FI3442956T3 - Menetelmä pyrviniumpamoaatin ja sen kiteisten muotojen valmistamiseksi - Google Patents
Menetelmä pyrviniumpamoaatin ja sen kiteisten muotojen valmistamiseksi Download PDFInfo
- Publication number
- FI3442956T3 FI3442956T3 FIEP17717678.1T FI17717678T FI3442956T3 FI 3442956 T3 FI3442956 T3 FI 3442956T3 FI 17717678 T FI17717678 T FI 17717678T FI 3442956 T3 FI3442956 T3 FI 3442956T3
- Authority
- FI
- Finland
- Prior art keywords
- crystalline form
- formula
- form iii
- pyrvinium pamoate
- pamoate salt
- Prior art date
Links
- 238000000034 method Methods 0.000 title claims 18
- OOPDAHSJBRZRPH-UHFFFAOYSA-L Pyrvinium pamoate Chemical compound C1=CC2=CC(N(C)C)=CC=C2[N+](C)=C1C=CC(=C1C)C=C(C)N1C1=CC=CC=C1.C1=CC2=CC(N(C)C)=CC=C2[N+](C)=C1C=CC(=C1C)C=C(C)N1C1=CC=CC=C1.C12=CC=CC=C2C=C(C([O-])=O)C(O)=C1CC1=C(O)C(C([O-])=O)=CC2=CC=CC=C12 OOPDAHSJBRZRPH-UHFFFAOYSA-L 0.000 title claims 9
- 238000002360 preparation method Methods 0.000 title claims 2
- 229960001077 pyrvinium pamoate Drugs 0.000 title 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims 8
- 150000001875 compounds Chemical class 0.000 claims 5
- 239000000203 mixture Substances 0.000 claims 5
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 claims 3
- YXFVVABEGXRONW-UHFFFAOYSA-N Toluene Chemical compound CC1=CC=CC=C1 YXFVVABEGXRONW-UHFFFAOYSA-N 0.000 claims 3
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 3
- QGZKDVFQNNGYKY-UHFFFAOYSA-N Ammonia Chemical group N QGZKDVFQNNGYKY-UHFFFAOYSA-N 0.000 claims 2
- NQRYJNQNLNOLGT-UHFFFAOYSA-N Piperidine Chemical compound C1CCNCC1 NQRYJNQNLNOLGT-UHFFFAOYSA-N 0.000 claims 2
- 229930195733 hydrocarbon Natural products 0.000 claims 2
- 150000002430 hydrocarbons Chemical class 0.000 claims 2
- 238000010992 reflux Methods 0.000 claims 2
- 239000002904 solvent Substances 0.000 claims 2
- 229910021529 ammonia Inorganic materials 0.000 claims 1
- 238000006243 chemical reaction Methods 0.000 claims 1
- 238000001816 cooling Methods 0.000 claims 1
- 125000004122 cyclic group Chemical group 0.000 claims 1
- VAYGXNSJCAHWJZ-UHFFFAOYSA-N dimethyl sulfate Chemical compound COS(=O)(=O)OC VAYGXNSJCAHWJZ-UHFFFAOYSA-N 0.000 claims 1
- YGLLICRFEVEWOZ-UHFFFAOYSA-L disodium;3-carboxy-1-[(3-carboxy-2-oxidonaphthalen-1-yl)methyl]naphthalen-2-olate Chemical compound [Na+].[Na+].C1=CC=C2C(CC3=C4C=CC=CC4=CC(=C3O)C([O-])=O)=C(O)C(C([O-])=O)=CC2=C1 YGLLICRFEVEWOZ-UHFFFAOYSA-L 0.000 claims 1
- 150000002170 ethers Chemical class 0.000 claims 1
- 229960002778 pyrvinium Drugs 0.000 claims 1
- -1 pyrvinium methyl sulfate salt Chemical class 0.000 claims 1
- 238000005406 washing Methods 0.000 claims 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4709—Non-condensed quinolines and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/10—Anthelmintics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/38—Nitrogen atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Tropical Medicine & Parasitology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP16382169.7A EP3231796A1 (en) | 2016-04-13 | 2016-04-13 | A process for the preparation of pyrvinium pamoate and crystalline forms thereof |
| PCT/EP2017/058773 WO2017178524A1 (en) | 2016-04-13 | 2017-04-12 | A process for the preparation of pyrvinium pamoate and crystalline forms thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| FI3442956T3 true FI3442956T3 (fi) | 2024-05-03 |
Family
ID=55809063
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FIEP17717678.1T FI3442956T3 (fi) | 2016-04-13 | 2017-04-12 | Menetelmä pyrviniumpamoaatin ja sen kiteisten muotojen valmistamiseksi |
Country Status (5)
| Country | Link |
|---|---|
| EP (2) | EP3231796A1 (enExample) |
| JP (1) | JP7021107B2 (enExample) |
| ES (2) | ES2689371B1 (enExample) |
| FI (1) | FI3442956T3 (enExample) |
| WO (1) | WO2017178524A1 (enExample) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US12447147B2 (en) | 2019-10-22 | 2025-10-21 | Thomas Jefferson University | Methods of treating, ameliorating, and/or preventing cancer using pyrvinium compositions |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2515912A (en) * | 1946-10-01 | 1950-07-18 | Eastman Kodak Co | Pyrrole dimethinecyanine dyes |
| BE572031A (enExample) | 1957-11-06 | |||
| JP2008527047A (ja) * | 2005-01-18 | 2008-07-24 | イミューソル インコーポレイテッド | 新規キノリニウム塩及び誘導体 |
-
2016
- 2016-04-13 EP EP16382169.7A patent/EP3231796A1/en not_active Withdrawn
-
2017
- 2017-03-29 ES ES201700479A patent/ES2689371B1/es not_active Expired - Fee Related
- 2017-04-12 JP JP2018553220A patent/JP7021107B2/ja active Active
- 2017-04-12 EP EP17717678.1A patent/EP3442956B1/en active Active
- 2017-04-12 WO PCT/EP2017/058773 patent/WO2017178524A1/en not_active Ceased
- 2017-04-12 ES ES17717678T patent/ES2977432T3/es active Active
- 2017-04-12 FI FIEP17717678.1T patent/FI3442956T3/fi active
Also Published As
| Publication number | Publication date |
|---|---|
| BR112018071009A2 (pt) | 2019-02-12 |
| JP7021107B2 (ja) | 2022-02-16 |
| EP3231796A1 (en) | 2017-10-18 |
| WO2017178524A1 (en) | 2017-10-19 |
| ES2689371A8 (es) | 2018-12-05 |
| ES2689371B1 (es) | 2019-08-22 |
| ES2689371A1 (es) | 2018-11-13 |
| EP3442956A1 (en) | 2019-02-20 |
| JP2019511523A (ja) | 2019-04-25 |
| ES2977432T3 (es) | 2024-08-23 |
| EP3442956B1 (en) | 2024-03-27 |
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