FR2302728A1 - Procede de production de composes de butyrophenone, nouveaux produits ainsi obtenus et leur utilisation comme agents presentant une activite de depression du systeme nerveux central - Google Patents

Procede de production de composes de butyrophenone, nouveaux produits ainsi obtenus et leur utilisation comme agents presentant une activite de depression du systeme nerveux central

Info

Publication number
FR2302728A1
FR2302728A1 FR7606032A FR7606032A FR2302728A1 FR 2302728 A1 FR2302728 A1 FR 2302728A1 FR 7606032 A FR7606032 A FR 7606032A FR 7606032 A FR7606032 A FR 7606032A FR 2302728 A1 FR2302728 A1 FR 2302728A1
Authority
FR
France
Prior art keywords
depression
agents
production
nervous system
central nervous
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR7606032A
Other languages
English (en)
Other versions
FR2302728B1 (fr
Inventor
Kikuo Sasajima
Keiichi Ono
Hisao Yamamoto
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sumitomo Chemical Co Ltd
Original Assignee
Sumitomo Chemical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from JP50027489A external-priority patent/JPS51125239A/ja
Priority claimed from JP50138836A external-priority patent/JPS596304B2/ja
Application filed by Sumitomo Chemical Co Ltd filed Critical Sumitomo Chemical Co Ltd
Publication of FR2302728A1 publication Critical patent/FR2302728A1/fr
Priority to FR7704817A priority Critical patent/FR2338245A1/fr
Priority to FR7704815A priority patent/FR2338260A1/fr
Application granted granted Critical
Publication of FR2302728B1 publication Critical patent/FR2302728B1/fr
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/10—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by doubly bound oxygen or sulphur atoms
    • C07D295/104—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by doubly bound oxygen or sulphur atoms with the ring nitrogen atoms and the doubly bound oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/108—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by doubly bound oxygen or sulphur atoms with the ring nitrogen atoms and the doubly bound oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D211/30—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by doubly bound oxygen or sulfur atoms or by two oxygen or sulfur atoms singly bound to the same carbon atom
    • C07D211/32—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by doubly bound oxygen or sulfur atoms or by two oxygen or sulfur atoms singly bound to the same carbon atom by oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/40—Oxygen atoms
    • C07D211/44—Oxygen atoms attached in position 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/40—Oxygen atoms
    • C07D211/44—Oxygen atoms attached in position 4
    • C07D211/52—Oxygen atoms attached in position 4 having an aryl radical as the second substituent in position 4

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
FR7606032A 1975-03-05 1976-03-03 Procede de production de composes de butyrophenone, nouveaux produits ainsi obtenus et leur utilisation comme agents presentant une activite de depression du systeme nerveux central Granted FR2302728A1 (fr)

Priority Applications (2)

Application Number Priority Date Filing Date Title
FR7704817A FR2338245A1 (fr) 1975-03-05 1977-02-18 Procede de preparation de composes de buthyrophenone a groupe cyclohexylamine ou phenoxyalkylamino et nouveaux produits ainsi obtenus, a activite psychotrope
FR7704815A FR2338260A1 (fr) 1975-03-05 1977-02-18 Procede de preparation de composes de butyrophenone a groupe piperidino, morpholino, pyrrolidino ou piperazino et nouveaux produits ainsi obtenus, a activite psychotrope

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP50027489A JPS51125239A (en) 1975-03-05 1975-03-05 Process for preparing new bytyrophenone derivatives
JP50138836A JPS596304B2 (ja) 1975-11-18 1975-11-18 シンキナブチロフエノンユウドウタイノセイホウ

Publications (2)

Publication Number Publication Date
FR2302728A1 true FR2302728A1 (fr) 1976-10-01
FR2302728B1 FR2302728B1 (fr) 1979-10-05

Family

ID=26365419

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7606032A Granted FR2302728A1 (fr) 1975-03-05 1976-03-03 Procede de production de composes de butyrophenone, nouveaux produits ainsi obtenus et leur utilisation comme agents presentant une activite de depression du systeme nerveux central

Country Status (20)

Country Link
US (1) US4235914A (fr)
AR (1) AR211006A1 (fr)
AT (1) AT346341B (fr)
AU (1) AU503943B2 (fr)
BE (1) BE839097A (fr)
CA (1) CA1077039A (fr)
CH (1) CH611598A5 (fr)
CS (1) CS188131B2 (fr)
DD (1) DD124116A5 (fr)
DE (1) DE2608801A1 (fr)
DK (1) DK93976A (fr)
ES (1) ES445775A1 (fr)
FI (1) FI60390C (fr)
FR (1) FR2302728A1 (fr)
GB (1) GB1506805A (fr)
HU (1) HU175175B (fr)
MX (1) MX3392E (fr)
NL (1) NL7602370A (fr)
PL (1) PL106528B1 (fr)
SE (1) SE7602049L (fr)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4894461A (en) * 1981-04-27 1990-01-16 Hoechst-Roussel Pharmaceuticals, Inc. 3-(γ-chloropropyl)-6-fluoro-1,2-benzisoxazole
US4396770A (en) * 1982-04-09 1983-08-02 Hoechst-Roussel Pharmaceuticals Inc. 1-[3-(6-Fluoro-1,2-benzisoxazol-3-yl)propyl]-4-hydroxy-4-phenylpiperidines
US4458075A (en) * 1982-04-09 1984-07-03 Hoechst-Roussel Pharmaceuticals Inc. 6-Fluoro-3-[3-(1-heterocyclo)propyl]-1,2-benzisoxazoles
US4610988A (en) * 1982-04-09 1986-09-09 Hoechst-Roussel Pharmaceuticals Inc. 1-[3-(6-fluoro-1,2-benzisoxazol-3-yl)propyl]-4-(substituted)piperazines useful for alleviating pain
US4609658A (en) * 1982-04-09 1986-09-02 Hoechst-Roussel Pharmaceuticals Inc. 1-[3-(6-fluoro-1,2-benzisoxazol-3-yl)propyl]-4-(substituted) piperazines useful for reducing blood pressure
US4390544A (en) * 1982-04-09 1983-06-28 Hoechst-Roussel Pharmaceuticals Inc. {1-[3-(6-Fluoro-1,2-benzisoxazol-3-yl)propyl]-4-(2-oxo-1-benzimidazolinyl}p
US4536578A (en) * 1982-04-09 1985-08-20 Hoechst-Roussel Pharmaceuticals Inc. 1-[3-(6-Fluoro-1,2-benzisoxazol-3-yl)propyl]-4-(substituted)piperazines
IL66866A (en) * 1982-04-09 1987-08-31 Hoechst Roussel Pharma 1-(3-(6-fluoro-1,2-benzisoxazol-3-yl)propyl)-4-(substituted)-piperazines and-piperidines,a process for the preparation thereof,and pharmaceutical compositions containing them
US4374245A (en) * 1982-04-09 1983-02-15 Hoechst-Roussel Pharmaceuticals Inc. 8-[3-(6-Fluoro-1,2-benzisoxazol-3-yl)propyl]-1-phenyl-1,3,8-triazaspiro[4.5]decan-4-one
US4420485A (en) * 1982-09-29 1983-12-13 Hoechst-Roussel Pharmaceuticals Inc. 1'-[3-(1,2-Benzisoxazol-3-yl) proply]spiro[benzofuran-2(3H),3' or 4'-piperidines or 3'-pyrrolidines]
KR910006138B1 (ko) * 1986-09-30 1991-08-16 에자이 가부시끼가이샤 환상아민 유도체
EP0661266A1 (fr) * 1993-12-27 1995-07-05 Toa Eiyo Ltd. Composés cycliques aminés substitués comme 5HT2 antagonistes

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3799932A (en) * 1970-03-20 1974-03-26 Sumitomo Chemical Co Gamma-piperidinobutyrophenones
JPS4718878U (fr) * 1971-04-05 1972-11-02
JPS5755714B2 (fr) * 1972-03-18 1982-11-25

Also Published As

Publication number Publication date
DK93976A (da) 1976-09-06
CS188131B2 (en) 1979-02-28
AU503943B2 (en) 1979-09-27
HU175175B (hu) 1980-05-28
ES445775A1 (es) 1977-10-16
DD124116A5 (fr) 1977-02-02
FI60390C (fi) 1982-01-11
MX3392E (es) 1980-10-28
DE2608801A1 (de) 1976-09-16
US4235914A (en) 1980-11-25
PL106528B1 (pl) 1979-12-31
NL7602370A (nl) 1976-09-07
FR2302728B1 (fr) 1979-10-05
BE839097A (fr) 1976-09-02
AU1173076A (en) 1977-09-08
ATA155776A (de) 1978-03-15
CA1077039A (fr) 1980-05-06
FI60390B (fi) 1981-09-30
GB1506805A (en) 1978-04-12
AR211006A1 (es) 1977-10-14
SE7602049L (sv) 1976-09-06
CH611598A5 (fr) 1979-06-15
AT346341B (de) 1978-11-10
FI760415A (fr) 1976-09-06

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