FI3681911T3 - Ihmisen trombiinireseptori PAR4:ään sitoutuvia proteiineja - Google Patents
Ihmisen trombiinireseptori PAR4:ään sitoutuvia proteiineja Download PDFInfo
- Publication number
- FI3681911T3 FI3681911T3 FIEP18853261.8T FI18853261T FI3681911T3 FI 3681911 T3 FI3681911 T3 FI 3681911T3 FI 18853261 T FI18853261 T FI 18853261T FI 3681911 T3 FI3681911 T3 FI 3681911T3
- Authority
- FI
- Finland
- Prior art keywords
- seq
- seo
- cdr2
- cdr1
- cdr3 sequences
- Prior art date
Links
- 108091008324 binding proteins Proteins 0.000 title claims 16
- 102000014914 Carrier Proteins Human genes 0.000 title 1
- 101001098529 Homo sapiens Proteinase-activated receptor 1 Proteins 0.000 title 1
- 101710162991 PRKC apoptosis WT1 regulator protein Proteins 0.000 title 1
- 102100040853 PRKC apoptosis WT1 regulator protein Human genes 0.000 title 1
- 101100112922 Candida albicans CDR3 gene Proteins 0.000 claims 32
- 102100035361 Cerebellar degeneration-related protein 2 Human genes 0.000 claims 32
- 101000737796 Homo sapiens Cerebellar degeneration-related protein 2 Proteins 0.000 claims 32
- 102100035360 Cerebellar degeneration-related antigen 1 Human genes 0.000 claims 29
- 101000737793 Homo sapiens Cerebellar degeneration-related antigen 1 Proteins 0.000 claims 29
- 102000004885 Protease-activated receptor 4 Human genes 0.000 claims 18
- 108090001010 Protease-activated receptor 4 Proteins 0.000 claims 18
- 102000023732 binding proteins Human genes 0.000 claims 15
- 102000004169 proteins and genes Human genes 0.000 claims 7
- 108090000623 proteins and genes Proteins 0.000 claims 7
- 239000000203 mixture Substances 0.000 claims 5
- 150000007523 nucleic acids Chemical class 0.000 claims 5
- 108020004707 nucleic acids Proteins 0.000 claims 3
- 102000039446 nucleic acids Human genes 0.000 claims 3
- 101100407050 Homo sapiens F2RL3 gene Proteins 0.000 claims 2
- 101100518982 Homo sapiens PAWR gene Proteins 0.000 claims 2
- 108091028043 Nucleic acid sequence Proteins 0.000 claims 2
- 108090000190 Thrombin Proteins 0.000 claims 2
- 239000000427 antigen Substances 0.000 claims 2
- 102000036639 antigens Human genes 0.000 claims 2
- 108091007433 antigens Proteins 0.000 claims 2
- 238000003776 cleavage reaction Methods 0.000 claims 2
- 150000001875 compounds Chemical class 0.000 claims 2
- 239000012634 fragment Substances 0.000 claims 2
- 230000007017 scission Effects 0.000 claims 2
- 229960004072 thrombin Drugs 0.000 claims 2
- 101100135626 Homo sapiens F2R gene Proteins 0.000 claims 1
- 101100135642 Homo sapiens F2RL2 gene Proteins 0.000 claims 1
- 101100082348 Homo sapiens PARD3 gene Proteins 0.000 claims 1
- 101001098560 Homo sapiens Proteinase-activated receptor 2 Proteins 0.000 claims 1
- 102000017727 Immunoglobulin Variable Region Human genes 0.000 claims 1
- 108010067060 Immunoglobulin Variable Region Proteins 0.000 claims 1
- 102100037132 Proteinase-activated receptor 2 Human genes 0.000 claims 1
- 102100037133 Proteinase-activated receptor 3 Human genes 0.000 claims 1
- 208000007536 Thrombosis Diseases 0.000 claims 1
- 210000004027 cell Anatomy 0.000 claims 1
- 239000000084 colloidal system Substances 0.000 claims 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 1
- 230000002265 prevention Effects 0.000 claims 1
- 108090000765 processed proteins & peptides Proteins 0.000 claims 1
- 230000001225 therapeutic effect Effects 0.000 claims 1
- 230000009424 thromboembolic effect Effects 0.000 claims 1
- 239000003053 toxin Substances 0.000 claims 1
- 231100000765 toxin Toxicity 0.000 claims 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6835—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
- A61K47/6849—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody targeting a receptor, a cell surface antigen or a cell surface determinant
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/52—Constant or Fc region; Isotype
- C07K2317/524—CH2 domain
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/52—Constant or Fc region; Isotype
- C07K2317/526—CH3 domain
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
- C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
- C07K2317/622—Single chain antibody (scFv)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Immunology (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Diabetes (AREA)
- General Chemical & Material Sciences (AREA)
- Hematology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Epidemiology (AREA)
- Cell Biology (AREA)
- Endocrinology (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| AU2017903685A AU2017903685A0 (en) | 2017-09-11 | Antagonists of the human thrombin receptor, PAR4 | |
| PCT/AU2018/050985 WO2019046912A1 (en) | 2017-09-11 | 2018-09-11 | HUMAN THROMBIN RECEPTOR BINDING PROTEINS, PAR4 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| FI3681911T3 true FI3681911T3 (fi) | 2024-12-30 |
Family
ID=65633328
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FIEP18853261.8T FI3681911T3 (fi) | 2017-09-11 | 2018-09-11 | Ihmisen trombiinireseptori PAR4:ään sitoutuvia proteiineja |
Country Status (17)
| Country | Link |
|---|---|
| US (2) | US11780915B2 (enExample) |
| EP (2) | EP3681911B1 (enExample) |
| JP (2) | JP7733443B2 (enExample) |
| KR (1) | KR102755742B1 (enExample) |
| CN (1) | CN111670198B (enExample) |
| AU (1) | AU2018328764B2 (enExample) |
| CA (1) | CA3075523A1 (enExample) |
| DK (1) | DK3681911T3 (enExample) |
| ES (1) | ES2999094T3 (enExample) |
| FI (1) | FI3681911T3 (enExample) |
| HR (1) | HRP20241684T1 (enExample) |
| HU (1) | HUE069649T2 (enExample) |
| IL (1) | IL273202B2 (enExample) |
| LT (1) | LT3681911T (enExample) |
| PT (1) | PT3681911T (enExample) |
| SI (1) | SI3681911T1 (enExample) |
| WO (1) | WO2019046912A1 (enExample) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3681911B1 (en) * | 2017-09-11 | 2024-11-27 | Monash University | Binding proteins to the human thrombin receptor, par4 |
| CN112852958A (zh) * | 2021-04-04 | 2021-05-28 | 吉林大学 | 一种检测替格瑞洛抗血小板效果的试剂盒 |
| CN115558015B (zh) * | 2022-10-12 | 2024-01-19 | 生工生物工程（上海）股份有限公司 | 一种从gst融合蛋白酶切后的产物中纯化无gst标签的目的蛋白的方法和产品 |
Family Cites Families (75)
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| US4676A (en) | 1846-07-31 | roller | ||
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| US4554101A (en) | 1981-01-09 | 1985-11-19 | New York Blood Center, Inc. | Identification and preparation of epitopes on antigens and allergens on the basis of hydrophilicity |
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| EP3681911B1 (en) | 2017-09-11 | 2024-11-27 | Monash University | Binding proteins to the human thrombin receptor, par4 |
-
2018
- 2018-09-11 EP EP18853261.8A patent/EP3681911B1/en active Active
- 2018-09-11 HR HRP20241684TT patent/HRP20241684T1/hr unknown
- 2018-09-11 US US16/646,554 patent/US11780915B2/en active Active
- 2018-09-11 SI SI201831187T patent/SI3681911T1/sl unknown
- 2018-09-11 WO PCT/AU2018/050985 patent/WO2019046912A1/en not_active Ceased
- 2018-09-11 PT PT188532618T patent/PT3681911T/pt unknown
- 2018-09-11 HU HUE18853261A patent/HUE069649T2/hu unknown
- 2018-09-11 CA CA3075523A patent/CA3075523A1/en active Pending
- 2018-09-11 AU AU2018328764A patent/AU2018328764B2/en active Active
- 2018-09-11 FI FIEP18853261.8T patent/FI3681911T3/fi active
- 2018-09-11 EP EP24208786.4A patent/EP4512469A3/en active Pending
- 2018-09-11 ES ES18853261T patent/ES2999094T3/es active Active
- 2018-09-11 KR KR1020207010495A patent/KR102755742B1/ko active Active
- 2018-09-11 DK DK18853261.8T patent/DK3681911T3/da active
- 2018-09-11 IL IL273202A patent/IL273202B2/en unknown
- 2018-09-11 LT LTEPPCT/AU2018/050985T patent/LT3681911T/lt unknown
- 2018-09-11 JP JP2020535276A patent/JP7733443B2/ja active Active
- 2018-09-11 CN CN201880072254.0A patent/CN111670198B/zh active Active
-
2023
- 2023-05-29 JP JP2023087663A patent/JP2023116543A/ja active Pending
- 2023-08-30 US US18/240,347 patent/US12441790B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| EP3681911B1 (en) | 2024-11-27 |
| DK3681911T3 (da) | 2024-12-09 |
| HRP20241684T1 (hr) | 2025-02-14 |
| US20240117031A1 (en) | 2024-04-11 |
| IL273202B2 (en) | 2024-08-01 |
| JP2020533022A (ja) | 2020-11-19 |
| IL273202A (en) | 2020-04-30 |
| EP4512469A3 (en) | 2025-05-21 |
| US20210179707A1 (en) | 2021-06-17 |
| SI3681911T1 (sl) | 2025-01-31 |
| JP7733443B2 (ja) | 2025-09-03 |
| EP3681911A1 (en) | 2020-07-22 |
| CN111670198A (zh) | 2020-09-15 |
| KR102755742B1 (ko) | 2025-01-15 |
| IL273202B1 (en) | 2024-04-01 |
| CA3075523A1 (en) | 2019-03-14 |
| KR20200063159A (ko) | 2020-06-04 |
| US11780915B2 (en) | 2023-10-10 |
| JP2023116543A (ja) | 2023-08-22 |
| EP3681911A4 (en) | 2021-06-02 |
| CN111670198B (zh) | 2023-12-15 |
| AU2018328764A1 (en) | 2020-04-02 |
| AU2018328764B2 (en) | 2025-01-09 |
| LT3681911T (lt) | 2025-01-10 |
| US12441790B2 (en) | 2025-10-14 |
| PT3681911T (pt) | 2024-12-18 |
| EP4512469A2 (en) | 2025-02-26 |
| HUE069649T2 (hu) | 2025-04-28 |
| WO2019046912A1 (en) | 2019-03-14 |
| ES2999094T3 (en) | 2025-02-24 |
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