MX9605971A - Factores neurotroficos pantropicos. - Google Patents
Factores neurotroficos pantropicos.Info
- Publication number
- MX9605971A MX9605971A MX9605971A MX9605971A MX9605971A MX 9605971 A MX9605971 A MX 9605971A MX 9605971 A MX9605971 A MX 9605971A MX 9605971 A MX9605971 A MX 9605971A MX 9605971 A MX9605971 A MX 9605971A
- Authority
- MX
- Mexico
- Prior art keywords
- neurotrophic factors
- pantropic
- pantropic neurotrophic
- neurotrophic
- factors
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/18—Growth factors; Growth regulators
- A61K38/185—Nerve growth factor [NGF]; Brain derived neurotrophic factor [BDNF]; Ciliary neurotrophic factor [CNTF]; Glial derived neurotrophic factor [GDNF]; Neurotrophins, e.g. NT-3
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/475—Growth factors; Growth regulators
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/475—Growth factors; Growth regulators
- C07K14/48—Nerve growth factor [NGF]
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Genetics & Genomics (AREA)
- Zoology (AREA)
- Biomedical Technology (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Medicinal Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biophysics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biochemistry (AREA)
- Gastroenterology & Hepatology (AREA)
- Toxicology (AREA)
- Wood Science & Technology (AREA)
- General Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Pharmacology & Pharmacy (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Microbiology (AREA)
- Epidemiology (AREA)
- Physics & Mathematics (AREA)
- Psychology (AREA)
- Plant Pathology (AREA)
- Immunology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Abstract
Se describen los factores neurotroficos pantropicos que tienen multiples especificidades neurotroficas. Los factores neurotroficos pantropicos de la presente invencion son utiles en el tratamiento de desordenes neuronales. Se proporcionan también los ácidos nucléicos y los vectores de expresion que codifican para las neuorotrofinas pantroficas.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US25393794A | 1994-06-03 | 1994-06-03 | |
PCT/US1995/006918 WO1995033829A1 (en) | 1994-06-03 | 1995-06-01 | Pantropic neurotrophic factors |
Publications (1)
Publication Number | Publication Date |
---|---|
MX9605971A true MX9605971A (es) | 1997-12-31 |
Family
ID=22962278
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX9605971A MX9605971A (es) | 1994-06-03 | 1995-06-01 | Factores neurotroficos pantropicos. |
Country Status (17)
Country | Link |
---|---|
US (6) | US5728803A (es) |
EP (1) | EP0763107B1 (es) |
JP (1) | JPH10501138A (es) |
CN (1) | CN1159439C (es) |
AT (1) | ATE280825T1 (es) |
AU (1) | AU695144B2 (es) |
BR (1) | BR9508019B1 (es) |
CA (1) | CA2191064C (es) |
DE (1) | DE69533698T2 (es) |
ES (1) | ES2231786T3 (es) |
FI (1) | FI120237B (es) |
IL (1) | IL113983A0 (es) |
MX (1) | MX9605971A (es) |
NO (1) | NO317938B1 (es) |
NZ (1) | NZ287762A (es) |
PT (1) | PT763107E (es) |
WO (1) | WO1995033829A1 (es) |
Families Citing this family (31)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5728803A (en) * | 1994-06-03 | 1998-03-17 | Genentech, Inc. | Pantropic neurotrophic factors |
DE19637718A1 (de) * | 1996-04-01 | 1997-10-02 | Boehringer Mannheim Gmbh | Rekombinante inaktive Core-Streptavidin Mutanten |
ES2293662T3 (es) | 1996-11-15 | 2008-03-16 | Genentech, Inc. | Purificacion de neurotrofinas. |
US6391571B1 (en) | 1997-04-01 | 2002-05-21 | Roche Diagnostics Gmbh | Recombinant inactive avidin mutants |
AU7154698A (en) * | 1997-04-25 | 1998-11-24 | Genentech Inc. | Ngf variants |
US6365373B2 (en) | 1997-04-25 | 2002-04-02 | Genentech, Inc. | Nucleic acids encoding NGF variants |
US7452863B1 (en) | 1997-04-29 | 2008-11-18 | Genentech, Inc. | NGF variants |
US6663899B2 (en) | 1997-06-13 | 2003-12-16 | Genentech, Inc. | Controlled release microencapsulated NGF formulation |
US6113947A (en) * | 1997-06-13 | 2000-09-05 | Genentech, Inc. | Controlled release microencapsulated NGF formulation |
US6652864B1 (en) * | 1998-12-21 | 2003-11-25 | Asilomar Pharmaceuticals, Inc. | Compounds for intracellular delivery of therapeutic moieties to nerve cells |
US20040120891A1 (en) * | 1998-12-21 | 2004-06-24 | Craig Hill | Compounds for intracellular delivery of therapeutic moieties to nerve cells |
GB0024550D0 (es) | 2000-10-06 | 2000-11-22 | Oxford Biomedica Ltd | |
KR20040049829A (ko) * | 2001-05-30 | 2004-06-12 | 제넨테크, 인크. | 다양한 질환의 치료에 유용한 항-엔지에프 항체 |
AU2003259846A1 (en) * | 2002-08-16 | 2004-03-03 | The General Hospital Corporation | Non-invasive functional imaging of peripheral nervous system activation in humans and animals |
ATE545429T1 (de) | 2002-12-20 | 2012-03-15 | Lundbeck & Co As H | Modulation der neurotrophinaktivität;screeningsverfahren |
WO2006072005A2 (en) * | 2004-12-30 | 2006-07-06 | The Johns Hopkins University | Methods for high efficiency survival/proliferation of human embyonic stem cells and human embyro survival in culture |
LT3225251T (lt) * | 2006-12-21 | 2020-04-10 | H. Lundbeck A/S | Proneurotrofinų veiklos moduliavimas |
WO2009062149A1 (en) * | 2007-11-08 | 2009-05-14 | Creighton University | Methods for maintaining inner ear neurons |
US8447409B2 (en) * | 2008-10-15 | 2013-05-21 | Cochlear Limited | Electroneural interface for a medical implant |
US8259461B2 (en) * | 2008-11-25 | 2012-09-04 | Micron Technology, Inc. | Apparatus for bypassing faulty connections |
US9884909B2 (en) | 2010-12-01 | 2018-02-06 | Alderbio Holdings Llc | Anti-NGF compositions and use thereof |
US9067988B2 (en) | 2010-12-01 | 2015-06-30 | Alderbio Holdings Llc | Methods of preventing or treating pain using anti-NGF antibodies |
US11214610B2 (en) | 2010-12-01 | 2022-01-04 | H. Lundbeck A/S | High-purity production of multi-subunit proteins such as antibodies in transformed microbes such as Pichia pastoris |
US9539324B2 (en) | 2010-12-01 | 2017-01-10 | Alderbio Holdings, Llc | Methods of preventing inflammation and treating pain using anti-NGF compositions |
US9783601B2 (en) | 2010-12-01 | 2017-10-10 | Alderbio Holdings Llc | Methods of preventing inflammation and treating pain using anti-NGF compositions |
US9078878B2 (en) | 2010-12-01 | 2015-07-14 | Alderbio Holdings Llc | Anti-NGF antibodies that selectively inhibit the association of NGF with TrkA, without affecting the association of NGF with p75 |
CN114671940B (zh) | 2016-03-18 | 2023-09-26 | 舒泰神(北京)生物制药股份有限公司 | 神经生长因子突变体 |
CN107286233B (zh) * | 2016-04-13 | 2020-11-06 | 舒泰神(北京)生物制药股份有限公司 | 低痛神经生长因子突变体 |
CN110183536B (zh) * | 2018-02-22 | 2021-01-15 | 中国科学院遗传与发育生物学研究所 | 一种复合支架材料及其应用 |
EP3823674A4 (en) | 2018-07-18 | 2022-12-28 | Manzanita Pharmaceuticals, Inc. | CONJUGATES FOR DELIVERING AN ANTI-CANCER AGENT TO NERVE CELLS, METHODS OF USE AND METHODS OF PRODUCTION THEREOF |
CN110812532A (zh) * | 2019-08-20 | 2020-02-21 | 中山大学 | 一种靶向促进皮质脊髓束连接以修复脊髓损伤的组织工程支架的构建方法 |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5169764A (en) * | 1990-08-08 | 1992-12-08 | Regeneron Pharmaceuticals, Inc. | Multitrophic and multifunctional chimeric neurotrophic factors, and nucleic acids and plasmids encoding the chimeras |
US5488099A (en) * | 1992-03-06 | 1996-01-30 | Persson, Deceased; Hakan B. | Multifunctional chimeric neurotrophic factors |
US5349055A (en) * | 1992-03-06 | 1994-09-20 | Persson Hakan B | Nerve growth factor having altered receptor binding specificities |
JPH07509600A (ja) * | 1992-06-12 | 1995-10-26 | リジェネロン ファーマシューティカルズ,インコーポレーテッド | ニューロトロフィン−4発現に基づく治療および診断法 |
US5753225A (en) | 1993-12-03 | 1998-05-19 | The Regents Of The University Of California | Antibodies that mimic actions of neurotrophins |
AU1282895A (en) * | 1993-12-29 | 1995-07-17 | Sumitomo Pharmaceuticals Company, Limited | Novel human ciliary neurotrophic factor |
US5728803A (en) * | 1994-06-03 | 1998-03-17 | Genentech, Inc. | Pantropic neurotrophic factors |
US7144983B1 (en) * | 1997-02-03 | 2006-12-05 | Genentech, Inc. | Pantropic neurotrophic factors |
-
1995
- 1995-05-12 US US08/440,049 patent/US5728803A/en not_active Expired - Lifetime
- 1995-05-15 US US08/441,513 patent/US5981480A/en not_active Expired - Lifetime
- 1995-06-01 CA CA002191064A patent/CA2191064C/en not_active Expired - Lifetime
- 1995-06-01 AT AT95921550T patent/ATE280825T1/de active
- 1995-06-01 EP EP95921550A patent/EP0763107B1/en not_active Expired - Lifetime
- 1995-06-01 DE DE69533698T patent/DE69533698T2/de not_active Expired - Lifetime
- 1995-06-01 PT PT95921550T patent/PT763107E/pt unknown
- 1995-06-01 ES ES95921550T patent/ES2231786T3/es not_active Expired - Lifetime
- 1995-06-01 IL IL11398395A patent/IL113983A0/xx not_active IP Right Cessation
- 1995-06-01 MX MX9605971A patent/MX9605971A/es active IP Right Grant
- 1995-06-01 WO PCT/US1995/006918 patent/WO1995033829A1/en active IP Right Grant
- 1995-06-01 NZ NZ287762A patent/NZ287762A/xx not_active IP Right Cessation
- 1995-06-01 BR BRPI9508019-8A patent/BR9508019B1/pt not_active IP Right Cessation
- 1995-06-01 CN CNB951933817A patent/CN1159439C/zh not_active Expired - Lifetime
- 1995-06-01 JP JP8501183A patent/JPH10501138A/ja active Pending
- 1995-06-01 AU AU26592/95A patent/AU695144B2/en not_active Expired
-
1996
- 1996-12-02 NO NO19965123A patent/NO317938B1/no not_active IP Right Cessation
- 1996-12-03 FI FI964833A patent/FI120237B/fi not_active IP Right Cessation
-
1997
- 1997-02-03 US US08/794,028 patent/US6503728B1/en not_active Expired - Fee Related
- 1997-04-25 US US08/845,541 patent/US6333310B1/en not_active Expired - Lifetime
-
2006
- 2006-05-30 US US11/443,576 patent/US7528233B2/en not_active Expired - Fee Related
-
2009
- 2009-03-10 US US12/401,483 patent/US7935671B2/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
US5728803A (en) | 1998-03-17 |
US20100184656A1 (en) | 2010-07-22 |
US7528233B2 (en) | 2009-05-05 |
DE69533698T2 (de) | 2006-02-09 |
CA2191064A1 (en) | 1995-12-14 |
US7935671B2 (en) | 2011-05-03 |
FI964833A (fi) | 1996-12-03 |
JPH10501138A (ja) | 1998-02-03 |
US6503728B1 (en) | 2003-01-07 |
US5981480A (en) | 1999-11-09 |
PT763107E (pt) | 2005-02-28 |
ATE280825T1 (de) | 2004-11-15 |
CN1159439C (zh) | 2004-07-28 |
NZ287762A (en) | 1999-01-28 |
BR9508019B1 (pt) | 2012-06-12 |
NO317938B1 (no) | 2005-01-10 |
EP0763107A1 (en) | 1997-03-19 |
AU695144B2 (en) | 1998-08-06 |
NO965123L (no) | 1997-02-03 |
CN1153528A (zh) | 1997-07-02 |
WO1995033829A1 (en) | 1995-12-14 |
BR9508019A (pt) | 1997-09-09 |
CA2191064C (en) | 2009-11-03 |
EP0763107B1 (en) | 2004-10-27 |
DE69533698D1 (de) | 2004-12-02 |
US20060270838A1 (en) | 2006-11-30 |
NO965123D0 (no) | 1996-12-02 |
IL113983A0 (en) | 1995-10-31 |
US6333310B1 (en) | 2001-12-25 |
FI964833A0 (fi) | 1996-12-03 |
ES2231786T3 (es) | 2005-05-16 |
FI120237B (fi) | 2009-08-14 |
AU2659295A (en) | 1996-01-04 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG | Grant or registration |