FI59336C - Foerfarande foer framstaellning av en oevermaettad isosorbiddinitratloesning - Google Patents
Foerfarande foer framstaellning av en oevermaettad isosorbiddinitratloesning Download PDFInfo
- Publication number
- FI59336C FI59336C FI771679A FI771679A FI59336C FI 59336 C FI59336 C FI 59336C FI 771679 A FI771679 A FI 771679A FI 771679 A FI771679 A FI 771679A FI 59336 C FI59336 C FI 59336C
- Authority
- FI
- Finland
- Prior art keywords
- isd
- solution
- ampoules
- concentration
- solutions
- Prior art date
Links
- 238000000034 method Methods 0.000 title description 8
- MOYKHGMNXAOIAT-JGWLITMVSA-N isosorbide dinitrate Chemical compound [O-][N+](=O)O[C@H]1CO[C@@H]2[C@H](O[N+](=O)[O-])CO[C@@H]21 MOYKHGMNXAOIAT-JGWLITMVSA-N 0.000 description 51
- 229960000201 isosorbide dinitrate Drugs 0.000 description 49
- 239000000243 solution Substances 0.000 description 31
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 12
- 238000002360 preparation method Methods 0.000 description 7
- 238000003860 storage Methods 0.000 description 6
- 238000011049 filling Methods 0.000 description 5
- 238000004519 manufacturing process Methods 0.000 description 5
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 description 4
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 4
- 238000004458 analytical method Methods 0.000 description 4
- 238000002474 experimental method Methods 0.000 description 4
- 238000003556 assay Methods 0.000 description 3
- 230000008033 biological extinction Effects 0.000 description 3
- 238000002425 crystallisation Methods 0.000 description 3
- 230000008025 crystallization Effects 0.000 description 3
- 238000010438 heat treatment Methods 0.000 description 3
- 238000001802 infusion Methods 0.000 description 3
- 239000003978 infusion fluid Substances 0.000 description 3
- 239000000203 mixture Substances 0.000 description 3
- 239000012086 standard solution Substances 0.000 description 3
- 239000012085 test solution Substances 0.000 description 3
- 239000003708 ampul Substances 0.000 description 2
- 201000010099 disease Diseases 0.000 description 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 2
- 238000001914 filtration Methods 0.000 description 2
- 238000007911 parenteral administration Methods 0.000 description 2
- 239000011780 sodium chloride Substances 0.000 description 2
- 239000007787 solid Substances 0.000 description 2
- 238000003756 stirring Methods 0.000 description 2
- 238000012360 testing method Methods 0.000 description 2
- 238000005303 weighing Methods 0.000 description 2
- 206010002383 Angina Pectoris Diseases 0.000 description 1
- 206010024119 Left ventricular failure Diseases 0.000 description 1
- GRYLNZFGIOXLOG-UHFFFAOYSA-N Nitric acid Chemical class O[N+]([O-])=O GRYLNZFGIOXLOG-UHFFFAOYSA-N 0.000 description 1
- ISWSIDIOOBJBQZ-UHFFFAOYSA-N Phenol Chemical compound OC1=CC=CC=C1 ISWSIDIOOBJBQZ-UHFFFAOYSA-N 0.000 description 1
- 206010037423 Pulmonary oedema Diseases 0.000 description 1
- 239000005862 Whey Substances 0.000 description 1
- 102000007544 Whey Proteins Human genes 0.000 description 1
- 108010046377 Whey Proteins Proteins 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 239000007864 aqueous solution Substances 0.000 description 1
- 238000009835 boiling Methods 0.000 description 1
- 238000004364 calculation method Methods 0.000 description 1
- 239000002775 capsule Substances 0.000 description 1
- 238000004587 chromatography analysis Methods 0.000 description 1
- 239000000470 constituent Substances 0.000 description 1
- 238000007796 conventional method Methods 0.000 description 1
- 239000007857 degradation product Substances 0.000 description 1
- 239000012153 distilled water Substances 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 238000005429 filling process Methods 0.000 description 1
- 239000000706 filtrate Substances 0.000 description 1
- 239000011521 glass Substances 0.000 description 1
- 239000000644 isotonic solution Substances 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 230000004060 metabolic process Effects 0.000 description 1
- 208000010125 myocardial infarction Diseases 0.000 description 1
- 150000002823 nitrates Chemical class 0.000 description 1
- 239000007935 oral tablet Substances 0.000 description 1
- 229940082615 organic nitrates used in cardiac disease Drugs 0.000 description 1
- 229940021222 peritoneal dialysis isotonic solution Drugs 0.000 description 1
- 239000011148 porous material Substances 0.000 description 1
- 208000005333 pulmonary edema Diseases 0.000 description 1
- 230000001954 sterilising effect Effects 0.000 description 1
- 238000004659 sterilization and disinfection Methods 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 238000004809 thin layer chromatography Methods 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Dermatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE2623800 | 1976-05-28 | ||
| DE19762623800 DE2623800C3 (de) | 1976-05-28 | 1976-05-28 | Obersättigte wässerige Isosorbiddinitrat-Lösung, Herstellungsverfahren und Verwendung |
| DE2659393 | 1976-12-29 | ||
| DE19762659393 DE2659393A1 (de) | 1976-12-29 | 1976-12-29 | Uebersaettigte isosorbiddinitrat- loesung, herstellungsverfahren und verwendung |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| FI771679A7 FI771679A7 (OSRAM) | 1977-11-29 |
| FI59336B FI59336B (fi) | 1981-04-30 |
| FI59336C true FI59336C (fi) | 1981-08-10 |
Family
ID=25770504
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FI771679A FI59336C (fi) | 1976-05-28 | 1977-05-26 | Foerfarande foer framstaellning av en oevermaettad isosorbiddinitratloesning |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US4156736A (OSRAM) |
| AT (1) | AT348131B (OSRAM) |
| CA (1) | CA1089365A (OSRAM) |
| DK (1) | DK157600C (OSRAM) |
| ES (1) | ES459214A1 (OSRAM) |
| FI (1) | FI59336C (OSRAM) |
| FR (1) | FR2352776A1 (OSRAM) |
| LU (1) | LU77432A1 (OSRAM) |
| NL (1) | NL183702C (OSRAM) |
| SE (1) | SE442376B (OSRAM) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2903927C2 (de) * | 1979-02-02 | 1981-03-12 | Sanol Schwarz-Monheim Gmbh, 4019 Monheim | Verfahren zur selektiven Herstellung von Isosorbid-5-nitrat |
| US4632937A (en) * | 1984-12-21 | 1986-12-30 | Ici Americas | Dentifrice formulation and method of treating teeth, mouth and throat therewith to reduce plaque accumulation and irritation |
| ATE183639T1 (de) * | 1991-02-18 | 1999-09-15 | Commw Scient Ind Res Org | Zusammensetzung zur verwendung in der transdermalen verabreichung |
| CN115073486B (zh) * | 2022-06-29 | 2024-02-20 | 江西东抚制药有限公司 | 一种硝酸异山梨酯及其注射液的制备方法 |
| CN116251057B (zh) * | 2022-12-29 | 2024-06-07 | 平光制药股份有限公司 | 一种硝酸异山梨酯注射液及其制备方法 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3422107A (en) * | 1964-09-05 | 1969-01-14 | Albert Ag Chem Werke | Certain oxoalkyldimethylxanthines and a process for the preparation thereof |
| JPS5537528B2 (OSRAM) * | 1972-12-11 | 1980-09-29 | ||
| US3972995A (en) * | 1975-04-14 | 1976-08-03 | American Home Products Corporation | Dosage form |
-
1977
- 1977-05-19 US US05/798,639 patent/US4156736A/en not_active Expired - Lifetime
- 1977-05-26 FI FI771679A patent/FI59336C/fi not_active IP Right Cessation
- 1977-05-26 SE SE7706196A patent/SE442376B/xx not_active IP Right Cessation
- 1977-05-27 NL NLAANVRAGE7705885,A patent/NL183702C/xx not_active IP Right Cessation
- 1977-05-27 ES ES459214A patent/ES459214A1/es not_active Expired
- 1977-05-27 AT AT380277A patent/AT348131B/de not_active IP Right Cessation
- 1977-05-27 DK DK234777A patent/DK157600C/da not_active IP Right Cessation
- 1977-05-27 LU LU77432A patent/LU77432A1/xx unknown
- 1977-05-27 CA CA279,316A patent/CA1089365A/en not_active Expired
- 1977-05-31 FR FR7716512A patent/FR2352776A1/fr active Granted
Also Published As
| Publication number | Publication date |
|---|---|
| ES459214A1 (es) | 1978-03-01 |
| FI771679A7 (OSRAM) | 1977-11-29 |
| SE7706196L (sv) | 1977-11-29 |
| NL7705885A (nl) | 1977-11-30 |
| NL183702C (nl) | 1989-01-02 |
| LU77432A1 (OSRAM) | 1977-09-09 |
| CA1089365A (en) | 1980-11-11 |
| FR2352776A1 (fr) | 1977-12-23 |
| DK157600C (da) | 1990-06-18 |
| FI59336B (fi) | 1981-04-30 |
| US4156736A (en) | 1979-05-29 |
| AT348131B (de) | 1979-01-25 |
| DK234777A (da) | 1977-11-29 |
| SE442376B (sv) | 1985-12-23 |
| FR2352776B1 (OSRAM) | 1980-10-24 |
| ATA380277A (de) | 1978-06-15 |
| NL183702B (nl) | 1988-08-01 |
| DK157600B (da) | 1990-01-29 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MA | Patent expired | ||
| MA | Patent expired |
Owner name: SANOL SCHWARZ-MONHEIM GMBH |