FI3672949T3 - 3-(1-oksoisoindolin-2-yyli)piperidiini-2,6-dionijohdannaisia ja niiden käyttöjä - Google Patents
3-(1-oksoisoindolin-2-yyli)piperidiini-2,6-dionijohdannaisia ja niiden käyttöjä Download PDFInfo
- Publication number
- FI3672949T3 FI3672949T3 FIEP18772885.2T FI18772885T FI3672949T3 FI 3672949 T3 FI3672949 T3 FI 3672949T3 FI 18772885 T FI18772885 T FI 18772885T FI 3672949 T3 FI3672949 T3 FI 3672949T3
- Authority
- FI
- Finland
- Prior art keywords
- piperidin
- dione
- oxoisoindolin
- yyl
- piperidinyl
- Prior art date
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- WENKGSGGXGQHSH-UHFFFAOYSA-N 3-(3-oxo-1h-isoindol-2-yl)piperidine-2,6-dione Chemical class C1C2=CC=CC=C2C(=O)N1C1CCC(=O)NC1=O WENKGSGGXGQHSH-UHFFFAOYSA-N 0.000 title 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 38
- KNCYXPMJDCCGSJ-UHFFFAOYSA-N piperidine-2,6-dione Chemical compound O=C1CCCC(=O)N1 KNCYXPMJDCCGSJ-UHFFFAOYSA-N 0.000 claims 31
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 claims 4
- LSBDFXRDZJMBSC-UHFFFAOYSA-N 2-phenylacetamide Chemical compound NC(=O)CC1=CC=CC=C1 LSBDFXRDZJMBSC-UHFFFAOYSA-N 0.000 claims 2
- GLKCQJUUCIBRTC-UHFFFAOYSA-N 3-[3-oxo-6-[1-(1-phenylethyl)piperidin-4-yl]-1H-isoindol-2-yl]piperidine-2,6-dione Chemical compound O=C1N(CC2=CC(=CC=C12)C1CCN(CC1)C(C)C1=CC=CC=C1)C1C(NC(CC1)=O)=O GLKCQJUUCIBRTC-UHFFFAOYSA-N 0.000 claims 2
- QTBSBXVTEAMEQO-UHFFFAOYSA-M Acetate Chemical compound CC([O-])=O QTBSBXVTEAMEQO-UHFFFAOYSA-M 0.000 claims 2
- 150000001875 compounds Chemical class 0.000 claims 2
- ZUOUZKKEUPVFJK-UHFFFAOYSA-N diphenyl Chemical group C1=CC=CC=C1C1=CC=CC=C1 ZUOUZKKEUPVFJK-UHFFFAOYSA-N 0.000 claims 2
- BAWUHTSBEAGGSA-XJKSGUPXSA-N (3R)-3-[6-[(3R)-1-acetylpyrrolidin-3-yl]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione Chemical compound C(C)(=O)N1C[C@H](CC1)C=1C=C2CN(C(C2=CC=1)=O)[C@H]1C(NC(CC1)=O)=O BAWUHTSBEAGGSA-XJKSGUPXSA-N 0.000 claims 1
- BAWUHTSBEAGGSA-BBRMVZONSA-N (3S)-3-[6-[(3R)-1-acetylpyrrolidin-3-yl]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione Chemical compound C(C)(=O)N1C[C@H](CC1)C=1C=C2CN(C(C2=CC=1)=O)[C@@H]1C(NC(CC1)=O)=O BAWUHTSBEAGGSA-BBRMVZONSA-N 0.000 claims 1
- URBKCTSNYKHEPM-UHFFFAOYSA-N 2-[4-[2-(2,6-dioxopiperidin-3-yl)-1-oxo-3H-isoindol-5-yl]piperidin-1-yl]-N-phenylacetamide Chemical compound O=C1NC(CCC1N1C(C2=CC=C(C=C2C1)C1CCN(CC1)CC(=O)NC1=CC=CC=C1)=O)=O URBKCTSNYKHEPM-UHFFFAOYSA-N 0.000 claims 1
- KIZAKWPMXFJRSX-UHFFFAOYSA-N 2-[4-[2-(2,6-dioxopiperidin-3-yl)-1-oxo-3H-isoindol-5-yl]piperidin-1-yl]acetic acid Chemical compound O=C1NC(CCC1N1C(C2=CC=C(C=C2C1)C1CCN(CC1)CC(=O)O)=O)=O KIZAKWPMXFJRSX-UHFFFAOYSA-N 0.000 claims 1
- IACWUKBYTLCAIJ-UHFFFAOYSA-N 2-[4-[[4-[2-(2,6-dioxopiperidin-3-yl)-1-oxo-3H-isoindol-5-yl]piperidin-1-yl]methyl]phenoxy]acetonitrile Chemical compound O=C1NC(CCC1N1C(C2=CC=C(C=C2C1)C1CCN(CC1)CC1=CC=C(OCC#N)C=C1)=O)=O IACWUKBYTLCAIJ-UHFFFAOYSA-N 0.000 claims 1
- ARHYWQBGKCRXLX-UHFFFAOYSA-N 2-[4-[[4-[2-(2,6-dioxopiperidin-3-yl)-1-oxo-3H-isoindol-5-yl]piperidin-1-yl]methyl]phenyl]acetic acid Chemical compound O=C1NC(CCC1N1C(C2=CC=C(C=C2C1)C1CCN(CC1)CC1=CC=C(C=C1)CC(=O)O)=O)=O ARHYWQBGKCRXLX-UHFFFAOYSA-N 0.000 claims 1
- RFTUDHBWVBMQLN-UHFFFAOYSA-N 2-[4-[[4-[2-(2,6-dioxopiperidin-3-yl)-1-oxo-3H-isoindol-5-yl]piperidin-1-yl]methyl]phenyl]acetonitrile Chemical compound O=C1NC(CCC1N1C(C2=CC=C(C=C2C1)C1CCN(CC1)CC1=CC=C(C=C1)CC#N)=O)=O RFTUDHBWVBMQLN-UHFFFAOYSA-N 0.000 claims 1
- XYOJJXVTLBLFBR-UHFFFAOYSA-N 2-[[4-[2-(2,6-dioxopiperidin-3-yl)-1-oxo-3H-isoindol-5-yl]piperidin-1-yl]methyl]pyrimidine-5-carbonitrile Chemical compound O=C1NC(CCC1N1C(C2=CC=C(C=C2C1)C1CCN(CC1)CC1=NC=C(C=N1)C#N)=O)=O XYOJJXVTLBLFBR-UHFFFAOYSA-N 0.000 claims 1
- MZBHUPFYEJLFFG-UHFFFAOYSA-N 3-[3-oxo-6-[1-(1,2,3,4-tetrahydronaphthalen-1-ylmethyl)piperidin-4-yl]-1H-isoindol-2-yl]piperidine-2,6-dione Chemical compound O=C1N(CC2=CC(=CC=C12)C1CCN(CC1)CC1CCCC2=CC=CC=C12)C1C(NC(CC1)=O)=O MZBHUPFYEJLFFG-UHFFFAOYSA-N 0.000 claims 1
- LDODCLGLAFSXDS-UHFFFAOYSA-N 3-[3-oxo-6-[1-(1H-pyrazol-4-ylmethyl)piperidin-4-yl]-1H-isoindol-2-yl]piperidine-2,6-dione Chemical compound N1N=CC(=C1)CN1CCC(CC1)C=1C=C2CN(C(C2=CC=1)=O)C1C(NC(CC1)=O)=O LDODCLGLAFSXDS-UHFFFAOYSA-N 0.000 claims 1
- LTLCETZUQJLBQH-UHFFFAOYSA-N 3-[3-oxo-6-[1-(1H-pyrrol-3-ylmethyl)piperidin-4-yl]-1H-isoindol-2-yl]piperidine-2,6-dione Chemical compound N1C=C(C=C1)CN1CCC(CC1)C=1C=C2CN(C(C2=CC=1)=O)C1C(NC(CC1)=O)=O LTLCETZUQJLBQH-UHFFFAOYSA-N 0.000 claims 1
- LVBQBELCGFNMTA-UHFFFAOYSA-N 3-[3-oxo-6-[1-(2,2,2-trifluoroethyl)piperidin-4-yl]-1H-isoindol-2-yl]piperidine-2,6-dione Chemical compound O=C1N(CC2=CC(=CC=C12)C1CCN(CC1)CC(F)(F)F)C1C(NC(CC1)=O)=O LVBQBELCGFNMTA-UHFFFAOYSA-N 0.000 claims 1
- DJVAALWZOAMVJC-UHFFFAOYSA-N 3-[3-oxo-6-[1-(2-piperidin-1-ylethyl)piperidin-4-yl]-1H-isoindol-2-yl]piperidine-2,6-dione Chemical compound O=C1N(CC2=CC(=CC=C12)C1CCN(CC1)CCN1CCCCC1)C1C(NC(CC1)=O)=O DJVAALWZOAMVJC-UHFFFAOYSA-N 0.000 claims 1
- YTJWRVYLFJZNPK-UHFFFAOYSA-N 3-[3-oxo-6-[1-(2-pyrrolidin-1-ylethyl)piperidin-4-yl]-1H-isoindol-2-yl]piperidine-2,6-dione Chemical compound O=C1N(CC2=CC(=CC=C12)C1CCN(CC1)CCN1CCCC1)C1C(NC(CC1)=O)=O YTJWRVYLFJZNPK-UHFFFAOYSA-N 0.000 claims 1
- QHODFIPSFXGMNX-UHFFFAOYSA-N 3-[3-oxo-6-[1-(5,6,7,8-tetrahydronaphthalen-1-ylmethyl)piperidin-4-yl]-1H-isoindol-2-yl]piperidine-2,6-dione Chemical compound O=C1N(CC2=CC(=CC=C12)C1CCN(CC1)CC1=CC=CC=2CCCCC1=2)C1C(NC(CC1)=O)=O QHODFIPSFXGMNX-UHFFFAOYSA-N 0.000 claims 1
- XILHMWHPEXIGHT-UHFFFAOYSA-N 3-[3-oxo-6-[1-(5,6,7,8-tetrahydronaphthalen-2-ylmethyl)piperidin-4-yl]-1H-isoindol-2-yl]piperidine-2,6-dione Chemical compound O=C1N(CC2=CC(=CC=C12)C1CCN(CC1)CC1=CC=2CCCCC=2C=C1)C1C(NC(CC1)=O)=O XILHMWHPEXIGHT-UHFFFAOYSA-N 0.000 claims 1
- DYVIFTWRNBHROW-UHFFFAOYSA-N 3-[3-oxo-6-[1-[(1-phenylpyrazol-4-yl)methyl]piperidin-4-yl]-1H-isoindol-2-yl]piperidine-2,6-dione Chemical compound O=C1N(CC2=CC(=CC=C12)C1CCN(CC1)CC=1C=NN(C=1)C1=CC=CC=C1)C1C(NC(CC1)=O)=O DYVIFTWRNBHROW-UHFFFAOYSA-N 0.000 claims 1
- UASFXRBDMBTBPZ-UHFFFAOYSA-N 3-[3-oxo-6-[1-[(1-propan-2-ylpyrazol-4-yl)methyl]piperidin-4-yl]-1H-isoindol-2-yl]piperidine-2,6-dione Chemical compound C(C)(C)N1N=CC(=C1)CN1CCC(CC1)C=1C=C2CN(C(C2=CC=1)=O)C1C(NC(CC1)=O)=O UASFXRBDMBTBPZ-UHFFFAOYSA-N 0.000 claims 1
- GLKCQJUUCIBRTC-LIXIDFRTSA-N 3-[3-oxo-6-[1-[(1R)-1-phenylethyl]piperidin-4-yl]-1H-isoindol-2-yl]piperidine-2,6-dione Chemical compound O=C1N(CC2=CC(=CC=C12)C1CCN(CC1)[C@H](C)C1=CC=CC=C1)C1C(NC(CC1)=O)=O GLKCQJUUCIBRTC-LIXIDFRTSA-N 0.000 claims 1
- GLKCQJUUCIBRTC-NVHKAFQKSA-N 3-[3-oxo-6-[1-[(1S)-1-phenylethyl]piperidin-4-yl]-1H-isoindol-2-yl]piperidine-2,6-dione Chemical compound O=C1N(CC2=CC(=CC=C12)C1CCN(CC1)[C@@H](C)C1=CC=CC=C1)C1C(NC(CC1)=O)=O GLKCQJUUCIBRTC-NVHKAFQKSA-N 0.000 claims 1
- DBXBUWWOEWFBNK-UHFFFAOYSA-N 3-[3-oxo-6-[1-[(2-oxo-1,3-dihydrobenzimidazol-5-yl)methyl]piperidin-4-yl]-1H-isoindol-2-yl]piperidine-2,6-dione Chemical compound O=C1N(CC2=CC(=CC=C12)C1CCN(CC1)CC1=CC2=C(NC(N2)=O)C=C1)C1C(NC(CC1)=O)=O DBXBUWWOEWFBNK-UHFFFAOYSA-N 0.000 claims 1
- DQUWKKBOYUGHKH-UHFFFAOYSA-N 3-[3-oxo-6-[1-[(2-phenylpyrazol-3-yl)methyl]piperidin-4-yl]-1H-isoindol-2-yl]piperidine-2,6-dione Chemical compound O=C1N(CC2=CC(=CC=C12)C1CCN(CC1)CC1=CC=NN1C1=CC=CC=C1)C1C(NC(CC1)=O)=O DQUWKKBOYUGHKH-UHFFFAOYSA-N 0.000 claims 1
- OBVIKDWKJAXHFY-UHFFFAOYSA-N 3-[3-oxo-6-[1-[(4-oxo-3H-thieno[3,2-d]pyrimidin-2-yl)methyl]piperidin-4-yl]-1H-isoindol-2-yl]piperidine-2,6-dione Chemical compound O=C1N(CC2=CC(=CC=C12)C1CCN(CC1)CC=1NC(C2=C(N=1)C=CS2)=O)C1C(NC(CC1)=O)=O OBVIKDWKJAXHFY-UHFFFAOYSA-N 0.000 claims 1
- FYHGDCNVRQYJDO-UHFFFAOYSA-N 3-[3-oxo-6-[1-[(4-pyrazol-1-ylphenyl)methyl]piperidin-4-yl]-1H-isoindol-2-yl]piperidine-2,6-dione Chemical compound N1(N=CC=C1)C1=CC=C(CN2CCC(CC2)C=2C=C3CN(C(C3=CC=2)=O)C2C(NC(CC2)=O)=O)C=C1 FYHGDCNVRQYJDO-UHFFFAOYSA-N 0.000 claims 1
- RUYRPSNPCYIYPZ-UHFFFAOYSA-N 3-[3-oxo-6-[1-[(4-thiophen-3-ylphenyl)methyl]piperidin-4-yl]-1H-isoindol-2-yl]piperidine-2,6-dione Chemical compound O=C1N(CC2=CC(=CC=C12)C1CCN(CC1)CC1=CC=C(C=C1)C1=CSC=C1)C1C(NC(CC1)=O)=O RUYRPSNPCYIYPZ-UHFFFAOYSA-N 0.000 claims 1
- CEURALOBJXIYIV-UHFFFAOYSA-N 3-[3-oxo-6-[1-[(5-phenyl-1H-pyrazol-4-yl)methyl]piperidin-4-yl]-1H-isoindol-2-yl]piperidine-2,6-dione Chemical compound O=C1N(CC2=CC(=CC=C12)C1CCN(CC1)CC=1C(=NNC=1)C1=CC=CC=C1)C1C(NC(CC1)=O)=O CEURALOBJXIYIV-UHFFFAOYSA-N 0.000 claims 1
- SHBMSQSXKGUHIJ-UHFFFAOYSA-N 3-[3-oxo-6-[1-[[2-(trifluoromethyl)phenyl]methyl]piperidin-4-yl]-1H-isoindol-2-yl]piperidine-2,6-dione Chemical compound O=C1N(CC2=CC(=CC=C12)C1CCN(CC1)CC1=C(C=CC=C1)C(F)(F)F)C1C(NC(CC1)=O)=O SHBMSQSXKGUHIJ-UHFFFAOYSA-N 0.000 claims 1
- LTBGQYCRSMKZFE-UHFFFAOYSA-N 3-[3-oxo-6-[1-[[4-(trifluoromethyl)phenyl]methyl]piperidin-4-yl]-1H-isoindol-2-yl]piperidine-2,6-dione Chemical compound O=C1N(CC2=CC(=CC=C12)C1CCN(CC1)CC1=CC=C(C=C1)C(F)(F)F)C1C(NC(CC1)=O)=O LTBGQYCRSMKZFE-UHFFFAOYSA-N 0.000 claims 1
- DYBUYHUAATVTOM-UHFFFAOYSA-N 3-[6-(1-acetyl-2,5-dihydropyrrol-3-yl)-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione Chemical compound C(C)(=O)N1CC(=CC1)C=1C=C2CN(C(C2=CC=1)=O)C1C(NC(CC1)=O)=O DYBUYHUAATVTOM-UHFFFAOYSA-N 0.000 claims 1
- ODHSWSXPLZDQHT-UHFFFAOYSA-N 3-[6-(1-acetylpiperidin-4-yl)-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione Chemical compound C(C)(=O)N1CCC(CC1)C=1C=C2CN(C(C2=CC=1)=O)C1C(NC(CC1)=O)=O ODHSWSXPLZDQHT-UHFFFAOYSA-N 0.000 claims 1
- KILGWHPUKBWHOY-UHFFFAOYSA-N 3-[6-(1-benzyl-2-methylpiperidin-4-yl)-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione Chemical compound C(C1=CC=CC=C1)N1C(CC(CC1)C=1C=C2CN(C(C2=CC=1)=O)C1C(NC(CC1)=O)=O)C KILGWHPUKBWHOY-UHFFFAOYSA-N 0.000 claims 1
- GINRDGRGHUJNHR-UHFFFAOYSA-N 3-[6-(1-benzyl-2-oxopiperidin-4-yl)-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione Chemical compound C(C1=CC=CC=C1)N1C(CC(CC1)C=1C=C2CN(C(C2=CC=1)=O)C1C(NC(CC1)=O)=O)=O GINRDGRGHUJNHR-UHFFFAOYSA-N 0.000 claims 1
- VEOSIOSDKGPVEG-UHFFFAOYSA-N 3-[6-(1-benzyl-3,4-dihydro-2H-quinolin-4-yl)-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione Chemical compound C(C1=CC=CC=C1)N1CCC(C2=CC=CC=C12)C=1C=C2CN(C(C2=CC=1)=O)C1C(NC(CC1)=O)=O VEOSIOSDKGPVEG-UHFFFAOYSA-N 0.000 claims 1
- LNJHUYBFNKAGSV-UHFFFAOYSA-N 3-[6-(1-benzyl-3-methylpiperidin-4-yl)-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione Chemical compound C(C1=CC=CC=C1)N1CC(C(CC1)C=1C=C2CN(C(C2=CC=1)=O)C1C(NC(CC1)=O)=O)C LNJHUYBFNKAGSV-UHFFFAOYSA-N 0.000 claims 1
- OMISHRJQMYQPMG-UHFFFAOYSA-N 3-[6-(1-benzylpiperidin-4-yl)-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione Chemical compound C(C1=CC=CC=C1)N1CCC(CC1)C=1C=C2CN(C(C2=CC=1)=O)C1C(NC(CC1)=O)=O OMISHRJQMYQPMG-UHFFFAOYSA-N 0.000 claims 1
- OHKHFPDSTNDZET-UHFFFAOYSA-N 3-[6-(1-benzylpyrrolidin-3-yl)-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione Chemical compound C(C1=CC=CC=C1)N1CC(CC1)C=1C=C2CN(C(C2=CC=1)=O)C1C(NC(CC1)=O)=O OHKHFPDSTNDZET-UHFFFAOYSA-N 0.000 claims 1
- XTYWOPNNGJRAKW-UHFFFAOYSA-N 3-[6-(1-methyl-2,3,6,7-tetrahydroazepin-4-yl)-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione Chemical compound CN1CCC(=CCC1)C=1C=C2CN(C(C2=CC=1)=O)C1C(NC(CC1)=O)=O XTYWOPNNGJRAKW-UHFFFAOYSA-N 0.000 claims 1
- DHHGMHKDJFZRLQ-UHFFFAOYSA-N 3-[6-(8-azabicyclo[3.2.1]octan-3-yl)-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione Chemical compound C12CC(CC(CC1)N2)C=1C=C2CN(C(C2=CC=1)=O)C1C(NC(CC1)=O)=O DHHGMHKDJFZRLQ-UHFFFAOYSA-N 0.000 claims 1
- KQLVHPSDHDZTDV-UHFFFAOYSA-N 3-[6-(azepan-4-yl)-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione Chemical compound N1CCC(CCC1)C=1C=C2CN(C(C2=CC=1)=O)C1C(NC(CC1)=O)=O KQLVHPSDHDZTDV-UHFFFAOYSA-N 0.000 claims 1
- KQLVHPSDHDZTDV-ZGTOLYCTSA-N 3-[6-[(4R)-azepan-4-yl]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione Chemical compound N1CC[C@@H](CCC1)C=1C=C2CN(C(C2=CC=1)=O)C1C(NC(CC1)=O)=O KQLVHPSDHDZTDV-ZGTOLYCTSA-N 0.000 claims 1
- KQLVHPSDHDZTDV-HKALDPMFSA-N 3-[6-[(4S)-azepan-4-yl]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione Chemical compound N1CC[C@H](CCC1)C=1C=C2CN(C(C2=CC=1)=O)C1C(NC(CC1)=O)=O KQLVHPSDHDZTDV-HKALDPMFSA-N 0.000 claims 1
- ANLFIKBFICRKTH-UHFFFAOYSA-N 3-[6-[1-(1H-indazol-4-ylmethyl)piperidin-4-yl]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione Chemical compound N1N=CC2=C(C=CC=C12)CN1CCC(CC1)C=1C=C2CN(C(C2=CC=1)=O)C1C(NC(CC1)=O)=O ANLFIKBFICRKTH-UHFFFAOYSA-N 0.000 claims 1
- JAEGXTSONZTMSX-UHFFFAOYSA-N 3-[6-[1-(1H-indazol-5-ylmethyl)piperidin-4-yl]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione Chemical compound N1N=CC2=CC(=CC=C12)CN1CCC(CC1)C=1C=C2CN(C(C2=CC=1)=O)C1C(NC(CC1)=O)=O JAEGXTSONZTMSX-UHFFFAOYSA-N 0.000 claims 1
- OILOJUCCPUSETC-UHFFFAOYSA-N 3-[6-[1-(cyclopentylmethyl)piperidin-4-yl]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione Chemical compound C1(CCCC1)CN1CCC(CC1)C=1C=C2CN(C(C2=CC=1)=O)C1C(NC(CC1)=O)=O OILOJUCCPUSETC-UHFFFAOYSA-N 0.000 claims 1
- UQAZOEVWXTWRGH-UHFFFAOYSA-N 3-[6-[1-(oxan-4-ylmethyl)piperidin-4-yl]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione Chemical compound O=C1N(CC2=CC(=CC=C12)C1CCN(CC1)CC1CCOCC1)C1C(NC(CC1)=O)=O UQAZOEVWXTWRGH-UHFFFAOYSA-N 0.000 claims 1
- QIOXFJSSQRJVBQ-UHFFFAOYSA-N 3-[6-[1-[(1-ethylpyrazol-3-yl)methyl]piperidin-4-yl]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione Chemical compound C(C)N1N=C(C=C1)CN1CCC(CC1)C=1C=C2CN(C(C2=CC=1)=O)C1C(NC(CC1)=O)=O QIOXFJSSQRJVBQ-UHFFFAOYSA-N 0.000 claims 1
- QDISJEOFPDXMGD-UHFFFAOYSA-N 3-[6-[1-[(1-methylpyrazol-3-yl)methyl]piperidin-4-yl]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione Chemical compound CN1N=C(C=C1)CN1CCC(CC1)C=1C=C2CN(C(C2=CC=1)=O)C1C(NC(CC1)=O)=O QDISJEOFPDXMGD-UHFFFAOYSA-N 0.000 claims 1
- XFDPVXAEZLNHRO-UHFFFAOYSA-N 3-[6-[1-[(1-methylpyrazol-4-yl)methyl]piperidin-4-yl]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione Chemical compound CN1N=CC(=C1)CN1CCC(CC1)C=1C=C2CN(C(C2=CC=1)=O)C1C(NC(CC1)=O)=O XFDPVXAEZLNHRO-UHFFFAOYSA-N 0.000 claims 1
- AMCXFEHISBTPPD-UHFFFAOYSA-N 3-[6-[1-[(2-chlorophenyl)methyl]piperidin-4-yl]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione Chemical compound ClC1=C(CN2CCC(CC2)C=2C=C3CN(C(C3=CC=2)=O)C2C(NC(CC2)=O)=O)C=CC=C1 AMCXFEHISBTPPD-UHFFFAOYSA-N 0.000 claims 1
- CSZIDYZKCSSUNK-UHFFFAOYSA-N 3-[6-[1-[(2-fluorophenyl)methyl]piperidin-4-yl]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione Chemical compound FC1=C(CN2CCC(CC2)C=2C=C3CN(C(C3=CC=2)=O)C2C(NC(CC2)=O)=O)C=CC=C1 CSZIDYZKCSSUNK-UHFFFAOYSA-N 0.000 claims 1
- SHSPYPHACMWHEU-UHFFFAOYSA-N 3-[6-[1-[(2-methylphenyl)methyl]piperidin-4-yl]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione Chemical compound CC1=C(CN2CCC(CC2)C=2C=C3CN(C(C3=CC=2)=O)C2C(NC(CC2)=O)=O)C=CC=C1 SHSPYPHACMWHEU-UHFFFAOYSA-N 0.000 claims 1
- IEHXPBDDBXFKDH-UHFFFAOYSA-N 3-[6-[1-[(2-tert-butyl-1,3-thiazol-4-yl)methyl]piperidin-4-yl]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione Chemical compound C(C)(C)(C)C=1SC=C(N=1)CN1CCC(CC1)C=1C=C2CN(C(C2=CC=1)=O)C1C(NC(CC1)=O)=O IEHXPBDDBXFKDH-UHFFFAOYSA-N 0.000 claims 1
- IOJSJTBXXZHPBV-UHFFFAOYSA-N 3-[6-[1-[(3,5-difluoro-4-hydroxyphenyl)methyl]piperidin-4-yl]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione Chemical compound FC=1C=C(CN2CCC(CC2)C=2C=C3CN(C(C3=CC=2)=O)C2C(NC(CC2)=O)=O)C=C(C=1O)F IOJSJTBXXZHPBV-UHFFFAOYSA-N 0.000 claims 1
- QCZOZNGYXAHBMF-UHFFFAOYSA-N 3-[6-[1-[(3,5-dimethyl-1,2-oxazol-4-yl)methyl]piperidin-4-yl]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione Chemical compound CC1=NOC(=C1CN1CCC(CC1)C=1C=C2CN(C(C2=CC=1)=O)C1C(NC(CC1)=O)=O)C QCZOZNGYXAHBMF-UHFFFAOYSA-N 0.000 claims 1
- XFELGEMMBRJKSO-UHFFFAOYSA-N 3-[6-[1-[(3-chlorophenyl)methyl]piperidin-4-yl]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione Chemical compound ClC=1C=C(CN2CCC(CC2)C=2C=C3CN(C(C3=CC=2)=O)C2C(NC(CC2)=O)=O)C=CC=1 XFELGEMMBRJKSO-UHFFFAOYSA-N 0.000 claims 1
- LNQRMJARZIDTFJ-UHFFFAOYSA-N 3-[6-[1-[(3-fluorophenyl)methyl]piperidin-4-yl]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione Chemical compound FC=1C=C(CN2CCC(CC2)C=2C=C3CN(C(C3=CC=2)=O)C2C(NC(CC2)=O)=O)C=CC=1 LNQRMJARZIDTFJ-UHFFFAOYSA-N 0.000 claims 1
- IGYOTWUTTRVOGO-UHFFFAOYSA-N 3-[6-[1-[(4-chlorophenyl)methyl]piperidin-4-yl]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione Chemical compound ClC1=CC=C(CN2CCC(CC2)C=2C=C3CN(C(C3=CC=2)=O)C2C(NC(CC2)=O)=O)C=C1 IGYOTWUTTRVOGO-UHFFFAOYSA-N 0.000 claims 1
- YFDRFOOVHSFPHI-UHFFFAOYSA-N 3-[6-[1-[(4-fluorophenyl)methyl]piperidin-4-yl]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione Chemical compound FC1=CC=C(CN2CCC(CC2)C=2C=C3CN(C(C3=CC=2)=O)C2C(NC(CC2)=O)=O)C=C1 YFDRFOOVHSFPHI-UHFFFAOYSA-N 0.000 claims 1
- LUAJKYYOMUOAIC-UHFFFAOYSA-N 3-[6-[1-[(4-methylphenyl)methyl]piperidin-4-yl]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione Chemical compound CC1=CC=C(CN2CCC(CC2)C=2C=C3CN(C(C3=CC=2)=O)C2C(NC(CC2)=O)=O)C=C1 LUAJKYYOMUOAIC-UHFFFAOYSA-N 0.000 claims 1
- SAPFFLAWNMHYCV-UHFFFAOYSA-N 3-[6-[1-[(6-methyl-1H-indol-3-yl)methyl]piperidin-4-yl]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione Chemical compound CC1=CC=C2C(=CNC2=C1)CN1CCC(CC1)C=1C=C2CN(C(C2=CC=1)=O)C1C(NC(CC1)=O)=O SAPFFLAWNMHYCV-UHFFFAOYSA-N 0.000 claims 1
- AFDKCPLAKBPUJA-UHFFFAOYSA-N 3-[6-[1-[(6-methylpyridin-2-yl)methyl]piperidin-4-yl]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione Chemical compound CC1=CC=CC(=N1)CN1CCC(CC1)C=1C=C2CN(C(C2=CC=1)=O)C1C(NC(CC1)=O)=O AFDKCPLAKBPUJA-UHFFFAOYSA-N 0.000 claims 1
- FBTOTZGPUPYJJA-UHFFFAOYSA-N 3-[6-[1-[(7-methyl-4-oxopyrido[1,2-a]pyrimidin-2-yl)methyl]piperidin-4-yl]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione Chemical compound CC=1C=CC=2N(C(C=C(N=2)CN2CCC(CC2)C=2C=C3CN(C(C3=CC=2)=O)C2C(NC(CC2)=O)=O)=O)C=1 FBTOTZGPUPYJJA-UHFFFAOYSA-N 0.000 claims 1
- WQMLEVGSCYDMJL-UHFFFAOYSA-N 3-[6-[1-[[2-amino-4-(trifluoromethyl)-1,3-thiazol-5-yl]methyl]piperidin-4-yl]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione Chemical compound NC=1SC(=C(N=1)C(F)(F)F)CN1CCC(CC1)C=1C=C2CN(C(C2=CC=1)=O)C1C(NC(CC1)=O)=O WQMLEVGSCYDMJL-UHFFFAOYSA-N 0.000 claims 1
- BQLURVNBMJCGKT-UHFFFAOYSA-N 3-[6-[1-[[3,5-bis(trifluoromethyl)phenyl]methyl]piperidin-4-yl]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione Chemical compound FC(C=1C=C(CN2CCC(CC2)C=2C=C3CN(C(C3=CC=2)=O)C2C(NC(CC2)=O)=O)C=C(C=1)C(F)(F)F)(F)F BQLURVNBMJCGKT-UHFFFAOYSA-N 0.000 claims 1
- NWMHBGNWMAQFRY-UHFFFAOYSA-N 3-[6-[1-[[3-(difluoromethoxy)phenyl]methyl]piperidin-4-yl]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione Chemical compound FC(OC=1C=C(CN2CCC(CC2)C=2C=C3CN(C(C3=CC=2)=O)C2C(NC(CC2)=O)=O)C=CC=1)F NWMHBGNWMAQFRY-UHFFFAOYSA-N 0.000 claims 1
- DKIXKCNLXZOQGY-UHFFFAOYSA-N 3-[6-[1-[[4-(2-methylbutan-2-yl)phenyl]methyl]piperidin-4-yl]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione Chemical compound O=C1N(CC2=CC(=CC=C12)C1CCN(CC1)CC1=CC=C(C=C1)C(C)(C)CC)C1C(NC(CC1)=O)=O DKIXKCNLXZOQGY-UHFFFAOYSA-N 0.000 claims 1
- IMVMTNVPVNYNDP-UHFFFAOYSA-N 3-[6-[1-[[4-(4-methoxypiperidin-1-yl)phenyl]methyl]piperidin-4-yl]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione Chemical compound COC1CCN(CC1)C1=CC=C(CN2CCC(CC2)C=2C=C3CN(C(C3=CC=2)=O)C2C(NC(CC2)=O)=O)C=C1 IMVMTNVPVNYNDP-UHFFFAOYSA-N 0.000 claims 1
- TTXDSMZYJLLGAC-UHFFFAOYSA-N 3-[6-[1-[[4-(difluoromethoxy)phenyl]methyl]piperidin-4-yl]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione Chemical compound FC(OC1=CC=C(CN2CCC(CC2)C=2C=C3CN(C(C3=CC=2)=O)C2C(NC(CC2)=O)=O)C=C1)F TTXDSMZYJLLGAC-UHFFFAOYSA-N 0.000 claims 1
- FNMPSWJULHUNOA-UHFFFAOYSA-N 3-[[4-[2-(2,6-dioxopiperidin-3-yl)-1-oxo-3H-isoindol-5-yl]piperidin-1-yl]methyl]benzamide Chemical compound O=C1NC(CCC1N1C(C2=CC=C(C=C2C1)C1CCN(CC1)CC=1C=C(C(=O)N)C=CC=1)=O)=O FNMPSWJULHUNOA-UHFFFAOYSA-N 0.000 claims 1
- HJHYQGLDRQGYIS-UHFFFAOYSA-N 3-[[4-[2-(2,6-dioxopiperidin-3-yl)-1-oxo-3H-isoindol-5-yl]piperidin-1-yl]methyl]benzoic acid Chemical compound O=C1NC(CCC1N1C(C2=CC=C(C=C2C1)C1CCN(CC1)CC=1C=C(C(=O)O)C=CC=1)=O)=O HJHYQGLDRQGYIS-UHFFFAOYSA-N 0.000 claims 1
- IZGOZHQIEMPOFK-UHFFFAOYSA-N 4-[[4-[2-(2,6-dioxopiperidin-3-yl)-1-oxo-3H-isoindol-5-yl]piperidin-1-yl]methyl]benzamide Chemical compound O=C1NC(CCC1N1C(C2=CC=C(C=C2C1)C1CCN(CC1)CC1=CC=C(C(=O)N)C=C1)=O)=O IZGOZHQIEMPOFK-UHFFFAOYSA-N 0.000 claims 1
- ZKJBVLDYYTVASX-UHFFFAOYSA-N 4-[[4-[2-(2,6-dioxopiperidin-3-yl)-1-oxo-3H-isoindol-5-yl]piperidin-1-yl]methyl]benzoic acid Chemical compound O=C1NC(CCC1N1C(C2=CC=C(C=C2C1)C1CCN(CC1)CC1=CC=C(C(=O)O)C=C1)=O)=O ZKJBVLDYYTVASX-UHFFFAOYSA-N 0.000 claims 1
- -1 5-fluoropyridin-2-yl Chemical group 0.000 claims 1
- 206010009944 Colon cancer Diseases 0.000 claims 1
- 208000001333 Colorectal Neoplasms Diseases 0.000 claims 1
- 101000599037 Homo sapiens Zinc finger protein Helios Proteins 0.000 claims 1
- 108091092878 Microsatellite Proteins 0.000 claims 1
- 102100037796 Zinc finger protein Helios Human genes 0.000 claims 1
- JKOOJGCNNXGATQ-UHFFFAOYSA-N benzyl 4-[2-(2,6-dioxopiperidin-3-yl)-1-oxo-3H-isoindol-5-yl]piperidine-1-carboxylate Chemical compound O=C1NC(CCC1N1C(C2=CC=C(C=C2C1)C1CCN(CC1)C(=O)OCC1=CC=CC=C1)=O)=O JKOOJGCNNXGATQ-UHFFFAOYSA-N 0.000 claims 1
- 235000010290 biphenyl Nutrition 0.000 claims 1
- 201000011243 gastrointestinal stromal tumor Diseases 0.000 claims 1
- PCKPOKGGNMTTTC-UHFFFAOYSA-N methyl 5-[[4-[2-(2,6-dioxopiperidin-3-yl)-1-oxo-3H-isoindol-5-yl]piperidin-1-yl]methyl]furan-2-carboxylate Chemical compound O=C1NC(CCC1N1C(C2=CC=C(C=C2C1)C1CCN(CC1)CC1=CC=C(O1)C(=O)OC)=O)=O PCKPOKGGNMTTTC-UHFFFAOYSA-N 0.000 claims 1
- 208000002154 non-small cell lung carcinoma Diseases 0.000 claims 1
- 125000003386 piperidinyl group Chemical group 0.000 claims 1
- 239000012453 solvate Substances 0.000 claims 1
- AODZMBWXTFQTSZ-UHFFFAOYSA-N tert-butyl 4-[[4-[2-(2,6-dioxopiperidin-3-yl)-1-oxo-3H-isoindol-5-yl]piperidin-1-yl]methyl]benzoate Chemical compound O=C1NC(CCC1N1C(C2=CC=C(C=C2C1)C1CCN(CC1)CC1=CC=C(C(=O)OC(C)(C)C)C=C1)=O)=O AODZMBWXTFQTSZ-UHFFFAOYSA-N 0.000 claims 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
- C07D407/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/08—Bridged systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Hydrogenated Pyridines (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Indole Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762549225P | 2017-08-23 | 2017-08-23 | |
| PCT/IB2018/056400 WO2019038717A1 (en) | 2017-08-23 | 2018-08-23 | 3- (1-OXOISOINDOLIN-2-YL) PIPERIDINE-2,6-DIONE DERIVATIVES AND USES THEREOF |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| FI3672949T3 true FI3672949T3 (fi) | 2023-03-23 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FIEP18772885.2T FI3672949T3 (fi) | 2017-08-23 | 2018-08-23 | 3-(1-oksoisoindolin-2-yyli)piperidiini-2,6-dionijohdannaisia ja niiden käyttöjä |
Country Status (38)
Families Citing this family (68)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20180228907A1 (en) | 2014-04-14 | 2018-08-16 | Arvinas, Inc. | Cereblon ligands and bifunctional compounds comprising the same |
| WO2017197055A1 (en) | 2016-05-10 | 2017-11-16 | C4 Therapeutics, Inc. | Heterocyclic degronimers for target protein degradation |
| TWI793151B (zh) | 2017-08-23 | 2023-02-21 | 瑞士商諾華公司 | 3-(1-氧異吲哚啉-2-基)之氫吡啶-2,6-二酮衍生物及其用途 |
| MX2020010571A (es) * | 2018-04-13 | 2021-01-08 | Arvinas Operations Inc | Ligandos de cereblon y compuestos bifuncionales que los comprenden. |
| DK3820573T3 (da) * | 2018-07-10 | 2023-10-23 | Novartis Ag | 3-(5-hydroxy-1-oxoisoindolin-2-yl)piperidin-2,6-dion-derivativer og anvendelse deraf ved behandling af ikaros family zinc finger 2 (ikzf2)-afhængige sygdomme |
| AR116109A1 (es) | 2018-07-10 | 2021-03-31 | Novartis Ag | Derivados de 3-(5-amino-1-oxoisoindolin-2-il)piperidina-2,6-diona y usos de los mismos |
| KR20210098960A (ko) | 2018-12-03 | 2021-08-11 | 다나-파버 캔서 인스티튜트 인크. | Helios의 소분자 분해제 및 사용 방법 |
| KR20210106437A (ko) * | 2018-12-20 | 2021-08-30 | 노파르티스 아게 | 3-(1-옥소이소인돌린-2-일)피페리딘-2,6-디온 유도체를 포함하는 투약 요법 및 약학적 조합물 |
| US12479817B2 (en) * | 2019-02-15 | 2025-11-25 | Novartis Ag | Substituted 3-(1-oxoisoindolin-2-yl)piperidine-2,6-dione derivatives and uses thereof |
| AU2020222345B2 (en) * | 2019-02-15 | 2022-11-17 | Novartis Ag | 3-(1-oxo-5-(piperidin-4-yl)isoindolin-2-yl)piperidine-2,6-dione derivatives and uses thereof |
| EA202192738A1 (ru) * | 2019-04-12 | 2022-03-17 | С4 Терапьютикс, Инк. | Трициклические соединения, обеспечивающие разрушение белка ikaros и белка aiolos |
| WO2020219742A1 (en) | 2019-04-24 | 2020-10-29 | Novartis Ag | Compositions and methods for selective protein degradation |
| WO2020243415A2 (en) | 2019-05-31 | 2020-12-03 | Ikena Oncology, Inc. | Tead inhibitors and uses thereof |
| MX2021014441A (es) | 2019-05-31 | 2022-01-06 | Ikena Oncology Inc | Inhibidores del dominio asociado mejorador de la transcripcion (tead) y usos de los mismos. |
| CA3154942A1 (en) * | 2019-10-30 | 2021-05-06 | Nathanael S. Gray | Small molecule degraders of helios and methods of use |
| CN110862395B (zh) * | 2019-11-13 | 2020-09-29 | 株洲千金药业股份有限公司 | 一种制备他达拉非重要杂质的原料化合物的制备方法 |
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| IL300417A (en) * | 2017-01-26 | 2023-04-01 | Arvinas Operations Inc | Bifunctional benzothiophene compounds, preparations containing them and their use in therapy |
| CN106932576A (zh) | 2017-03-22 | 2017-07-07 | 山东大学深圳研究院 | 一种人调节性t细胞的免疫抑制功能的检测方法 |
| TWI793151B (zh) | 2017-08-23 | 2023-02-21 | 瑞士商諾華公司 | 3-(1-氧異吲哚啉-2-基)之氫吡啶-2,6-二酮衍生物及其用途 |
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