FI2760882T3 - Viruksen kaltaisen partikkelin saantojen lisääminen kasveissa - Google Patents
Viruksen kaltaisen partikkelin saantojen lisääminen kasveissa Download PDFInfo
- Publication number
- FI2760882T3 FI2760882T3 FIEP12836545.9T FI12836545T FI2760882T3 FI 2760882 T3 FI2760882 T3 FI 2760882T3 FI 12836545 T FI12836545 T FI 12836545T FI 2760882 T3 FI2760882 T3 FI 2760882T3
- Authority
- FI
- Finland
- Prior art keywords
- plant
- influenza
- protein
- seq
- vlp
- Prior art date
Links
- 239000002245 particle Substances 0.000 title claims 4
- 241000196324 Embryophyta Species 0.000 claims 20
- 238000000034 method Methods 0.000 claims 18
- 101710154606 Hemagglutinin Proteins 0.000 claims 14
- 101710093908 Outer capsid protein VP4 Proteins 0.000 claims 14
- 101710135467 Outer capsid protein sigma-1 Proteins 0.000 claims 14
- 101710176177 Protein A56 Proteins 0.000 claims 14
- 239000000185 hemagglutinin Substances 0.000 claims 13
- 206010022000 influenza Diseases 0.000 claims 8
- 108020004707 nucleic acids Proteins 0.000 claims 8
- 102000039446 nucleic acids Human genes 0.000 claims 8
- 150000007523 nucleic acids Chemical class 0.000 claims 8
- 239000002773 nucleotide Substances 0.000 claims 7
- 125000003729 nucleotide group Chemical group 0.000 claims 7
- 108090000623 proteins and genes Proteins 0.000 claims 6
- 102000004169 proteins and genes Human genes 0.000 claims 6
- 230000009466 transformation Effects 0.000 claims 6
- 108091006146 Channels Proteins 0.000 claims 5
- 102000034573 Channels Human genes 0.000 claims 4
- 241000723607 Comovirus Species 0.000 claims 4
- 208000037797 influenza A Diseases 0.000 claims 4
- 230000001105 regulatory effect Effects 0.000 claims 4
- 241000702463 Geminiviridae Species 0.000 claims 3
- 208000037798 influenza B Diseases 0.000 claims 3
- 239000000463 material Substances 0.000 claims 3
- 108091029795 Intergenic region Proteins 0.000 claims 2
- 230000003321 amplification Effects 0.000 claims 2
- 239000003623 enhancer Substances 0.000 claims 2
- 238000004519 manufacturing process Methods 0.000 claims 2
- 238000003199 nucleic acid amplification method Methods 0.000 claims 2
- 230000002797 proteolythic effect Effects 0.000 claims 2
- 241000710073 Bean yellow mosaic virus Species 0.000 claims 1
- 108010042653 IgA receptor Proteins 0.000 claims 1
- 102100034014 Prolyl 3-hydroxylase 3 Human genes 0.000 claims 1
- 241000700605 Viruses Species 0.000 claims 1
- 235000015872 dietary supplement Nutrition 0.000 claims 1
- 230000030279 gene silencing Effects 0.000 claims 1
- 239000003112 inhibitor Substances 0.000 claims 1
- 108010026228 mRNA guanylyltransferase Proteins 0.000 claims 1
- 230000003584 silencer Effects 0.000 claims 1
- 230000001052 transient effect Effects 0.000 claims 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
- A61K39/145—Orthomyxoviridae, e.g. influenza virus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/08—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses
- C07K16/10—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses from RNA viruses
- C07K16/1018—Orthomyxoviridae, e.g. influenza virus
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
- C12N15/8241—Phenotypically and genetically modified plants via recombinant DNA technology
- C12N15/8242—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits
- C12N15/8257—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits for the production of primary gene products, e.g. pharmaceutical products, interferon
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
- C12N15/8241—Phenotypically and genetically modified plants via recombinant DNA technology
- C12N15/8242—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits
- C12N15/8257—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits for the production of primary gene products, e.g. pharmaceutical products, interferon
- C12N15/8258—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits for the production of primary gene products, e.g. pharmaceutical products, interferon for the production of oral vaccines (antigens) or immunoglobulins
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
- C12N2760/00011—Details
- C12N2760/16011—Orthomyxoviridae
- C12N2760/16211—Influenzavirus B, i.e. influenza B virus
- C12N2760/16223—Virus like particles [VLP]
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
- C12N2760/00011—Details
- C12N2760/16011—Orthomyxoviridae
- C12N2760/16211—Influenzavirus B, i.e. influenza B virus
- C12N2760/16234—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
- C12N2760/00011—Details
- C12N2760/16011—Orthomyxoviridae
- C12N2760/16211—Influenzavirus B, i.e. influenza B virus
- C12N2760/16251—Methods of production or purification of viral material
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Genetics & Genomics (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Medicinal Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- General Health & Medical Sciences (AREA)
- Biomedical Technology (AREA)
- General Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Virology (AREA)
- Immunology (AREA)
- Biochemistry (AREA)
- Microbiology (AREA)
- Pharmacology & Pharmacy (AREA)
- Biophysics (AREA)
- Cell Biology (AREA)
- Physics & Mathematics (AREA)
- Plant Pathology (AREA)
- Pulmonology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Communicable Diseases (AREA)
- Epidemiology (AREA)
- Mycology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Oncology (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161541780P | 2011-09-30 | 2011-09-30 | |
| PCT/CA2012/050681 WO2013044390A1 (en) | 2011-09-30 | 2012-09-28 | Increasing virus-like particle yield in plants |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| FI2760882T3 true FI2760882T3 (fi) | 2023-07-17 |
Family
ID=47994080
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FIEP12836545.9T FI2760882T3 (fi) | 2011-09-30 | 2012-09-28 | Viruksen kaltaisen partikkelin saantojen lisääminen kasveissa |
Country Status (27)
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IN2014CN03077A (cg-RX-API-DMAC7.html) | 2011-09-30 | 2015-07-03 | Medicago Inc | |
| US11390878B2 (en) | 2011-09-30 | 2022-07-19 | Medicago Inc. | Increasing protein yield in plants |
| AU2014245779B2 (en) * | 2013-03-28 | 2020-02-06 | Aramis Biotechnologies Inc. | Influenza virus-like particle production in plants |
| US12467058B2 (en) | 2013-03-28 | 2025-11-11 | Aramis Biotechnologies Inc. | Influenza virus-like particle production in plants |
| DK3092309T3 (da) | 2014-01-10 | 2021-04-12 | Medicago Inc | Cpmv-forstærkerelementer |
| CN106460005B (zh) * | 2014-03-27 | 2020-01-03 | 莫迪卡戈公司 | 修饰的cpmv增强子元件 |
| EP3765618A4 (en) * | 2018-03-14 | 2022-01-05 | Medicago Inc. | PLANT EXPRESSION ACTIVATOR |
| CN112654707B (zh) * | 2018-06-27 | 2025-02-28 | 阿拉米斯生物技术公司 | 流感病毒血凝素突变体 |
| BR112021017899A2 (pt) * | 2019-03-14 | 2021-12-21 | Medicago Inc | Intensificador de expressão vegetal endógeno |
| WO2021236908A2 (en) * | 2020-05-20 | 2021-11-25 | Biomarin Pharmaceutical Inc. | Use of regulatory proteins for the production of adeno-associated virus |
Family Cites Families (43)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5428147A (en) | 1983-04-15 | 1995-06-27 | Mycogen Plant Science, Inc. | Octopine T-DNA promoters |
| US5100792A (en) | 1984-11-13 | 1992-03-31 | Cornell Research Foundation, Inc. | Method for transporting substances into living cells and tissues |
| US5036006A (en) | 1984-11-13 | 1991-07-30 | Cornell Research Foundation, Inc. | Method for transporting substances into living cells and tissues and apparatus therefor |
| US4945050A (en) | 1984-11-13 | 1990-07-31 | Cornell Research Foundation, Inc. | Method for transporting substances into living cells and tissues and apparatus therefor |
| US4962028A (en) | 1986-07-09 | 1990-10-09 | Dna Plant Technology Corporation | Plant promotors |
| US5232833A (en) | 1988-09-14 | 1993-08-03 | Stressgen Biotechnologies Corporation | Accumulation of heat shock proteins for evaluating biological damage due to chronic exposure of an organism to sublethal levels of pollutants |
| US5805417A (en) | 1995-10-13 | 1998-09-08 | Hitachi, Ltd. | Heat dissipation structure in a portable computer including a heat dissipation block extending from a heat dissipation plate through a first circuit board to a CPU on a second circuit board |
| WO2000020557A2 (en) | 1998-10-07 | 2000-04-13 | Boyce Institute For Plant Research At Cornell University | Gemini virus vectors for gene expression in plants |
| US7125978B1 (en) | 1999-10-04 | 2006-10-24 | Medicago Inc. | Promoter for regulating expression of foreign genes |
| RU2164148C1 (ru) * | 2000-08-09 | 2001-03-20 | Петров Рэм Викторович | Вакцина против вируса гриппа и способ ее получения |
| NZ543348A (en) * | 2003-05-05 | 2008-08-29 | Thompson Boyce Plant Res | Vectors and cells for preparing immunoprotective compositions derived from transgenic plants |
| US20040268442A1 (en) | 2003-05-05 | 2004-12-30 | Dow Agrosciences Llc | Stable immunoprophylactic and therapeutic compositions derived from transgenic plant cells and methods for production |
| PT2374892T (pt) * | 2005-04-29 | 2018-03-29 | Univ Cape Town | Expressão de proteínas virais em plantas |
| US7871626B2 (en) * | 2005-08-04 | 2011-01-18 | St. Jude Children's Research Hospital | Modified influenza virus for monitoring and improving vaccine efficiency |
| AU2006304640B2 (en) | 2005-10-18 | 2012-10-11 | Novavax, Inc. | Functional influenza virus like particles (VLPs) |
| US20090169576A1 (en) * | 2005-10-26 | 2009-07-02 | Roberto Crea | Influenza combinatorial antigen vaccine |
| US20090208531A1 (en) | 2006-02-16 | 2009-08-20 | National Institutes Of Health Office Of Technology | Antiviral agents and vaccines against influenza |
| EP2476432B1 (en) | 2006-03-07 | 2015-08-19 | Vaxinnate Corporation | Compositions that include hemagglutinin, methods of making and methods of use thereof |
| US20100143393A1 (en) | 2006-05-11 | 2010-06-10 | Gale Smith | Novel influenza m2 vaccines |
| WO2007135480A1 (en) | 2006-05-22 | 2007-11-29 | Plant Bioscience Limited | Bipartite system, method and composition for the constitutive and inducible expression of high levels of foreign proteins in plants |
| CN101472607A (zh) * | 2006-06-16 | 2009-07-01 | 美国陶氏益农公司 | 禽流感血凝素的新型dna序列、载体和蛋白质 |
| US8697088B2 (en) | 2007-05-25 | 2014-04-15 | Novavax, Inc. | VLPs derived from cells that do not express a viral matrix or core protein |
| BRPI0812538B1 (pt) | 2007-06-15 | 2021-03-16 | Medicago Inc. | processo para a síntese de uma proteína de interesse com fucosilação e xilosilação reduzidas, ácido nucleico, e proteína híbrida gnt1-galt |
| CA2615372A1 (en) * | 2007-07-13 | 2009-01-13 | Marc-Andre D'aoust | Influenza virus-like particles (vlps) comprising hemagglutinin |
| NZ587108A (en) | 2007-11-27 | 2013-04-26 | Medicago Inc | Recombinant influenza virus-like particles (vlps) produced in transgenic plants expressing hemagglutinin |
| GB0800272D0 (en) | 2008-01-08 | 2008-02-13 | Plant Bioscience Ltd | Protein expression systems |
| KR101956910B1 (ko) | 2008-01-21 | 2019-03-12 | 메디카고 인코포레이티드 | 헤마글루티닌을 발현하는 트랜스제닉 식물에서 생산된 재조합 인플루엔자 바이러스-유사 입자(ＶＬＰｓ) |
| EP2294202B1 (en) | 2008-07-08 | 2015-05-20 | Medicago Inc. | Soluble recombinant influenza antigens |
| JP5813505B2 (ja) | 2008-07-18 | 2015-11-17 | メディカゴ インコーポレイテッド | 新規インフルエンザウイルス免疫エピトープ |
| US8513397B2 (en) | 2008-08-27 | 2013-08-20 | The Arizona Board Of Regents For And On Behalf Of Arizona State University | DNA replicon system for high-level rapid production of vaccines and monoclonal antibody therapeutics in plants |
| JP2012521786A (ja) * | 2009-03-30 | 2012-09-20 | モウント シナイ スクール オフ メディシネ | インフルエンザウイルスワクチン及びその使用 |
| JP5871796B2 (ja) | 2009-06-24 | 2016-03-01 | メディカゴ インコーポレイテッド | ヘマグルチニンを含むキメラインフルエンザウイルス様粒子 |
| FR2947875B1 (fr) | 2009-07-10 | 2011-07-08 | Raymond A & Cie | Dispositif de fixation a elements de fixation multiples dont l'un est flottant |
| WO2011011390A1 (en) * | 2009-07-20 | 2011-01-27 | Novavax, Inc. | Purified recombinant influenza virus ha proteins |
| RU2579903C2 (ru) | 2009-09-22 | 2016-04-10 | Медикаго Инк. | Способ получения вирусоподобных частиц растений |
| JP2013520167A (ja) * | 2010-02-18 | 2013-06-06 | テクノヴァックス，インコーポレイテッド | 万能ウイルス様粒子（ｖｌｐ）インフルエンザワクチン |
| SG189236A1 (en) | 2010-10-04 | 2013-05-31 | Massachusetts Inst Technology | Hemagglutinin polypeptides, and reagents and methods relating thereto |
| TWI526539B (zh) | 2010-12-22 | 2016-03-21 | 苜蓿股份有限公司 | 植物中生產類病毒顆粒(vlp)的方法及以該方法生產之vlp |
| PL220281B1 (pl) | 2011-09-23 | 2015-09-30 | Inst Biochemii I Biofizyki Polskiej Akademii Nauk | Szczepionka DNA, sposób indukowania odpowiedzi immunologicznej, przeciwciała specyficznie rozpoznające białko hemaglutyniny H5 wirusa grypy i zastosowanie szczepionki DNA |
| IN2014CN03077A (cg-RX-API-DMAC7.html) | 2011-09-30 | 2015-07-03 | Medicago Inc | |
| US11390878B2 (en) * | 2011-09-30 | 2022-07-19 | Medicago Inc. | Increasing protein yield in plants |
| US9555094B2 (en) | 2012-07-23 | 2017-01-31 | The Institute Of Biological Resources | Isolated nucleic acid for the production of a vaccine against virus |
| AU2014245779B2 (en) | 2013-03-28 | 2020-02-06 | Aramis Biotechnologies Inc. | Influenza virus-like particle production in plants |
-
2012
- 2012-09-28 IN IN3077CHN2014 patent/IN2014CN03077A/en unknown
- 2012-09-28 NZ NZ622731A patent/NZ622731A/en not_active IP Right Cessation
- 2012-09-28 SG SG10201708052XA patent/SG10201708052XA/en unknown
- 2012-09-28 US US14/347,804 patent/US11155581B2/en active Active
- 2012-09-28 HR HRP20230695TT patent/HRP20230695T1/hr unknown
- 2012-09-28 AU AU2012315421A patent/AU2012315421C1/en active Active
- 2012-09-28 PL PL12836545.9T patent/PL2760882T3/pl unknown
- 2012-09-28 PH PH1/2014/500640A patent/PH12014500640A1/en unknown
- 2012-09-28 MX MX2014003776A patent/MX358883B/es active IP Right Grant
- 2012-09-28 DK DK12836545.9T patent/DK2760882T5/da active
- 2012-09-28 EP EP12836545.9A patent/EP2760882B1/en active Active
- 2012-09-28 CN CN201280047819.2A patent/CN103930435A/zh active Pending
- 2012-09-28 BR BR112014007474A patent/BR112014007474A2/pt not_active Application Discontinuation
- 2012-09-28 CN CN202310130025.2A patent/CN116218900A/zh active Pending
- 2012-09-28 PT PT128365459T patent/PT2760882T/pt unknown
- 2012-09-28 FI FIEP12836545.9T patent/FI2760882T3/fi active
- 2012-09-28 TW TW101135891A patent/TWI700368B/zh not_active IP Right Cessation
- 2012-09-28 SG SG11201400712VA patent/SG11201400712VA/en unknown
- 2012-09-28 SI SI201232036T patent/SI2760882T1/sl unknown
- 2012-09-28 WO PCT/CA2012/050681 patent/WO2013044390A1/en not_active Ceased
- 2012-09-28 CA CA2850407A patent/CA2850407C/en active Active
- 2012-09-28 ES ES12836545T patent/ES2951259T3/es active Active
- 2012-09-28 MY MYPI2014700716A patent/MY184072A/en unknown
- 2012-09-28 EP EP19205918.6A patent/EP3626733B1/en active Active
- 2012-09-28 HU HUE12836545A patent/HUE062759T2/hu unknown
- 2012-09-28 RU RU2014116371A patent/RU2682752C2/ru active
- 2012-09-28 JP JP2014532198A patent/JP6248040B2/ja active Active
- 2012-09-28 KR KR1020147011886A patent/KR101974017B1/ko active Active
-
2014
- 2014-03-19 IL IL231587A patent/IL231587B/en active IP Right Grant
- 2014-03-28 MX MX2018006627A patent/MX2018006627A/es unknown
- 2014-04-29 ZA ZA2014/03059A patent/ZA201403059B/en unknown
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