FI57949C - Foerfarande foer framstaellning av terapeutiskt anvaendbara 4-oxo-6,7,8,9-tetrahydropyrido (1,2-a) pyrimidinderivat - Google Patents
Foerfarande foer framstaellning av terapeutiskt anvaendbara 4-oxo-6,7,8,9-tetrahydropyrido (1,2-a) pyrimidinderivat Download PDFInfo
- Publication number
- FI57949C FI57949C FI940/74A FI94074A FI57949C FI 57949 C FI57949 C FI 57949C FI 940/74 A FI940/74 A FI 940/74A FI 94074 A FI94074 A FI 94074A FI 57949 C FI57949 C FI 57949C
- Authority
- FI
- Finland
- Prior art keywords
- oxo
- formula
- pyrido
- pyrimidine
- group
- Prior art date
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- 238000000034 method Methods 0.000 title claims description 13
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- 229960002510 mandelic acid Drugs 0.000 description 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 1
- 125000000325 methylidene group Chemical group [H]C([H])=* 0.000 description 1
- 150000007522 mineralic acids Chemical class 0.000 description 1
- 229960005181 morphine Drugs 0.000 description 1
- 230000007935 neutral effect Effects 0.000 description 1
- 238000006386 neutralization reaction Methods 0.000 description 1
- MUMZUERVLWJKNR-UHFFFAOYSA-N oxoplatinum Chemical compound [Pt]=O MUMZUERVLWJKNR-UHFFFAOYSA-N 0.000 description 1
- 230000000144 pharmacologic effect Effects 0.000 description 1
- DDBREPKUVSBGFI-UHFFFAOYSA-N phenobarbital Chemical compound C=1C=CC=CC=1C1(CC)C(=O)NC(=O)NC1=O DDBREPKUVSBGFI-UHFFFAOYSA-N 0.000 description 1
- 229910052698 phosphorus Inorganic materials 0.000 description 1
- 239000011574 phosphorus Substances 0.000 description 1
- DLYUQMMRRRQYAE-UHFFFAOYSA-N phosphorus pentoxide Inorganic materials O1P(O2)(=O)OP3(=O)OP1(=O)OP2(=O)O3 DLYUQMMRRRQYAE-UHFFFAOYSA-N 0.000 description 1
- 229910052697 platinum Inorganic materials 0.000 description 1
- 229910003446 platinum oxide Inorganic materials 0.000 description 1
- ZSIALBZCWCLSOG-UHFFFAOYSA-N pyrimidine;hydroiodide Chemical compound I.C1=CN=CN=C1 ZSIALBZCWCLSOG-UHFFFAOYSA-N 0.000 description 1
- 239000012429 reaction media Substances 0.000 description 1
- 238000006798 ring closing metathesis reaction Methods 0.000 description 1
- 238000007363 ring formation reaction Methods 0.000 description 1
- 238000004062 sedimentation Methods 0.000 description 1
- 239000000741 silica gel Substances 0.000 description 1
- 229910002027 silica gel Inorganic materials 0.000 description 1
- 229910000029 sodium carbonate Inorganic materials 0.000 description 1
- 238000007920 subcutaneous administration Methods 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 150000003467 sulfuric acid derivatives Chemical class 0.000 description 1
- 239000000725 suspension Substances 0.000 description 1
- 231100001274 therapeutic index Toxicity 0.000 description 1
- LBLYYCQCTBFVLH-UHFFFAOYSA-M toluenesulfonate group Chemical group C=1(C(=CC=CC1)S(=O)(=O)[O-])C LBLYYCQCTBFVLH-UHFFFAOYSA-M 0.000 description 1
- 238000010626 work up procedure Methods 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pain & Pain Management (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Rheumatology (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| HUCI001361 | 1973-03-30 | ||
| HUCI1361A HU168014B (enrdf_load_html_response) | 1973-03-30 | 1973-03-30 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| FI57949B FI57949B (fi) | 1980-07-31 |
| FI57949C true FI57949C (fi) | 1980-11-10 |
Family
ID=10994473
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FI940/74A FI57949C (fi) | 1973-03-30 | 1974-03-27 | Foerfarande foer framstaellning av terapeutiskt anvaendbara 4-oxo-6,7,8,9-tetrahydropyrido (1,2-a) pyrimidinderivat |
Country Status (20)
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| HU173438B (hu) * | 1975-11-27 | 1979-05-28 | Chinoin Gyogyszer Es Vegyeszet | Sposob poluchenija novykh proizvodnykh 4-okso-1,6,7,8-/tetragidro-4h-pirido/1,2/pirimidina s zaderzhivajuhhejj vozgoranie aktivnot'ju i protivosvertivajuhhem effektom |
| HU174693B (hu) * | 1976-02-12 | 1980-03-28 | Chinoin Gyogyszer Es Vegyeszet | Sposob poluchenija kondensirovannykh proizvodnykh pirimidina |
| HU174901B (hu) * | 1976-06-25 | 1980-04-28 | Chinoin Gyogyszer Es Vegyeszet | Sposob poluchenija novykh proizvodnykh pirido/1,2-a/pirimidina |
| HU178910B (en) * | 1977-08-19 | 1982-07-28 | Chinoin Gyogyszer Es Vegyeszet | Process for preparing 2,3-disubstituted-4-oxo-4h-pyrido/1,2-a/-pyrimidines |
| HU180701B (en) * | 1977-12-29 | 1983-04-29 | Chinoin Gyogyszer Es Vegyeszet | Process for preparing pyrido-/1,2-a/pyrimidines containing a carboxylic or ester group on the pirimidimering |
| HU178496B (en) * | 1977-12-29 | 1982-05-28 | Chinoin Gyogyszer Es Vegyeszet | Process for preparing 6,7,8,9-tetrahydro-4h-pyrido/1,2-a/pyrimidine derivatives with antiallergic activity |
| HU185925B (en) * | 1977-12-29 | 1985-04-28 | Chinoin Gyogyszer Es Vegyeszet | Process for preparing compounds with nitrogen bridge head |
| HU179143B (en) * | 1977-12-29 | 1982-08-28 | Chinoin Gyogyszer Es Vegyeszet | Process for producing 9-hydroxy-groops-containing 6,7-dihydro-pyrido-square bracket-1,2-a-square bracket closed-pyrimidin derivatives and esters thereof |
| AT376675B (de) * | 1979-05-08 | 1984-12-27 | Erba Farmitalia | Verfahren zum herstellen von neuen substituierten pyrido(1,2-a)pyrimidinen |
| US4661592A (en) * | 1984-06-27 | 1987-04-28 | G. D. Searle & Co. | 4H-pyrimido[2,1-a]isoquinolin-4-one derivatives |
| HU201551B (en) * | 1988-02-03 | 1990-11-28 | Chinoin Gyogyszer Es Vegyeszet | Process for producing 4-oxo-4h-pyrido(1,2-a)pyrimidine-3-carboxylic acid amide derivatives and pharmaceutical compositions comprising same |
| WO2009109987A2 (en) * | 2008-01-11 | 2009-09-11 | Glenmark Pharmaceuticals, S.A. | Fused pyrimidine derivatives as trpv3 modulators |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AT302311B (de) * | 1966-11-02 | 1972-09-15 | Chinoin Gyogyszer Es Vegyeszet | Verfahren zur herstellung von homopyrimidazol-derivaten und deren saeureadditionssalzen und quaternaeren ammoniumsalzen |
-
1973
- 1973-03-30 HU HUCI1361A patent/HU168014B/hu unknown
-
1974
- 1974-03-13 IL IL44417A patent/IL44417A/xx unknown
- 1974-03-22 NL NL7403901A patent/NL7403901A/xx unknown
- 1974-03-26 SE SE7404074A patent/SE418087B/xx unknown
- 1974-03-27 AT AT252674A patent/AT336624B/de not_active IP Right Cessation
- 1974-03-27 CS CS742217A patent/CS189872B1/cs unknown
- 1974-03-27 FI FI940/74A patent/FI57949C/fi active
- 1974-03-27 DE DE2414751A patent/DE2414751A1/de not_active Withdrawn
- 1974-03-28 FR FR7410831A patent/FR2223036B1/fr not_active Expired
- 1974-03-28 CA CA196,195A patent/CA1032938A/en not_active Expired
- 1974-03-29 ES ES424758A patent/ES424758A1/es not_active Expired
- 1974-03-29 SU SU7402014577A patent/SU566524A3/ru active
- 1974-03-29 CH CH446974A patent/CH605940A5/xx not_active IP Right Cessation
- 1974-03-29 PL PL1974169922A patent/PL93755B1/pl unknown
- 1974-03-29 DD DD177572A patent/DD110661A1/xx unknown
- 1974-03-29 BE BE142608A patent/BE813021A/xx unknown
- 1974-03-29 DK DK174074AA patent/DK138327B/da not_active Application Discontinuation
- 1974-03-29 NO NO741125A patent/NO140821C/no unknown
- 1974-03-30 JP JP49036582A patent/JPS505396A/ja active Pending
- 1974-04-01 GB GB1290874A patent/GB1454312A/en not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| SE418087B (sv) | 1981-05-04 |
| DD110661A1 (enrdf_load_html_response) | 1975-01-05 |
| BE813021A (fr) | 1974-07-15 |
| NO140821C (no) | 1979-11-21 |
| NL7403901A (enrdf_load_html_response) | 1974-10-02 |
| FR2223036A1 (enrdf_load_html_response) | 1974-10-25 |
| NO140821B (no) | 1979-08-13 |
| GB1454312A (en) | 1976-11-03 |
| ES424758A1 (es) | 1976-06-16 |
| PL93755B1 (en) | 1977-06-30 |
| IL44417A0 (en) | 1974-06-30 |
| SU566524A3 (ru) | 1977-07-25 |
| CS189872B1 (en) | 1979-05-31 |
| FI57949B (fi) | 1980-07-31 |
| AT336624B (de) | 1977-05-10 |
| IL44417A (en) | 1978-01-31 |
| AU6670474A (en) | 1975-09-18 |
| FR2223036B1 (enrdf_load_html_response) | 1977-05-06 |
| NO741125A (no) | 1974-10-01 |
| DK138327B (da) | 1978-08-14 |
| ATA252674A (de) | 1976-09-15 |
| DK138327C (enrdf_load_html_response) | 1979-01-22 |
| CA1032938A (en) | 1978-06-13 |
| DE2414751A1 (de) | 1974-10-10 |
| JPS505396A (enrdf_load_html_response) | 1975-01-21 |
| CH605940A5 (enrdf_load_html_response) | 1978-10-13 |
| HU168014B (enrdf_load_html_response) | 1976-02-28 |
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