FI120237B - Pantrofiininen neurotroofiini-polypeptidi - Google Patents

Pantrofiininen neurotroofiini-polypeptidi Download PDF

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Publication number
FI120237B
FI120237B FI964833A FI964833A FI120237B FI 120237 B FI120237 B FI 120237B FI 964833 A FI964833 A FI 964833A FI 964833 A FI964833 A FI 964833A FI 120237 B FI120237 B FI 120237B
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FI
Finland
Prior art keywords
hngf
trka
binding
ngf
neurotrophin
Prior art date
Application number
FI964833A
Other languages
English (en)
Finnish (fi)
Swedish (sv)
Other versions
FI964833A (fi
FI964833A0 (fi
Inventor
Leonard G Presta
Roman Urfer
John Winslow
Original Assignee
Genentech Inc
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Publication date
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Application filed by Genentech Inc filed Critical Genentech Inc
Publication of FI964833A publication Critical patent/FI964833A/fi
Publication of FI964833A0 publication Critical patent/FI964833A0/fi
Application granted granted Critical
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/18—Growth factors; Growth regulators
    • A61K38/185—Nerve growth factor [NGF]; Brain derived neurotrophic factor [BDNF]; Ciliary neurotrophic factor [CNTF]; Glial derived neurotrophic factor [GDNF]; Neurotrophins, e.g. NT-3
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • C07K14/48—Nerve growth factor [NGF]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Toxicology (AREA)
  • General Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Biotechnology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Immunology (AREA)
  • Physics & Mathematics (AREA)
  • Epidemiology (AREA)
  • Plant Pathology (AREA)
  • Microbiology (AREA)
  • Psychology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
FI964833A 1994-06-03 1996-12-03 Pantrofiininen neurotroofiini-polypeptidi FI120237B (fi)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US25393794A 1994-06-03 1994-06-03
US25393794 1994-06-03
US9506918 1995-06-01
PCT/US1995/006918 WO1995033829A1 (en) 1994-06-03 1995-06-01 Pantropic neurotrophic factors

Publications (3)

Publication Number Publication Date
FI964833A FI964833A (fi) 1996-12-03
FI964833A0 FI964833A0 (fi) 1996-12-03
FI120237B true FI120237B (fi) 2009-08-14

Family

ID=22962278

Family Applications (1)

Application Number Title Priority Date Filing Date
FI964833A FI120237B (fi) 1994-06-03 1996-12-03 Pantrofiininen neurotroofiini-polypeptidi

Country Status (17)

Country Link
US (6) US5728803A (xx)
EP (1) EP0763107B1 (xx)
JP (1) JPH10501138A (xx)
CN (1) CN1159439C (xx)
AT (1) ATE280825T1 (xx)
AU (1) AU695144B2 (xx)
BR (1) BR9508019B1 (xx)
CA (1) CA2191064C (xx)
DE (1) DE69533698T2 (xx)
ES (1) ES2231786T3 (xx)
FI (1) FI120237B (xx)
IL (1) IL113983A0 (xx)
MX (1) MX9605971A (xx)
NO (1) NO317938B1 (xx)
NZ (1) NZ287762A (xx)
PT (1) PT763107E (xx)
WO (1) WO1995033829A1 (xx)

Families Citing this family (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5728803A (en) * 1994-06-03 1998-03-17 Genentech, Inc. Pantropic neurotrophic factors
DE19637718A1 (de) * 1996-04-01 1997-10-02 Boehringer Mannheim Gmbh Rekombinante inaktive Core-Streptavidin Mutanten
DE69738074T2 (de) * 1996-11-15 2008-05-21 Genentech, Inc., South San Francisco Reinigung von neurotrophinen
US6391571B1 (en) 1997-04-01 2002-05-21 Roche Diagnostics Gmbh Recombinant inactive avidin mutants
WO1998049308A1 (en) * 1997-04-25 1998-11-05 Genentech, Inc. Ngf variants
US6365373B2 (en) 1997-04-25 2002-04-02 Genentech, Inc. Nucleic acids encoding NGF variants
US7452863B1 (en) 1997-04-29 2008-11-18 Genentech, Inc. NGF variants
US6663899B2 (en) 1997-06-13 2003-12-16 Genentech, Inc. Controlled release microencapsulated NGF formulation
US6113947A (en) * 1997-06-13 2000-09-05 Genentech, Inc. Controlled release microencapsulated NGF formulation
US6652864B1 (en) * 1998-12-21 2003-11-25 Asilomar Pharmaceuticals, Inc. Compounds for intracellular delivery of therapeutic moieties to nerve cells
US20040120891A1 (en) * 1998-12-21 2004-06-24 Craig Hill Compounds for intracellular delivery of therapeutic moieties to nerve cells
GB0024550D0 (xx) 2000-10-06 2000-11-22 Oxford Biomedica Ltd
CA2975521A1 (en) * 2001-05-30 2002-12-05 Genentech, Inc. Anti-ngf antibodies for the treatment of various disorders
US20040096089A1 (en) * 2002-08-16 2004-05-20 David Borsook Non-invasive functional imaging of peripheral nervous system activation in humans and animals
DK1891966T3 (da) * 2002-12-20 2012-04-02 Lundbeck & Co As H Modulation af neurotrophinaktivitet; fremgangsmåde til screening
EP1841858A4 (en) * 2004-12-30 2010-02-10 Univ Johns Hopkins PROCESS FOR HIGHLY EFFICIENT SURVIVAL OR BZW. For the highly efficient proliferation of human embryonic stem cells in culture
RS55914B1 (sr) * 2006-12-21 2017-09-29 H Lundbeck As Modulacija aktivnosti proneurotrofina
WO2009062149A1 (en) * 2007-11-08 2009-05-14 Creighton University Methods for maintaining inner ear neurons
US8447409B2 (en) * 2008-10-15 2013-05-21 Cochlear Limited Electroneural interface for a medical implant
US8259461B2 (en) * 2008-11-25 2012-09-04 Micron Technology, Inc. Apparatus for bypassing faulty connections
US9539324B2 (en) 2010-12-01 2017-01-10 Alderbio Holdings, Llc Methods of preventing inflammation and treating pain using anti-NGF compositions
US8911734B2 (en) 2010-12-01 2014-12-16 Alderbio Holdings Llc Methods of preventing or treating pain using anti-NGF antibodies that selectively inhibit the association of NGF with TrkA, without affecting the association of NGF with p75
US9884909B2 (en) 2010-12-01 2018-02-06 Alderbio Holdings Llc Anti-NGF compositions and use thereof
US11214610B2 (en) 2010-12-01 2022-01-04 H. Lundbeck A/S High-purity production of multi-subunit proteins such as antibodies in transformed microbes such as Pichia pastoris
US9078878B2 (en) 2010-12-01 2015-07-14 Alderbio Holdings Llc Anti-NGF antibodies that selectively inhibit the association of NGF with TrkA, without affecting the association of NGF with p75
US9067988B2 (en) 2010-12-01 2015-06-30 Alderbio Holdings Llc Methods of preventing or treating pain using anti-NGF antibodies
CN109071678B (zh) * 2016-03-18 2022-05-20 舒泰神（北京）生物制药股份有限公司 神经生长因子融合蛋白、制备方法及其用途
CN112409471B (zh) * 2016-04-13 2022-07-29 舒泰神（北京）生物制药股份有限公司 低痛神经生长因子突变体
CN110183536B (zh) * 2018-02-22 2021-01-15 中国科学院遗传与发育生物学研究所 一种复合支架材料及其应用
EP3823674A4 (en) 2018-07-18 2022-12-28 Manzanita Pharmaceuticals, Inc. CONJUGATES FOR DELIVERING AN ANTI-CANCER AGENT TO NERVE CELLS, METHODS OF USE AND METHODS OF PRODUCTION THEREOF
CN110812532A (zh) * 2019-08-20 2020-02-21 中山大学 一种靶向促进皮质脊髓束连接以修复脊髓损伤的组织工程支架的构建方法

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5169764A (en) * 1990-08-08 1992-12-08 Regeneron Pharmaceuticals, Inc. Multitrophic and multifunctional chimeric neurotrophic factors, and nucleic acids and plasmids encoding the chimeras
US5488099A (en) * 1992-03-06 1996-01-30 Persson, Deceased; Hakan B. Multifunctional chimeric neurotrophic factors
US5349055A (en) * 1992-03-06 1994-09-20 Persson Hakan B Nerve growth factor having altered receptor binding specificities
EP0644937A4 (en) * 1992-06-12 1995-05-03 Regeneron Pharmaceuticals, Inc. Therapeutic and diagnostic methods based on neurotrophin-4 expression.
US5753225A (en) 1993-12-03 1998-05-19 The Regents Of The University Of California Antibodies that mimic actions of neurotrophins
US5939534A (en) * 1993-12-29 1999-08-17 Sumitomo Pharmaceuticals Company, Limited Factors mutated in the D1 cap region
US7144983B1 (en) * 1997-02-03 2006-12-05 Genentech, Inc. Pantropic neurotrophic factors
US5728803A (en) * 1994-06-03 1998-03-17 Genentech, Inc. Pantropic neurotrophic factors

Also Published As

Publication number Publication date
NZ287762A (en) 1999-01-28
BR9508019B1 (pt) 2012-06-12
US20060270838A1 (en) 2006-11-30
WO1995033829A1 (en) 1995-12-14
FI964833A (fi) 1996-12-03
CA2191064C (en) 2009-11-03
NO317938B1 (no) 2005-01-10
NO965123L (no) 1997-02-03
AU2659295A (en) 1996-01-04
EP0763107A1 (en) 1997-03-19
AU695144B2 (en) 1998-08-06
MX9605971A (es) 1997-12-31
DE69533698D1 (de) 2004-12-02
IL113983A0 (en) 1995-10-31
CA2191064A1 (en) 1995-12-14
JPH10501138A (ja) 1998-02-03
US5981480A (en) 1999-11-09
CN1159439C (zh) 2004-07-28
US5728803A (en) 1998-03-17
US7528233B2 (en) 2009-05-05
DE69533698T2 (de) 2006-02-09
US7935671B2 (en) 2011-05-03
US6333310B1 (en) 2001-12-25
FI964833A0 (fi) 1996-12-03
EP0763107B1 (en) 2004-10-27
BR9508019A (pt) 1997-09-09
NO965123D0 (no) 1996-12-02
CN1153528A (zh) 1997-07-02
ATE280825T1 (de) 2004-11-15
US20100184656A1 (en) 2010-07-22
ES2231786T3 (es) 2005-05-16
PT763107E (pt) 2005-02-28
US6503728B1 (en) 2003-01-07

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