AU2018328764B2 - Binding proteins to the human thrombin receptor, PAR4 - Google Patents

Binding proteins to the human thrombin receptor, PAR4 Download PDF

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Publication number
AU2018328764B2
AU2018328764B2 AU2018328764A AU2018328764A AU2018328764B2 AU 2018328764 B2 AU2018328764 B2 AU 2018328764B2 AU 2018328764 A AU2018328764 A AU 2018328764A AU 2018328764 A AU2018328764 A AU 2018328764A AU 2018328764 B2 AU2018328764 B2 AU 2018328764B2
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seq
par4
sequence
set forth
antibody
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AU2018328764A1 (en
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Justin Hamilton
Mark Sleeman
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Monash University
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Monash University
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Priority claimed from AU2017903685A external-priority patent/AU2017903685A0/en
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A61K47/6835—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
    • A61K47/6849—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody targeting a receptor, a cell surface antigen or a cell surface determinant
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C07K2317/524—CH2 domain
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C07K2317/526—CH3 domain
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
    • C07K2317/622—Single chain antibody (scFv)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Immunology (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Diabetes (AREA)
  • General Chemical & Material Sciences (AREA)
  • Hematology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Cell Biology (AREA)
  • Endocrinology (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
AU2018328764A 2017-09-11 2018-09-11 Binding proteins to the human thrombin receptor, PAR4 Active AU2018328764B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
AU2017903685A AU2017903685A0 (en) 2017-09-11 Antagonists of the human thrombin receptor, PAR4
AU2017903685 2017-09-11
PCT/AU2018/050985 WO2019046912A1 (en) 2017-09-11 2018-09-11 HUMAN THROMBIN RECEPTOR BINDING PROTEINS, PAR4

Publications (2)

Publication Number Publication Date
AU2018328764A1 AU2018328764A1 (en) 2020-04-02
AU2018328764B2 true AU2018328764B2 (en) 2025-01-09

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AU2018328764A Active AU2018328764B2 (en) 2017-09-11 2018-09-11 Binding proteins to the human thrombin receptor, PAR4

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EP (2) EP3681911B1 (enExample)
JP (2) JP7733443B2 (enExample)
KR (1) KR102755742B1 (enExample)
CN (1) CN111670198B (enExample)
AU (1) AU2018328764B2 (enExample)
CA (1) CA3075523A1 (enExample)
DK (1) DK3681911T3 (enExample)
ES (1) ES2999094T3 (enExample)
FI (1) FI3681911T3 (enExample)
HR (1) HRP20241684T1 (enExample)
HU (1) HUE069649T2 (enExample)
IL (1) IL273202B2 (enExample)
LT (1) LT3681911T (enExample)
PT (1) PT3681911T (enExample)
SI (1) SI3681911T1 (enExample)
WO (1) WO2019046912A1 (enExample)

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Publication number Priority date Publication date Assignee Title
EP3681911B1 (en) * 2017-09-11 2024-11-27 Monash University Binding proteins to the human thrombin receptor, par4
CN112852958A (zh) * 2021-04-04 2021-05-28 吉林大学 一种检测替格瑞洛抗血小板效果的试剂盒
CN115558015B (zh) * 2022-10-12 2024-01-19 生工生物工程（上海）股份有限公司 一种从gst融合蛋白酶切后的产物中纯化无gst标签的目的蛋白的方法和产品

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Also Published As

Publication number Publication date
EP3681911B1 (en) 2024-11-27
DK3681911T3 (da) 2024-12-09
HRP20241684T1 (hr) 2025-02-14
US20240117031A1 (en) 2024-04-11
IL273202B2 (en) 2024-08-01
JP2020533022A (ja) 2020-11-19
IL273202A (en) 2020-04-30
EP4512469A3 (en) 2025-05-21
US20210179707A1 (en) 2021-06-17
FI3681911T3 (fi) 2024-12-30
SI3681911T1 (sl) 2025-01-31
JP7733443B2 (ja) 2025-09-03
EP3681911A1 (en) 2020-07-22
CN111670198A (zh) 2020-09-15
KR102755742B1 (ko) 2025-01-15
IL273202B1 (en) 2024-04-01
CA3075523A1 (en) 2019-03-14
KR20200063159A (ko) 2020-06-04
US11780915B2 (en) 2023-10-10
JP2023116543A (ja) 2023-08-22
EP3681911A4 (en) 2021-06-02
CN111670198B (zh) 2023-12-15
AU2018328764A1 (en) 2020-04-02
LT3681911T (lt) 2025-01-10
US12441790B2 (en) 2025-10-14
PT3681911T (pt) 2024-12-18
EP4512469A2 (en) 2025-02-26
HUE069649T2 (hu) 2025-04-28
WO2019046912A1 (en) 2019-03-14
ES2999094T3 (en) 2025-02-24

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