FI115397B - Menetelmä kiraalisen tetralonin valmistamiseksi - Google Patents

Menetelmä kiraalisen tetralonin valmistamiseksi Download PDF

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Publication number
FI115397B
FI115397B FI962250A FI962250A FI115397B FI 115397 B FI115397 B FI 115397B FI 962250 A FI962250 A FI 962250A FI 962250 A FI962250 A FI 962250A FI 115397 B FI115397 B FI 115397B
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FI
Finland
Prior art keywords
tetralone
phenyl
formula
alkyl
compound
Prior art date
Application number
FI962250A
Other languages
English (en)
Finnish (fi)
Swedish (sv)
Other versions
FI962250A (fi
FI962250A0 (fi
Inventor
George J Quallich
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Publication of FI962250A publication Critical patent/FI962250A/fi
Publication of FI962250A0 publication Critical patent/FI962250A0/fi
Application granted granted Critical
Publication of FI115397B publication Critical patent/FI115397B/fi

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/587—Unsaturated compounds containing a keto groups being part of a ring
    • C07C49/687—Unsaturated compounds containing a keto groups being part of a ring containing halogen
    • C07C49/697—Unsaturated compounds containing a keto groups being part of a ring containing halogen containing six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B53/00—Asymmetric syntheses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C29/00—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring
    • C07C29/132—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring by reduction of an oxygen containing functional group
    • C07C29/136—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring by reduction of an oxygen containing functional group of >C=O containing groups, e.g. —COOH
    • C07C29/143—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring by reduction of an oxygen containing functional group of >C=O containing groups, e.g. —COOH of ketones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C35/00—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a ring other than a six-membered aromatic ring
    • C07C35/22—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a ring other than a six-membered aromatic ring polycyclic, at least one hydroxy group bound to a condensed ring system
    • C07C35/23—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a ring other than a six-membered aromatic ring polycyclic, at least one hydroxy group bound to a condensed ring system with hydroxy on a condensed ring system having two rings
    • C07C35/36—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a ring other than a six-membered aromatic ring polycyclic, at least one hydroxy group bound to a condensed ring system with hydroxy on a condensed ring system having two rings the condensed ring system being a (4.4.0) system, e.g. naphols
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/27—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by oxidation
    • C07C45/30—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by oxidation with halogen containing compounds, e.g. hypohalogenation
    • C07C45/305—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by oxidation with halogen containing compounds, e.g. hypohalogenation with halogenochromate reagents, e.g. pyridinium chlorochromate
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
    • C07C45/67—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07—Optical isomers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2602/00—Systems containing two condensed rings
    • C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
    • C07C2602/04—One of the condensed rings being a six-membered aromatic ring
    • C07C2602/10—One of the condensed rings being a six-membered aromatic ring the other ring being six-membered, e.g. tetraline

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
FI962250A 1993-11-30 1996-05-29 Menetelmä kiraalisen tetralonin valmistamiseksi FI115397B (fi)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US15915693A 1993-11-30 1993-11-30
US15915693 1993-11-30
PCT/IB1994/000263 WO1995015299A1 (fr) 1993-11-30 1994-09-02 Procede de preparation d'une tetralone chirale
IB9400263 1994-09-02

Publications (3)

Publication Number Publication Date
FI962250A FI962250A (fi) 1996-05-29
FI962250A0 FI962250A0 (fi) 1996-05-29
FI115397B true FI115397B (fi) 2005-04-29

Family

ID=22571320

Family Applications (1)

Application Number Title Priority Date Filing Date
FI962250A FI115397B (fi) 1993-11-30 1996-05-29 Menetelmä kiraalisen tetralonin valmistamiseksi

Country Status (11)

Country Link
US (1) US5750794A (fr)
EP (1) EP0724552B1 (fr)
JP (1) JP2686366B2 (fr)
AT (1) ATE159706T1 (fr)
CA (1) CA2176500C (fr)
DE (1) DE69406553T2 (fr)
DK (1) DK0724552T3 (fr)
ES (1) ES2108484T3 (fr)
FI (1) FI115397B (fr)
GR (1) GR3025223T3 (fr)
WO (1) WO1995015299A1 (fr)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH06329679A (ja) * 1993-01-20 1994-11-29 Nissan Chem Ind Ltd 光学活性β−アミノアルコキシボラン錯体
US5831132A (en) * 1994-10-28 1998-11-03 Sumika Fine Chemicals Company, Ltd. Process for producing optically active carbinols
US6410794B1 (en) 1994-12-16 2002-06-25 Uop Llc Process for preparation of pharmaceutically desired chiral tetralone from tetralones
US6103938A (en) * 1998-04-23 2000-08-15 Ciba Specialty Chemicals Corporation Process for preparing 4-(substituted phenyl)-3,4-dihydro-2H-naphthalen-1-ones
IL132500A0 (en) * 1998-10-29 2001-03-19 Pfizer Prod Inc Stereoselective microbial reduction of a racemic tetralone
IN187170B (fr) 2000-01-04 2002-02-23 Sun Pharmaceutical Ind Ltd
US6720003B2 (en) * 2001-02-16 2004-04-13 Andrx Corporation Serotonin reuptake inhibitor formulations
US6683220B2 (en) * 2001-10-31 2004-01-27 Pfizer, Inc. Process for the preparation of optically pure or enriched racemic tetralone
EP1545485A2 (fr) * 2002-09-16 2005-06-29 Sepracor Inc. TRAITEMENT DE TROUBLES DU SNC PAR i TRANS /i 4-(3,4-DICHLOROPHENYL)-1,2,3,4-TETRAHYDRO- i N /i -METHYL-1-NAPTHALENAMINE
US7772240B2 (en) 2003-08-18 2010-08-10 H. Lundbeck A/S Trans-1(6-chloro-3-phenylindan-1-yl)-3,3-dimethylpiperazine
TWI376373B (en) 2005-02-16 2012-11-11 Lundbeck & Co As H Crystalline base of a pharmaceutical compound
TWI453198B (zh) 2005-02-16 2014-09-21 Lundbeck & Co As H 製造反式-1-((1r,3s)-6-氯基-3-苯基茚滿-1-基) -3 , 3 -二甲基六氫吡與其鹽類之方法及製造4-((1r , 3s）-6 -氯基-3-苯基茚滿-1-基 )-1,2,2-三甲基六氫吡與其鹽類之方法

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4536518A (en) * 1979-11-01 1985-08-20 Pfizer Inc. Antidepressant derivatives of cis-4-phenyl-1,2,3,4-tetrahydro-1-naphthalenamine
US4556676A (en) * 1979-11-01 1985-12-03 Pfizer Inc. Antidepressant derivatives of trans-4-phenyl-1,2,3,4-tetrahydro-1-naphthalenamine
JPH0621109B2 (ja) * 1984-07-09 1994-03-23 ダイキン工業株式会社 含フツ素アクリル酸エステル
US4772752A (en) * 1986-08-29 1988-09-20 Aldrich-Boranes, Inc. Mono- and diisopinocampheylhaloboranes as new chiral reducing agents
US4839104A (en) * 1987-06-11 1989-06-13 Pfizer, Inc. Process for preparing sertraline intermediates
US4777288A (en) * 1987-06-11 1988-10-11 Pfizer Inc. Process for preparing a 4,4-diphenylbutanoic acid derivative
FI95572C (fi) * 1987-06-22 1996-02-26 Eisai Co Ltd Menetelmä lääkeaineena käyttökelpoisen piperidiinijohdannaisten tai sen farmaseuttisen suolan valmistamiseksi
US4943635A (en) * 1987-08-27 1990-07-24 President & Fellows Of Harvard College Enantioselective reduction of ketones
FR2632633B1 (fr) * 1988-06-08 1991-04-05 Delalande Sa Procede de preparation de 4-aryl-1-tetralones
US5189177A (en) * 1990-04-18 1993-02-23 Merck & Co., Inc. Chiral boron catalysts for reduction of ketones and process for their preparation
US5082970A (en) * 1991-03-06 1992-01-21 Pfizer Inc. Process for recycling amine isomer
US5196607A (en) * 1992-02-14 1993-03-23 Pfizer Inc. Process for preparing ketone enantiomer
SE470242B (sv) * 1992-05-12 1993-12-13 Ericsson Telefon Ab L M Anordning för generering av slumptal
CA2134096C (fr) * 1992-05-14 1997-11-25 George J. Quallich Catalyseurs d'oxazaborolidine enantioselectifs

Also Published As

Publication number Publication date
FI962250A (fi) 1996-05-29
GR3025223T3 (en) 1998-02-27
DE69406553D1 (de) 1997-12-04
DE69406553T2 (de) 1998-02-26
FI962250A0 (fi) 1996-05-29
EP0724552A1 (fr) 1996-08-07
CA2176500A1 (fr) 1995-06-08
DK0724552T3 (da) 1997-12-22
JPH09500390A (ja) 1997-01-14
CA2176500C (fr) 1999-09-28
ATE159706T1 (de) 1997-11-15
ES2108484T3 (es) 1997-12-16
US5750794A (en) 1998-05-12
EP0724552B1 (fr) 1997-10-29
WO1995015299A1 (fr) 1995-06-08
JP2686366B2 (ja) 1997-12-08

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