|
GB0622195D0
(en)
*
|
2006-11-08 |
2006-12-20 |
Angeletti P Ist Richerche Bio |
Therapeutic agents
|
|
WO2009063244A1
(en)
*
|
2007-11-15 |
2009-05-22 |
Istituto Di Ricerche Di Biologia Molecolare P. Angeletti S.P.A. |
Pyridazinone derivatives as parp inhibitors
|
|
DE102008019907A1
(de)
*
|
2008-04-21 |
2009-10-22 |
Merck Patent Gmbh |
Pyridazinonderivate
|
|
US8501946B2
(en)
*
|
2009-04-29 |
2013-08-06 |
Glaxo Group Limited |
5,6,7,8-tetrahydro[1,2,4]triazolo[4,3-a]pyrazine derivatives as P2X7 modulators
|
|
GB0907515D0
(en)
*
|
2009-04-30 |
2009-06-10 |
Glaxo Group Ltd |
Compounds
|
|
US10065960B2
(en)
|
2010-04-02 |
2018-09-04 |
Ogeda Sa |
NK-3 receptor selective antagonist compounds, pharmaceutical composition and methods for use in NK-3 receptors mediated disorders
|
|
EP2552920B1
(en)
|
2010-04-02 |
2017-03-15 |
Ogeda Sa |
Novel nk-3 receptor selective antagonist compounds, pharmaceutical composition and methods for use in nk-3 receptors mediated disorders
|
|
EP2569307A2
(en)
|
2010-05-10 |
2013-03-20 |
Radikal Therapeutics Inc. |
Lipoic acid and nitroxide derivatives and uses thereof
|
|
CN102372716A
(zh)
*
|
2010-08-09 |
2012-03-14 |
江苏恒瑞医药股份有限公司 |
酞嗪酮类衍生物、其制备方法及其在医药上的应用
|
|
EP3925962A1
(en)
|
2011-05-31 |
2021-12-22 |
Rakovina Therapeutics Inc. |
Tricyclic inhibitors of poly(adp-ribose) polymerase
|
|
HUE028858T2
(hu)
|
2011-10-03 |
2017-01-30 |
Euroscreen Sa |
Új királis N-acil-5,6,7,(8-szubsztituált)-tetrahidro-[1,2,4]triazolo[4,3-A]pirazinok mint szelektív NK-3 receptor antagonisták, gyógyászati készítmény és eljárások NK-3 receptor által közvetített rendellenességek során történõ alkalmazásra
|
|
CN103570725B
(zh)
|
2012-08-01 |
2017-03-22 |
中国科学院上海药物研究所 |
哌嗪并三唑类化合物及其制备方法和用途
|
|
CN103833756B
(zh)
*
|
2012-11-26 |
2016-12-21 |
中国科学院上海药物研究所 |
一类哒嗪酮类化合物及其制备方法和用途
|
|
ES2469990B1
(es)
*
|
2012-12-19 |
2015-01-26 |
Universidade De Vigo |
Compuestos de estructura híbrida piridazinona ditiocarbamato con actividad antineoplásica
|
|
DK2938598T3
(en)
*
|
2012-12-31 |
2017-02-13 |
Cadila Healthcare Ltd |
Substituted phthalazine-1 (2H) -one derivatives as selective inhibitors of poly (adp-ribose) polymerase-1
|
|
HRP20191860T1
(hr)
|
2013-03-13 |
2019-12-27 |
Forma Therapeutics, Inc. |
Derivati 2-hidroksi-1-{4-[(4-fenilfenil)karbonil]piperazin-1-il}etan-1-ona i srodni spojevi kao inhibitori sintaze masnih kiselina (fasn) za liječenje raka
|
|
NZ711182A
(en)
*
|
2013-03-13 |
2020-05-29 |
Chugai Pharmaceutical Co Ltd |
Dihydropyridazine-3,5-dione derivative
|
|
CA2907814C
(en)
|
2013-03-29 |
2021-07-13 |
Euroscreen Sa |
Novel n-acyl-(3-substituted)-(8-methyl)-5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazines as selective nk-3 receptor antagonists, pharmaceutical composition, methods for use in nk-3 receptor-mediated disorders
|
|
NO2948455T3
(enExample)
|
2013-03-29 |
2018-02-24 |
|
|
|
US10183948B2
(en)
|
2013-03-29 |
2019-01-22 |
Ogeda Sa |
N-acyl-(3-substituted)-(8-substituted)-5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazines as selective NK-3 receptor antagonists
|
|
AU2014242907B2
(en)
|
2013-03-29 |
2018-06-28 |
Ogeda Sa |
Novel N-acyl-(3-substituted)-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazines as selective NK-3 receptor antagonists, pharmaceutical composition, methods for use in NK-3 receptor-mediated disorders
|
|
KR101670126B1
(ko)
|
2013-09-13 |
2016-10-27 |
일동제약(주) |
신규 프탈라지논 유도체 및 그 제조방법
|
|
ES2544869B2
(es)
*
|
2014-03-04 |
2016-01-18 |
Universidade De Vigo |
Derivados de piridazin-3(2H)-ona inhibidores selectivos de la isoforma B de la monoaminooxidasa
|
|
US10550108B2
(en)
|
2014-10-03 |
2020-02-04 |
Institute For Cancer Research |
Poly(ADP-ribose) polymerase 1 inhibitors structurally unrelated to NAD
|
|
US10472664B2
(en)
|
2014-10-03 |
2019-11-12 |
Institute For Cancer Research |
Screening assay for identification of poly(ADP-ribose) polymerase 1 inhibitors
|
|
JP6871169B2
(ja)
|
2015-03-02 |
2021-05-12 |
シナイ ヘルス システム |
相同組換え因子
|
|
ES2879434T3
(es)
|
2015-07-23 |
2021-11-22 |
Inst Curie |
Uso de una combinación de molécula Dbait e inhibidores de PARP para tratamiento del cáncer
|
|
CN106749261A
(zh)
|
2015-11-23 |
2017-05-31 |
中国科学院上海药物研究所 |
一类取代三唑并哌嗪类parp抑制剂及其制备方法和用途
|
|
WO2018162439A1
(en)
|
2017-03-08 |
2018-09-13 |
Onxeo |
New predictive biomarker for the sensitivity to a treatment of cancer with a dbait molecule
|
|
EP3680241A1
(en)
|
2017-03-20 |
2020-07-15 |
Forma Therapeutics, Inc. |
Pyrrolopyrrole compositions as pyruvate kinase (pkr) activators
|
|
CN109232575B
(zh)
*
|
2017-07-10 |
2022-01-25 |
中国科学院上海药物研究所 |
吡咯[1,2-b]哒嗪类化合物或其可药用盐及它们的用途
|
|
KR20200130856A
(ko)
|
2018-03-13 |
2020-11-20 |
옹쎄오 |
암 치료에서 획득한 내성에 대한 디베이트 분자
|
|
SI3788040T1
(sl)
|
2018-04-30 |
2023-07-31 |
Ribon Therapeutics Inc. |
Piridazinoni kot zaviralci parp7
|
|
US10675274B2
(en)
|
2018-09-19 |
2020-06-09 |
Forma Therapeutics, Inc. |
Activating pyruvate kinase R
|
|
WO2020061255A1
(en)
|
2018-09-19 |
2020-03-26 |
Forma Therapeutics, Inc. |
Activating pyruvate kinase r
|
|
TWI767148B
(zh)
|
2018-10-10 |
2022-06-11 |
美商弗瑪治療公司 |
抑制脂肪酸合成酶(fasn)
|
|
WO2020092395A1
(en)
|
2018-10-29 |
2020-05-07 |
Forma Therapeutics, Inc. |
SOLID FORMS OF (4-(2-FLUORO-4-(1-METHYL-1 H-BENZO[d]IMIDAZOL-5-YL)BENZOYL) PIPERAZIN-1-YL)(1-HYDROXYCYCLOPROPYL)METHANONE
|
|
US12371421B2
(en)
|
2019-04-29 |
2025-07-29 |
Ribon Therapeutics, Inc. |
Solid forms of a PARP7 inhibitor
|
|
HUE072832T2
(hu)
|
2019-09-19 |
2025-12-28 |
Novo Nordisk Healthcare Ag |
Piruvát kináz R-t (PKR) aktiváló készítmények
|
|
MX2022005216A
(es)
|
2019-10-30 |
2022-06-02 |
Ribon Therapeutics Inc |
Piridazinonas como inhibidores de poli(adp-ribosa) polimerasa 7 (parp7).
|
|
WO2021148581A1
(en)
|
2020-01-22 |
2021-07-29 |
Onxeo |
Novel dbait molecule and its use
|
|
CA3176219A1
(en)
|
2020-04-21 |
2021-10-28 |
Kunhee LEE |
Crystalline forms of phthalazinone compound
|
|
US12060345B2
(en)
|
2020-04-21 |
2024-08-13 |
Idience Co., Ltd. |
Process for preparing a phthalazinone derivative and intermediates thereof
|
|
US12059419B2
(en)
|
2020-10-16 |
2024-08-13 |
Idience Co., Ltd. |
Pharmaceutical composition comprising phthalazinone derivatives
|
|
US12128035B2
(en)
|
2021-03-19 |
2024-10-29 |
Novo Nordisk Health Care Ag |
Activating pyruvate kinase R
|
|
CN117083274A
(zh)
*
|
2021-04-23 |
2023-11-17 |
四川海思科制药有限公司 |
一种并环杂环衍生物及其在医药上的应用
|
|
CN115477640A
(zh)
*
|
2021-05-31 |
2022-12-16 |
由理生物医药(上海)有限公司 |
作为parp7抑制剂的哒嗪酮类化合物
|
|
WO2023006013A1
(zh)
*
|
2021-07-29 |
2023-02-02 |
上海齐鲁制药研究中心有限公司 |
新型parp7抑制剂及其应用
|
|
US20240343727A1
(en)
*
|
2021-08-17 |
2024-10-17 |
InventisBio Co., Ltd. |
Pyridazinone or pyridinone compounds, preparation methods and uses thereof
|
|
AU2022375782B2
(en)
|
2021-10-28 |
2026-02-26 |
Gilead Sciences, Inc. |
Pyridizin-3(2h)-one derivatives
|
|
CN115745971B
(zh)
*
|
2021-12-20 |
2024-07-30 |
北京华森英诺生物科技有限公司 |
Parp7抑制剂及其应用
|
|
EP4338737A4
(en)
*
|
2022-04-01 |
2024-11-06 |
Novostar Pharmaceuticals, Ltd. |
PARP7 INHIBITOR AND ITS USE
|
|
EP4594314A1
(en)
*
|
2022-09-30 |
2025-08-06 |
Azkarra Therapeutics, Inc. |
Pyridazin-3(2h)-one and pyridin-2(1h)-one parp inhibitor compounds
|
|
CN121712509A
(zh)
|
2023-05-04 |
2026-03-20 |
锐新医药公司 |
用于ras相关疾病或病症的组合疗法
|
|
CN121398822A
(zh)
|
2023-06-21 |
2026-01-23 |
四方生物科学有限公司 |
用于在治疗hr功能正常的癌症的方法中的用途的包含脱氧胞苷衍生物和parp抑制剂的组合
|
|
US20250049810A1
(en)
|
2023-08-07 |
2025-02-13 |
Revolution Medicines, Inc. |
Methods of treating a ras protein-related disease or disorder
|
|
IL327306A
(en)
|
2023-10-12 |
2026-05-01 |
Revolution Medicines Inc |
Macrocyclic RAS inhibitors
|
|
WO2025171296A1
(en)
|
2024-02-09 |
2025-08-14 |
Revolution Medicines, Inc. |
Ras inhibitors
|
|
WO2025217307A1
(en)
|
2024-04-09 |
2025-10-16 |
Revolution Medicines, Inc. |
Methods for predicting response to a ras(on) inhibitor and combination therapies
|
|
WO2025240847A1
(en)
|
2024-05-17 |
2025-11-20 |
Revolution Medicines, Inc. |
Ras inhibitors
|
|
WO2025255438A1
(en)
|
2024-06-07 |
2025-12-11 |
Revolution Medicines, Inc. |
Methods of treating a ras protein-related disease or disorder
|
|
WO2025265060A1
(en)
|
2024-06-21 |
2025-12-26 |
Revolution Medicines, Inc. |
Therapeutic compositions and methods for managing treatment-related effects
|
|
WO2026006747A1
(en)
|
2024-06-28 |
2026-01-02 |
Revolution Medicines, Inc. |
Ras inhibitors
|
|
WO2026015790A1
(en)
|
2024-07-12 |
2026-01-15 |
Revolution Medicines, Inc. |
Methods of treating a ras related disease or disorder
|
|
WO2026015801A1
(en)
|
2024-07-12 |
2026-01-15 |
Revolution Medicines, Inc. |
Methods of treating a ras related disease or disorder
|
|
WO2026015796A1
(en)
|
2024-07-12 |
2026-01-15 |
Revolution Medicines, Inc. |
Methods of treating a ras related disease or disorder
|
|
WO2026015825A1
(en)
|
2024-07-12 |
2026-01-15 |
Revolution Medicines, Inc. |
Use of ras inhibitor for treating pancreatic cancer
|
|
WO2026050446A1
(en)
|
2024-08-29 |
2026-03-05 |
Revolution Medicines, Inc. |
Ras inhibitors
|
|
WO2026072904A2
(en)
|
2024-09-26 |
2026-04-02 |
Revolution Medicines, Inc. |
Compositions and methods for treating lung cancer
|
|
WO2026090116A2
(en)
|
2024-10-21 |
2026-04-30 |
Revolution Medicines, Inc. |
Ras inhibitors
|
|
US20260108528A1
(en)
|
2024-10-22 |
2026-04-23 |
Revolution Medicines, Inc. |
Methods of treating a ras protein-related disease or disorder
|
|
WO2026090245A1
(en)
|
2024-10-22 |
2026-04-30 |
Revolution Medicines, Inc. |
Use of ras inhibitors for treating cancer
|