FI3630967T3 - Proteaasi ja sitoutuva polypeptidi o-glykoproteiineja varten - Google Patents
Proteaasi ja sitoutuva polypeptidi o-glykoproteiineja varten Download PDFInfo
- Publication number
- FI3630967T3 FI3630967T3 FIEP18728576.2T FI18728576T FI3630967T3 FI 3630967 T3 FI3630967 T3 FI 3630967T3 FI 18728576 T FI18728576 T FI 18728576T FI 3630967 T3 FI3630967 T3 FI 3630967T3
- Authority
- FI
- Finland
- Prior art keywords
- polypeptide
- amino acid
- glycoprotein
- sequence
- optionally
- Prior art date
Links
- 229920001184 polypeptide Polymers 0.000 title claims 24
- 102000004196 processed proteins & peptides Human genes 0.000 title claims 24
- 108090000765 processed proteins & peptides Proteins 0.000 title claims 24
- 108091005804 Peptidases Proteins 0.000 title 1
- 239000004365 Protease Substances 0.000 title 1
- 102100037486 Reverse transcriptase/ribonuclease H Human genes 0.000 title 1
- 239000000203 mixture Substances 0.000 claims 17
- 238000000034 method Methods 0.000 claims 14
- 125000003275 alpha amino acid group Chemical group 0.000 claims 13
- 108090000623 proteins and genes Proteins 0.000 claims 6
- 102000004169 proteins and genes Human genes 0.000 claims 6
- 108090000288 Glycoproteins Proteins 0.000 claims 5
- 102000003886 Glycoproteins Human genes 0.000 claims 5
- 150000001413 amino acids Chemical class 0.000 claims 5
- 101710118538 Protease Proteins 0.000 claims 3
- 229910052799 carbon Inorganic materials 0.000 claims 3
- 230000000694 effects Effects 0.000 claims 3
- 239000012634 fragment Substances 0.000 claims 3
- 229910052698 phosphorus Inorganic materials 0.000 claims 3
- 102000002068 Glycopeptides Human genes 0.000 claims 2
- 108010015899 Glycopeptides Proteins 0.000 claims 2
- 102000005348 Neuraminidase Human genes 0.000 claims 2
- 108010006232 Neuraminidase Proteins 0.000 claims 2
- 108091006033 O-glycosylated proteins Proteins 0.000 claims 2
- 238000001042 affinity chromatography Methods 0.000 claims 2
- 238000004458 analytical method Methods 0.000 claims 2
- 230000013595 glycosylation Effects 0.000 claims 2
- 238000006206 glycosylation reaction Methods 0.000 claims 2
- 230000003301 hydrolyzing effect Effects 0.000 claims 2
- 238000004949 mass spectrometry Methods 0.000 claims 2
- 229930182817 methionine Natural products 0.000 claims 2
- 125000001360 methionine group Chemical group N[C@@H](CCSC)C(=O)* 0.000 claims 2
- 229910052757 nitrogen Inorganic materials 0.000 claims 2
- 238000000926 separation method Methods 0.000 claims 2
- 238000002415 sodium dodecyl sulfate polyacrylamide gel electrophoresis Methods 0.000 claims 2
- DQJCDTNMLBYVAY-ZXXIYAEKSA-N (2S,5R,10R,13R)-16-{[(2R,3S,4R,5R)-3-{[(2S,3R,4R,5S,6R)-3-acetamido-4,5-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy}-5-(ethylamino)-6-hydroxy-2-(hydroxymethyl)oxan-4-yl]oxy}-5-(4-aminobutyl)-10-carbamoyl-2,13-dimethyl-4,7,12,15-tetraoxo-3,6,11,14-tetraazaheptadecan-1-oic acid Chemical compound NCCCC[C@H](C(=O)N[C@@H](C)C(O)=O)NC(=O)CC[C@H](C(N)=O)NC(=O)[C@@H](C)NC(=O)C(C)O[C@@H]1[C@@H](NCC)C(O)O[C@H](CO)[C@H]1O[C@H]1[C@H](NC(C)=O)[C@@H](O)[C@H](O)[C@@H](CO)O1 DQJCDTNMLBYVAY-ZXXIYAEKSA-N 0.000 claims 1
- 238000002965 ELISA Methods 0.000 claims 1
- 102000004856 Lectins Human genes 0.000 claims 1
- 108090001090 Lectins Proteins 0.000 claims 1
- XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Chemical compound NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 claims 1
- 230000015572 biosynthetic process Effects 0.000 claims 1
- 239000004202 carbamide Substances 0.000 claims 1
- 238000003776 cleavage reaction Methods 0.000 claims 1
- 238000001514 detection method Methods 0.000 claims 1
- 239000003599 detergent Substances 0.000 claims 1
- 230000007062 hydrolysis Effects 0.000 claims 1
- 238000006460 hydrolysis reaction Methods 0.000 claims 1
- 230000002209 hydrophobic effect Effects 0.000 claims 1
- 239000002523 lectin Substances 0.000 claims 1
- 239000000463 material Substances 0.000 claims 1
- 229910052760 oxygen Inorganic materials 0.000 claims 1
- 230000007017 scission Effects 0.000 claims 1
- 229910052717 sulfur Inorganic materials 0.000 claims 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/24—Hydrolases (3) acting on glycosyl compounds (3.2)
- C12N9/2402—Hydrolases (3) acting on glycosyl compounds (3.2) hydrolysing O- and S- glycosyl compounds (3.2.1)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/52—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from bacteria or Archaea
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
- C12Y304/24—Metalloendopeptidases (3.4.24)
- C12Y304/24057—O-Sialoglycoprotein endopeptidase (3.4.24.57), i.e. glycoprotease
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/84—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving inorganic compounds or pH
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/90—Enzymes; Proenzymes
- G01N2333/914—Hydrolases (3)
- G01N2333/924—Hydrolases (3) acting on glycosyl compounds (3.2)
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/90—Enzymes; Proenzymes
- G01N2333/914—Hydrolases (3)
- G01N2333/948—Hydrolases (3) acting on peptide bonds (3.4)
- G01N2333/95—Proteinases, i.e. endopeptidases (3.4.21-3.4.99)
- G01N2333/952—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from bacteria
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- Organic Chemistry (AREA)
- Genetics & Genomics (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Medicinal Chemistry (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- Immunology (AREA)
- General Engineering & Computer Science (AREA)
- General Physics & Mathematics (AREA)
- Food Science & Technology (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Cell Biology (AREA)
- Pathology (AREA)
- Inorganic Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Peptides Or Proteins (AREA)
- Enzymes And Modification Thereof (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB1708476.5A GB201708476D0 (en) | 2017-05-26 | 2017-05-26 | Tools for glycan analysis |
| GBGB1708471.6A GB201708471D0 (en) | 2017-05-26 | 2017-05-26 | Polypeptide |
| GBGB1806655.5A GB201806655D0 (en) | 2018-04-24 | 2018-04-24 | Polypeptide |
| PCT/EP2018/063832 WO2018215656A1 (en) | 2017-05-26 | 2018-05-25 | Protease and binding polypeptide for o-glycoproteins |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| FI3630967T3 true FI3630967T3 (fi) | 2024-08-12 |
Family
ID=62492612
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FIEP18728576.2T FI3630967T3 (fi) | 2017-05-26 | 2018-05-25 | Proteaasi ja sitoutuva polypeptidi o-glykoproteiineja varten |
| FIEP18728577.0T FI3630968T3 (fi) | 2017-05-26 | 2018-05-25 | Entsyymejä glykaanien analysointiin |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FIEP18728577.0T FI3630968T3 (fi) | 2017-05-26 | 2018-05-25 | Entsyymejä glykaanien analysointiin |
Country Status (14)
| Country | Link |
|---|---|
| US (3) | US11584922B2 (enExample) |
| EP (2) | EP3630968B8 (enExample) |
| JP (3) | JP2020521460A (enExample) |
| KR (2) | KR102609790B1 (enExample) |
| CN (2) | CN111183220B (enExample) |
| AU (2) | AU2018272400B2 (enExample) |
| CA (2) | CA3063815A1 (enExample) |
| DK (2) | DK3630968T3 (enExample) |
| ES (2) | ES2986557T3 (enExample) |
| FI (2) | FI3630967T3 (enExample) |
| IL (2) | IL270950B2 (enExample) |
| PL (2) | PL3630968T3 (enExample) |
| PT (2) | PT3630967T (enExample) |
| WO (2) | WO2018215657A1 (enExample) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PL3630968T3 (pl) | 2017-05-26 | 2024-10-07 | Genovis Ab | Enzymy do analizy glikanów |
| AU2020301037A1 (en) * | 2019-07-03 | 2022-02-03 | Palleon Pharmaceuticals Inc. | Recombinant human sialidases, sialidase fusion proteins, and methods of using the same |
| CN112795583A (zh) * | 2020-11-16 | 2021-05-14 | 上海大学 | 重组唾液酸外切酶的制备方法、表达基因、重组表达载体及构建方法 |
| WO2023114931A1 (en) * | 2021-12-15 | 2023-06-22 | Danisco Us Inc. | Compositions and methods involving proteases specific for mannose-modified proteins |
| KR20250115409A (ko) * | 2022-11-28 | 2025-07-30 | 암젠 인크 | 에타너셉트를 프로세싱하는 방법 |
| US20260092921A1 (en) | 2024-09-27 | 2026-04-02 | Roche Diagnostics Gmbh | Mutated neuroaminidase |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6720165B2 (en) | 2001-06-14 | 2004-04-13 | Zyomix, Inc. | Methods for making antibody fragments and compositions resulting therefrom |
| US7807174B2 (en) * | 2002-11-22 | 2010-10-05 | Nexbio, Inc. | Class of therapeutic protein based molecules |
| GB0624874D0 (en) | 2006-12-13 | 2007-01-24 | Hansa Medical Ab | Treatment |
| WO2009129086A2 (en) | 2008-04-18 | 2009-10-22 | New England Biolabs, Inc. | Endoglycosidases that cleave o-linked glycans |
| EP2166085A1 (en) | 2008-07-16 | 2010-03-24 | Suomen Punainen Risti Veripalvelu | Divalent modified cells |
| WO2010111691A2 (en) | 2009-03-27 | 2010-09-30 | Life Technologies Corp | Conjugates of biomolecules to nanoparticles |
| GB201115841D0 (en) | 2011-09-13 | 2011-10-26 | Genovis Ab | Protein and method |
| GB201316744D0 (en) | 2013-09-20 | 2013-11-06 | Genovis Ab | Method |
| US10080787B2 (en) | 2014-07-02 | 2018-09-25 | New England Biolabs, Inc. | Universal N-glycan binding reagent |
| WO2017052433A1 (en) | 2015-09-24 | 2017-03-30 | Saab Ab | A modular fluid actuator system |
| AU2017214441B2 (en) | 2016-02-04 | 2021-08-19 | Genovis Ab | New Streptococcal proteases |
| PL3630968T3 (pl) * | 2017-05-26 | 2024-10-07 | Genovis Ab | Enzymy do analizy glikanów |
-
2018
- 2018-05-25 PL PL18728577.0T patent/PL3630968T3/pl unknown
- 2018-05-25 PT PT187285762T patent/PT3630967T/pt unknown
- 2018-05-25 PL PL18728576.2T patent/PL3630967T3/pl unknown
- 2018-05-25 US US16/616,827 patent/US11584922B2/en active Active
- 2018-05-25 JP JP2019565178A patent/JP2020521460A/ja active Pending
- 2018-05-25 CN CN201880050240.9A patent/CN111183220B/zh active Active
- 2018-05-25 DK DK18728577.0T patent/DK3630968T3/da active
- 2018-05-25 FI FIEP18728576.2T patent/FI3630967T3/fi active
- 2018-05-25 IL IL270950A patent/IL270950B2/en unknown
- 2018-05-25 KR KR1020197036837A patent/KR102609790B1/ko active Active
- 2018-05-25 WO PCT/EP2018/063833 patent/WO2018215657A1/en not_active Ceased
- 2018-05-25 WO PCT/EP2018/063832 patent/WO2018215656A1/en not_active Ceased
- 2018-05-25 ES ES18728577T patent/ES2986557T3/es active Active
- 2018-05-25 ES ES18728576T patent/ES2986910T3/es active Active
- 2018-05-25 CN CN201880050251.7A patent/CN111183221B/zh active Active
- 2018-05-25 CA CA3063815A patent/CA3063815A1/en active Pending
- 2018-05-25 PT PT187285770T patent/PT3630968T/pt unknown
- 2018-05-25 EP EP18728577.0A patent/EP3630968B8/en active Active
- 2018-05-25 EP EP18728576.2A patent/EP3630967B8/en active Active
- 2018-05-25 US US16/616,872 patent/US12448614B2/en active Active
- 2018-05-25 AU AU2018272400A patent/AU2018272400B2/en active Active
- 2018-05-25 CA CA3063828A patent/CA3063828A1/en active Pending
- 2018-05-25 JP JP2019565188A patent/JP7195008B2/ja active Active
- 2018-05-25 DK DK18728576.2T patent/DK3630967T3/da active
- 2018-05-25 FI FIEP18728577.0T patent/FI3630968T3/fi active
- 2018-05-25 AU AU2018272984A patent/AU2018272984B2/en active Active
- 2018-05-25 IL IL270949A patent/IL270949B2/en unknown
- 2018-05-25 KR KR1020197036845A patent/KR102608876B1/ko active Active
-
2022
- 2022-12-22 US US18/145,807 patent/US12529044B2/en active Active
-
2023
- 2023-04-13 JP JP2023065981A patent/JP7557896B2/ja active Active
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