FI120237B - Pantrofiininen neurotroofiini-polypeptidi - Google Patents

Pantrofiininen neurotroofiini-polypeptidi Download PDF

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Publication number
FI120237B
FI120237B FI964833A FI964833A FI120237B FI 120237 B FI120237 B FI 120237B FI 964833 A FI964833 A FI 964833A FI 964833 A FI964833 A FI 964833A FI 120237 B FI120237 B FI 120237B
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FI
Finland
Prior art keywords
hngf
trka
binding
ngf
neurotrophin
Prior art date
Application number
FI964833A
Other languages
English (en)
Finnish (fi)
Swedish (sv)
Other versions
FI964833A0 (fi
FI964833A (fi
Inventor
Leonard G Presta
Roman Urfer
John Winslow
Original Assignee
Genentech Inc
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Publication date
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Application filed by Genentech Inc filed Critical Genentech Inc
Publication of FI964833A0 publication Critical patent/FI964833A0/fi
Publication of FI964833A publication Critical patent/FI964833A/fi
Application granted granted Critical
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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/18—Growth factors; Growth regulators
    • A61K38/185—Nerve growth factor [NGF]; Brain derived neurotrophic factor [BDNF]; Ciliary neurotrophic factor [CNTF]; Glial derived neurotrophic factor [GDNF]; Neurotrophins, e.g. NT-3
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • C07K14/48—Nerve growth factor [NGF]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Toxicology (AREA)
  • Wood Science & Technology (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Epidemiology (AREA)
  • Plant Pathology (AREA)
  • Immunology (AREA)
  • Psychology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
FI964833A 1994-06-03 1996-12-03 Pantrofiininen neurotroofiini-polypeptidi FI120237B (fi)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US25393794A 1994-06-03 1994-06-03
US25393794 1994-06-03
PCT/US1995/006918 WO1995033829A1 (en) 1994-06-03 1995-06-01 Pantropic neurotrophic factors
US9506918 1995-06-01

Publications (3)

Publication Number Publication Date
FI964833A0 FI964833A0 (fi) 1996-12-03
FI964833A FI964833A (fi) 1996-12-03
FI120237B true FI120237B (fi) 2009-08-14

Family

ID=22962278

Family Applications (1)

Application Number Title Priority Date Filing Date
FI964833A FI120237B (fi) 1994-06-03 1996-12-03 Pantrofiininen neurotroofiini-polypeptidi

Country Status (17)

Country Link
US (6) US5728803A (es)
EP (1) EP0763107B1 (es)
JP (1) JPH10501138A (es)
CN (1) CN1159439C (es)
AT (1) ATE280825T1 (es)
AU (1) AU695144B2 (es)
BR (1) BR9508019B1 (es)
CA (1) CA2191064C (es)
DE (1) DE69533698T2 (es)
ES (1) ES2231786T3 (es)
FI (1) FI120237B (es)
IL (1) IL113983A0 (es)
MX (1) MX9605971A (es)
NO (1) NO317938B1 (es)
NZ (1) NZ287762A (es)
PT (1) PT763107E (es)
WO (1) WO1995033829A1 (es)

Families Citing this family (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5728803A (en) * 1994-06-03 1998-03-17 Genentech, Inc. Pantropic neurotrophic factors
DE19637718A1 (de) 1996-04-01 1997-10-02 Boehringer Mannheim Gmbh Rekombinante inaktive Core-Streptavidin Mutanten
CZ300296B6 (cs) * 1996-11-15 2009-04-15 Genentech, Inc. Zpusob izolace rekombinantního lidského neurotrofinu, neurotrofinový prostredek a zpusob cištení neurotrofinu
US6391571B1 (en) 1997-04-01 2002-05-21 Roche Diagnostics Gmbh Recombinant inactive avidin mutants
US6365373B2 (en) 1997-04-25 2002-04-02 Genentech, Inc. Nucleic acids encoding NGF variants
AU7154698A (en) * 1997-04-25 1998-11-24 Genentech Inc. Ngf variants
US7452863B1 (en) 1997-04-29 2008-11-18 Genentech, Inc. NGF variants
US6113947A (en) * 1997-06-13 2000-09-05 Genentech, Inc. Controlled release microencapsulated NGF formulation
US6663899B2 (en) 1997-06-13 2003-12-16 Genentech, Inc. Controlled release microencapsulated NGF formulation
US6652864B1 (en) * 1998-12-21 2003-11-25 Asilomar Pharmaceuticals, Inc. Compounds for intracellular delivery of therapeutic moieties to nerve cells
US20040120891A1 (en) * 1998-12-21 2004-06-24 Craig Hill Compounds for intracellular delivery of therapeutic moieties to nerve cells
GB0024550D0 (es) 2000-10-06 2000-11-22 Oxford Biomedica Ltd
EP2340849A1 (en) * 2001-05-30 2011-07-06 Genentech, Inc. Anti-NGF antibodies for the treatment of various disorders
WO2004016167A1 (en) * 2002-08-16 2004-02-26 The General Hospital Corporation Non-invasive functional imaging of peripheral nervous system activation in humans and animals
EP1891966B1 (en) * 2002-12-20 2012-02-15 H. Lundbeck A/S Modulation of activity of neurotrophins; screening method
WO2006072005A2 (en) * 2004-12-30 2006-07-06 The Johns Hopkins University Methods for high efficiency survival/proliferation of human embyonic stem cells and human embyro survival in culture
DK2120997T3 (en) * 2006-12-21 2017-05-08 H Lundbeck As MODULATION OF PRO-NEUROTROPHIN ACTIVITY
WO2009062149A1 (en) * 2007-11-08 2009-05-14 Creighton University Methods for maintaining inner ear neurons
US8447409B2 (en) * 2008-10-15 2013-05-21 Cochlear Limited Electroneural interface for a medical implant
US8259461B2 (en) * 2008-11-25 2012-09-04 Micron Technology, Inc. Apparatus for bypassing faulty connections
US9884909B2 (en) 2010-12-01 2018-02-06 Alderbio Holdings Llc Anti-NGF compositions and use thereof
US9539324B2 (en) 2010-12-01 2017-01-10 Alderbio Holdings, Llc Methods of preventing inflammation and treating pain using anti-NGF compositions
US11214610B2 (en) 2010-12-01 2022-01-04 H. Lundbeck A/S High-purity production of multi-subunit proteins such as antibodies in transformed microbes such as Pichia pastoris
US9078878B2 (en) 2010-12-01 2015-07-14 Alderbio Holdings Llc Anti-NGF antibodies that selectively inhibit the association of NGF with TrkA, without affecting the association of NGF with p75
US9067988B2 (en) 2010-12-01 2015-06-30 Alderbio Holdings Llc Methods of preventing or treating pain using anti-NGF antibodies
CN103619879A (zh) 2010-12-01 2014-03-05 奥尔德生物控股有限责任公司 抗ngf组合物及其用途
WO2017157326A1 (zh) 2016-03-18 2017-09-21 舒泰神（北京）生物制药股份有限公司 神经生长因子突变体
CN107286233B (zh) * 2016-04-13 2020-11-06 舒泰神（北京）生物制药股份有限公司 低痛神经生长因子突变体
CN110183536B (zh) * 2018-02-22 2021-01-15 中国科学院遗传与发育生物学研究所 一种复合支架材料及其应用
EP3823674A4 (en) 2018-07-18 2022-12-28 Manzanita Pharmaceuticals, Inc. CONJUGATES FOR DELIVERING AN ANTI-CANCER AGENT TO NERVE CELLS, METHODS OF USE AND METHODS OF PRODUCTION THEREOF
CN110812532A (zh) * 2019-08-20 2020-02-21 中山大学 一种靶向促进皮质脊髓束连接以修复脊髓损伤的组织工程支架的构建方法

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5169764A (en) * 1990-08-08 1992-12-08 Regeneron Pharmaceuticals, Inc. Multitrophic and multifunctional chimeric neurotrophic factors, and nucleic acids and plasmids encoding the chimeras
US5349055A (en) * 1992-03-06 1994-09-20 Persson Hakan B Nerve growth factor having altered receptor binding specificities
US5488099A (en) * 1992-03-06 1996-01-30 Persson, Deceased; Hakan B. Multifunctional chimeric neurotrophic factors
EP0644937A4 (en) * 1992-06-12 1995-05-03 Regeneron Pharmaceuticals, Inc. Therapeutic and diagnostic methods based on neurotrophin-4 expression.
US5753225A (en) * 1993-12-03 1998-05-19 The Regents Of The University Of California Antibodies that mimic actions of neurotrophins
EP0749980A4 (en) * 1993-12-29 1999-09-29 Sumitomo Pharma NEW CELLAR FACTOR FROM HUMAN
US7144983B1 (en) * 1997-02-03 2006-12-05 Genentech, Inc. Pantropic neurotrophic factors
US5728803A (en) * 1994-06-03 1998-03-17 Genentech, Inc. Pantropic neurotrophic factors

Also Published As

Publication number Publication date
JPH10501138A (ja) 1998-02-03
DE69533698T2 (de) 2006-02-09
NO965123L (no) 1997-02-03
DE69533698D1 (de) 2004-12-02
AU2659295A (en) 1996-01-04
NZ287762A (en) 1999-01-28
EP0763107B1 (en) 2004-10-27
MX9605971A (es) 1997-12-31
FI964833A0 (fi) 1996-12-03
IL113983A0 (en) 1995-10-31
CA2191064A1 (en) 1995-12-14
US5981480A (en) 1999-11-09
ATE280825T1 (de) 2004-11-15
CN1153528A (zh) 1997-07-02
EP0763107A1 (en) 1997-03-19
US7528233B2 (en) 2009-05-05
CN1159439C (zh) 2004-07-28
FI964833A (fi) 1996-12-03
ES2231786T3 (es) 2005-05-16
NO317938B1 (no) 2005-01-10
US5728803A (en) 1998-03-17
US6333310B1 (en) 2001-12-25
BR9508019B1 (pt) 2012-06-12
US20060270838A1 (en) 2006-11-30
BR9508019A (pt) 1997-09-09
US7935671B2 (en) 2011-05-03
CA2191064C (en) 2009-11-03
US6503728B1 (en) 2003-01-07
NO965123D0 (no) 1996-12-02
WO1995033829A1 (en) 1995-12-14
PT763107E (pt) 2005-02-28
US20100184656A1 (en) 2010-07-22
AU695144B2 (en) 1998-08-06

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