FI963802A - Trombolyyttisesti aktiivisten proteiinien ja antikoagulanttien yhdistelmiä ja niiden käyttöjä - Google Patents

Trombolyyttisesti aktiivisten proteiinien ja antikoagulanttien yhdistelmiä ja niiden käyttöjä Download PDF

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Publication number
FI963802A
FI963802A FI963802A FI963802A FI963802A FI 963802 A FI963802 A FI 963802A FI 963802 A FI963802 A FI 963802A FI 963802 A FI963802 A FI 963802A FI 963802 A FI963802 A FI 963802A
Authority
FI
Finland
Prior art keywords
thrombolytically
thrombolytically active
anticoagulants
combinations
anticoagulant
Prior art date
Application number
FI963802A
Other languages
English (en)
Swedish (sv)
Other versions
FI963802A0 (fi
FI120182B (fi
Inventor
Ulrich Martin
Stephan Fischer
Original Assignee
Boehringer Mannheim Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=22811809&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=FI963802(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Boehringer Mannheim Gmbh filed Critical Boehringer Mannheim Gmbh
Publication of FI963802A publication Critical patent/FI963802A/fi
Publication of FI963802A0 publication Critical patent/FI963802A0/fi
Application granted granted Critical
Publication of FI120182B publication Critical patent/FI120182B/fi

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/55—Protease inhibitors
    • A61K38/57—Protease inhibitors from animals; from humans
    • A61K38/58—Protease inhibitors from animals; from humans from leeches, e.g. hirudin, eglin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
    • A61K38/49—Urokinase; Tissue plasminogen activator
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Epidemiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Zoology (AREA)
  • Biomedical Technology (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Diabetes (AREA)
  • Communicable Diseases (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
FI963802A 1994-03-25 1996-09-24 Trombolyyttisesti aktiivisten proteiinien ja antikoagulanttien yhdistelmiä ja niiden käyttöjä FI120182B (fi)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US08/217,618 US5510330A (en) 1994-03-25 1994-03-25 Combinations of thrombolytically active proteins and non-heparin anticoagulants, and uses thereof.
US21761894 1994-03-25
PCT/EP1995/001061 WO1995026202A1 (en) 1994-03-25 1995-03-22 Combinations of thrombolytically active proteins and anticoagulants, and uses thereof
EP9501061 1995-03-22

Publications (3)

Publication Number Publication Date
FI963802A true FI963802A (fi) 1996-09-24
FI963802A0 FI963802A0 (fi) 1996-09-24
FI120182B FI120182B (fi) 2009-07-31

Family

ID=22811809

Family Applications (1)

Application Number Title Priority Date Filing Date
FI963802A FI120182B (fi) 1994-03-25 1996-09-24 Trombolyyttisesti aktiivisten proteiinien ja antikoagulanttien yhdistelmiä ja niiden käyttöjä

Country Status (21)

Country Link
US (1) US5510330A (fi)
EP (2) EP0850648A3 (fi)
JP (1) JPH09510439A (fi)
KR (1) KR100366982B1 (fi)
CN (1) CN1090029C (fi)
AT (1) ATE167631T1 (fi)
AU (1) AU702470B2 (fi)
BR (1) BR9507189A (fi)
CA (1) CA2186390A1 (fi)
CZ (1) CZ279596A3 (fi)
DE (1) DE69503120T3 (fi)
DK (1) DK0751785T4 (fi)
ES (1) ES2119411T5 (fi)
FI (1) FI120182B (fi)
MX (1) MX9603925A (fi)
NO (1) NO316584B1 (fi)
NZ (1) NZ282417A (fi)
PL (1) PL182165B1 (fi)
RU (1) RU2166326C2 (fi)
UA (1) UA41398C2 (fi)
WO (1) WO1995026202A1 (fi)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
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US7550005B2 (en) * 1995-06-07 2009-06-23 Cook Incorporated Coated implantable medical device
US7846202B2 (en) 1995-06-07 2010-12-07 Cook Incorporated Coated implantable medical device
US20070203520A1 (en) * 1995-06-07 2007-08-30 Dennis Griffin Endovascular filter
US6774278B1 (en) 1995-06-07 2004-08-10 Cook Incorporated Coated implantable medical device
US7896914B2 (en) * 1995-06-07 2011-03-01 Cook Incorporated Coated implantable medical device
US7867275B2 (en) * 1995-06-07 2011-01-11 Cook Incorporated Coated implantable medical device method
US7611533B2 (en) * 1995-06-07 2009-11-03 Cook Incorporated Coated implantable medical device
US5840733A (en) * 1996-07-01 1998-11-24 Redcell, Canada, Inc. Methods and compositions for producing novel conjugates of thrombin inhibitors and endogenous carriers resulting in anti-thrombins with extended lifetimes
US6010911A (en) * 1997-04-30 2000-01-04 Medtronic, Inc. Apparatus for performing a heparin-independent high sensitivity platelet function evaluation technique
US6750201B1 (en) * 1997-10-17 2004-06-15 The Trustees Of The University Of Pennsylvania Compositions and methods for promoting internalization and degradation of urokinase-type plasminogen activator
US6517814B2 (en) 2001-01-09 2003-02-11 Bristol-Myers Squibb Pharma Company Macrocyclic chelants useful for metallopharmaceuticals
DE10115740A1 (de) * 2001-03-26 2002-10-02 Ulrich Speck Zubereitung für die Restenoseprophylaxe
DE10153601A1 (de) * 2001-11-02 2003-05-22 Paion Gmbh DSPA zur Behandlung von Schlaganfall
FI20020197A0 (fi) * 2002-02-01 2002-02-01 Orion Corp Yhdistelmä akuutin myokardiilisen infarktin hoitoon
US7084118B2 (en) * 2002-02-22 2006-08-01 Genentech, Inc. Combination treatment with t-PA variant and low molecular weight heparin
ATE495769T1 (de) * 2002-07-12 2011-02-15 Cook Inc Beschichtete medizinische vorrichtung
DE10244847A1 (de) 2002-09-20 2004-04-01 Ulrich Prof. Dr. Speck Medizinische Vorrichtung zur Arzneimittelabgabe
WO2005116623A2 (en) * 2004-05-17 2005-12-08 Medtronic, Inc. Point of care heparin determination system
US20060222640A1 (en) * 2005-03-29 2006-10-05 Boehringer Ingelheim International Gmbh New pharmaceutical compositions for treatment of thrombosis
TWI482628B (zh) * 2007-10-18 2015-05-01 Lundbeck & Co As H 新穎之血栓溶解病患次群
WO2009080054A1 (en) * 2007-12-21 2009-07-02 Ifxa A/S Protease inhibitor
CA2966332C (en) 2014-11-03 2024-04-16 Thrombolytic Science, Llc Methods and compositions for safe and effective thrombolysis
KR101721068B1 (ko) * 2015-01-30 2017-03-29 고려대학교 산학협력단 베르베논 유도체 및 재관류 치료제를 포함하는 뇌혈관 질환, 동맥경화증 또는 심혈관 질환 치료 또는 예방용 병용 제제
RU2622006C2 (ru) * 2015-06-15 2017-06-08 Федеральное государственное автономное образовательное учреждение высшего профессионального образования "Казанский (Приволжский) федеральный университет" (ФГАОУВПО КФУ) Применение рекомбинантного штамма bacillus subtilis eo-11 вкпм в-11978 в качестве продуцента субтилизиноподобной протеиназы, вещества с тромболитическими и антикоагулянтными свойствами
CN105396127A (zh) * 2015-11-13 2016-03-16 中国人民解放军第四军医大学 一种用于急性心肌梗死的冠状动脉溶栓剂
WO2018232305A1 (en) * 2017-06-16 2018-12-20 Thrombolytic Science, Llc Methods and compositions for thrombolysis
CN114292765B (zh) * 2021-09-24 2023-04-07 江西康之康中药科技有限公司 枯草芽孢杆菌纳豆亚种r3及其在发酵水蛭低温干燥品中的应用

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8508717D0 (en) * 1985-04-03 1985-05-09 Beecham Group Plc Composition
DK43387A (da) † 1986-01-29 1987-07-30 Beecham Group Plc Fibrinolytisk enzym
US5084274A (en) * 1987-11-17 1992-01-28 Scripps Clinic And Research Foundation Inhibition of arterial thrombotic occlusion or thromboembolism
DE3804600A1 (de) * 1988-02-13 1989-08-24 Basf Ag Mischung aus einer thrombolytisch wirkenden und einer antithrombotischen substanz
GB8822147D0 (en) * 1988-09-21 1988-10-26 Ciba Geigy Ag Pharmaceutically active combination
US5204323B1 (en) * 1988-10-06 1995-07-18 Ciba Geigy Corp Hirudin antidotal compositions and methods
GB8826428D0 (en) * 1988-11-11 1988-12-14 Biopharm Ltd Antithrombin
US4980165A (en) * 1989-01-27 1990-12-25 Genetics Institute, Inc. Pharmaceutical formulations of plasminogen activator proteins
DE3903581A1 (de) * 1989-02-07 1990-08-16 Boehringer Mannheim Gmbh Gewebs-plasminogenaktivator-derivat
EP0482069A1 (en) * 1989-07-20 1992-04-29 Biogen, Inc. Combinations and methods for treating or preventing thrombotic diseases
US5240913A (en) * 1989-08-18 1993-08-31 Biogen, Inc. Inhibitors of thrombin
US5196404B1 (en) * 1989-08-18 1996-09-10 Biogen Inc Inhibitors of thrombin
US5049132A (en) * 1990-01-08 1991-09-17 Cordis Corporation Balloon catheter for delivering therapeutic agents
US5189019A (en) * 1990-04-23 1993-02-23 Merck & Co., Inc. Antistasin derived anticoagulant protein
US5242810A (en) * 1990-12-07 1993-09-07 Biogen, Inc. Bifunctional inhibitors of thrombin and platelet activation
US5242688A (en) * 1990-12-24 1993-09-07 Eli Lilly And Company Method of treating thromboembolic disorders by administration of diglycosylated t-pa variants
DK0580685T3 (da) † 1991-04-16 1996-03-04 Boehringer Mannheim Gmbh Farmaceutisk emballageenhed indeholdende plasminogenaktivatorer til flerfoldig bolusindgift
DE69312493T2 (de) † 1992-06-03 1998-01-15 Genentech Inc Varianten des gewebeplasminogenaktivators mit verbesserter therapeutischer wirkung

Also Published As

Publication number Publication date
RU2166326C2 (ru) 2001-05-10
DE69503120T3 (de) 2003-08-14
ES2119411T3 (es) 1998-10-01
CN1144489A (zh) 1997-03-05
CA2186390A1 (en) 1995-10-05
EP0751785B2 (en) 2001-12-19
NZ282417A (en) 1998-02-26
NO964007L (no) 1996-11-25
EP0751785B1 (en) 1998-06-24
CZ279596A3 (cs) 1998-01-14
DE69503120D1 (de) 1998-07-30
ATE167631T1 (de) 1998-07-15
DE69503120T2 (de) 1998-11-12
WO1995026202A1 (en) 1995-10-05
PL316449A1 (en) 1997-01-20
JPH09510439A (ja) 1997-10-21
NO964007D0 (no) 1996-09-24
EP0751785A1 (en) 1997-01-08
AU702470B2 (en) 1999-02-25
DK0751785T4 (da) 2002-04-15
MX9603925A (es) 1997-04-30
AU1951195A (en) 1995-10-17
EP0850648A2 (en) 1998-07-01
CN1090029C (zh) 2002-09-04
BR9507189A (pt) 1997-09-09
PL182165B1 (pl) 2001-11-30
NO316584B1 (no) 2004-03-01
DK0751785T3 (da) 1999-04-06
KR100366982B1 (ko) 2003-08-02
FI963802A0 (fi) 1996-09-24
UA41398C2 (uk) 2001-09-17
ES2119411T5 (es) 2002-08-01
FI120182B (fi) 2009-07-31
EP0850648A3 (en) 2004-03-31
US5510330A (en) 1996-04-23

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