07-16 2013-06-12 美国科技环球有限公司 新颖的环孢霉素a衍生物在病毒感染的治疗和预防中的应用
WO2012021796A2 (en) 2010-08-12 2012-02-16 S&T Global, Inc. Novel cyclosporin derivatives for the treatment and prevention of a viral infection
US9890198B2 (en) 2010-12-03 2018-02-13 S&T Global Inc. Cyclosporin derivatives and uses thereof
HUE042490T2 (hu) 2010-12-15 2019-07-29 Contravir Pharmaceuticals Inc 1-es és 3-as aminosav-pozícióban módosított ciklosporin analóg molekulák
WO2012145427A1 (en) 2011-04-18 2012-10-26 The Trustees Of Columbia University In The City Of New York Methods to treat cancer using cyclosporine and cyclosporine derivatives
US8906853B2 (en) 2012-11-28 2014-12-09 Enanta Pharmaceuticals, Inc. [N-Me-4-hydroxyleucine]-9-cyclosporin analogues for treatment and prevention of hepatitis C infection
CA2921961A1 (en) 2013-08-26 2015-03-05 Enanta Pharmaceuticals, Inc. Cyclosporin analogues for preventing or treating hepatitis c
US9669095B2 (en) 2014-11-03 2017-06-06 Enanta Pharmaceuticals, Inc. Cyclosporin analogues for preventing or treating hepatitis C infection

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2455859C2 (de) * 1973-12-06 1983-12-15 Sandoz-Patent-GmbH, 7850 Lörrach Das Antibiotikum Cyclosporin A (S 7481/F-1), seine Herstellung und Verwendung

Also Published As

Publication number Publication date
PH14725A (en) 1981-11-13
BE847941A (fr) 1977-05-03
JPS6277399A (ja) 1987-04-09
ATA812276A (de) 1980-04-15
AU513538B2 (en) 1980-12-11
DE2661031C2 (ko) 1988-05-05
FR2338251A1 (fr) 1977-08-12
DK148907C (da) 1986-04-07
FI60701B (fi) 1981-11-30
JPS5259180A (en) 1977-05-16
CH619735A5 (ko) 1980-10-15
US4108985A (en) 1978-08-22
CA1087609A (en) 1980-10-14
PT65791A (fr) 1976-12-01
SE7611906L (sv) 1977-05-05
FI763049A (ko) 1977-05-05
NZ182496A (en) 1981-12-15
GB1567201A (en) 1980-05-14
NO763667L (ko) 1977-05-05
DK483176A (da) 1977-05-05
CH614931A5 (ko) 1979-12-28
DE2648121A1 (de) 1977-05-12
SE8202039L (sv) 1982-03-30
DK148907B (da) 1985-11-11
ZA766340B (en) 1978-06-28
PT65791B (fr) 1978-07-05
AU1926276A (en) 1978-05-11
ES452942A1 (es) 1978-01-16
DE2648121C2 (de) 1986-05-28
FR2338251B1 (ko) 1984-01-13
IE44750L (en) 1977-05-04
YU270076A (en) 1982-05-31
GB1567202A (en) 1980-05-14
FR2330387B1 (ko) 1980-03-14
FR2330387A1 (fr) 1977-06-03
JPS6210240B2 (ko) 1987-03-05
JPS6253520B2 (ko) 1987-11-10
IL50836A0 (en) 1977-01-31
IE44749B1 (en) 1982-03-24
IE44749L (en) 1977-05-04
IE44750B1 (en) 1982-03-24
SE432247B (sv) 1984-03-26
IL50836A (en) 1979-10-31
NL7612026A (nl) 1977-05-06
AT359642B (de) 1980-11-25

Similar Documents

Publication Publication Date Title
FI60701C (fi) Foerfarande foer framstaellning av terapeutiskt anvaendbar dihydrocyklosporin c
US4210581A (en) Organic compounds
Biard et al. Lepadiformine, a new marine cytotoxic alkaloid from Clavelina lepadiformis Müller
DK148751B (da) Fremgangsmaade til fremstilling af cyclosporinderivater
Pettit et al. Isolation and structure of bryostatins 14 and 15
Chi et al. Identification of the in vivo metabolites of the antimalarial arteether by thermospray high‐performance liquid chromatography/mass spectrometry
Calcagno et al. New phytoecdysteroids from roots of Ajuga reptans varieties
Rao et al. E-73: An antitumor substance. Part I. isolation and characterization1
Klohs et al. Alkaloids of Rauwolfia serpentina Benth. II. 1 The Isolation of Naturally Occurring Py-tetrahydroserpentine (Ajmalicine) and a Contribution Toward its Structure
UENO et al. Studies on the lupin alkaloids. VII. Isolation and structure of (-)-Δ7-dehydrosophoramine
US8586626B2 (en) Metabolites of wortmannin analogs and methods of using the same
CN104892714B (zh) 一种新的灵芝三萜及其制备方法和医药用途
CN108558606B (zh) 一种二倍半萜类化合物peniroquesines及其制备方法和应用
Michel et al. NEW AZASTEROIDAL ANTIFUNGAL ANTIBIOTICS FROM GEOTRICHUM FLAVO-BRUNNEUM II. ISOLATION AND CHARACTERIZATION
Chu et al. A new potent antifungal agent from Actinoplanes sp
CA1106303A (en) Cyclosporin c from tolypocladium or cylindrocarbon
Goud et al. Two new bromotyrosine-derived metabolites from the sponge Psammaplysilla purpurea
CN105218442B (zh) 一种吡啶酮类生物碱及其制备方法
Clericuzio et al. Structural characterisation of metabolites from Pholiota spumosa (Basidiomycetes)
CN108676013B (zh) 具有自噬激活活性的黄醇酮类化合物、其制备方法及其制药应用
FI60718C (fi) En ny ringpeptid cyklosporin c anvaendbar som mellanprodukt vid framstaellning av dihydrocyklosporin c och ett foerfarande foer dess framstaellning
CN108822119B (zh) 具有自噬激活活性的红醇酮类化合物、其制备方法及其制药应用
CN114507139B (zh) 环丙烷类化合物及其制备方法与抗流感病毒的应用
CN105902552A (zh) 甾体类化合物在制备治疗类风湿关节炎药物中的应用
FI63742B (fi) Foerfarande foer framstaellning av terapeutiskt anvaendbart diydrocyklosporin

Legal Events

Date Code Title Description
MM Patent lapsed

Owner name: SANDOZ AG