FI117436B - Menetelmä levobupivakaiinin ja sen analogien optisesti rikastuneen muodon rasemisoimiseksi - Google Patents
Menetelmä levobupivakaiinin ja sen analogien optisesti rikastuneen muodon rasemisoimiseksi Download PDFInfo
- Publication number
- FI117436B FI117436B FI971202A FI971202A FI117436B FI 117436 B FI117436 B FI 117436B FI 971202 A FI971202 A FI 971202A FI 971202 A FI971202 A FI 971202A FI 117436 B FI117436 B FI 117436B
- Authority
- FI
- Finland
- Prior art keywords
- acid
- compound
- racemization
- optically enriched
- pct
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/60—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B53/00—Asymmetric syntheses
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B55/00—Racemisation; Complete or partial inversion
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Hydrogenated Pyridines (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
- Saccharide Compounds (AREA)
- Measurement Of Radiation (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Applications Claiming Priority (6)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP94306962 | 1994-09-23 | ||
| EP94306962 | 1994-09-23 | ||
| GB9504927 | 1995-03-10 | ||
| GBGB9504927.6A GB9504927D0 (en) | 1995-03-10 | 1995-03-10 | Racemisation and asymmetric transformation |
| GB9502247 | 1995-09-22 | ||
| PCT/GB1995/002247 WO1996009290A1 (en) | 1994-09-23 | 1995-09-22 | Racemisation and asymmetric transformation processes used in the manufacture of levobupivacaine and analogues thereof |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| FI971202A FI971202A (fi) | 1997-03-21 |
| FI971202A0 FI971202A0 (fi) | 1997-03-21 |
| FI117436B true FI117436B (fi) | 2006-10-13 |
Family
ID=26137306
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FI971202A FI117436B (fi) | 1994-09-23 | 1997-03-21 | Menetelmä levobupivakaiinin ja sen analogien optisesti rikastuneen muodon rasemisoimiseksi |
Country Status (18)
| Country | Link |
|---|---|
| US (1) | US5786484A (pt) |
| EP (1) | EP0782569B1 (pt) |
| JP (1) | JP3898220B2 (pt) |
| KR (1) | KR100393133B1 (pt) |
| CN (1) | CN1104416C (pt) |
| AT (1) | ATE214695T1 (pt) |
| AU (1) | AU695479B2 (pt) |
| CA (1) | CA2200490C (pt) |
| DE (1) | DE69525950T2 (pt) |
| DK (1) | DK0782569T3 (pt) |
| ES (1) | ES2173194T3 (pt) |
| FI (1) | FI117436B (pt) |
| HU (1) | HU216291B (pt) |
| MX (1) | MX9702210A (pt) |
| NO (1) | NO308074B1 (pt) |
| PL (1) | PL183204B1 (pt) |
| PT (1) | PT782569E (pt) |
| WO (1) | WO1996009290A1 (pt) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6384227B2 (en) | 1995-01-18 | 2002-05-07 | Darwin Discovery Ltd. | Racemisation process for use in the manufacture of levobupivacaine and related piperidinecarboxanilide anaesthetic agents |
| JP2000256359A (ja) * | 1999-03-11 | 2000-09-19 | Japan Science & Technology Corp | 面性キラリティーを有する分子群の高選択的不斉変換法 |
| US6288280B1 (en) * | 1999-07-09 | 2001-09-11 | Hoffmann-La Roche Inc. | Racemization of atropisomeric bis(phosphine oxide) compounds |
| BR0002246A (pt) | 2000-04-06 | 2003-04-15 | Cristalia Prod Quimicos Farm | Processo de obtenção dos enantiÈmeros da bupivacaìna racêmica, processo de obtenção de composições farmacêuticas a base de levobupivacaìna: composições farmacêuticas a base de levobupivacaìna formuladas nas formas básicas ou sais farmaceuticamente aceitáveis e utilização das composições farmacêuticas a base de levobupivacaìna formuladas nas formas básicas ou sais farmaceuticamente aceitáveis |
| US6962998B2 (en) | 2000-06-14 | 2005-11-08 | Toray Industries, Inc. | Processes for producing racemic piperidine derivative and for producing optically active piperidine derivative |
| DE10029851A1 (de) * | 2000-06-16 | 2001-12-20 | Boehringer Ingelheim Pharma | Enantiomerentrennung von Piperidon-Derivaten unter gleichzeitiger in situ Racemisierung des unerwünschten Enantiomers |
| US6495694B2 (en) | 2000-06-16 | 2002-12-17 | Boehringer Ingelheim Pharma Kg | Efficient separation of enantiomers of piperidone derivatives by precipitation of the desired eantiomer during in situ racemization of the unwanted enantiomer |
| BRPI0104491B8 (pt) * | 2001-10-10 | 2021-05-25 | Cristalia Produtos Quim Farmaceuticos Ltda | n-(2,6-dimetilfenil)-1-propil-2-piperidinocarboxamida; processo de obtenção dos enantiômeros; mistura não racêmica dos anantiômeros e seu processo de obtenção e composição farmacêutica. |
| US20040001889A1 (en) | 2002-06-25 | 2004-01-01 | Guohua Chen | Short duration depot formulations |
| EP2218448B1 (en) | 2002-12-13 | 2015-09-23 | Durect Corporation | Oral drug delivery system comprising high viscosity liquid carrier materials |
| CA2581287C (en) * | 2004-09-17 | 2015-08-25 | Durect Corporation | Sustained local anesthetic composition containing bupivacaine and saib |
| US20070027105A1 (en) | 2005-07-26 | 2007-02-01 | Alza Corporation | Peroxide removal from drug delivery vehicle |
| AU2007325918B2 (en) | 2006-11-03 | 2013-10-17 | Durect Corporation | Transdermal delivery systems comprising bupivacaine |
| JP2011506319A (ja) | 2007-12-06 | 2011-03-03 | デュレクト コーポレーション | 疼痛、関節炎症状、または慢性疾患に伴う炎症の治療に有用な方法 |
| US20100260844A1 (en) | 2008-11-03 | 2010-10-14 | Scicinski Jan J | Oral pharmaceutical dosage forms |
| CN102093284B (zh) * | 2010-12-29 | 2013-05-08 | 宜昌人福药业有限责任公司 | 富集哌啶-2-甲酰苯胺类旋光化合物的方法 |
| AU2014233453A1 (en) | 2013-03-15 | 2015-10-01 | Durect Corporation | Compositions with a rheological modifier to reduce dissolution variability |
| CN103664744B (zh) * | 2013-11-30 | 2015-07-15 | 山东永泰化工有限公司 | 一种左布比卡因的制备方法 |
| CA3100706A1 (en) * | 2018-05-18 | 2019-11-21 | Kura Oncology, Inc. | Synthesis of tipifarnib |
| BR112022013784A2 (pt) | 2020-01-13 | 2022-10-11 | Durect Corp | Sistemas de distribuição de fármacos de liberação prolongada com impurezas reduzidas e métodos relacionados |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SE451840B (sv) * | 1986-01-03 | 1987-11-02 | Astra Laekemedel Ab | Optiskt rent monohydrat av s-(-)-1-propyl-2',6'-pipekoloxylididhydroklorid, sett att framstella denna och farmaceutiska beredningar for lokalbedovning |
-
1995
- 1995-09-22 ES ES95932092T patent/ES2173194T3/es not_active Expired - Lifetime
- 1995-09-22 HU HU9702212A patent/HU216291B/hu unknown
- 1995-09-22 EP EP95932092A patent/EP0782569B1/en not_active Expired - Lifetime
- 1995-09-22 JP JP51069496A patent/JP3898220B2/ja not_active Expired - Lifetime
- 1995-09-22 AU AU35279/95A patent/AU695479B2/en not_active Expired
- 1995-09-22 CN CN95195252A patent/CN1104416C/zh not_active Expired - Lifetime
- 1995-09-22 AT AT95932092T patent/ATE214695T1/de active
- 1995-09-22 DK DK95932092T patent/DK0782569T3/da active
- 1995-09-22 KR KR1019970701774A patent/KR100393133B1/ko not_active IP Right Cessation
- 1995-09-22 CA CA002200490A patent/CA2200490C/en not_active Expired - Lifetime
- 1995-09-22 US US08/809,941 patent/US5786484A/en not_active Expired - Lifetime
- 1995-09-22 PL PL95319368A patent/PL183204B1/pl unknown
- 1995-09-22 MX MX9702210A patent/MX9702210A/es unknown
- 1995-09-22 WO PCT/GB1995/002247 patent/WO1996009290A1/en active IP Right Grant
- 1995-09-22 DE DE69525950T patent/DE69525950T2/de not_active Expired - Lifetime
- 1995-09-22 PT PT95932092T patent/PT782569E/pt unknown
-
1997
- 1997-03-21 NO NO971358A patent/NO308074B1/no not_active IP Right Cessation
- 1997-03-21 FI FI971202A patent/FI117436B/fi not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| PL183204B1 (pl) | 2002-06-28 |
| DE69525950D1 (de) | 2002-04-25 |
| AU3527995A (en) | 1996-04-09 |
| ES2173194T3 (es) | 2002-10-16 |
| PT782569E (pt) | 2002-09-30 |
| JP3898220B2 (ja) | 2007-03-28 |
| DE69525950T2 (de) | 2002-09-19 |
| US5786484A (en) | 1998-07-28 |
| NO971358L (no) | 1997-03-21 |
| EP0782569B1 (en) | 2002-03-20 |
| PL319368A1 (en) | 1997-08-04 |
| DK0782569T3 (da) | 2002-07-22 |
| CN1104416C (zh) | 2003-04-02 |
| AU695479B2 (en) | 1998-08-13 |
| NO971358D0 (no) | 1997-03-21 |
| KR100393133B1 (ko) | 2003-11-17 |
| ATE214695T1 (de) | 2002-04-15 |
| NO308074B1 (no) | 2000-07-17 |
| CA2200490C (en) | 2007-01-09 |
| WO1996009290A1 (en) | 1996-03-28 |
| CA2200490A1 (en) | 1996-03-28 |
| FI971202A (fi) | 1997-03-21 |
| JPH10505855A (ja) | 1998-06-09 |
| FI971202A0 (fi) | 1997-03-21 |
| HU216291B (hu) | 1999-06-28 |
| MX9702210A (es) | 1998-05-31 |
| HUT77055A (hu) | 1998-03-02 |
| CN1159184A (zh) | 1997-09-10 |
| EP0782569A1 (en) | 1997-07-09 |
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| FG | Patent granted |
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