FI120182B - Trombolyyttisesti aktiivisten proteiinien ja antikoagulanttien yhdistelmiä ja niiden käyttöjä - Google Patents

Trombolyyttisesti aktiivisten proteiinien ja antikoagulanttien yhdistelmiä ja niiden käyttöjä Download PDF

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Publication number
FI120182B
FI120182B FI963802A FI963802A FI120182B FI 120182 B FI120182 B FI 120182B FI 963802 A FI963802 A FI 963802A FI 963802 A FI963802 A FI 963802A FI 120182 B FI120182 B FI 120182B
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FI
Finland
Prior art keywords
heparin
anticoagulant
active protein
pharmaceutical combination
administration
Prior art date
Application number
FI963802A
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English (en)
Finnish (fi)
Swedish (sv)
Other versions
FI963802A (fi
FI963802A0 (fi
Inventor
Stephan Fischer
Ulrich Martin
Original Assignee
Roche Diagnostics Gmbh
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Publication date
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Application filed by Roche Diagnostics Gmbh filed Critical Roche Diagnostics Gmbh
Publication of FI963802A publication Critical patent/FI963802A/fi
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Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/55Protease inhibitors
    • A61K38/57Protease inhibitors from animals; from humans
    • A61K38/58Protease inhibitors from animals; from humans from leeches, e.g. hirudin, eglin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46Hydrolases (3)
    • A61K38/48Hydrolases (3) acting on peptide bonds (3.4)
    • A61K38/49Urokinase; Tissue plasminogen activator
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/08Vasodilators for multiple indications
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/10Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Zoology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Biomedical Technology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
FI963802A 1994-03-25 1996-09-24 Trombolyyttisesti aktiivisten proteiinien ja antikoagulanttien yhdistelmiä ja niiden käyttöjä FI120182B (fi)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US21761894 1994-03-25
US08/217,618 US5510330A (en) 1994-03-25 1994-03-25 Combinations of thrombolytically active proteins and non-heparin anticoagulants, and uses thereof.
EP9501061 1995-03-22
PCT/EP1995/001061 WO1995026202A1 (en) 1994-03-25 1995-03-22 Combinations of thrombolytically active proteins and anticoagulants, and uses thereof

Publications (3)

Publication Number Publication Date
FI963802A FI963802A (fi) 1996-09-24
FI963802A0 FI963802A0 (fi) 1996-09-24
FI120182B true FI120182B (fi) 2009-07-31

Family

ID=22811809

Family Applications (1)

Application Number Title Priority Date Filing Date
FI963802A FI120182B (fi) 1994-03-25 1996-09-24 Trombolyyttisesti aktiivisten proteiinien ja antikoagulanttien yhdistelmiä ja niiden käyttöjä

Country Status (21)

Country Link
US (1) US5510330A (ko)
EP (2) EP0751785B2 (ko)
JP (1) JPH09510439A (ko)
KR (1) KR100366982B1 (ko)
CN (1) CN1090029C (ko)
AT (1) ATE167631T1 (ko)
AU (1) AU702470B2 (ko)
BR (1) BR9507189A (ko)
CA (1) CA2186390A1 (ko)
CZ (1) CZ279596A3 (ko)
DE (1) DE69503120T3 (ko)
DK (1) DK0751785T4 (ko)
ES (1) ES2119411T5 (ko)
FI (1) FI120182B (ko)
MX (1) MX9603925A (ko)
NO (1) NO316584B1 (ko)
NZ (1) NZ282417A (ko)
PL (1) PL182165B1 (ko)
RU (1) RU2166326C2 (ko)
UA (1) UA41398C2 (ko)
WO (1) WO1995026202A1 (ko)

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US20070203520A1 (en) * 1995-06-07 2007-08-30 Dennis Griffin Endovascular filter
US7550005B2 (en) 1995-06-07 2009-06-23 Cook Incorporated Coated implantable medical device
US7896914B2 (en) * 1995-06-07 2011-03-01 Cook Incorporated Coated implantable medical device
US7611533B2 (en) * 1995-06-07 2009-11-03 Cook Incorporated Coated implantable medical device
US6774278B1 (en) * 1995-06-07 2004-08-10 Cook Incorporated Coated implantable medical device
US7846202B2 (en) 1995-06-07 2010-12-07 Cook Incorporated Coated implantable medical device
US7867275B2 (en) * 1995-06-07 2011-01-11 Cook Incorporated Coated implantable medical device method
US5840733A (en) * 1996-07-01 1998-11-24 Redcell, Canada, Inc. Methods and compositions for producing novel conjugates of thrombin inhibitors and endogenous carriers resulting in anti-thrombins with extended lifetimes
US6010911A (en) * 1997-04-30 2000-01-04 Medtronic, Inc. Apparatus for performing a heparin-independent high sensitivity platelet function evaluation technique
US6750201B1 (en) * 1997-10-17 2004-06-15 The Trustees Of The University Of Pennsylvania Compositions and methods for promoting internalization and degradation of urokinase-type plasminogen activator
US6517814B2 (en) 2001-01-09 2003-02-11 Bristol-Myers Squibb Pharma Company Macrocyclic chelants useful for metallopharmaceuticals
DE10115740A1 (de) * 2001-03-26 2002-10-02 Ulrich Speck Zubereitung für die Restenoseprophylaxe
DE10153601A1 (de) * 2001-11-02 2003-05-22 Paion Gmbh DSPA zur Behandlung von Schlaganfall
FI20020197A0 (fi) * 2002-02-01 2002-02-01 Orion Corp Yhdistelmä akuutin myokardiilisen infarktin hoitoon
US7084118B2 (en) 2002-02-22 2006-08-01 Genentech, Inc. Combination treatment with t-PA variant and low molecular weight heparin
DE60335801D1 (de) * 2002-07-12 2011-03-03 Cook William Europ Beschichtete medizinische vorrichtung
DE10244847A1 (de) 2002-09-20 2004-04-01 Ulrich Prof. Dr. Speck Medizinische Vorrichtung zur Arzneimittelabgabe
WO2005116623A2 (en) * 2004-05-17 2005-12-08 Medtronic, Inc. Point of care heparin determination system
US20060222640A1 (en) * 2005-03-29 2006-10-05 Boehringer Ingelheim International Gmbh New pharmaceutical compositions for treatment of thrombosis
TWI482628B (zh) * 2007-10-18 2015-05-01 Lundbeck & Co As H 新穎之血栓溶解病患次群
WO2009080054A1 (en) * 2007-12-21 2009-07-02 Ifxa A/S Protease inhibitor
CA2966332C (en) 2014-11-03 2024-04-16 Thrombolytic Science, Llc Methods and compositions for safe and effective thrombolysis
KR101721068B1 (ko) * 2015-01-30 2017-03-29 고려대학교 산학협력단 베르베논 유도체 및 재관류 치료제를 포함하는 뇌혈관 질환, 동맥경화증 또는 심혈관 질환 치료 또는 예방용 병용 제제
RU2622006C2 (ru) * 2015-06-15 2017-06-08 Федеральное государственное автономное образовательное учреждение высшего профессионального образования "Казанский (Приволжский) федеральный университет" (ФГАОУВПО КФУ) Применение рекомбинантного штамма bacillus subtilis eo-11 вкпм в-11978 в качестве продуцента субтилизиноподобной протеиназы, вещества с тромболитическими и антикоагулянтными свойствами
CN105396127A (zh) * 2015-11-13 2016-03-16 中国人民解放军第四军医大学 一种用于急性心肌梗死的冠状动脉溶栓剂
WO2018232305A1 (en) * 2017-06-16 2018-12-20 Thrombolytic Science, Llc Methods and compositions for thrombolysis
CN117534731A (zh) * 2021-09-24 2024-02-09 江西康之康中药科技有限公司 一种抗凝血肽及其在抗凝血产品上的应用

Family Cites Families (18)

* Cited by examiner, † Cited by third party
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GB8508717D0 (en) * 1985-04-03 1985-05-09 Beecham Group Plc Composition
DK43387A (da) 1986-01-29 1987-07-30 Beecham Group Plc Fibrinolytisk enzym
US5084274A (en) * 1987-11-17 1992-01-28 Scripps Clinic And Research Foundation Inhibition of arterial thrombotic occlusion or thromboembolism
DE3804600A1 (de) * 1988-02-13 1989-08-24 Basf Ag Mischung aus einer thrombolytisch wirkenden und einer antithrombotischen substanz
GB8822147D0 (en) * 1988-09-21 1988-10-26 Ciba Geigy Ag Pharmaceutically active combination
US5204323B1 (en) * 1988-10-06 1995-07-18 Ciba Geigy Corp Hirudin antidotal compositions and methods
GB8826428D0 (en) * 1988-11-11 1988-12-14 Biopharm Ltd Antithrombin
US4980165A (en) * 1989-01-27 1990-12-25 Genetics Institute, Inc. Pharmaceutical formulations of plasminogen activator proteins
DE3903581A1 (de) * 1989-02-07 1990-08-16 Boehringer Mannheim Gmbh Gewebs-plasminogenaktivator-derivat
WO1991001142A1 (en) * 1989-07-20 1991-02-07 Biogen, Inc. Combinations and methods for treating or preventing thrombotic diseases
US5240913A (en) * 1989-08-18 1993-08-31 Biogen, Inc. Inhibitors of thrombin
US5196404B1 (en) * 1989-08-18 1996-09-10 Biogen Inc Inhibitors of thrombin
US5049132A (en) * 1990-01-08 1991-09-17 Cordis Corporation Balloon catheter for delivering therapeutic agents
US5189019A (en) * 1990-04-23 1993-02-23 Merck & Co., Inc. Antistasin derived anticoagulant protein
US5242810A (en) * 1990-12-07 1993-09-07 Biogen, Inc. Bifunctional inhibitors of thrombin and platelet activation
US5242688A (en) * 1990-12-24 1993-09-07 Eli Lilly And Company Method of treating thromboembolic disorders by administration of diglycosylated t-pa variants
EP0580685B1 (de) 1991-04-16 1996-01-03 Roche Diagnostics GmbH Pharmazeutische verpackungseinheit enthaltend plasminogenaktivatoren zur mehrfachbolusgabe
ATE155816T1 (de) 1992-06-03 1997-08-15 Genentech Inc Varianten des gewebeplasminogenaktivators mit verbesserter therapeutischer wirkung

Also Published As

Publication number Publication date
AU702470B2 (en) 1999-02-25
CA2186390A1 (en) 1995-10-05
ES2119411T3 (es) 1998-10-01
DE69503120D1 (de) 1998-07-30
DE69503120T3 (de) 2003-08-14
NO964007D0 (no) 1996-09-24
UA41398C2 (uk) 2001-09-17
FI963802A (fi) 1996-09-24
PL316449A1 (en) 1997-01-20
EP0850648A2 (en) 1998-07-01
NZ282417A (en) 1998-02-26
DK0751785T3 (da) 1999-04-06
WO1995026202A1 (en) 1995-10-05
EP0751785B1 (en) 1998-06-24
NO316584B1 (no) 2004-03-01
BR9507189A (pt) 1997-09-09
AU1951195A (en) 1995-10-17
JPH09510439A (ja) 1997-10-21
PL182165B1 (pl) 2001-11-30
RU2166326C2 (ru) 2001-05-10
EP0850648A3 (en) 2004-03-31
ES2119411T5 (es) 2002-08-01
CZ279596A3 (cs) 1998-01-14
EP0751785B2 (en) 2001-12-19
ATE167631T1 (de) 1998-07-15
DE69503120T2 (de) 1998-11-12
FI963802A0 (fi) 1996-09-24
MX9603925A (es) 1997-04-30
NO964007L (no) 1996-11-25
DK0751785T4 (da) 2002-04-15
EP0751785A1 (en) 1997-01-08
CN1090029C (zh) 2002-09-04
CN1144489A (zh) 1997-03-05
US5510330A (en) 1996-04-23
KR100366982B1 (ko) 2003-08-02

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