FI3852748T3 - Farnesoid x -reseptoriagonisteja ja niiden käyttötapoja - Google Patents
Farnesoid x -reseptoriagonisteja ja niiden käyttötapojaInfo
- Publication number
- FI3852748T3 FI3852748T3 FIEP19862391.0T FI19862391T FI3852748T3 FI 3852748 T3 FI3852748 T3 FI 3852748T3 FI 19862391 T FI19862391 T FI 19862391T FI 3852748 T3 FI3852748 T3 FI 3852748T3
- Authority
- FI
- Finland
- Prior art keywords
- alkyl
- pharmaceutically acceptable
- solvate
- acceptable salt
- compound according
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
- C07D471/14—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Gastroenterology & Hepatology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Rheumatology (AREA)
- Pain & Pain Management (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Virology (AREA)
- Molecular Biology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Biotechnology (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201862733006P | 2018-09-18 | 2018-09-18 | |
| US201862733004P | 2018-09-18 | 2018-09-18 | |
| US201962881560P | 2019-08-01 | 2019-08-01 | |
| PCT/US2019/051603 WO2020061113A1 (en) | 2018-09-18 | 2019-09-17 | Farnesoid x receptor agonists and uses thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| FI3852748T3 true FI3852748T3 (fi) | 2025-10-22 |
Family
ID=69887982
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FIEP19862391.0T FI3852748T3 (fi) | 2018-09-18 | 2019-09-17 | Farnesoid x -reseptoriagonisteja ja niiden käyttötapoja |
Country Status (27)
| Country | Link |
|---|---|
| US (4) | US11084817B2 (enExample) |
| EP (2) | EP4596543A3 (enExample) |
| JP (1) | JP7554739B2 (enExample) |
| KR (2) | KR102810978B1 (enExample) |
| CN (1) | CN113056271B (enExample) |
| AU (2) | AU2019344903B2 (enExample) |
| BR (1) | BR112021004919A2 (enExample) |
| CA (1) | CA3112411A1 (enExample) |
| CL (1) | CL2021000632A1 (enExample) |
| DK (1) | DK3852748T3 (enExample) |
| ES (1) | ES3051007T3 (enExample) |
| FI (1) | FI3852748T3 (enExample) |
| HR (1) | HRP20251321T1 (enExample) |
| IL (1) | IL281475B2 (enExample) |
| LT (1) | LT3852748T (enExample) |
| MA (1) | MA53665B1 (enExample) |
| MD (1) | MD3852748T2 (enExample) |
| MX (1) | MX2021003110A (enExample) |
| PH (1) | PH12021550605A1 (enExample) |
| PL (1) | PL3852748T3 (enExample) |
| PT (1) | PT3852748T (enExample) |
| RS (1) | RS67371B1 (enExample) |
| SG (1) | SG11202102651SA (enExample) |
| SI (1) | SI3852748T1 (enExample) |
| SM (1) | SMT202600076T1 (enExample) |
| TW (1) | TWI833805B (enExample) |
| WO (1) | WO2020061113A1 (enExample) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| LT3609888T (lt) * | 2017-03-15 | 2025-11-10 | Farnezoidinio x receptoriaus agonistai ir jų panaudojimas | |
| IL269068B (en) | 2017-03-15 | 2022-09-01 | Metacrine Inc | Paranoid x receptor agonists and uses thereof |
| CN113056271B (zh) | 2018-09-18 | 2024-10-29 | 奥加诺沃公司 | 法尼醇x受体激动剂及其用途 |
| WO2021144330A1 (en) | 2020-01-15 | 2021-07-22 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Use of fxr agonists for treating an infection by hepatitis d virus |
| WO2021188695A1 (en) * | 2020-03-18 | 2021-09-23 | Metacrine, Inc. | Formulations of a farnesoid x receptor agonist |
| CN120732854A (zh) * | 2020-03-18 | 2025-10-03 | 伊莱利利公司 | 用于治疗疾病的法尼醇x受体激动剂 |
| IL296532A (en) * | 2020-03-18 | 2022-11-01 | Metacrine Inc | Crystal forms of farnesoid x receptor agonist |
| KR20230154806A (ko) | 2021-01-14 | 2023-11-09 | 엔요 파마 | Hbv 감염 치료를 위한 fxr 작용제 및 ifn의 상승작용효과 |
| CN117320722A (zh) | 2021-04-28 | 2023-12-29 | 埃尼奥制药公司 | 使用fxr激动剂作为联合治疗强烈增强tlr3激动剂的作用 |
| CN116554121A (zh) * | 2023-05-05 | 2023-08-08 | 济南悟通生物科技有限公司 | 一种2-异丁基噻唑的合成方法 |
Family Cites Families (68)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE60023492T2 (de) | 1999-05-17 | 2006-07-20 | Novo Nordisk A/S | Glucagon antagonisten/inverse agonisten |
| WO2000071518A2 (en) | 1999-05-25 | 2000-11-30 | Sepracor, Inc. | Heterocyclic analgesic compounds and their use |
| US6511980B2 (en) | 2000-05-05 | 2003-01-28 | Ortho Mcneil Pharmaceutical, Inc. | Substituted diamine derivatives useful as motilin antagonists |
| AU2001216218A1 (en) | 2000-05-25 | 2001-12-11 | Sepracor, Inc. | Heterocyclic analgesic compounds and method of use thereof |
| US20040102431A1 (en) | 2000-09-25 | 2004-05-27 | Christoph Boss | Substituted amino-aza-cycloalkanes useful against malaria |
| FR2815032B1 (fr) | 2000-10-10 | 2003-08-08 | Pf Medicament | Nouveaux derives d'aminophenyle piperazine ou d'amino phenyle piperide inhibiteurs de proteines prenyl transferase ainsi que leurs preparations |
| FR2825706B1 (fr) | 2001-06-06 | 2003-12-12 | Pf Medicament | Nouveaux derives de benzothienyle ou d'indole, leur preparation et leur utilisation comme inhibiteurs de proteines prenyl transferase |
| FR2839974B1 (fr) | 2002-05-24 | 2004-07-16 | Pf Medicament | Derives de phenyl-furane ou de phenyl-thiophene,leur preparation et leur application a titre de medicament |
| WO2004009549A2 (en) | 2002-07-18 | 2004-01-29 | Actelion Pharmaceuticals Ltd | Piperidines useful for the treatment of central nervous system disorders |
| WO2004026823A1 (en) | 2002-09-20 | 2004-04-01 | Pfizer Products Inc. | Amide and sulfonamide ligands for the estrogen receptor |
| AU2003290796A1 (en) | 2002-11-14 | 2004-06-15 | The Scripps Research Institute | Non-steroidal fxr agonists |
| US20050143449A1 (en) | 2002-11-15 | 2005-06-30 | The Salk Institute For Biological Studies | Non-steroidal farnesoid X receptor modulators and methods for the use thereof |
| AU2003298654A1 (en) | 2002-11-15 | 2004-06-15 | The Salk Institute For Biological Studies | Structure of the farnesoid x receptor ligand binding domain and methods of use therefor |
| GB0309781D0 (en) | 2003-04-29 | 2003-06-04 | Glaxo Group Ltd | Compounds |
| PL1648874T3 (pl) | 2003-07-30 | 2012-04-30 | Xenon Pharmaceuticals Inc | Pochodne piperazyny i ich zastosowanie jako środków leczniczych |
| US7754711B2 (en) | 2003-07-30 | 2010-07-13 | Xenon Pharmaceuticals Inc. | Pyridazine derivatives and their use as therapeutic agents |
| US7759348B2 (en) | 2003-07-30 | 2010-07-20 | Xenon Pharmaceuticals Inc. | Pyridazine derivatives and their use as therapeutic agents |
| WO2005058822A1 (en) | 2003-12-17 | 2005-06-30 | Actelion Pharmaceuticals Ltd | Substituted amino-cycloalkanes |
| JP2007530582A (ja) | 2004-03-26 | 2007-11-01 | ライジェル ファーマシューティカルズ， インコーポレイテッド | 代謝可能部分を含む複素環抗ウイルス化合物およびその使用 |
| WO2005113522A1 (en) | 2004-05-07 | 2005-12-01 | Janssen Pharmaceutica, N.V. | Azole carboxamide inhibitors of bacterial type iii protein secretion systems |
| JP2006199656A (ja) | 2005-01-24 | 2006-08-03 | Kowa Co | アミド基を有する環状アミン化合物 |
| MY144229A (en) | 2006-01-26 | 2011-08-15 | Xenon Pharmaceuticals Inc | Pyridazine derivatives and their use as therapeutic agents |
| MX2008012404A (es) | 2006-03-28 | 2008-10-09 | Novartis Ag | Derivados de amida y su aplicacion para el tratamiento de enfermedades relacionadas con proteina-g. |
| US20080081824A1 (en) | 2006-09-29 | 2008-04-03 | Bristol-Myers Squibb Company | Substituted piperidines as modulators of chemokine receptor activity |
| WO2008065500A2 (en) | 2006-11-30 | 2008-06-05 | Pfizer Products Inc. | Heteroaryl amides as type i glycine transport inhibitors |
| CN101903351B (zh) | 2007-12-19 | 2014-09-10 | 贝林格尔.英格海姆国际有限公司 | 病毒聚合酶抑制剂 |
| WO2010001869A1 (ja) | 2008-06-30 | 2010-01-07 | 武田薬品工業株式会社 | ４置換ベンゼン化合物およびその用途 |
| JP2010077109A (ja) | 2008-08-28 | 2010-04-08 | Takeda Chem Ind Ltd | 複素環化合物およびその用途 |
| CN102471339A (zh) | 2009-07-15 | 2012-05-23 | 雅培制药有限公司 | 激酶的吡咯并吡啶抑制剂 |
| JP2012532914A (ja) | 2009-07-15 | 2012-12-20 | メルク セローノ ソシエテ アノニム | テトラゾール誘導体 |
| FR2963005B1 (fr) | 2010-07-23 | 2012-08-17 | Sanofi Aventis | Derives d'oxadiazoles et de pyridazines, leur preparation et leur application en therapeutique |
| SI2688403T1 (sl) | 2011-03-23 | 2017-08-31 | Trevena, Inc. | Ligandi opioidnih receptorjev in metode uporabe in izdelave istega |
| EP2545964A1 (en) | 2011-07-13 | 2013-01-16 | Phenex Pharmaceuticals AG | Novel FXR (NR1H4) binding and activity modulating compounds |
| US9492763B2 (en) | 2011-07-13 | 2016-11-15 | M. Technique Co., Ltd. | Method for producing microparticles having controlled crystallite diameter |
| RU2543485C2 (ru) | 2013-02-26 | 2015-03-10 | Андрей Александрович Иващенко | Гетероциклические агонисты рецепторов желчных кислот tgr5, фармацевтическая композиция, способы их получения и применения |
| GB201316824D0 (en) | 2013-09-23 | 2013-11-06 | R & D Vernalis Ltd | New Chemical Entities |
| US20150258052A1 (en) | 2014-03-13 | 2015-09-17 | Salk Institute For Biological Studies | Methods of using fexaramine and agents that increase sympathetic nervous system activity to promote browning of white adipose tissue |
| AU2015229055B2 (en) | 2014-03-13 | 2019-09-12 | Salk Institute For Biological Studies | Analogs of fexaramine and methods of making and using |
| US10301268B2 (en) | 2014-03-13 | 2019-05-28 | The Salk Institute For Biological Studies | Analogs of fexaramine and methods of making and using |
| US10077268B2 (en) | 2014-03-13 | 2018-09-18 | Salk Institute For Biological Studies | FXR agonists and methods for making and using |
| EP3116878A4 (en) | 2014-03-13 | 2018-02-14 | Salk Institute for Biological Studies | Fxr agonists and methods for making and using |
| WO2016116054A1 (en) | 2015-01-22 | 2016-07-28 | Xiamen University | Modulators of farnesoid x receptor and methods for the use thereof |
| JP2018510866A (ja) | 2015-03-13 | 2018-04-19 | ソーク インスティテュート フォー バイオロジカル スタディーズ | 腸受容体を活性化させるための、ファルネソイドｘ受容体アゴニストでの、成体の潜在性自己免疫性糖尿病の治療 |
| WO2017018751A1 (ko) | 2015-07-24 | 2017-02-02 | 동국대학교 산학협력단 | Blt 저해 활성을 갖는 신규 화합물 및 이를 유효성분으로 포함하는 염증성 질환 예방 또는 치료용 조성물 |
| JP2018536016A (ja) * | 2015-09-16 | 2018-12-06 | メタクリン，インク． | ファルネソイドｘ受容体アゴニストとその使用 |
| EP3350166A4 (en) * | 2015-09-16 | 2019-05-01 | Metacrine, Inc. | FARNESOID-X RECEPTOR AGONISTS AND USES THEREOF |
| WO2017049173A1 (en) | 2015-09-16 | 2017-03-23 | Metacrine, Inc. | Farnesoid x receptor agonists and uses thereof |
| EP3350158A4 (en) | 2015-09-16 | 2019-05-08 | Metacrine, Inc. | Farnesoid x receptor agonists and uses thereof |
| CN105477636B (zh) * | 2015-10-16 | 2019-09-17 | 厦门大学 | 使用阿维菌素及其衍生物治疗代谢疾病的方法 |
| CN107126419B (zh) | 2016-02-26 | 2020-06-19 | 石药集团中诺药业（石家庄）有限公司 | 一种奥贝胆酸片剂及其制备方法 |
| WO2017170182A1 (ja) | 2016-03-31 | 2017-10-05 | 株式会社Adeka | 感光性組成物及び新規化合物 |
| WO2018170165A1 (en) | 2017-03-15 | 2018-09-20 | Metacrine, Inc. | Farnesoid x receptor agonists and uses thereof |
| WO2018170167A1 (en) | 2017-03-15 | 2018-09-20 | Metacrine, Inc. | Farnesoid x receptor agonists and uses thereof |
| IL269068B (en) | 2017-03-15 | 2022-09-01 | Metacrine Inc | Paranoid x receptor agonists and uses thereof |
| WO2018170173A1 (en) | 2017-03-15 | 2018-09-20 | Metacrine, Inc. | Farnesoid x receptor agonists and uses thereof |
| LT3609888T (lt) | 2017-03-15 | 2025-11-10 | Farnezoidinio x receptoriaus agonistai ir jų panaudojimas | |
| CZ2017298A3 (cs) | 2017-05-26 | 2018-12-05 | Zentiva, K.S. | Amorfní formy obeticholové kyseliny |
| WO2020060007A1 (ko) | 2018-09-17 | 2020-03-26 | 엘지전자 주식회사 | 5g 이동통신에서 pdu 세션을 핸들링하는 방법 및 무선 기기 |
| MA53671A (fr) | 2018-09-18 | 2021-07-28 | Metacrine Inc | Formes cristallines d'un agoniste du récepteur farnésoïde x |
| EA202190661A1 (ru) | 2018-09-18 | 2021-08-13 | Метакрайн, Инк. | Агонисты фарнезоидного х-рецептора для лечения заболевания |
| WO2020061118A1 (en) | 2018-09-18 | 2020-03-26 | Metacrine, Inc. | Farnesoid x receptor agonists and uses thereof |
| CN113056271B (zh) | 2018-09-18 | 2024-10-29 | 奥加诺沃公司 | 法尼醇x受体激动剂及其用途 |
| WO2020061116A1 (en) | 2018-09-18 | 2020-03-26 | Metacrine, Inc. | Farnesoid x receptor agonists and uses thereof |
| US20220054469A1 (en) | 2018-09-18 | 2022-02-24 | Metacrine, Inc. | Farnesoid x receptor agonists and uses thereof |
| JP2022500393A (ja) | 2018-09-18 | 2022-01-04 | メタクリン，インク． | ファルネソイドｘ受容体アゴニストおよびその使用 |
| IL296532A (en) | 2020-03-18 | 2022-11-01 | Metacrine Inc | Crystal forms of farnesoid x receptor agonist |
| CN120732854A (zh) | 2020-03-18 | 2025-10-03 | 伊莱利利公司 | 用于治疗疾病的法尼醇x受体激动剂 |
| WO2021188695A1 (en) | 2020-03-18 | 2021-09-23 | Metacrine, Inc. | Formulations of a farnesoid x receptor agonist |
-
2019
- 2019-09-17 CN CN201980075902.2A patent/CN113056271B/zh active Active
- 2019-09-17 SI SI201930976T patent/SI3852748T1/sl unknown
- 2019-09-17 PT PT198623910T patent/PT3852748T/pt unknown
- 2019-09-17 DK DK19862391.0T patent/DK3852748T3/da active
- 2019-09-17 TW TW108133441A patent/TWI833805B/zh active
- 2019-09-17 ES ES19862391T patent/ES3051007T3/es active Active
- 2019-09-17 BR BR112021004919-3A patent/BR112021004919A2/pt unknown
- 2019-09-17 WO PCT/US2019/051603 patent/WO2020061113A1/en not_active Ceased
- 2019-09-17 SG SG11202102651SA patent/SG11202102651SA/en unknown
- 2019-09-17 EP EP25178478.1A patent/EP4596543A3/en active Pending
- 2019-09-17 LT LTEPPCT/US2019/051603T patent/LT3852748T/lt unknown
- 2019-09-17 CA CA3112411A patent/CA3112411A1/en active Pending
- 2019-09-17 AU AU2019344903A patent/AU2019344903B2/en active Active
- 2019-09-17 EP EP19862391.0A patent/EP3852748B1/en active Active
- 2019-09-17 MA MA53665A patent/MA53665B1/fr unknown
- 2019-09-17 JP JP2021513407A patent/JP7554739B2/ja active Active
- 2019-09-17 KR KR1020217011359A patent/KR102810978B1/ko active Active
- 2019-09-17 HR HRP20251321TT patent/HRP20251321T1/hr unknown
- 2019-09-17 RS RS20251101A patent/RS67371B1/sr unknown
- 2019-09-17 FI FIEP19862391.0T patent/FI3852748T3/fi active
- 2019-09-17 KR KR1020257016139A patent/KR20250073553A/ko active Pending
- 2019-09-17 MX MX2021003110A patent/MX2021003110A/es unknown
- 2019-09-17 SM SM20260076T patent/SMT202600076T1/it unknown
- 2019-09-17 MD MDE20210696T patent/MD3852748T2/ro unknown
- 2019-09-17 IL IL281475A patent/IL281475B2/en unknown
- 2019-09-17 PL PL19862391.0T patent/PL3852748T3/pl unknown
- 2019-09-17 US US16/573,993 patent/US11084817B2/en active Active
-
2021
- 2021-03-16 CL CL2021000632A patent/CL2021000632A1/es unknown
- 2021-03-17 PH PH12021550605A patent/PH12021550605A1/en unknown
- 2021-06-16 US US17/349,757 patent/US11773094B2/en active Active
-
2023
- 2023-07-17 US US18/353,659 patent/US20230382913A1/en not_active Abandoned
-
2024
- 2024-10-31 US US18/933,587 patent/US20250289821A1/en active Pending
-
2025
- 2025-05-22 AU AU2025203804A patent/AU2025203804A1/en active Pending
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| FI3852748T3 (fi) | Farnesoid x -reseptoriagonisteja ja niiden käyttötapoja | |
| CL2021002883A1 (es) | Moduladores de thr-ß y métodos de uso de estos | |
| JP2016518434A5 (enExample) | ||
| SI2997033T1 (en) | FUZYCLE TRICYCLE HETEROCYCLIC COMPOUNDS AS HIV INTEGRATED INHIBITORS | |
| AR089865A1 (es) | Derivados de bencimidazol e imidazopiridinas como moduladores de canales de sodio | |
| RU2004139063A (ru) | Ингибиторы 11-бэта-гидроксистероидной дегидрогеназы 1, полезные для лечения сахарного диабета, ожирения и дислипидемии | |
| JP2017537940A5 (enExample) | ||
| JP2018510139A5 (enExample) | ||
| AR060618A1 (es) | Compuesto de ciclohexilpirazol-lactama composicion farmaceutica que comprende dicho compuesto su uso para la preparacion de un medicamento e intermediarios para prepararlo | |
| MX2015011878A (es) | Compuestos aromaticos sustituidos y metodo relacionado para el tratamiento de la fibrosis. | |
| AR074171A1 (es) | Derivados de pirazolopiridina, composicion farmaceutica que los comprende y su uso en el tratamiento de afecciones mediadas por pkctheta | |
| NI202000055A (es) | Inhibidores de arginasa y sus métodos de uso | |
| AR116694A1 (es) | COMPUESTOS AGONISTAS b DEL RECEPTOR DE LA HORMONA TIROIDEA | |
| AR020727A1 (es) | Uso de compuestos derivados 3-amino-4-aril-maleimidas para la preparacion de medicamentos para condiciones asociadas a una necesidad de inhibicion de lagsk-3, dichos compuestos, procedimiento para su preparacion y composiciones farmaceuticas que los comprenden | |
| AR072373A1 (es) | Tiadiazoliloxifenilamidinas, el uso de las mismas como fungicidas en composiciones y metodos de uso, proceso para su preparacion e intermediarios de sus sintesis. | |
| AR049284A1 (es) | Compuestos derivados de 1,3-tiazol; composiciones farmaceuticas que los contienen y su uso en la preparacion de medicamentos para el tratamiento de enfermedades asociadas a la actividad de los ppard | |
| AR074352A1 (es) | Acidos naftalen-2-il-aceticos sustituidos, composiciones farmaceuticas que los contienen, y uso de los mismos en el tratamiento de enfermedades alergicas,tales como rinitis, asma y dermatitis atopica. | |
| CO5160338A1 (es) | 2-(arilimino)tiazolidinas-oxazolidinas y anillos homologos de las mismas, y composiciones que los contienen para ser usadas como agentes de union de receptores de progesterona | |
| RU2020132293A (ru) | Амидные пролекарства низкомолекулярных модуляторов ядерных рецепторов | |
| AR062396A1 (es) | Uso de derivados de 2,5-dihidroxibenceno para el tratamiento de enfermedades angiogenicas | |
| MX9100675A (es) | 2-amino-1,2,3,4-tetrahidronaftalenos,3-aminocromanos y 3-aminotiocromanos substituidos en el anillo,procedimiento para su preparacion y composiciones farmaceuticas que los contienen | |
| JP2008543785A5 (enExample) | ||
| AR062405A1 (es) | Derivados de isoindol | |
| JP2019535813A5 (enExample) | ||
| AR110590A1 (es) | Activador de nrf2 |