FI60390C - Foerfarande foer framstaellning av neuroleptiska butyrofenoner - Google Patents

Foerfarande foer framstaellning av neuroleptiska butyrofenoner Download PDF

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Publication number
FI60390C
FI60390C FI760415A FI760415A FI60390C FI 60390 C FI60390 C FI 60390C FI 760415 A FI760415 A FI 760415A FI 760415 A FI760415 A FI 760415A FI 60390 C FI60390 C FI 60390C
Authority
FI
Finland
Prior art keywords
compound
group
formula
neuroleptic
trifluoromethylphenyl
Prior art date
Application number
FI760415A
Other languages
English (en)
Finnish (fi)
Other versions
FI760415A7 (cs
FI60390B (fi
Inventor
Kikuo Sasajima
Keiichi Ono
Hisao Yamamoto
Original Assignee
Sumitomo Chemical Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from JP50027489A external-priority patent/JPS51125239A/ja
Priority claimed from JP50138836A external-priority patent/JPS596304B2/ja
Application filed by Sumitomo Chemical Co filed Critical Sumitomo Chemical Co
Publication of FI760415A7 publication Critical patent/FI760415A7/fi
Application granted granted Critical
Publication of FI60390B publication Critical patent/FI60390B/fi
Publication of FI60390C publication Critical patent/FI60390C/fi

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/10—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by doubly bound oxygen or sulphur atoms
    • C07D295/104—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by doubly bound oxygen or sulphur atoms with the ring nitrogen atoms and the doubly bound oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/108—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by doubly bound oxygen or sulphur atoms with the ring nitrogen atoms and the doubly bound oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D211/30—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by doubly bound oxygen or sulfur atoms or by two oxygen or sulfur atoms singly bound to the same carbon atom
    • C07D211/32—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by doubly bound oxygen or sulfur atoms or by two oxygen or sulfur atoms singly bound to the same carbon atom by oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/40—Oxygen atoms
    • C07D211/44—Oxygen atoms attached in position 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/40—Oxygen atoms
    • C07D211/44—Oxygen atoms attached in position 4
    • C07D211/52—Oxygen atoms attached in position 4 having an aryl radical as the second substituent in position 4

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Hydrogenated Pyridines (AREA)
FI760415A 1975-03-05 1976-02-19 Foerfarande foer framstaellning av neuroleptiska butyrofenoner FI60390C (fi)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
JP2748975 1975-03-05
JP50027489A JPS51125239A (en) 1975-03-05 1975-03-05 Process for preparing new bytyrophenone derivatives
JP50138836A JPS596304B2 (ja) 1975-11-18 1975-11-18 シンキナブチロフエノンユウドウタイノセイホウ
JP13883675 1975-11-18

Publications (3)

Publication Number Publication Date
FI760415A7 FI760415A7 (cs) 1976-09-06
FI60390B FI60390B (fi) 1981-09-30
FI60390C true FI60390C (fi) 1982-01-11

Family

ID=26365419

Family Applications (1)

Application Number Title Priority Date Filing Date
FI760415A FI60390C (fi) 1975-03-05 1976-02-19 Foerfarande foer framstaellning av neuroleptiska butyrofenoner

Country Status (20)

Country Link
US (1) US4235914A (cs)
AR (1) AR211006A1 (cs)
AT (1) AT346341B (cs)
AU (1) AU503943B2 (cs)
BE (1) BE839097A (cs)
CA (1) CA1077039A (cs)
CH (1) CH611598A5 (cs)
CS (1) CS188131B2 (cs)
DD (1) DD124116A5 (cs)
DE (1) DE2608801A1 (cs)
DK (1) DK93976A (cs)
ES (1) ES445775A1 (cs)
FI (1) FI60390C (cs)
FR (1) FR2302728A1 (cs)
GB (1) GB1506805A (cs)
HU (1) HU175175B (cs)
MX (1) MX3392E (cs)
NL (1) NL7602370A (cs)
PL (1) PL106528B1 (cs)
SE (1) SE7602049L (cs)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4396770A (en) * 1982-04-09 1983-08-02 Hoechst-Roussel Pharmaceuticals Inc. 1-[3-(6-Fluoro-1,2-benzisoxazol-3-yl)propyl]-4-hydroxy-4-phenylpiperidines
US4894461A (en) * 1981-04-27 1990-01-16 Hoechst-Roussel Pharmaceuticals, Inc. 3-(γ-chloropropyl)-6-fluoro-1,2-benzisoxazole
US4390544A (en) * 1982-04-09 1983-06-28 Hoechst-Roussel Pharmaceuticals Inc. {1-[3-(6-Fluoro-1,2-benzisoxazol-3-yl)propyl]-4-(2-oxo-1-benzimidazolinyl}p
US4458075A (en) * 1982-04-09 1984-07-03 Hoechst-Roussel Pharmaceuticals Inc. 6-Fluoro-3-[3-(1-heterocyclo)propyl]-1,2-benzisoxazoles
US4609658A (en) * 1982-04-09 1986-09-02 Hoechst-Roussel Pharmaceuticals Inc. 1-[3-(6-fluoro-1,2-benzisoxazol-3-yl)propyl]-4-(substituted) piperazines useful for reducing blood pressure
US4374245A (en) * 1982-04-09 1983-02-15 Hoechst-Roussel Pharmaceuticals Inc. 8-[3-(6-Fluoro-1,2-benzisoxazol-3-yl)propyl]-1-phenyl-1,3,8-triazaspiro[4.5]decan-4-one
IL66866A (en) * 1982-04-09 1987-08-31 Hoechst Roussel Pharma 1-(3-(6-fluoro-1,2-benzisoxazol-3-yl)propyl)-4-(substituted)-piperazines and-piperidines,a process for the preparation thereof,and pharmaceutical compositions containing them
US4536578A (en) * 1982-04-09 1985-08-20 Hoechst-Roussel Pharmaceuticals Inc. 1-[3-(6-Fluoro-1,2-benzisoxazol-3-yl)propyl]-4-(substituted)piperazines
US4610988A (en) * 1982-04-09 1986-09-09 Hoechst-Roussel Pharmaceuticals Inc. 1-[3-(6-fluoro-1,2-benzisoxazol-3-yl)propyl]-4-(substituted)piperazines useful for alleviating pain
US4420485A (en) * 1982-09-29 1983-12-13 Hoechst-Roussel Pharmaceuticals Inc. 1'-[3-(1,2-Benzisoxazol-3-yl) proply]spiro[benzofuran-2(3H),3' or 4'-piperidines or 3'-pyrrolidines]
KR910006138B1 (ko) * 1986-09-30 1991-08-16 에자이 가부시끼가이샤 환상아민 유도체
EP0661266A1 (en) * 1993-12-27 1995-07-05 Toa Eiyo Ltd. Substituted cyclic amine compounds as 5HT2 antagonists

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3799932A (en) * 1970-03-20 1974-03-26 Sumitomo Chemical Co Gamma-piperidinobutyrophenones
JPS4718878U (cs) * 1971-04-05 1972-11-02
JPS5755714B2 (cs) * 1972-03-18 1982-11-25

Also Published As

Publication number Publication date
FR2302728A1 (fr) 1976-10-01
FR2302728B1 (cs) 1979-10-05
FI760415A7 (cs) 1976-09-06
AT346341B (de) 1978-11-10
CA1077039A (en) 1980-05-06
CS188131B2 (en) 1979-02-28
FI60390B (fi) 1981-09-30
MX3392E (es) 1980-10-28
DK93976A (da) 1976-09-06
SE7602049L (sv) 1976-09-06
ATA155776A (de) 1978-03-15
US4235914A (en) 1980-11-25
CH611598A5 (cs) 1979-06-15
HU175175B (hu) 1980-05-28
GB1506805A (en) 1978-04-12
ES445775A1 (es) 1977-10-16
DE2608801A1 (de) 1976-09-16
AU1173076A (en) 1977-09-08
BE839097A (fr) 1976-09-02
PL106528B1 (pl) 1979-12-31
DD124116A5 (cs) 1977-02-02
AU503943B2 (en) 1979-09-27
AR211006A1 (es) 1977-10-14
NL7602370A (nl) 1976-09-07

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MM Patent lapsed

Owner name: SUMITOMO CHEMICAL COMPANY, LIMITED