FI56536C - Mot aktivitetsfoerlust stabiliserat ureaspreparat - Google Patents
Mot aktivitetsfoerlust stabiliserat ureaspreparat Download PDFInfo
- Publication number
- FI56536C FI56536C FI770294A FI770294A FI56536C FI 56536 C FI56536 C FI 56536C FI 770294 A FI770294 A FI 770294A FI 770294 A FI770294 A FI 770294A FI 56536 C FI56536 C FI 56536C
- Authority
- FI
- Finland
- Prior art keywords
- urease
- activity
- stabilized
- mot
- ureaspreparat
- Prior art date
Links
- 108010046334 Urease Proteins 0.000 description 28
- 230000000694 effects Effects 0.000 description 24
- RWSXRVCMGQZWBV-WDSKDSINSA-N glutathione Chemical compound OC(=O)[C@@H](N)CCC(=O)N[C@@H](CS)C(=O)NCC(O)=O RWSXRVCMGQZWBV-WDSKDSINSA-N 0.000 description 12
- 238000002360 preparation method Methods 0.000 description 12
- 229920002307 Dextran Polymers 0.000 description 11
- 241000282326 Felis catus Species 0.000 description 9
- QGZKDVFQNNGYKY-UHFFFAOYSA-N Ammonia Chemical compound N QGZKDVFQNNGYKY-UHFFFAOYSA-N 0.000 description 8
- KCXVZYZYPLLWCC-UHFFFAOYSA-N EDTA Chemical compound OC(=O)CN(CC(O)=O)CCN(CC(O)=O)CC(O)=O KCXVZYZYPLLWCC-UHFFFAOYSA-N 0.000 description 8
- 239000000203 mixture Substances 0.000 description 8
- KRKNYBCHXYNGOX-UHFFFAOYSA-K Citrate Chemical compound [O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O KRKNYBCHXYNGOX-UHFFFAOYSA-K 0.000 description 7
- 108090000790 Enzymes Proteins 0.000 description 7
- 102000004190 Enzymes Human genes 0.000 description 7
- 108010024636 Glutathione Proteins 0.000 description 6
- 235000013877 carbamide Nutrition 0.000 description 6
- 238000004108 freeze drying Methods 0.000 description 6
- 229960003180 glutathione Drugs 0.000 description 6
- 238000011282 treatment Methods 0.000 description 6
- 210000002700 urine Anatomy 0.000 description 6
- XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Chemical compound NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 description 5
- 239000004202 carbamide Substances 0.000 description 5
- 239000003381 stabilizer Substances 0.000 description 5
- 239000003513 alkali Substances 0.000 description 4
- 229910021529 ammonia Inorganic materials 0.000 description 4
- 238000002474 experimental method Methods 0.000 description 4
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 4
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 3
- 210000004369 blood Anatomy 0.000 description 3
- 239000008280 blood Substances 0.000 description 3
- 239000004615 ingredient Substances 0.000 description 3
- 210000002966 serum Anatomy 0.000 description 3
- 230000006641 stabilisation Effects 0.000 description 3
- 238000011105 stabilization Methods 0.000 description 3
- ZPLCXHWYPWVJDL-UHFFFAOYSA-N 4-[(4-hydroxyphenyl)methyl]-1,3-oxazolidin-2-one Chemical compound C1=CC(O)=CC=C1CC1NC(=O)OC1 ZPLCXHWYPWVJDL-UHFFFAOYSA-N 0.000 description 2
- 238000006243 chemical reaction Methods 0.000 description 2
- 239000003086 colorant Substances 0.000 description 2
- 238000001514 detection method Methods 0.000 description 2
- 239000012535 impurity Substances 0.000 description 2
- 239000012528 membrane Substances 0.000 description 2
- 238000000034 method Methods 0.000 description 2
- 239000007793 ph indicator Substances 0.000 description 2
- 239000000243 solution Substances 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- IXPNQXFRVYWDDI-UHFFFAOYSA-N 1-methyl-2,4-dioxo-1,3-diazinane-5-carboximidamide Chemical compound CN1CC(C(N)=N)C(=O)NC1=O IXPNQXFRVYWDDI-UHFFFAOYSA-N 0.000 description 1
- CDOUZKKFHVEKRI-UHFFFAOYSA-N 3-bromo-n-[(prop-2-enoylamino)methyl]propanamide Chemical compound BrCCC(=O)NCNC(=O)C=C CDOUZKKFHVEKRI-UHFFFAOYSA-N 0.000 description 1
- 241000283690 Bos taurus Species 0.000 description 1
- XUJNEKJLAYXESH-REOHCLBHSA-N L-Cysteine Chemical compound SC[C@H](N)C(O)=O XUJNEKJLAYXESH-REOHCLBHSA-N 0.000 description 1
- 229910019142 PO4 Inorganic materials 0.000 description 1
- 229920005654 Sephadex Polymers 0.000 description 1
- 102000007562 Serum Albumin Human genes 0.000 description 1
- 108010071390 Serum Albumin Proteins 0.000 description 1
- 239000007864 aqueous solution Substances 0.000 description 1
- 239000011230 binding agent Substances 0.000 description 1
- BVKZGUZCCUSVTD-UHFFFAOYSA-N carbonic acid Chemical compound OC(O)=O BVKZGUZCCUSVTD-UHFFFAOYSA-N 0.000 description 1
- 239000000969 carrier Substances 0.000 description 1
- 239000012876 carrier material Substances 0.000 description 1
- 238000006555 catalytic reaction Methods 0.000 description 1
- 239000003153 chemical reaction reagent Substances 0.000 description 1
- 238000004440 column chromatography Methods 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 238000002425 crystallisation Methods 0.000 description 1
- 230000008025 crystallization Effects 0.000 description 1
- XUJNEKJLAYXESH-UHFFFAOYSA-N cysteine Natural products SCC(N)C(O)=O XUJNEKJLAYXESH-UHFFFAOYSA-N 0.000 description 1
- 235000018417 cysteine Nutrition 0.000 description 1
- 235000019329 dioctyl sodium sulphosuccinate Nutrition 0.000 description 1
- BNIILDVGGAEEIG-UHFFFAOYSA-L disodium hydrogen phosphate Chemical compound [Na+].[Na+].OP([O-])([O-])=O BNIILDVGGAEEIG-UHFFFAOYSA-L 0.000 description 1
- 239000006185 dispersion Substances 0.000 description 1
- DNJIEGIFACGWOD-UHFFFAOYSA-N ethyl mercaptane Natural products CCS DNJIEGIFACGWOD-UHFFFAOYSA-N 0.000 description 1
- 238000009472 formulation Methods 0.000 description 1
- 230000002452 interceptive effect Effects 0.000 description 1
- VZCYOOQTPOCHFL-UPHRSURJSA-N maleic acid Chemical compound OC(=O)\C=C/C(O)=O VZCYOOQTPOCHFL-UPHRSURJSA-N 0.000 description 1
- 238000002156 mixing Methods 0.000 description 1
- 239000002808 molecular sieve Substances 0.000 description 1
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 1
- 239000010452 phosphate Substances 0.000 description 1
- 229920002689 polyvinyl acetate Polymers 0.000 description 1
- 239000011118 polyvinyl acetate Substances 0.000 description 1
- 230000002035 prolonged effect Effects 0.000 description 1
- 238000000746 purification Methods 0.000 description 1
- 235000010413 sodium alginate Nutrition 0.000 description 1
- 229940005550 sodium alginate Drugs 0.000 description 1
- 239000000661 sodium alginate Substances 0.000 description 1
- URGAHOPLAPQHLN-UHFFFAOYSA-N sodium aluminosilicate Chemical compound [Na+].[Al+3].[O-][Si]([O-])=O.[O-][Si]([O-])=O URGAHOPLAPQHLN-UHFFFAOYSA-N 0.000 description 1
- 230000000087 stabilizing effect Effects 0.000 description 1
- 125000003396 thiol group Chemical group [H]S* 0.000 description 1
- VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 description 1
- 150000003672 ureas Chemical class 0.000 description 1
- NWONKYPBYAMBJT-UHFFFAOYSA-L zinc sulfate Chemical compound [Zn+2].[O-]S([O-])(=O)=O NWONKYPBYAMBJT-UHFFFAOYSA-L 0.000 description 1
- DGVVWUTYPXICAM-UHFFFAOYSA-N β‐Mercaptoethanol Chemical compound OCCS DGVVWUTYPXICAM-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/58—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving urea or urease
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/78—Hydrolases (3) acting on carbon to nitrogen bonds other than peptide bonds (3.5)
- C12N9/80—Hydrolases (3) acting on carbon to nitrogen bonds other than peptide bonds (3.5) acting on amide bonds in linear amides (3.5.1)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/96—Stabilising an enzyme by forming an adduct or a composition; Forming enzyme conjugates
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Genetics & Genomics (AREA)
- General Health & Medical Sciences (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- Biomedical Technology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Biophysics (AREA)
- Immunology (AREA)
- Enzymes And Modification Thereof (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE2612726A DE2612726C3 (de) | 1976-03-25 | 1976-03-25 | Stabilisierte Urease |
| DE2612726 | 1976-03-25 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| FI770294A7 FI770294A7 (fa) | 1977-09-26 |
| FI56536B FI56536B (fi) | 1979-10-31 |
| FI56536C true FI56536C (fi) | 1980-02-11 |
Family
ID=5973424
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FI770294A FI56536C (fi) | 1976-03-25 | 1977-01-28 | Mot aktivitetsfoerlust stabiliserat ureaspreparat |
Country Status (19)
| Country | Link |
|---|---|
| US (1) | US4188465A (fa) |
| JP (1) | JPS6027516B2 (fa) |
| AR (1) | AR210632A1 (fa) |
| AT (1) | AT349651B (fa) |
| AU (1) | AU509593B2 (fa) |
| BE (1) | BE852791A (fa) |
| BR (1) | BR7701770A (fa) |
| CA (1) | CA1086615A (fa) |
| CH (1) | CH629535A5 (fa) |
| DD (1) | DD129692A5 (fa) |
| DE (1) | DE2612726C3 (fa) |
| FI (1) | FI56536C (fa) |
| FR (1) | FR2345460A1 (fa) |
| GB (1) | GB1517146A (fa) |
| HU (1) | HU179124B (fa) |
| IT (1) | IT1076016B (fa) |
| NL (1) | NL188169C (fa) |
| SE (1) | SE428475B (fa) |
| SU (1) | SU743600A3 (fa) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4465770A (en) * | 1979-09-11 | 1984-08-14 | Modrovich Ivan Endre | Stabilized enzymic solutions for determining urea |
| US4282316A (en) * | 1979-09-11 | 1981-08-04 | Modrovich Ivan Endre | Stabilized enzymic solutions for determining urea |
| US4378430A (en) * | 1979-09-11 | 1983-03-29 | Modrovich Ivan Endre | Method of forming stabilized urease solutions |
| US4350659A (en) * | 1981-07-30 | 1982-09-21 | Corning Glass Works | Stabilization of sensitive biologically active intermediate metabolites such as folic acid derivatives |
| EP0213156A1 (en) * | 1985-02-11 | 1987-03-11 | Travenol-Genentech Diagnostics | Stabilized enzyme substrate solutions |
| AU2003296492A1 (en) * | 2002-12-11 | 2004-06-30 | Instrumentation Laboratory Company | Multi-analyte reference solutions |
| US20040154933A1 (en) * | 2003-02-11 | 2004-08-12 | Instrumentation Laboratory Company | Polymeric membranes for use in electrochemical sensors |
| US20040256227A1 (en) * | 2003-02-11 | 2004-12-23 | Jungwon Shin | Electrochemical urea sensors and methods of making the same |
| US20050176650A1 (en) * | 2004-02-09 | 2005-08-11 | Xanodyne Pharmacal, Inc. | Stable parenteral formulation of levomepromazine and a method for stabilizing said formulation |
| CN101854960B (zh) | 2006-12-15 | 2014-06-25 | 生命连结有限公司 | 明胶-转谷氨酰胺酶止血敷料和密封材料 |
| WO2009153748A2 (en) * | 2008-06-18 | 2009-12-23 | Lifebond Ltd | Methods and devices for use with sealants |
| EP2487206A3 (en) | 2008-06-18 | 2012-11-28 | Lifebond Ltd | Cross-linkable gelatin-based compositions |
| WO2009153751A2 (en) * | 2008-06-18 | 2009-12-23 | Lifebond Ltd | A method for enzymatic cross-linking of a protein |
| DE102009057050A1 (de) * | 2009-12-04 | 2011-06-09 | Torsten Beel | Urin-Indikator-Mittel |
| US9066991B2 (en) | 2009-12-22 | 2015-06-30 | Lifebond Ltd. | Modification of enzymatic crosslinkers for controlling properties of crosslinked matrices |
| DK2600910T3 (en) | 2010-08-05 | 2016-04-04 | Lifebond Ltd | Wound dressings and adhesives COMPREHENSIVE DRYING FORMATIONS |
| RU2563834C2 (ru) | 2010-08-20 | 2015-09-20 | Цитонет Гмбх Унд Ко. Кг | Способ выделения мочевины с удалением нежелательного со2 |
| US11998654B2 (en) | 2018-07-12 | 2024-06-04 | Bard Shannon Limited | Securing implants and medical devices |
| EP4731187A1 (en) * | 2023-06-20 | 2026-04-29 | Awak Technologies Pte Ltd | Immobilised urease formulations with improved shelf life |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR1321659A (fr) * | 1961-03-20 | 1963-03-22 | Albert L Chaney Chemical Lab | Méthode de dosage de l'azote dans les fluides biologiques |
| USRE26125E (en) * | 1962-05-08 | 1966-12-13 | Reagents and analysis of nitrogen | |
| US3527674A (en) * | 1966-06-30 | 1970-09-08 | Calbiochem | Reagent material and method for urea assay |
| US3542649A (en) * | 1967-04-07 | 1970-11-24 | Hoffmann La Roche | Color developing composition consisting of an enzyme,a salicylate and a hypochlorite donor |
| DE1758581C3 (de) * | 1968-06-29 | 1974-01-10 | Demag Ag, 4100 Duisburg | Stützvorrichtung für ein metallurgisches Gefäß, insbesondere für einen Stahlwerkskonverter |
| ZA733611B (en) * | 1972-10-11 | 1974-04-24 | Merck Patent Gmbh | Indicator for the determination of urea |
| DE2329174C2 (de) * | 1973-06-07 | 1975-07-24 | Boehringer Mannheim Gmbh, 6800 Mannheim | Verfahren zur quantitativen Bestimmung von Blutammoniak |
-
1976
- 1976-03-25 DE DE2612726A patent/DE2612726C3/de not_active Expired
-
1977
- 1977-01-07 AT AT05477A patent/AT349651B/de not_active IP Right Cessation
- 1977-01-12 AR AR266169A patent/AR210632A1/es active
- 1977-01-24 NL NLAANVRAGE7700686,A patent/NL188169C/xx not_active IP Right Cessation
- 1977-01-24 IT IT19581/77A patent/IT1076016B/it active
- 1977-01-24 CA CA270,368A patent/CA1086615A/en not_active Expired
- 1977-01-28 FI FI770294A patent/FI56536C/fi not_active IP Right Cessation
- 1977-02-15 SU SU772453752A patent/SU743600A3/ru active
- 1977-03-21 SE SE7703206A patent/SE428475B/xx not_active IP Right Cessation
- 1977-03-22 GB GB11994/77A patent/GB1517146A/en not_active Expired
- 1977-03-22 FR FR7708519A patent/FR2345460A1/fr active Granted
- 1977-03-23 CH CH369777A patent/CH629535A5/de not_active IP Right Cessation
- 1977-03-23 DD DD7700198026A patent/DD129692A5/xx unknown
- 1977-03-23 BR BR7701770A patent/BR7701770A/pt unknown
- 1977-03-23 AU AU23562/77A patent/AU509593B2/en not_active Expired
- 1977-03-23 BE BE176043A patent/BE852791A/xx not_active IP Right Cessation
- 1977-03-24 HU HU77BO1657A patent/HU179124B/hu unknown
- 1977-03-24 JP JP52032754A patent/JPS6027516B2/ja not_active Expired
- 1977-03-25 US US05/781,222 patent/US4188465A/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| FR2345460B1 (fa) | 1982-12-17 |
| HU179124B (en) | 1982-08-28 |
| SE428475B (sv) | 1983-07-04 |
| AT349651B (de) | 1979-04-25 |
| AR210632A1 (es) | 1977-08-31 |
| AU509593B2 (en) | 1980-05-15 |
| IT1076016B (it) | 1985-04-22 |
| SU743600A3 (ru) | 1980-06-25 |
| BE852791A (fr) | 1977-09-23 |
| US4188465A (en) | 1980-02-12 |
| DE2612726C3 (de) | 1979-03-15 |
| AU2356277A (en) | 1978-09-28 |
| DE2612726B2 (de) | 1978-07-06 |
| FI56536B (fi) | 1979-10-31 |
| BR7701770A (pt) | 1978-01-17 |
| CH629535A5 (de) | 1982-04-30 |
| CA1086615A (en) | 1980-09-30 |
| NL188169C (nl) | 1992-04-16 |
| FR2345460A1 (fr) | 1977-10-21 |
| NL7700686A (nl) | 1977-09-27 |
| DD129692A5 (de) | 1978-02-01 |
| JPS52117488A (en) | 1977-10-01 |
| DE2612726A1 (de) | 1977-10-06 |
| FI770294A7 (fa) | 1977-09-26 |
| JPS6027516B2 (ja) | 1985-06-29 |
| SE7703206L (sv) | 1977-09-26 |
| NL188169B (nl) | 1991-11-18 |
| GB1517146A (en) | 1978-07-12 |
| ATA5477A (de) | 1978-09-15 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MM | Patent lapsed | ||
| MM | Patent lapsed |
Owner name: BOEHRINGER MANNHEIM GMBH |