FI119911B - Kombinerad terapeutisk behandling av hyperproliferativa sjukdomar - Google Patents
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- FI119911B FI119911B FI973023A FI973023A FI119911B FI 119911 B FI119911 B FI 119911B FI 973023 A FI973023 A FI 973023A FI 973023 A FI973023 A FI 973023A FI 119911 B FI119911 B FI 119911B
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/24—Heavy metals; Compounds thereof
- A61K33/243—Platinum; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/19—Cytokines; Lymphokines; Interferons
- A61K38/191—Tumor necrosis factors [TNF], e.g. lymphotoxin [LT], i.e. TNF-beta
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Immunology (AREA)
- Gastroenterology & Hepatology (AREA)
- Zoology (AREA)
- Molecular Biology (AREA)
- Inorganic Chemistry (AREA)
- Cardiology (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Oncology (AREA)
- Heart & Thoracic Surgery (AREA)
- Hematology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Claims (22)
1. Medicinsk kombination av en eller flera nukle-insyror, som ätminstone partiellt inhiberar onkogena cell- 5 signaleringsrutter, och ett terapeutiskt anticancerämne för samtidig, separat eller tidsmässigt periodiserad an-vändning för behandling av hypertrofipatologier.
2. Kombination enligt patentkrav 1, känneteck-nad av att nukleinsyran är deoxiribonukleinsyra (DNA) el- 10 ler ribonttkleinsyra (RNA) , som kodar en produkt, som Strains tone- partiellt inhiberar onkogena cellsignaleringsrut-ter.
3. Kombination enligt patentkrav 2, kannet eck-n a d av att nukleinsyran är DMA, som kodar antisense-RNA.
4. Kombination enligt patentkrav 2, kanneteck- n a d av att nukleinsyran är DNA, som kodar ligand-RNA.
5. Kombination enligt patentkrav 2, kanneteck-nad av att nukleinsyran är DNA, som kodar en negativ dominant . 2 0
6 . Kombination enligt patentkrav 2, känneteck- nad av att nukleinsyran är DNA, som kodar ScFv.
7. Kombination enligt patentkrav 2, känneteck-n a d av att nukleinsyran är DNA, som kodar en tumorsup-pr e s s o rp r o t e in :.
8. Kombination enligt patentkrav 1, känneteck- n a d av att nukleinsyran är en antisense-oligonukleotid, som eventuellt modifierats kemiskt.
9. Kombination enligt nägot av föregäende patentkrav, kännetecknad av att nukleinsyran är innesluten 30. en vektor..
10. Kombination enligt patentkrav 9, kännetecknad ay att vektorn väljs bland liposomer, nanopar-tiklar, peptidkomplex, katjoniska lipider och lipopoiyami-ner.
11. Kombination enligt patentkrav 9, känne tecknad av att vektorn Ir en virusvektor, som härstänv-mar frän retrovirus, adenovirus;, herpesvirus, AAV, ko-koppsvirus.
12. Kombination enligt näcrot av fpregäende patent-krav, k a n n e t e c k n a d av at t. nukleinsyran adminis treras direkt i det Etalle soin behandias.
13. Kombination enligt patentkrav 1, kanne-5 te cknad av att det: terapeutiska antic an c e r äinne t är ett kemoterapeutiskt ämne valt bland följande* cisplatina, taxQider, etoposid, TItfF, aäriamyein, kamptotecin, vinca-alkaloider och navellein.
14. Kombination enligt patentkrav 13, kanne- 10 te okria d av att det kemoterapeutiska anticanceräinnet är en taxoid.
15. Kombination enligt patentkrav 14, känne tecknad av att det kemoterapeutiska anticanceräinnet väljs bland taxol, docetaxel oeh paclitaxel.
16. Kombination enligt nägot av patentkraven 13 - 15, Itänne te cknad av att det kemoterapeutiska anticancerämnet administreras parenteralt.
17. Kombination enligt nägot av foregdende patentkrav, kännetecknad av att nukleinsyran och det kemo- 20 terapeutiska anticancerämnet används samtidigt.
18. Kombination enligt nägot av patentkraven 1 - 16, kännetecknad av att nukleinsyran ädministreras fore det kemoterapeutiska anticancerämnet.
19. Medicinsk koinbination av en eller flera tumor- 25 suppressorgener och en taxoid för samtidig, separat eller tidsmässigt periodiserad användning för behandling av hy-pertröfipatologier.
20. Kombination enligt patentkrav 19, känne tecknad av att suppressorgenen kodan vild typ p53-pro- 30 tein.
21. Kombination enligt patentkrav 19, kähne- te cknad av att suppressorgenen kodar wafl-protein.
22. Kombination enligt patentkrav 1, kännetecknad av att det terapeutiskä anticancerämnet är ett 35 radioterapeutdskt ämne.
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR9500436 | 1995-01-17 | ||
| FR9500436A FR2729295A1 (fr) | 1995-01-17 | 1995-01-17 | Traitement therapeutique combine des pathologies hyperproliferatives |
| PCT/FR1996/000056 WO1996022101A1 (fr) | 1995-01-17 | 1996-01-12 | Traitement therapeutique combine des pathologies hyperproliferatives |
| FR9600056 | 1996-01-12 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| FI973023A FI973023A (sv) | 1997-07-16 |
| FI973023A0 FI973023A0 (sv) | 1997-07-16 |
| FI119911B true FI119911B (sv) | 2009-05-15 |
Family
ID=9475169
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FI973023A FI119911B (sv) | 1995-01-17 | 1997-07-16 | Kombinerad terapeutisk behandling av hyperproliferativa sjukdomar |
Country Status (21)
| Country | Link |
|---|---|
| US (3) | US6262032B1 (sv) |
| EP (1) | EP0800399B1 (sv) |
| JP (3) | JP4580469B2 (sv) |
| KR (1) | KR100385266B1 (sv) |
| AT (1) | ATE222109T1 (sv) |
| AU (1) | AU716364B2 (sv) |
| BR (1) | BR9606969A (sv) |
| CA (1) | CA2209771C (sv) |
| CZ (1) | CZ298710B6 (sv) |
| DE (1) | DE69622989T2 (sv) |
| DK (1) | DK0800399T3 (sv) |
| ES (1) | ES2180729T3 (sv) |
| FI (1) | FI119911B (sv) |
| FR (1) | FR2729295A1 (sv) |
| HU (1) | HU229484B1 (sv) |
| MX (1) | MX9704490A (sv) |
| NO (1) | NO325418B1 (sv) |
| PT (1) | PT800399E (sv) |
| SI (1) | SI0800399T1 (sv) |
| SK (1) | SK283989B6 (sv) |
| WO (1) | WO1996022101A1 (sv) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20030044396A1 (en) * | 1998-04-21 | 2003-03-06 | Elia James P. | Methods for treating diseases and increasing longevity |
| FR2729295A1 (fr) * | 1995-01-17 | 1996-07-19 | Rhone Poulenc Rorer Sa | Traitement therapeutique combine des pathologies hyperproliferatives |
| US7087582B1 (en) | 1995-09-26 | 2006-08-08 | Regents Of The University Of Michigan | Combination for site-specifically transforming cells in vivo comprising a double-balloon catheter and nucleic acid comprising a gene encoding P21 |
| US5744460A (en) * | 1996-03-07 | 1998-04-28 | Novartis Corporation | Combination for treatment of proliferative diseases |
| US20030060434A1 (en) * | 1997-02-18 | 2003-03-27 | Loretta Nielsen | Combined tumor suppressor gene therapy and chemotherapy in the treatment of neoplasms |
| US20030064949A1 (en) * | 1998-02-17 | 2003-04-03 | Loretta Nielsen | Combined tumor suppressor gene therapy and chemotherapy in the treatment of neoplasms |
| JP4458746B2 (ja) * | 2001-01-16 | 2010-04-28 | グラクソ グループ リミテッド | 癌の治療方法 |
| KR101051785B1 (ko) * | 2003-06-30 | 2011-07-26 | 유니베르시떼 드 로잔느 | 암세포를 선택적으로 사멸시키기 위한 ＲａｓＧＡＰ 유래펩티드 |
| WO2005061007A1 (ja) * | 2003-12-24 | 2005-07-07 | St. Marianna University School Of Medicine | 癌の抑制方法 |
| JPWO2005061001A1 (ja) * | 2003-12-24 | 2007-07-12 | 株式会社ロコモジェン | 癌の抑制方法 |
| GB0406415D0 (en) * | 2004-03-22 | 2004-04-21 | Inst Of Cancer Res The | Materials and methods for treatment of cancer |
| US8124598B2 (en) | 2006-09-14 | 2012-02-28 | Sharon Sageman | 7-keto DHEA for psychiatric use |
| US20100111874A1 (en) * | 2007-03-19 | 2010-05-06 | University Of Medicine And Dentistry Of New Jresey | Method of cancer detection and treatment |
| US20100160274A1 (en) * | 2007-09-07 | 2010-06-24 | Sharon Sageman | 7-KETO DHEA for Psychiatric Use |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3751307T2 (de) * | 1986-03-28 | 1995-09-21 | Univ Illinois | Zubereitungen und verfahren für klone, die, mit mehrfacharzneimittelresistenz assoziierte, dna-sequenzen in menschlichen zellen enthalten. |
| US6410010B1 (en) | 1992-10-13 | 2002-06-25 | Board Of Regents, The University Of Texas System | Recombinant P53 adenovirus compositions |
| US5747469A (en) | 1991-03-06 | 1998-05-05 | Board Of Regents, The University Of Texas System | Methods and compositions comprising DNA damaging agents and p53 |
| CA2136091A1 (en) * | 1992-05-20 | 1993-11-25 | Daniel S. Martin | Chemotherapeutic drug combinations |
| ATE195869T1 (de) * | 1992-05-28 | 2000-09-15 | Xenova Ltd | Acridin carboxamide zur behandlung von krebs |
| FR2694296B1 (fr) * | 1992-07-30 | 1994-09-02 | Rhone Poulenc Rorer Sa | Peptides inhibant l'activité des protéines ras, préparation et utilisation. |
| JPH08504095A (ja) * | 1992-09-18 | 1996-05-07 | カンジ，インコーポレイテッド | 腫瘍抑制遺伝子を有するレトロウイルスベクターによる遺伝子療法 |
| FR2697752B1 (fr) * | 1992-11-10 | 1995-04-14 | Rhone Poulenc Rorer Sa | Compositions antitumorales contenant des dérivés du taxane. |
| TW442569B (en) | 1993-10-25 | 2001-06-23 | Canji Inc | Recombinant adenoviral vector |
| FR2729295A1 (fr) * | 1995-01-17 | 1996-07-19 | Rhone Poulenc Rorer Sa | Traitement therapeutique combine des pathologies hyperproliferatives |
| US5789244A (en) | 1996-01-08 | 1998-08-04 | Canji, Inc. | Compositions and methods for the treatment of cancer using recombinant viral vector delivery systems |
| US6054467A (en) | 1996-07-05 | 2000-04-25 | Sidney Kimmel Cancer Center | Down-regulation of DNA repair to enhance sensitivity to P53-mediated apoptosis |
-
1995
- 1995-01-17 FR FR9500436A patent/FR2729295A1/fr active Granted
-
1996
- 1996-01-12 EP EP96901387A patent/EP0800399B1/fr not_active Expired - Lifetime
- 1996-01-12 MX MX9704490A patent/MX9704490A/es unknown
- 1996-01-12 AT AT96901387T patent/ATE222109T1/de not_active IP Right Cessation
- 1996-01-12 DE DE69622989T patent/DE69622989T2/de not_active Expired - Lifetime
- 1996-01-12 SI SI9630511T patent/SI0800399T1/xx unknown
- 1996-01-12 WO PCT/FR1996/000056 patent/WO1996022101A1/fr active IP Right Grant
- 1996-01-12 KR KR1019970704839A patent/KR100385266B1/ko not_active IP Right Cessation
- 1996-01-12 HU HU9802423A patent/HU229484B1/hu unknown
- 1996-01-12 SK SK957-97A patent/SK283989B6/sk not_active IP Right Cessation
- 1996-01-12 JP JP52207896A patent/JP4580469B2/ja not_active Expired - Lifetime
- 1996-01-12 ES ES96901387T patent/ES2180729T3/es not_active Expired - Lifetime
- 1996-01-12 DK DK96901387T patent/DK0800399T3/da active
- 1996-01-12 CA CA2209771A patent/CA2209771C/fr not_active Expired - Lifetime
- 1996-01-12 BR BR9606969A patent/BR9606969A/pt not_active Application Discontinuation
- 1996-01-12 AU AU45429/96A patent/AU716364B2/en not_active Expired
- 1996-01-12 CZ CZ0226297A patent/CZ298710B6/cs not_active IP Right Cessation
- 1996-01-12 PT PT96901387T patent/PT800399E/pt unknown
- 1996-01-12 US US08/875,222 patent/US6262032B1/en not_active Expired - Lifetime
-
1997
- 1997-07-09 NO NO19973197A patent/NO325418B1/no not_active IP Right Cessation
- 1997-07-16 FI FI973023A patent/FI119911B/sv not_active IP Right Cessation
-
2001
- 2001-03-26 US US09/816,144 patent/US20010021395A1/en not_active Abandoned
-
2003
- 2003-04-14 US US10/412,684 patent/US7884082B2/en not_active Expired - Fee Related
-
2008
- 2008-01-09 JP JP2008001848A patent/JP2008133291A/ja not_active Withdrawn
-
2011
- 2011-09-22 JP JP2011206858A patent/JP5031921B2/ja not_active Expired - Lifetime
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